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UniProtKB - P24071 (FCAR_HUMAN)

Protein

Immunoglobulin alpha Fc receptor

Gene

FCAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.1 Publication

GO - Molecular functioni

  • IgA binding Source: CAFA
  • IgA receptor activity Source: CAFA
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionIgA-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI43.951

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin alpha Fc receptor
Short name:
IgA Fc receptor
Alternative name(s):
CD_antigen: CD89
Gene namesi
Name:FCAR
Synonyms:CD89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186431.18
HGNCiHGNC:3608 FCAR
MIMi147045 gene
neXtProtiNX_P24071

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 227ExtracellularSequence analysisAdd BLAST206
Transmembranei228 – 246HelicalSequence analysisAdd BLAST19
Topological domaini247 – 287CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2204
OpenTargetsiENSG00000186431
PharmGKBiPA28055

Chemistry databases

GuidetoPHARMACOLOGYi2991

Polymorphism and mutation databases

BioMutaiFCAR
DMDMi119860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001513822 – 287Immunoglobulin alpha Fc receptorAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100Combined sources2 Publications
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi146 ↔ 193Combined sources2 Publications
Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24071
PeptideAtlasiP24071
PRIDEiP24071
ProteomicsDBi54181
54182 [P24071-10]
54183 [P24071-11]
54184 [P24071-2]
54185 [P24071-3]
54186 [P24071-4]
54187 [P24071-5]
54188 [P24071-6]
54189 [P24071-7]
54190 [P24071-8]
54191 [P24071-9]

PTM databases

iPTMnetiP24071
PhosphoSitePlusiP24071

Expressioni

Tissue specificityi

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.2 Publications

Gene expression databases

BgeeiENSG00000186431 Expressed in 87 organ(s), highest expression level in blood
CleanExiHS_FCAR
ExpressionAtlasiP24071 baseline and differential
GenevisibleiP24071 HS

Organism-specific databases

HPAiHPA014050

Interactioni

Subunit structurei

Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.2 Publications

Protein-protein interaction databases

BioGridi108498, 5 interactors
IntActiP24071, 3 interactors
STRINGi9606.ENSP00000347714

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00311
ProteinModelPortaliP24071
SMRiP24071
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24071

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini139 – 200Ig-like C2-type 2Add BLAST62

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG5T Eukaryota
ENOG4111BK0 LUCA
GeneTreeiENSGT00930000151071
HOGENOMiHOG000234395
HOVERGENiHBG004337
InParanoidiP24071
KOiK06513
OMAiGRYQCRY
OrthoDBiEOG091G0FVY
PhylomeDBiP24071
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

Sequences (11+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform A.1 (identifier: P24071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ 
        60         70         80         90        100
AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC 
       110        120        130        140        150
QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH 
       160        170        180        190        200
IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS 
       210        220        230        240        250
PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH 
       260        270        280 
SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
Length:287
Mass (Da):32,265
Last modified:March 1, 1992 - v1
Checksum:iA2CCA68467CD45F7
GO
Isoform A.2 (identifier: P24071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.

Show »
Length:265
Mass (Da):29,683
Checksum:i81F71B405469B93A
GO
Isoform A.3 (identifier: P24071-3) [UniParc]FASTAAdd to basket
Also known as: RLA2

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.

Show »
Length:191
Mass (Da):21,694
Checksum:iB5B6854F0437AEBE
GO
Isoform B (identifier: P24071-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Show »
Length:239
Mass (Da):26,996
Checksum:i4B080309BFAB38E5
GO
Isoform B-delta-S2 (identifier: P24071-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:227
Mass (Da):25,656
Checksum:i6C8D9A590920EA83
GO
Isoform U02 (identifier: P24071-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.

Show »
Length:291
Mass (Da):32,629
Checksum:i1DF65E4E613DA0C3
GO
Isoform L10 (identifier: P24071-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     24-120: Missing.

Show »
Length:178
Mass (Da):19,593
Checksum:iCD9549BF14EE74DF
GO
Isoform U09 (identifier: P24071-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG

Show »
Length:209
Mass (Da):23,394
Checksum:i0C10F3D72BEC5366
GO
Isoform U10 (identifier: P24071-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     115-210: Missing.

Show »
Length:179
Mass (Da):20,354
Checksum:iD31062C1B384F6BB
GO
Isoform U11 (identifier: P24071-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.

Show »
Length:275
Mass (Da):30,925
Checksum:i47B8C498C56C82A8
GO
Isoform U13 (identifier: P24071-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     195-216: Missing.

Show »
Length:253
Mass (Da):28,343
Checksum:i6081B1C3F5BDED61
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPP7A0A0G2JPP7_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
191Annotation score:
A0A0G2JLU6A0A0G2JLU6_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
287Annotation score:
A0A0G2JNS3A0A0G2JNS3_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
239Annotation score:
A0A0G2JM53A0A0G2JM53_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
142Annotation score:
A0A0G2JPZ4A0A0G2JPZ4_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
265Annotation score:
A0A0G2JP11A0A0G2JP11_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
227Annotation score:
A0A0G2JM27A0A0G2JM27_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
253Annotation score:
A0A0G2JNH4A0A0G2JNH4_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
275Annotation score:
A0A0G2JPZ0A0A0G2JPZ0_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
117Annotation score:
A0A0G2JM28A0A0G2JM28_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
117Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049996113D → N1 PublicationCorresponds to variant dbSNP:rs11666735Ensembl.1
Natural variantiVAR_049997269S → G1 PublicationCorresponds to variant dbSNP:rs16986050Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00263212 – 23Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_04356524 – 120Missing in isoform L10. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_00263324G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02. 1 Publication1
Alternative sequenceiVSP_043566115 – 210Missing in isoform U10. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_002634121 – 216Missing in isoform A.3. 3 PublicationsAdd BLAST96
Alternative sequenceiVSP_043567193 – 287CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_002635195 – 216Missing in isoform A.2, isoform U02 and isoform U13. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_002636217 – 287DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2. CuratedAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA Translation: CAA38089.1
X87767
, X87768, X87769, X87766, X87765 Genomic DNA Translation: CAA61039.1
U43774 mRNA Translation: AAC50639.1
U43677 mRNA Translation: AAC50595.1
U56236 mRNA Translation: AAB00566.1
U56237 mRNA Translation: AAB00567.1
S82919 mRNA Translation: AAD14421.1
D87853 mRNA Translation: BAA13471.1
D87854 mRNA Translation: BAA13472.1
D87855 mRNA Translation: BAA13473.1
D87856 mRNA Translation: BAA13474.1
D87857 mRNA Translation: BAA13475.1
D87859 mRNA Translation: BAA13477.1
D87861 mRNA Translation: BAA13479.1
D87862 mRNA Translation: BAA13480.1
DQ075334 mRNA Translation: AAZ76577.1
DQ075335 mRNA Translation: AAZ76578.1
DQ075336 mRNA Translation: AAZ76579.1
DQ075337 mRNA Translation: AAZ76580.1
DQ075338 mRNA Translation: AAZ76581.1
DQ075339 mRNA Translation: AAZ76582.1
AC011501 Genomic DNA No translation available.
BC027953 mRNA Translation: AAH27953.1
CCDSiCCDS12907.1 [P24071-1]
CCDS12908.1 [P24071-3]
CCDS12909.1 [P24071-10]
CCDS12910.1 [P24071-7]
CCDS42622.1 [P24071-2]
CCDS42623.1 [P24071-11]
CCDS42624.1 [P24071-9]
CCDS42625.1 [P24071-8]
PIRiG02630
JH0332
RefSeqiNP_001991.1, NM_002000.3 [P24071-1]
NP_579803.1, NM_133269.3 [P24071-2]
NP_579805.1, NM_133271.3 [P24071-3]
NP_579806.1, NM_133272.3 [P24071-10]
NP_579807.1, NM_133273.3 [P24071-9]
NP_579808.1, NM_133274.3 [P24071-8]
NP_579811.1, NM_133277.3 [P24071-7]
NP_579812.1, NM_133278.3 [P24071-11]
UniGeneiHs.659872

Genome annotation databases

EnsembliENST00000345937; ENSP00000338257; ENSG00000186431 [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431 [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431 [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431 [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431 [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431 [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431 [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431 [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431 [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431 [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136 [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269 [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858 [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970 [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738 [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738 [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564 [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136 [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985 [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985 [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970 [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269 [P24071-8]
ENST00000612918; ENSP00000482056; ENSG00000274580 [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858 [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580 [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269 [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738 [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564 [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564 [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985 [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970 [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985 [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738 [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738 [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970 [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858 [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858 [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580 [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738 [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136 [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136 [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985 [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580 [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580 [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269 [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136 [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564 [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985 [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580 [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580 [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858 [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269 [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738 [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564 [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985 [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564 [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985 [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970 [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269 [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269 [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738 [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970 [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269 [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858 [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136 [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858 [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415 [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985 [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985 [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970 [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269 [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269 [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970 [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970 [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136 [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580 [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858 [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136 [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970 [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580 [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564 [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858 [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580 [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564 [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738 [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738 [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136 [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858 [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136 [P24071-11]
ENST00000638206; ENSP00000492749; ENSG00000284061 [P24071-3]
ENST00000638212; ENSP00000492230; ENSG00000284061 [P24071-1]
ENST00000638238; ENSP00000492629; ENSG00000283750 [P24071-11]
ENST00000638242; ENSP00000492364; ENSG00000283750 [P24071-8]
ENST00000638244; ENSP00000492699; ENSG00000283953 [P24071-7]
ENST00000638285; ENSP00000491595; ENSG00000284061 [P24071-8]
ENST00000638290; ENSP00000492003; ENSG00000283750 [P24071-9]
ENST00000638453; ENSP00000491493; ENSG00000284061 [P24071-4]
ENST00000638527; ENSP00000491362; ENSG00000284245 [P24071-2]
ENST00000638553; ENSP00000491372; ENSG00000284004 [P24071-7]
ENST00000638625; ENSP00000492755; ENSG00000283953 [P24071-9]
ENST00000638882; ENSP00000492226; ENSG00000283953 [P24071-3]
ENST00000638900; ENSP00000491778; ENSG00000283953 [P24071-8]
ENST00000638906; ENSP00000492268; ENSG00000283750 [P24071-7]
ENST00000638945; ENSP00000492228; ENSG00000284245 [P24071-9]
ENST00000638966; ENSP00000491307; ENSG00000283953 [P24071-11]
ENST00000638995; ENSP00000491741; ENSG00000284004 [P24071-3]
ENST00000639014; ENSP00000491039; ENSG00000284245 [P24071-8]
ENST00000639163; ENSP00000491556; ENSG00000284061 [P24071-7]
ENST00000639178; ENSP00000492137; ENSG00000284061 [P24071-2]
ENST00000639193; ENSP00000491447; ENSG00000284004 [P24071-2]
ENST00000639223; ENSP00000492274; ENSG00000284061 [P24071-10]
ENST00000639337; ENSP00000491914; ENSG00000283750 [P24071-3]
ENST00000639392; ENSP00000492068; ENSG00000283750 [P24071-2]
ENST00000639402; ENSP00000492442; ENSG00000284245 [P24071-1]
ENST00000639426; ENSP00000492415; ENSG00000284004 [P24071-10]
ENST00000639428; ENSP00000491642; ENSG00000284061 [P24071-11]
ENST00000639455; ENSP00000491849; ENSG00000284061 [P24071-9]
ENST00000639575; ENSP00000492321; ENSG00000283953 [P24071-2]
ENST00000639763; ENSP00000491420; ENSG00000284004 [P24071-8]
ENST00000640025; ENSP00000492529; ENSG00000283750 [P24071-10]
ENST00000640032; ENSP00000492077; ENSG00000284004 [P24071-9]
ENST00000640047; ENSP00000490997; ENSG00000284245 [P24071-7]
ENST00000640063; ENSP00000491889; ENSG00000284004 [P24071-11]
ENST00000640070; ENSP00000491192; ENSG00000283750 [P24071-4]
ENST00000640239; ENSP00000492762; ENSG00000283953 [P24071-1]
ENST00000640405; ENSP00000491490; ENSG00000284004 [P24071-1]
ENST00000640415; ENSP00000491274; ENSG00000284245 [P24071-10]
ENST00000640430; ENSP00000492494; ENSG00000283953 [P24071-4]
ENST00000640462; ENSP00000491298; ENSG00000284245 [P24071-3]
ENST00000640562; ENSP00000492074; ENSG00000283750 [P24071-5]
ENST00000640582; ENSP00000492447; ENSG00000283750 [P24071-1]
ENST00000640584; ENSP00000491818; ENSG00000284061 [P24071-5]
ENST00000640618; ENSP00000491815; ENSG00000284245 [P24071-5]
ENST00000640687; ENSP00000492597; ENSG00000283953 [P24071-5]
ENST00000640761; ENSP00000492411; ENSG00000284004 [P24071-4]
ENST00000640811; ENSP00000492678; ENSG00000283953 [P24071-10]
ENST00000640878; ENSP00000492686; ENSG00000284245 [P24071-11]
ENST00000640908; ENSP00000492162; ENSG00000284245 [P24071-4]
ENST00000640918; ENSP00000491746; ENSG00000284004 [P24071-5]
GeneIDi2204
KEGGihsa:2204
UCSCiuc002qhq.4 human [P24071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA Translation: CAA38089.1
X87767
, X87768, X87769, X87766, X87765 Genomic DNA Translation: CAA61039.1
U43774 mRNA Translation: AAC50639.1
U43677 mRNA Translation: AAC50595.1
U56236 mRNA Translation: AAB00566.1
U56237 mRNA Translation: AAB00567.1
S82919 mRNA Translation: AAD14421.1
D87853 mRNA Translation: BAA13471.1
D87854 mRNA Translation: BAA13472.1
D87855 mRNA Translation: BAA13473.1
D87856 mRNA Translation: BAA13474.1
D87857 mRNA Translation: BAA13475.1
D87859 mRNA Translation: BAA13477.1
D87861 mRNA Translation: BAA13479.1
D87862 mRNA Translation: BAA13480.1
DQ075334 mRNA Translation: AAZ76577.1
DQ075335 mRNA Translation: AAZ76578.1
DQ075336 mRNA Translation: AAZ76579.1
DQ075337 mRNA Translation: AAZ76580.1
DQ075338 mRNA Translation: AAZ76581.1
DQ075339 mRNA Translation: AAZ76582.1
AC011501 Genomic DNA No translation available.
BC027953 mRNA Translation: AAH27953.1
CCDSiCCDS12907.1 [P24071-1]
CCDS12908.1 [P24071-3]
CCDS12909.1 [P24071-10]
CCDS12910.1 [P24071-7]
CCDS42622.1 [P24071-2]
CCDS42623.1 [P24071-11]
CCDS42624.1 [P24071-9]
CCDS42625.1 [P24071-8]
PIRiG02630
JH0332
RefSeqiNP_001991.1, NM_002000.3 [P24071-1]
NP_579803.1, NM_133269.3 [P24071-2]
NP_579805.1, NM_133271.3 [P24071-3]
NP_579806.1, NM_133272.3 [P24071-10]
NP_579807.1, NM_133273.3 [P24071-9]
NP_579808.1, NM_133274.3 [P24071-8]
NP_579811.1, NM_133277.3 [P24071-7]
NP_579812.1, NM_133278.3 [P24071-11]
UniGeneiHs.659872

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]
DisProtiDP00311
ProteinModelPortaliP24071
SMRiP24071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108498, 5 interactors
IntActiP24071, 3 interactors
STRINGi9606.ENSP00000347714

Chemistry databases

GuidetoPHARMACOLOGYi2991

Protein family/group databases

MEROPSiI43.951

PTM databases

iPTMnetiP24071
PhosphoSitePlusiP24071

Polymorphism and mutation databases

BioMutaiFCAR
DMDMi119860

Proteomic databases

PaxDbiP24071
PeptideAtlasiP24071
PRIDEiP24071
ProteomicsDBi54181
54182 [P24071-10]
54183 [P24071-11]
54184 [P24071-2]
54185 [P24071-3]
54186 [P24071-4]
54187 [P24071-5]
54188 [P24071-6]
54189 [P24071-7]
54190 [P24071-8]
54191 [P24071-9]

Protocols and materials databases

DNASUi2204
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345937; ENSP00000338257; ENSG00000186431 [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431 [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431 [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431 [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431 [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431 [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431 [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431 [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431 [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431 [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136 [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269 [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858 [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970 [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738 [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738 [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564 [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136 [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985 [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985 [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970 [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269 [P24071-8]
ENST00000612918; ENSP00000482056; ENSG00000274580 [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858 [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580 [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269 [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738 [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564 [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564 [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985 [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970 [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985 [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738 [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738 [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970 [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858 [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858 [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580 [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738 [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136 [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136 [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985 [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580 [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580 [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269 [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136 [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564 [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985 [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580 [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580 [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858 [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269 [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738 [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564 [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985 [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564 [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985 [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970 [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269 [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269 [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738 [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970 [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269 [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858 [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136 [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858 [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415 [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985 [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985 [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970 [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269 [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269 [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970 [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970 [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136 [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580 [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858 [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136 [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970 [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580 [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564 [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858 [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580 [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564 [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738 [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738 [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136 [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858 [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136 [P24071-11]
ENST00000638206; ENSP00000492749; ENSG00000284061 [P24071-3]
ENST00000638212; ENSP00000492230; ENSG00000284061 [P24071-1]
ENST00000638238; ENSP00000492629; ENSG00000283750 [P24071-11]
ENST00000638242; ENSP00000492364; ENSG00000283750 [P24071-8]
ENST00000638244; ENSP00000492699; ENSG00000283953 [P24071-7]
ENST00000638285; ENSP00000491595; ENSG00000284061 [P24071-8]
ENST00000638290; ENSP00000492003; ENSG00000283750 [P24071-9]
ENST00000638453; ENSP00000491493; ENSG00000284061 [P24071-4]
ENST00000638527; ENSP00000491362; ENSG00000284245 [P24071-2]
ENST00000638553; ENSP00000491372; ENSG00000284004 [P24071-7]
ENST00000638625; ENSP00000492755; ENSG00000283953 [P24071-9]
ENST00000638882; ENSP00000492226; ENSG00000283953 [P24071-3]
ENST00000638900; ENSP00000491778; ENSG00000283953 [P24071-8]
ENST00000638906; ENSP00000492268; ENSG00000283750 [P24071-7]
ENST00000638945; ENSP00000492228; ENSG00000284245 [P24071-9]
ENST00000638966; ENSP00000491307; ENSG00000283953 [P24071-11]
ENST00000638995; ENSP00000491741; ENSG00000284004 [P24071-3]
ENST00000639014; ENSP00000491039; ENSG00000284245 [P24071-8]
ENST00000639163; ENSP00000491556; ENSG00000284061 [P24071-7]
ENST00000639178; ENSP00000492137; ENSG00000284061 [P24071-2]
ENST00000639193; ENSP00000491447; ENSG00000284004 [P24071-2]
ENST00000639223; ENSP00000492274; ENSG00000284061 [P24071-10]
ENST00000639337; ENSP00000491914; ENSG00000283750 [P24071-3]
ENST00000639392; ENSP00000492068; ENSG00000283750 [P24071-2]
ENST00000639402; ENSP00000492442; ENSG00000284245 [P24071-1]
ENST00000639426; ENSP00000492415; ENSG00000284004 [P24071-10]
ENST00000639428; ENSP00000491642; ENSG00000284061 [P24071-11]
ENST00000639455; ENSP00000491849; ENSG00000284061 [P24071-9]
ENST00000639575; ENSP00000492321; ENSG00000283953 [P24071-2]
ENST00000639763; ENSP00000491420; ENSG00000284004 [P24071-8]
ENST00000640025; ENSP00000492529; ENSG00000283750 [P24071-10]
ENST00000640032; ENSP00000492077; ENSG00000284004 [P24071-9]
ENST00000640047; ENSP00000490997; ENSG00000284245 [P24071-7]
ENST00000640063; ENSP00000491889; ENSG00000284004 [P24071-11]
ENST00000640070; ENSP00000491192; ENSG00000283750 [P24071-4]
ENST00000640239; ENSP00000492762; ENSG00000283953 [P24071-1]
ENST00000640405; ENSP00000491490; ENSG00000284004 [P24071-1]
ENST00000640415; ENSP00000491274; ENSG00000284245 [P24071-10]
ENST00000640430; ENSP00000492494; ENSG00000283953 [P24071-4]
ENST00000640462; ENSP00000491298; ENSG00000284245 [P24071-3]
ENST00000640562; ENSP00000492074; ENSG00000283750 [P24071-5]
ENST00000640582; ENSP00000492447; ENSG00000283750 [P24071-1]
ENST00000640584; ENSP00000491818; ENSG00000284061 [P24071-5]
ENST00000640618; ENSP00000491815; ENSG00000284245 [P24071-5]
ENST00000640687; ENSP00000492597; ENSG00000283953 [P24071-5]
ENST00000640761; ENSP00000492411; ENSG00000284004 [P24071-4]
ENST00000640811; ENSP00000492678; ENSG00000283953 [P24071-10]
ENST00000640878; ENSP00000492686; ENSG00000284245 [P24071-11]
ENST00000640908; ENSP00000492162; ENSG00000284245 [P24071-4]
ENST00000640918; ENSP00000491746; ENSG00000284004 [P24071-5]
GeneIDi2204
KEGGihsa:2204
UCSCiuc002qhq.4 human [P24071-1]

Organism-specific databases

CTDi2204
DisGeNETi2204
EuPathDBiHostDB:ENSG00000186431.18
GeneCardsiFCAR
HGNCiHGNC:3608 FCAR
HPAiHPA014050
MIMi147045 gene
neXtProtiNX_P24071
OpenTargetsiENSG00000186431
PharmGKBiPA28055
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG5T Eukaryota
ENOG4111BK0 LUCA
GeneTreeiENSGT00930000151071
HOGENOMiHOG000234395
HOVERGENiHBG004337
InParanoidiP24071
KOiK06513
OMAiGRYQCRY
OrthoDBiEOG091G0FVY
PhylomeDBiP24071
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiFCAR human
EvolutionaryTraceiP24071
GeneWikiiFCAR
GenomeRNAii2204
PROiPR:P24071
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186431 Expressed in 87 organ(s), highest expression level in blood
CleanExiHS_FCAR
ExpressionAtlasiP24071 baseline and differential
GenevisibleiP24071 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCAR_HUMAN
AccessioniPrimary (citable) accession number: P24071
Secondary accession number(s): Q13603
, Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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