Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P24071 (FCAR_HUMAN)

Protein

Immunoglobulin alpha Fc receptor

Gene

FCAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • IgA binding Source: CAFA
  • IgA receptor activity Source: CAFA
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIgA-binding protein, Receptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...MEROPSi		I43.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin alpha Fc receptor
Short name:
IgA Fc receptor
Alternative name(s):
CD_antigen: CD89
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCAR
Synonyms:CD89
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000186431.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:3608 FCAR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147045 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P24071

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 227ExtracellularSequence analysisAdd BLAST206
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei228 – 246HelicalSequence analysisAdd BLAST19
Topological domaini247 – 287CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2204

Open Targets

More...OpenTargetsi		ENSG00000186431

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28055

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2991

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FCAR

Domain mapping of disease mutations (DMDM)

More...DMDMi		119860

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001513822 – 287Immunoglobulin alpha Fc receptorAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 100Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi146 ↔ 193Combined sources2 Publications
Glycosylationi177N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P24071

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24071

PeptideAtlas

More...PeptideAtlasi		P24071

PRoteomics IDEntifications database

More...PRIDEi		P24071

ProteomicsDB human proteome resource

More...ProteomicsDBi		54181
54182 [P24071-10]
54183 [P24071-11]
54184 [P24071-2]
54185 [P24071-3]
54186 [P24071-4]
54187 [P24071-5]
54188 [P24071-6]
54189 [P24071-7]
54190 [P24071-8]
54191 [P24071-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24071

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P24071

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186431 Expressed in 87 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...CleanExi		HS_FCAR

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24071 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24071 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA014050

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108498, 5 interactors

Protein interaction database and analysis system

More...IntActi		P24071, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347714

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]

Database of protein disorder

More...DisProti		DP00311

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P24071

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24071

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P24071

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini139 – 200Ig-like C2-type 2Add BLAST62

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IG5T Eukaryota
ENOG4111BK0 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234395

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004337

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24071

KEGG Orthology (KO)

More...KOi		K06513

Identification of Orthologs from Complete Genome Data

More...OMAi		GRYQCRY

Database of Orthologous Groups

More...OrthoDBi		1327293at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24071

TreeFam database of animal gene trees

More...TreeFami		TF336644

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 11 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform A.1 (identifier: P24071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ 
        60         70         80         90        100
AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC 
       110        120        130        140        150
QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH 
       160        170        180        190        200
IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS 
       210        220        230        240        250
PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH 
       260        270        280 
SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
Length:287
Mass (Da):32,265
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2CCA68467CD45F7
GO
Isoform A.2 (identifier: P24071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-216: Missing.

Show »
Length:265
Mass (Da):29,683
Checksum:i81F71B405469B93A
GO
Isoform A.3 (identifier: P24071-3) [UniParc]FASTAAdd to basket
Also known as: RLA2

The sequence of this isoform differs from the canonical sequence as follows:
     121-216: Missing.

Show »
Length:191
Mass (Da):21,694
Checksum:iB5B6854F0437AEBE
GO
Isoform B (identifier: P24071-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Show »
Length:239
Mass (Da):26,996
Checksum:i4B080309BFAB38E5
GO
Isoform B-delta-S2 (identifier: P24071-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     217-287: DSIHQDYTTQ...TFARTPSVCK → GRYRPVQPCVWVGCPGPCHRAGI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:227
Mass (Da):25,656
Checksum:i6C8D9A590920EA83
GO
Isoform U02 (identifier: P24071-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: G → GRYISEHFWCRSLGCNPVNDASAQRPG
     195-216: Missing.

Show »
Length:291
Mass (Da):32,629
Checksum:i1DF65E4E613DA0C3
GO
Isoform L10 (identifier: P24071-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     24-120: Missing.

Show »
Length:178
Mass (Da):19,593
Checksum:iCD9549BF14EE74DF
GO
Isoform U09 (identifier: P24071-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     193-287: CYGWYNRSPY...TFARTPSVCK → LHPPRLHDAELDPHGRGRTGPRGSLGHTG

Show »
Length:209
Mass (Da):23,394
Checksum:i0C10F3D72BEC5366
GO
Isoform U10 (identifier: P24071-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     115-210: Missing.

Show »
Length:179
Mass (Da):20,354
Checksum:iD31062C1B384F6BB
GO
Isoform U11 (identifier: P24071-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.

Show »
Length:275
Mass (Da):30,925
Checksum:i47B8C498C56C82A8
GO
Isoform U13 (identifier: P24071-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-23: Missing.
     195-216: Missing.

Show »
Length:253
Mass (Da):28,343
Checksum:i6081B1C3F5BDED61
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPP7A0A0G2JPP7_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLU6A0A0G2JLU6_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNS3A0A0G2JNS3_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPZ4A0A0G2JPZ4_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM53A0A0G2JM53_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JP11A0A0G2JP11_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM27A0A0G2JM27_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNH4A0A0G2JNH4_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JM28A0A0G2JM28_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPZ0A0A0G2JPZ0_HUMAN
Immunoglobulin alpha Fc receptor
FCAR
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049996113D → N1 PublicationCorresponds to variant dbSNP:rs11666735Ensembl.1
Natural variantiVAR_049997269S → G1 PublicationCorresponds to variant dbSNP:rs16986050Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00263212 – 23Missing in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_04356524 – 120Missing in isoform L10. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_00263324G → GRYISEHFWCRSLGCNPVND ASAQRPG in isoform U02. 1 Publication1
Alternative sequenceiVSP_043566115 – 210Missing in isoform U10. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_002634121 – 216Missing in isoform A.3. 3 PublicationsAdd BLAST96
Alternative sequenceiVSP_043567193 – 287CYGWY…PSVCK → LHPPRLHDAELDPHGRGRTG PRGSLGHTG in isoform U09. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_002635195 – 216Missing in isoform A.2, isoform U02 and isoform U13. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_002636217 – 287DSIHQ…PSVCK → GRYRPVQPCVWVGCPGPCHR AGI in isoform B and isoform B-delta-S2. CuratedAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X54150 mRNA Translation: CAA38089.1
X87767
, X87768, X87769, X87766, X87765 Genomic DNA Translation: CAA61039.1
U43774 mRNA Translation: AAC50639.1
U43677 mRNA Translation: AAC50595.1
U56236 mRNA Translation: AAB00566.1
U56237 mRNA Translation: AAB00567.1
S82919 mRNA Translation: AAD14421.1
D87853 mRNA Translation: BAA13471.1
D87854 mRNA Translation: BAA13472.1
D87855 mRNA Translation: BAA13473.1
D87856 mRNA Translation: BAA13474.1
D87857 mRNA Translation: BAA13475.1
D87859 mRNA Translation: BAA13477.1
D87861 mRNA Translation: BAA13479.1
D87862 mRNA Translation: BAA13480.1
DQ075334 mRNA Translation: AAZ76577.1
DQ075335 mRNA Translation: AAZ76578.1
DQ075336 mRNA Translation: AAZ76579.1
DQ075337 mRNA Translation: AAZ76580.1
DQ075338 mRNA Translation: AAZ76581.1
DQ075339 mRNA Translation: AAZ76582.1
AC011501 Genomic DNA No translation available.
BC027953 mRNA Translation: AAH27953.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12907.1 [P24071-1]
CCDS12908.1 [P24071-3]
CCDS12909.1 [P24071-10]
CCDS12910.1 [P24071-7]
CCDS42622.1 [P24071-2]
CCDS42623.1 [P24071-11]
CCDS42624.1 [P24071-9]
CCDS42625.1 [P24071-8]

Protein sequence database of the Protein Information Resource

More...PIRi		G02630
JH0332

NCBI Reference Sequences

More...RefSeqi		NP_001991.1, NM_002000.3 [P24071-1]
NP_579803.1, NM_133269.3 [P24071-2]
NP_579805.1, NM_133271.3 [P24071-3]
NP_579806.1, NM_133272.3 [P24071-10]
NP_579807.1, NM_133273.3 [P24071-9]
NP_579808.1, NM_133274.3 [P24071-8]
NP_579811.1, NM_133277.3 [P24071-7]
NP_579812.1, NM_133278.3 [P24071-11]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.659872

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000345937; ENSP00000338257; ENSG00000186431 [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431 [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431 [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431 [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431 [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431 [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431 [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431 [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431 [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431 [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136 [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269 [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858 [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970 [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738 [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738 [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564 [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136 [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985 [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985 [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970 [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269 [P24071-8]
ENST00000612918; ENSP00000482056; ENSG00000274580 [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858 [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580 [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269 [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738 [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564 [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564 [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985 [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970 [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985 [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738 [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738 [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970 [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858 [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858 [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580 [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738 [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136 [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136 [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985 [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580 [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580 [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269 [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136 [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564 [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985 [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580 [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580 [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858 [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269 [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738 [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564 [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985 [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564 [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985 [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970 [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269 [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269 [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738 [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970 [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269 [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858 [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136 [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858 [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415 [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985 [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985 [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970 [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269 [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269 [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970 [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970 [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136 [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580 [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858 [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136 [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970 [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580 [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564 [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858 [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580 [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564 [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738 [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738 [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136 [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858 [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136 [P24071-11]
ENST00000638206; ENSP00000492749; ENSG00000284061 [P24071-3]
ENST00000638212; ENSP00000492230; ENSG00000284061 [P24071-1]
ENST00000638238; ENSP00000492629; ENSG00000283750 [P24071-11]
ENST00000638242; ENSP00000492364; ENSG00000283750 [P24071-8]
ENST00000638244; ENSP00000492699; ENSG00000283953 [P24071-7]
ENST00000638285; ENSP00000491595; ENSG00000284061 [P24071-8]
ENST00000638290; ENSP00000492003; ENSG00000283750 [P24071-9]
ENST00000638453; ENSP00000491493; ENSG00000284061 [P24071-4]
ENST00000638527; ENSP00000491362; ENSG00000284245 [P24071-2]
ENST00000638553; ENSP00000491372; ENSG00000284004 [P24071-7]
ENST00000638625; ENSP00000492755; ENSG00000283953 [P24071-9]
ENST00000638882; ENSP00000492226; ENSG00000283953 [P24071-3]
ENST00000638900; ENSP00000491778; ENSG00000283953 [P24071-8]
ENST00000638906; ENSP00000492268; ENSG00000283750 [P24071-7]
ENST00000638945; ENSP00000492228; ENSG00000284245 [P24071-9]
ENST00000638966; ENSP00000491307; ENSG00000283953 [P24071-11]
ENST00000638995; ENSP00000491741; ENSG00000284004 [P24071-3]
ENST00000639014; ENSP00000491039; ENSG00000284245 [P24071-8]
ENST00000639163; ENSP00000491556; ENSG00000284061 [P24071-7]
ENST00000639178; ENSP00000492137; ENSG00000284061 [P24071-2]
ENST00000639193; ENSP00000491447; ENSG00000284004 [P24071-2]
ENST00000639223; ENSP00000492274; ENSG00000284061 [P24071-10]
ENST00000639337; ENSP00000491914; ENSG00000283750 [P24071-3]
ENST00000639392; ENSP00000492068; ENSG00000283750 [P24071-2]
ENST00000639402; ENSP00000492442; ENSG00000284245 [P24071-1]
ENST00000639426; ENSP00000492415; ENSG00000284004 [P24071-10]
ENST00000639428; ENSP00000491642; ENSG00000284061 [P24071-11]
ENST00000639455; ENSP00000491849; ENSG00000284061 [P24071-9]
ENST00000639575; ENSP00000492321; ENSG00000283953 [P24071-2]
ENST00000639763; ENSP00000491420; ENSG00000284004 [P24071-8]
ENST00000640025; ENSP00000492529; ENSG00000283750 [P24071-10]
ENST00000640032; ENSP00000492077; ENSG00000284004 [P24071-9]
ENST00000640047; ENSP00000490997; ENSG00000284245 [P24071-7]
ENST00000640063; ENSP00000491889; ENSG00000284004 [P24071-11]
ENST00000640070; ENSP00000491192; ENSG00000283750 [P24071-4]
ENST00000640239; ENSP00000492762; ENSG00000283953 [P24071-1]
ENST00000640405; ENSP00000491490; ENSG00000284004 [P24071-1]
ENST00000640415; ENSP00000491274; ENSG00000284245 [P24071-10]
ENST00000640430; ENSP00000492494; ENSG00000283953 [P24071-4]
ENST00000640462; ENSP00000491298; ENSG00000284245 [P24071-3]
ENST00000640562; ENSP00000492074; ENSG00000283750 [P24071-5]
ENST00000640582; ENSP00000492447; ENSG00000283750 [P24071-1]
ENST00000640584; ENSP00000491818; ENSG00000284061 [P24071-5]
ENST00000640618; ENSP00000491815; ENSG00000284245 [P24071-5]
ENST00000640687; ENSP00000492597; ENSG00000283953 [P24071-5]
ENST00000640761; ENSP00000492411; ENSG00000284004 [P24071-4]
ENST00000640811; ENSP00000492678; ENSG00000283953 [P24071-10]
ENST00000640878; ENSP00000492686; ENSG00000284245 [P24071-11]
ENST00000640908; ENSP00000492162; ENSG00000284245 [P24071-4]
ENST00000640918; ENSP00000491746; ENSG00000284004 [P24071-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2204

UCSC genome browser

More...UCSCi		uc002qhq.4 human [P24071-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54150 mRNA Translation: CAA38089.1
X87767
, X87768, X87769, X87766, X87765 Genomic DNA Translation: CAA61039.1
U43774 mRNA Translation: AAC50639.1
U43677 mRNA Translation: AAC50595.1
U56236 mRNA Translation: AAB00566.1
U56237 mRNA Translation: AAB00567.1
S82919 mRNA Translation: AAD14421.1
D87853 mRNA Translation: BAA13471.1
D87854 mRNA Translation: BAA13472.1
D87855 mRNA Translation: BAA13473.1
D87856 mRNA Translation: BAA13474.1
D87857 mRNA Translation: BAA13475.1
D87859 mRNA Translation: BAA13477.1
D87861 mRNA Translation: BAA13479.1
D87862 mRNA Translation: BAA13480.1
DQ075334 mRNA Translation: AAZ76577.1
DQ075335 mRNA Translation: AAZ76578.1
DQ075336 mRNA Translation: AAZ76579.1
DQ075337 mRNA Translation: AAZ76580.1
DQ075338 mRNA Translation: AAZ76581.1
DQ075339 mRNA Translation: AAZ76582.1
AC011501 Genomic DNA No translation available.
BC027953 mRNA Translation: AAH27953.1
CCDSiCCDS12907.1 [P24071-1]
CCDS12908.1 [P24071-3]
CCDS12909.1 [P24071-10]
CCDS12910.1 [P24071-7]
CCDS42622.1 [P24071-2]
CCDS42623.1 [P24071-11]
CCDS42624.1 [P24071-9]
CCDS42625.1 [P24071-8]
PIRiG02630
JH0332
RefSeqiNP_001991.1, NM_002000.3 [P24071-1]
NP_579803.1, NM_133269.3 [P24071-2]
NP_579805.1, NM_133271.3 [P24071-3]
NP_579806.1, NM_133272.3 [P24071-10]
NP_579807.1, NM_133273.3 [P24071-9]
NP_579808.1, NM_133274.3 [P24071-8]
NP_579811.1, NM_133277.3 [P24071-7]
NP_579812.1, NM_133278.3 [P24071-11]
UniGeneiHs.659872

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVZX-ray3.00A/B22-216[»]
1OW0X-ray3.10C/D22-216[»]
1UCTX-ray2.10A21-229[»]
DisProtiDP00311
ProteinModelPortaliP24071
SMRiP24071
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108498, 5 interactors
IntActiP24071, 3 interactors
STRINGi9606.ENSP00000347714

Chemistry databases

GuidetoPHARMACOLOGYi2991

Protein family/group databases

MEROPSiI43.951

PTM databases

iPTMnetiP24071
PhosphoSitePlusiP24071

Polymorphism and mutation databases

BioMutaiFCAR
DMDMi119860

Proteomic databases

jPOSTiP24071
PaxDbiP24071
PeptideAtlasiP24071
PRIDEiP24071
ProteomicsDBi54181
54182 [P24071-10]
54183 [P24071-11]
54184 [P24071-2]
54185 [P24071-3]
54186 [P24071-4]
54187 [P24071-5]
54188 [P24071-6]
54189 [P24071-7]
54190 [P24071-8]
54191 [P24071-9]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		2204
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345937; ENSP00000338257; ENSG00000186431 [P24071-3]
ENST00000353758; ENSP00000338058; ENSG00000186431 [P24071-7]
ENST00000355524; ENSP00000347714; ENSG00000186431 [P24071-1]
ENST00000359272; ENSP00000352218; ENSG00000186431 [P24071-10]
ENST00000391723; ENSP00000375603; ENSG00000186431 [P24071-8]
ENST00000391724; ENSP00000375604; ENSG00000186431 [P24071-11]
ENST00000391725; ENSP00000375605; ENSG00000186431 [P24071-2]
ENST00000391726; ENSP00000375606; ENSG00000186431 [P24071-9]
ENST00000469767; ENSP00000473814; ENSG00000186431 [P24071-4]
ENST00000488066; ENSP00000474512; ENSG00000186431 [P24071-5]
ENST00000610340; ENSP00000477610; ENSG00000275136 [P24071-8]
ENST00000610397; ENSP00000480965; ENSG00000275269 [P24071-3]
ENST00000610786; ENSP00000483121; ENSG00000276858 [P24071-8]
ENST00000611018; ENSP00000484483; ENSG00000275970 [P24071-11]
ENST00000611130; ENSP00000484917; ENSG00000273738 [P24071-11]
ENST00000611871; ENSP00000482976; ENSG00000273738 [P24071-10]
ENST00000611943; ENSP00000482273; ENSG00000275564 [P24071-2]
ENST00000612150; ENSP00000478233; ENSG00000275136 [P24071-3]
ENST00000612159; ENSP00000484662; ENSG00000276985 [P24071-9]
ENST00000612505; ENSP00000479792; ENSG00000276985 [P24071-8]
ENST00000612803; ENSP00000478454; ENSG00000275970 [P24071-8]
ENST00000612815; ENSP00000483503; ENSG00000275269 [P24071-8]
ENST00000612918; ENSP00000482056; ENSG00000274580 [P24071-3]
ENST00000613199; ENSP00000478465; ENSG00000276858 [P24071-1]
ENST00000613201; ENSP00000482108; ENSG00000274580 [P24071-4]
ENST00000613298; ENSP00000482451; ENSG00000275269 [P24071-9]
ENST00000613318; ENSP00000481560; ENSG00000273738 [P24071-4]
ENST00000613663; ENSP00000483437; ENSG00000275564 [P24071-4]
ENST00000613685; ENSP00000481230; ENSG00000275564 [P24071-11]
ENST00000614226; ENSP00000483099; ENSG00000276985 [P24071-1]
ENST00000614298; ENSP00000483472; ENSG00000275970 [P24071-9]
ENST00000614433; ENSP00000480748; ENSG00000276985 [P24071-2]
ENST00000614689; ENSP00000480013; ENSG00000273738 [P24071-5]
ENST00000614893; ENSP00000477966; ENSG00000273738 [P24071-2]
ENST00000614917; ENSP00000479831; ENSG00000275970 [P24071-2]
ENST00000614954; ENSP00000479924; ENSG00000276858 [P24071-9]
ENST00000615040; ENSP00000477656; ENSG00000276858 [P24071-10]
ENST00000615110; ENSP00000484276; ENSG00000274580 [P24071-2]
ENST00000615361; ENSP00000482741; ENSG00000273738 [P24071-9]
ENST00000615703; ENSP00000484868; ENSG00000275136 [P24071-4]
ENST00000615719; ENSP00000482518; ENSG00000275136 [P24071-7]
ENST00000615800; ENSP00000483841; ENSG00000276985 [P24071-4]
ENST00000615829; ENSP00000482623; ENSG00000274580 [P24071-1]
ENST00000615937; ENSP00000478075; ENSG00000274580 [P24071-11]
ENST00000616340; ENSP00000481676; ENSG00000275269 [P24071-10]
ENST00000616878; ENSP00000480970; ENSG00000275136 [P24071-9]
ENST00000616969; ENSP00000479039; ENSG00000275564 [P24071-5]
ENST00000617025; ENSP00000481129; ENSG00000276985 [P24071-3]
ENST00000617609; ENSP00000481394; ENSG00000274580 [P24071-10]
ENST00000617696; ENSP00000482670; ENSG00000274580 [P24071-9]
ENST00000617762; ENSP00000484136; ENSG00000276858 [P24071-5]
ENST00000617766; ENSP00000479230; ENSG00000275269 [P24071-4]
ENST00000617778; ENSP00000480498; ENSG00000273738 [P24071-3]
ENST00000617964; ENSP00000484141; ENSG00000275564 [P24071-7]
ENST00000618271; ENSP00000484741; ENSG00000276985 [P24071-7]
ENST00000618287; ENSP00000481668; ENSG00000275564 [P24071-10]
ENST00000618328; ENSP00000480496; ENSG00000276985 [P24071-10]
ENST00000618658; ENSP00000479688; ENSG00000275970 [P24071-4]
ENST00000618805; ENSP00000481985; ENSG00000275269 [P24071-2]
ENST00000618985; ENSP00000480323; ENSG00000275269 [P24071-5]
ENST00000619073; ENSP00000479360; ENSG00000273738 [P24071-8]
ENST00000619155; ENSP00000480461; ENSG00000275970 [P24071-5]
ENST00000619385; ENSP00000482334; ENSG00000275269 [P24071-1]
ENST00000619414; ENSP00000478163; ENSG00000276858 [P24071-2]
ENST00000619822; ENSP00000483250; ENSG00000275136 [P24071-2]
ENST00000620162; ENSP00000483258; ENSG00000276858 [P24071-11]
ENST00000620179; ENSP00000478315; ENSG00000278415 [P24071-7]
ENST00000620270; ENSP00000482022; ENSG00000276985 [P24071-11]
ENST00000620397; ENSP00000477584; ENSG00000276985 [P24071-5]
ENST00000620801; ENSP00000481195; ENSG00000275970 [P24071-1]
ENST00000620822; ENSP00000483327; ENSG00000275269 [P24071-7]
ENST00000620873; ENSP00000479099; ENSG00000275269 [P24071-11]
ENST00000621004; ENSP00000484816; ENSG00000275970 [P24071-10]
ENST00000621009; ENSP00000482025; ENSG00000275970 [P24071-3]
ENST00000621289; ENSP00000481366; ENSG00000275136 [P24071-5]
ENST00000621417; ENSP00000478634; ENSG00000274580 [P24071-5]
ENST00000621684; ENSP00000479239; ENSG00000276858 [P24071-3]
ENST00000621702; ENSP00000482807; ENSG00000275136 [P24071-1]
ENST00000621755; ENSP00000484906; ENSG00000275970 [P24071-7]
ENST00000621882; ENSP00000484272; ENSG00000274580 [P24071-7]
ENST00000622157; ENSP00000481502; ENSG00000275564 [P24071-1]
ENST00000622470; ENSP00000477673; ENSG00000276858 [P24071-7]
ENST00000622491; ENSP00000477643; ENSG00000274580 [P24071-8]
ENST00000622543; ENSP00000483402; ENSG00000275564 [P24071-3]
ENST00000622646; ENSP00000480406; ENSG00000273738 [P24071-7]
ENST00000622737; ENSP00000479738; ENSG00000273738 [P24071-1]
ENST00000622777; ENSP00000481345; ENSG00000275136 [P24071-10]
ENST00000622883; ENSP00000479880; ENSG00000276858 [P24071-4]
ENST00000622904; ENSP00000480444; ENSG00000275136 [P24071-11]
ENST00000638206; ENSP00000492749; ENSG00000284061 [P24071-3]
ENST00000638212; ENSP00000492230; ENSG00000284061 [P24071-1]
ENST00000638238; ENSP00000492629; ENSG00000283750 [P24071-11]
ENST00000638242; ENSP00000492364; ENSG00000283750 [P24071-8]
ENST00000638244; ENSP00000492699; ENSG00000283953 [P24071-7]
ENST00000638285; ENSP00000491595; ENSG00000284061 [P24071-8]
ENST00000638290; ENSP00000492003; ENSG00000283750 [P24071-9]
ENST00000638453; ENSP00000491493; ENSG00000284061 [P24071-4]
ENST00000638527; ENSP00000491362; ENSG00000284245 [P24071-2]
ENST00000638553; ENSP00000491372; ENSG00000284004 [P24071-7]
ENST00000638625; ENSP00000492755; ENSG00000283953 [P24071-9]
ENST00000638882; ENSP00000492226; ENSG00000283953 [P24071-3]
ENST00000638900; ENSP00000491778; ENSG00000283953 [P24071-8]
ENST00000638906; ENSP00000492268; ENSG00000283750 [P24071-7]
ENST00000638945; ENSP00000492228; ENSG00000284245 [P24071-9]
ENST00000638966; ENSP00000491307; ENSG00000283953 [P24071-11]
ENST00000638995; ENSP00000491741; ENSG00000284004 [P24071-3]
ENST00000639014; ENSP00000491039; ENSG00000284245 [P24071-8]
ENST00000639163; ENSP00000491556; ENSG00000284061 [P24071-7]
ENST00000639178; ENSP00000492137; ENSG00000284061 [P24071-2]
ENST00000639193; ENSP00000491447; ENSG00000284004 [P24071-2]
ENST00000639223; ENSP00000492274; ENSG00000284061 [P24071-10]
ENST00000639337; ENSP00000491914; ENSG00000283750 [P24071-3]
ENST00000639392; ENSP00000492068; ENSG00000283750 [P24071-2]
ENST00000639402; ENSP00000492442; ENSG00000284245 [P24071-1]
ENST00000639426; ENSP00000492415; ENSG00000284004 [P24071-10]
ENST00000639428; ENSP00000491642; ENSG00000284061 [P24071-11]
ENST00000639455; ENSP00000491849; ENSG00000284061 [P24071-9]
ENST00000639575; ENSP00000492321; ENSG00000283953 [P24071-2]
ENST00000639763; ENSP00000491420; ENSG00000284004 [P24071-8]
ENST00000640025; ENSP00000492529; ENSG00000283750 [P24071-10]
ENST00000640032; ENSP00000492077; ENSG00000284004 [P24071-9]
ENST00000640047; ENSP00000490997; ENSG00000284245 [P24071-7]
ENST00000640063; ENSP00000491889; ENSG00000284004 [P24071-11]
ENST00000640070; ENSP00000491192; ENSG00000283750 [P24071-4]
ENST00000640239; ENSP00000492762; ENSG00000283953 [P24071-1]
ENST00000640405; ENSP00000491490; ENSG00000284004 [P24071-1]
ENST00000640415; ENSP00000491274; ENSG00000284245 [P24071-10]
ENST00000640430; ENSP00000492494; ENSG00000283953 [P24071-4]
ENST00000640462; ENSP00000491298; ENSG00000284245 [P24071-3]
ENST00000640562; ENSP00000492074; ENSG00000283750 [P24071-5]
ENST00000640582; ENSP00000492447; ENSG00000283750 [P24071-1]
ENST00000640584; ENSP00000491818; ENSG00000284061 [P24071-5]
ENST00000640618; ENSP00000491815; ENSG00000284245 [P24071-5]
ENST00000640687; ENSP00000492597; ENSG00000283953 [P24071-5]
ENST00000640761; ENSP00000492411; ENSG00000284004 [P24071-4]
ENST00000640811; ENSP00000492678; ENSG00000283953 [P24071-10]
ENST00000640878; ENSP00000492686; ENSG00000284245 [P24071-11]
ENST00000640908; ENSP00000492162; ENSG00000284245 [P24071-4]
ENST00000640918; ENSP00000491746; ENSG00000284004 [P24071-5]
GeneIDi2204
KEGGihsa:2204
UCSCiuc002qhq.4 human [P24071-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2204
DisGeNETi2204
EuPathDBiHostDB:ENSG00000186431.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		FCAR
HGNCiHGNC:3608 FCAR
HPAiHPA014050
MIMi147045 gene
neXtProtiNX_P24071
OpenTargetsiENSG00000186431
PharmGKBiPA28055

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IG5T Eukaryota
ENOG4111BK0 LUCA
GeneTreeiENSGT00940000153328
HOGENOMiHOG000234395
HOVERGENiHBG004337
InParanoidiP24071
KOiK06513
OMAiGRYQCRY
OrthoDBi1327293at2759
PhylomeDBiP24071
TreeFamiTF336644

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FCAR human
EvolutionaryTraceiP24071

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FCAR

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2204

Protein Ontology

More...PROi		PR:P24071

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186431 Expressed in 87 organ(s), highest expression level in blood
CleanExiHS_FCAR
ExpressionAtlasiP24071 baseline and differential
GenevisibleiP24071 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCAR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24071
Secondary accession number(s): Q13603
, Q13604, Q15727, Q15728, Q1AJL7, Q1AJL8, Q1AJL9, Q53X38, Q53X39, Q92587, Q92588, Q92590, Q92592, Q92593, Q9UEK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: January 16, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again