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Entry version 145 (10 Feb 2021)
Sequence version 2 (01 Nov 1997)
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Protein

Enterobactin exporter EntS

Gene

entS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of an export pathway for enterobactin (PubMed:12068807). Overexpression reduces intracellular arabinose concentrations (PubMed:22952739).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YBDA-MONOMER
MetaCyc:YBDA-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.38.1, the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enterobactin exporter EntSUniRule annotationCurated
Alternative name(s):
Protein p43
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:entS1 PublicationUniRule annotation
Synonyms:ybdA
Ordered Locus Names:b0591, JW0583
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicUniRule annotationCuratedAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Topological domaini43 – 55PeriplasmicUniRule annotationCuratedAdd BLAST13
Transmembranei56 – 76HelicalUniRule annotationAdd BLAST21
Topological domaini77 – 83CytoplasmicUniRule annotationCurated7
Transmembranei84 – 104HelicalUniRule annotationAdd BLAST21
Topological domaini105 – 109PeriplasmicUniRule annotationCurated5
Transmembranei110 – 130HelicalUniRule annotationAdd BLAST21
Topological domaini131 – 156CytoplasmicUniRule annotationCuratedAdd BLAST26
Transmembranei157 – 177HelicalUniRule annotationAdd BLAST21
Topological domaini178PeriplasmicUniRule annotationCurated1
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Topological domaini200 – 218CytoplasmicUniRule annotationCuratedAdd BLAST19
Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Topological domaini240 – 256PeriplasmicUniRule annotationCuratedAdd BLAST17
Transmembranei257 – 277HelicalUniRule annotationAdd BLAST21
Topological domaini278 – 287CytoplasmicUniRule annotationCurated10
Transmembranei288 – 307HelicalUniRule annotationAdd BLAST20
Topological domaini308 – 313PeriplasmicUniRule annotationCurated6
Transmembranei314 – 336HelicalUniRule annotationAdd BLAST23
Topological domaini337 – 356CytoplasmicUniRule annotationCuratedAdd BLAST20
Transmembranei357 – 377HelicalUniRule annotationAdd BLAST21
Topological domaini378PeriplasmicUniRule annotationCurated1
Transmembranei379 – 399HelicalUniRule annotationAdd BLAST21
Topological domaini400 – 416CytoplasmicUniRule annotation1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant is unable to secrete enterobactin efficiently. It secretes little, if any, enterobactin, but elevated levels of enterobactin breakdown products 2,3-dihydroxybenzoylserine (DHBS) monomer, dimer and trimer.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001686611 – 416Enterobactin exporter EntSAdd BLAST416

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24077

PRoteomics IDEntifications database

More...
PRIDEi
P24077

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260903, 384 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b0591

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family. [View classification]UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0477, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034180_11_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24077

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24077

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01436, MFS_EntS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023722, Enterobactin_exp_EntS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR010290, TM_effector

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05977, MFS_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P24077-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKQSWLLNL SLLKTHPAFR AVFLARFISI VSLGLLGVAV PVQIQMMTHS
60 70 80 90 100
TWQVGLSVTL TGGAMFVGLM VGGVLADRYE RKKVILLARG TCGIGFIGLC
110 120 130 140 150
LNALLPEPSL LAIYLLGLWD GFFASLGVTA LLAATPALVG RENLMQAGAI
160 170 180 190 200
TMLTVRLGSV ISPMIGGLLL ATGGVAWNYG LAAAGTFITL LPLLSLPALP
210 220 230 240 250
PPPQPREHPL KSLLAGFRFL LASPLVGGIA LLGGLLTMAS AVRVLYPALA
260 270 280 290 300
DNWQMSAAQI GFLYAAIPLG AAIGALTSGK LAHSARPGLL MLLSTLGSFL
310 320 330 340 350
AIGLFGLMPM WILGVVCLAL FGWLSAVSSL LQYTMLQTQT PEAMLGRING
360 370 380 390 400
LWTAQNVTGD AIGAALLGGL GAMMTPVASA SASGFGLLII GVLLLLVLVE
410
LRHFRQTPPQ VTASDS
Length:416
Mass (Da):43,282
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i64FCCF9AF99AC25A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123F → S in CAA40706 (PubMed:1838574).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57470 Genomic DNA Translation: CAA40706.1
X59402 Genomic DNA Translation: CAA42044.1
U82598 Genomic DNA Translation: AAB40790.1
U00096 Genomic DNA Translation: AAC73692.1
AP009048 Genomic DNA Translation: BAE76346.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S16306

NCBI Reference Sequences

More...
RefSeqi
NP_415123.1, NC_000913.3
WP_001041786.1, NZ_SSZK01000032.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73692; AAC73692; b0591
BAE76346; BAE76346; BAE76346

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57728858
946268

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0583
eco:b0591

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1678

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57470 Genomic DNA Translation: CAA40706.1
X59402 Genomic DNA Translation: CAA42044.1
U82598 Genomic DNA Translation: AAB40790.1
U00096 Genomic DNA Translation: AAC73692.1
AP009048 Genomic DNA Translation: BAE76346.1
PIRiS16306
RefSeqiNP_415123.1, NC_000913.3
WP_001041786.1, NZ_SSZK01000032.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260903, 384 interactors
STRINGi511145.b0591

Protein family/group databases

TCDBi2.A.1.38.1, the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiP24077
PRIDEiP24077

Genome annotation databases

EnsemblBacteriaiAAC73692; AAC73692; b0591
BAE76346; BAE76346; BAE76346
GeneIDi57728858
946268
KEGGiecj:JW0583
eco:b0591
PATRICifig|1411691.4.peg.1678

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1096

Phylogenomic databases

eggNOGiCOG0477, Bacteria
HOGENOMiCLU_034180_11_0_6
InParanoidiP24077
PhylomeDBiP24077

Enzyme and pathway databases

BioCyciEcoCyc:YBDA-MONOMER
MetaCyc:YBDA-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P24077

Family and domain databases

HAMAPiMF_01436, MFS_EntS, 1 hit
InterProiView protein in InterPro
IPR023722, Enterobactin_exp_EntS
IPR020846, MFS_dom
IPR036259, MFS_trans_sf
IPR010290, TM_effector
PfamiView protein in Pfam
PF05977, MFS_3, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENTS_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24077
Secondary accession number(s): Q2MBL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1997
Last modified: February 10, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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