UniProtKB - P24071 (FCAR_HUMAN)
Immunoglobulin alpha Fc receptor
FCAR
Functioni
GO - Molecular functioni
- IgA binding Source: CAFA
- IgA receptor activity Source: CAFA
GO - Biological processi
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: CAFA
- cellular response to interferon-alpha Source: CAFA
- cellular response to interferon-gamma Source: CAFA
- cellular response to interleukin-6 Source: CAFA
- cellular response to lipopolysaccharide Source: CAFA
- cellular response to tumor necrosis factor Source: CAFA
- Fc receptor signaling pathway Source: CAFA
- immune response Source: ProtInc
- neutrophil activation Source: CAFA
- neutrophil degranulation Source: Reactome
- neutrophil mediated immunity Source: CAFA
- positive regulation of neutrophil apoptotic process Source: CAFA
- positive regulation of oxidative stress-induced cell death Source: CAFA
Keywordsi
Molecular function | IgA-binding protein, Receptor |
Enzyme and pathway databases
PathwayCommonsi | P24071 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Protein family/group databases
MEROPSi | I43.951 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin alpha Fc receptorShort name: IgA Fc receptor Alternative name(s): CD_antigen: CD89 |
Gene namesi | Name:FCAR Synonyms:CD89 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3608, FCAR |
MIMi | 147045, gene |
neXtProti | NX_P24071 |
VEuPathDBi | HostDB:ENSG00000186431.18 |
Subcellular locationi
Plasma membrane
Plasma membrane
Plasma membrane
Extracellular region or secreted
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: CAFA
Other locations
- ficolin-1-rich granule membrane Source: Reactome
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 227 | ExtracellularSequence analysisAdd BLAST | 206 | |
Transmembranei | 228 – 246 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 247 – 287 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 2204 |
OpenTargetsi | ENSG00000186431 |
PharmGKBi | PA28055 |
Miscellaneous databases
Pharosi | P24071, Tbio |
Chemistry databases
GuidetoPHARMACOLOGYi | 2991 |
Genetic variation databases
BioMutai | FCAR |
DMDMi | 119860 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000015138 | 22 – 287 | Immunoglobulin alpha Fc receptorAdd BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 100 | Combined sources2 Publications | ||
Glycosylationi | 65 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 79 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 141 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 146 ↔ 193 | Combined sources2 Publications | ||
Glycosylationi | 177 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 186 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P24071 |
PaxDbi | P24071 |
PeptideAtlasi | P24071 |
PRIDEi | P24071 |
ProteomicsDBi | 54181 [P24071-1] 54182 [P24071-10] 54183 [P24071-11] 54184 [P24071-2] 54185 [P24071-3] 54186 [P24071-4] 54187 [P24071-5] 54188 [P24071-6] 54189 [P24071-7] 54190 [P24071-8] 54191 [P24071-9] |
PTM databases
GlyGeni | P24071, 5 sites |
iPTMneti | P24071 |
PhosphoSitePlusi | P24071 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000186431, Expressed in bone marrow and 110 other tissues |
ExpressionAtlasi | P24071, baseline and differential |
Genevisiblei | P24071, HS |
Organism-specific databases
HPAi | ENSG00000186431, Tissue enhanced (bone marrow, lung, lymphoid tissue) |
Interactioni
Subunit structurei
Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.
2 Publications(Microbial infection) Interacts with Staphylococcus aureus protein SSL11.
1 PublicationProtein-protein interaction databases
BioGRIDi | 108498, 5 interactors |
IntActi | P24071, 3 interactors |
STRINGi | 9606.ENSP00000347714 |
Miscellaneous databases
RNActi | P24071, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P24071 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24071 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 107 | Ig-like C2-type 1Add BLAST | 66 | |
Domaini | 139 – 200 | Ig-like C2-type 2Add BLAST | 62 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RCU0, Eukaryota |
GeneTreei | ENSGT01000000214458 |
HOGENOMi | CLU_021100_1_3_1 |
InParanoidi | P24071 |
OMAi | GSVKILC |
OrthoDBi | 1327293at2759 |
PhylomeDBi | P24071 |
TreeFami | TF336644 |
Family and domain databases
DisProti | DP00311 |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
s (11+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 11 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 11 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ
60 70 80 90 100
AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC
110 120 130 140 150
QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH
160 170 180 190 200
IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS
210 220 230 240 250
PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH
260 270 280
SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
The sequence of this isoform differs from the canonical sequence as follows:
195-216: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
121-216: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
12-23: Missing.
217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI
The sequence of this isoform differs from the canonical sequence as follows:
24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
195-216: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
12-23: Missing.
24-120: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
12-23: Missing.
193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG
The sequence of this isoform differs from the canonical sequence as follows:
12-23: Missing.
115-210: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
12-23: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
12-23: Missing.
195-216: Missing.
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JPP7 | A0A0G2JPP7_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 191 | Annotation score: | ||
A0A0G2JLU6 | A0A0G2JLU6_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 287 | Annotation score: | ||
A0A0G2JNS3 | A0A0G2JNS3_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 239 | Annotation score: | ||
A0A0G2JPZ4 | A0A0G2JPZ4_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 265 | Annotation score: | ||
A0A0G2JM53 | A0A0G2JM53_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 142 | Annotation score: | ||
A0A0G2JNH4 | A0A0G2JNH4_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 275 | Annotation score: | ||
A0A0G2JP11 | A0A0G2JP11_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 227 | Annotation score: | ||
A0A0G2JM27 | A0A0G2JM27_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 253 | Annotation score: | ||
A0A0G2JM28 | A0A0G2JM28_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 117 | Annotation score: | ||
A0A0G2JPZ0 | A0A0G2JPZ0_HUMAN | Immunoglobulin alpha Fc receptor | FCAR | 117 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049996 | 113 | D → N1 PublicationCorresponds to variant dbSNP:rs11666735Ensembl. | 1 | |
Natural variantiVAR_049997 | 269 | S → G1 PublicationCorresponds to variant dbSNP:rs16986050Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002632 | 12 – 23 | Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_043565 | 24 – 120 | Missing in isoform L10. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_002633 | 24 | G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02. 1 Publication | 1 | |
Alternative sequenceiVSP_043566 | 115 – 210 | Missing in isoform U10. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_002634 | 121 – 216 | Missing in isoform A.3. 3 PublicationsAdd BLAST | 96 | |
Alternative sequenceiVSP_043567 | 193 – 287 | CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09. 1 PublicationAdd BLAST | 95 | |
Alternative sequenceiVSP_002635 | 195 – 216 | Missing in isoform A.2, isoform U02 and isoform U13. 2 PublicationsAdd BLAST | 22 | |
Alternative sequenceiVSP_002636 | 217 – 287 | DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2. CuratedAdd BLAST | 71 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OVZ | X-ray | 3.00 | A/B | 22-216 | [»] | |
1OW0 | X-ray | 3.10 | C/D | 22-216 | [»] | |
1UCT | X-ray | 2.10 | A | 21-229 | [»] | |
SMRi | P24071 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108498, 5 interactors |
IntActi | P24071, 3 interactors |
STRINGi | 9606.ENSP00000347714 |
Chemistry databases
GuidetoPHARMACOLOGYi | 2991 |
Protein family/group databases
MEROPSi | I43.951 |
PTM databases
GlyGeni | P24071, 5 sites |
iPTMneti | P24071 |
PhosphoSitePlusi | P24071 |
Genetic variation databases
BioMutai | FCAR |
DMDMi | 119860 |
Proteomic databases
MassIVEi | P24071 |
PaxDbi | P24071 |
PeptideAtlasi | P24071 |
PRIDEi | P24071 |
ProteomicsDBi | 54181 [P24071-1] 54182 [P24071-10] 54183 [P24071-11] 54184 [P24071-2] 54185 [P24071-3] 54186 [P24071-4] 54187 [P24071-5] 54188 [P24071-6] 54189 [P24071-7] 54190 [P24071-8] 54191 [P24071-9] |
Protocols and materials databases
Antibodypediai | 2709, 661 antibodies |
DNASUi | 2204 |
Genome annotation databases
Organism-specific databases
CTDi | 2204 |
DisGeNETi | 2204 |
GeneCardsi | FCAR |
HGNCi | HGNC:3608, FCAR |
HPAi | ENSG00000186431, Tissue enhanced (bone marrow, lung, lymphoid tissue) |
MIMi | 147045, gene |
neXtProti | NX_P24071 |
OpenTargetsi | ENSG00000186431 |
PharmGKBi | PA28055 |
VEuPathDBi | HostDB:ENSG00000186431.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RCU0, Eukaryota |
GeneTreei | ENSGT01000000214458 |
HOGENOMi | CLU_021100_1_3_1 |
InParanoidi | P24071 |
OMAi | GSVKILC |
OrthoDBi | 1327293at2759 |
PhylomeDBi | P24071 |
TreeFami | TF336644 |
Enzyme and pathway databases
PathwayCommonsi | P24071 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 2204, 5 hits in 979 CRISPR screens |
ChiTaRSi | FCAR, human |
EvolutionaryTracei | P24071 |
GeneWikii | FCAR |
GenomeRNAii | 2204 |
Pharosi | P24071, Tbio |
PROi | PR:P24071 |
RNActi | P24071, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186431, Expressed in bone marrow and 110 other tissues |
ExpressionAtlasi | P24071, baseline and differential |
Genevisiblei | P24071, HS |
Family and domain databases
DisProti | DP00311 |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FCAR_HUMAN | |
Accessioni | P24071Primary (citable) accession number: P24071 Secondary accession number(s): Q13603 Q9UEK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references