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Protein

Gamma-aminobutyric acid receptor subunit rho-1

Gene

GABRR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-977442 GABA A (rho) receptor activation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P24046

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.9.5.5 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-1
Alternative name(s):
GABA(A) receptor subunit rho-1
GABA(C) receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GABRR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000146276.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4090 GABRR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
137161 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P24046

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 281ExtracellularCuratedAdd BLAST260
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei282 – 305HelicalCuratedAdd BLAST24
Transmembranei309 – 331HelicalCuratedAdd BLAST23
Transmembranei343 – 365HelicalCuratedAdd BLAST23
Topological domaini366 – 457CytoplasmicCuratedAdd BLAST92
Transmembranei458 – 479HelicalCuratedAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2569

Open Targets

More...
OpenTargetsi
ENSG00000146276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28505

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3561

Drug and drug target database

More...
DrugBanki
DB00546 Adinazolam
DB01558 Bromazepam
DB01594 Cinolazepam
DB01559 Clotiazepam
DB00829 Diazepam
DB01215 Estazolam
DB01567 Fludiazepam
DB00690 Flurazepam
DB00801 Halazepam
DB00683 Midazolam
DB01595 Nitrazepam
DB00842 Oxazepam
DB00466 Picrotoxin
DB01588 Prazepam
DB01589 Quazepam
DB00231 Temazepam
DB00897 Triazolam

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GABRR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
223590210

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000048522 – 479Gamma-aminobutyric acid receptor subunit rho-1Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi198 ↔ 212By similarity
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P24046

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P24046

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24046

PeptideAtlas

More...
PeptideAtlasi
P24046

PRoteomics IDEntifications database

More...
PRIDEi
P24046

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54179
54180 [P24046-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24046

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P24046

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the retina and in a lesser extent in brain, lung and thymus.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146276 Expressed in 48 organ(s), highest expression level in descending thoracic aorta

CleanEx database of gene expression profiles

More...
CleanExi
HS_GABRR1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P24046 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P24046 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108843, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P24046, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412673

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P24046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P24046

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24046

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3643 Eukaryota
ENOG410XPWH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231335

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051707

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24046

KEGG Orthology (KO)

More...
KOi
K05190

Identification of Orthologs from Complete Genome Data

More...
OMAi
RMMVQLA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0805

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24046

TreeFam database of animal gene trees

More...
TreeFami
TF315453

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008058 GABAAa_rho1_rcpt
IPR008057 GABAAa_rho_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS

The PANTHER Classification System

More...
PANTHERi
PTHR18945 PTHR18945, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00253 GABAARECEPTR
PR01670 GABAARRHO
PR01671 GABAARRHO1
PR00252 NRIONCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00860 LIC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P24046-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAVPNMRFG IFLLWWGWVL ATESRMHWPG REVHEMSKKG RPQRQRREVH
60 70 80 90 100
EDAHKQVSPI LRRSPDITKS PLTKSEQLLR IDDHDFSMRP GFGGPAIPVG
110 120 130 140 150
VDVQVESLDS ISEVDMDFTM TLYLRHYWKD ERLSFPSTNN LSMTFDGRLV
160 170 180 190 200
KKIWVPDMFF VHSKRSFIHD TTTDNVMLRV QPDGKVLYSL RVTVTAMCNM
210 220 230 240 250
DFSRFPLDTQ TCSLEIESYA YTEDDLMLYW KKGNDSLKTD ERISLSQFLI
260 270 280 290 300
QEFHTTTKLA FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW
310 320 330 340 350
VSFWIDRRAV PARVPLGITT VLTMSTIITG VNASMPRVSY IKAVDIYLWV
360 370 380 390 400
SFVFVFLSVL EYAAVNYLTT VQERKEQKLR EKLPCTSGLP PPRTAMLDGN
410 420 430 440 450
YSDGEVNDLD NYMPENGEKP DRMMVQLTLA SERSSPQRKS QRSSYVSMRI
460 470
DTHAIDKYSR IIFPAAYILF NLIYWSIFS
Length:479
Mass (Da):55,883
Last modified:February 10, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0C1985F16C18231
GO
Isoform 2 (identifier: P24046-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-57: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):53,732
Checksum:iB10A3E99D285154A
GO
Isoform 3 (identifier: P24046-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):45,516
Checksum:i691103DF1AA72646
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WB88F8WB88_HUMAN
Gamma-aminobutyric acid receptor su...
GABRR1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52509 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI30345 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40G → GS in AAI30345 (PubMed:15489334).Curated1
Sequence conflicti424 – 425MV → VM in BAG61047 (PubMed:14702039).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05442626M → V1 PublicationCorresponds to variant dbSNP:rs12200969Ensembl.1
Natural variantiVAR_02436127H → R. Corresponds to variant dbSNP:rs1186902Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0466651 – 87Missing in isoform 3. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_03636341 – 57Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62400 mRNA Translation: AAA52509.1 Different initiation.
AK296124 mRNA Translation: BAG58870.1
AK298948 mRNA Translation: BAG61047.1
AL353659 Genomic DNA No translation available.
AL353135 Genomic DNA No translation available.
BC130344 mRNA Translation: AAI30345.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5019.2 [P24046-1]
CCDS59028.1 [P24046-3]
CCDS59029.1 [P24046-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A38627

NCBI Reference Sequences

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RefSeqi
NP_001243632.1, NM_001256703.1 [P24046-2]
NP_001243633.1, NM_001256704.1 [P24046-3]
NP_001254511.1, NM_001267582.1 [P24046-3]
NP_002033.2, NM_002042.4 [P24046-1]
XP_016866178.1, XM_017010689.1 [P24046-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.99927

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369451; ENSP00000358463; ENSG00000146276 [P24046-3]
ENST00000435811; ENSP00000394687; ENSG00000146276 [P24046-2]
ENST00000454853; ENSP00000412673; ENSG00000146276 [P24046-1]
ENST00000611484; ENSP00000478846; ENSG00000146276 [P24046-3]
ENST00000621627; ENSP00000481986; ENSG00000146276 [P24046-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2569

UCSC genome browser

More...
UCSCi
uc003pna.3 human [P24046-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62400 mRNA Translation: AAA52509.1 Different initiation.
AK296124 mRNA Translation: BAG58870.1
AK298948 mRNA Translation: BAG61047.1
AL353659 Genomic DNA No translation available.
AL353135 Genomic DNA No translation available.
BC130344 mRNA Translation: AAI30345.1 Different initiation.
CCDSiCCDS5019.2 [P24046-1]
CCDS59028.1 [P24046-3]
CCDS59029.1 [P24046-2]
PIRiA38627
RefSeqiNP_001243632.1, NM_001256703.1 [P24046-2]
NP_001243633.1, NM_001256704.1 [P24046-3]
NP_001254511.1, NM_001267582.1 [P24046-3]
NP_002033.2, NM_002042.4 [P24046-1]
XP_016866178.1, XM_017010689.1 [P24046-3]
UniGeneiHs.99927

3D structure databases

ProteinModelPortaliP24046
SMRiP24046
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108843, 12 interactors
IntActiP24046, 1 interactor
STRINGi9606.ENSP00000412673

Chemistry databases

BindingDBiP24046
ChEMBLiCHEMBL3561
DrugBankiDB00546 Adinazolam
DB01558 Bromazepam
DB01594 Cinolazepam
DB01559 Clotiazepam
DB00829 Diazepam
DB01215 Estazolam
DB01567 Fludiazepam
DB00690 Flurazepam
DB00801 Halazepam
DB00683 Midazolam
DB01595 Nitrazepam
DB00842 Oxazepam
DB00466 Picrotoxin
DB01588 Prazepam
DB01589 Quazepam
DB00231 Temazepam
DB00897 Triazolam

Protein family/group databases

TCDBi1.A.9.5.5 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetiP24046
PhosphoSitePlusiP24046

Polymorphism and mutation databases

BioMutaiGABRR1
DMDMi223590210

Proteomic databases

EPDiP24046
MaxQBiP24046
PaxDbiP24046
PeptideAtlasiP24046
PRIDEiP24046
ProteomicsDBi54179
54180 [P24046-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2569
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369451; ENSP00000358463; ENSG00000146276 [P24046-3]
ENST00000435811; ENSP00000394687; ENSG00000146276 [P24046-2]
ENST00000454853; ENSP00000412673; ENSG00000146276 [P24046-1]
ENST00000611484; ENSP00000478846; ENSG00000146276 [P24046-3]
ENST00000621627; ENSP00000481986; ENSG00000146276 [P24046-3]
GeneIDi2569
KEGGihsa:2569
UCSCiuc003pna.3 human [P24046-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2569
DisGeNETi2569
EuPathDBiHostDB:ENSG00000146276.11

GeneCards: human genes, protein and diseases

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GeneCardsi
GABRR1
HGNCiHGNC:4090 GABRR1
MIMi137161 gene
neXtProtiNX_P24046
OpenTargetsiENSG00000146276
PharmGKBiPA28505

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00940000158591
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP24046
KOiK05190
OMAiRMMVQLA
OrthoDBiEOG091G0805
PhylomeDBiP24046
TreeFamiTF315453

Enzyme and pathway databases

ReactomeiR-HSA-977442 GABA A (rho) receptor activation
SignaLinkiP24046

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GABRR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2569

Protein Ontology

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PROi
PR:P24046

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146276 Expressed in 48 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_GABRR1
ExpressionAtlasiP24046 baseline and differential
GenevisibleiP24046 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008058 GABAAa_rho1_rcpt
IPR008057 GABAAa_rho_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01670 GABAARRHO
PR01671 GABAARRHO1
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBRR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24046
Secondary accession number(s): A1L401
, B4DJK8, B4DQT5, B7ZBQ7, Q9BX06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: February 10, 2009
Last modified: December 5, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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