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Protein

Laminin subunit alpha-2

Gene

LAMA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-8874081 MET activates PTK2 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P24043

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit alpha-2
Alternative name(s):
Laminin M chain
Laminin-12 subunit alpha
Laminin-2 subunit alpha
Laminin-4 subunit alpha
Merosin heavy chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA2
Synonyms:LAMM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196569.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6482 LAMA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
156225 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P24043

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Merosin-deficient congenital muscular dystrophy 1A (MDC1A)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCharacterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
See also OMIM:607855
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015743527C → Y in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs121913574EnsemblClinVar.1
Natural variantiVAR_015744862C → R in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs121913573EnsemblClinVar.1
Natural variantiVAR_0157452564L → P in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs121913570EnsemblClinVar.1
Natural variantiVAR_0765602889G → R in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs886039896EnsemblClinVar.1

Keywords - Diseasei

Congenital muscular dystrophy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3908

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
LAMA2

MalaCards human disease database

More...
MalaCardsi
LAMA2
MIMi607855 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196569

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
258 Congenital muscular dystrophy type 1A

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30271

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAMA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274259

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001705623 – 3122Laminin subunit alpha-2Add BLAST3100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi287 ↔ 296By similarity
Disulfide bondi289 ↔ 307By similarity
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 318By similarity
Disulfide bondi321 ↔ 341By similarity
Disulfide bondi344 ↔ 353By similarity
Disulfide bondi346 ↔ 378By similarity
Glycosylationi363N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi381 ↔ 390By similarity
Disulfide bondi393 ↔ 411By similarity
Disulfide bondi414 ↔ 426By similarity
Disulfide bondi416 ↔ 442By similarity
Disulfide bondi444 ↔ 453By similarity
Disulfide bondi456 ↔ 466By similarity
Disulfide bondi469 ↔ 482By similarity
Glycosylationi470N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi471 ↔ 486By similarity
Disulfide bondi488 ↔ 497By similarity
Disulfide bondi500 ↔ 515By similarity
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi757 ↔ 766By similarity
Disulfide bondi759 ↔ 773By similarity
Disulfide bondi776 ↔ 785By similarity
Disulfide bondi788 ↔ 804By similarity
Disulfide bondi807 ↔ 822By similarity
Disulfide bondi809 ↔ 832By similarity
Disulfide bondi835 ↔ 844By similarity
Disulfide bondi847 ↔ 862By similarity
Disulfide bondi865 ↔ 879By similarity
Disulfide bondi867 ↔ 886By similarity
Disulfide bondi889 ↔ 898By similarity
Disulfide bondi901 ↔ 915By similarity
Disulfide bondi918 ↔ 930By similarity
Disulfide bondi920 ↔ 937By similarity
Disulfide bondi939 ↔ 948By similarity
Disulfide bondi951 ↔ 964By similarity
Disulfide bondi967 ↔ 979By similarity
Disulfide bondi969 ↔ 985By similarity
Disulfide bondi987 ↔ 996By similarity
Disulfide bondi999 ↔ 1011By similarity
Disulfide bondi1014 ↔ 1023By similarity
Disulfide bondi1016 ↔ 1030By similarity
Disulfide bondi1032 ↔ 1041By similarity
Disulfide bondi1044 ↔ 1057By similarity
Disulfide bondi1060 ↔ 1072By similarity
Glycosylationi1061N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1062 ↔ 1079By similarity
Disulfide bondi1081 ↔ 1090By similarity
Disulfide bondi1093 ↔ 1103By similarity
Disulfide bondi1106 ↔ 1118By similarity
Disulfide bondi1108 ↔ 1134By similarity
Disulfide bondi1136 ↔ 1145By similarity
Disulfide bondi1148 ↔ 1163By similarity
Disulfide bondi1420 ↔ 1429By similarity
Disulfide bondi1422 ↔ 1436By similarity
Disulfide bondi1439 ↔ 1448By similarity
Disulfide bondi1451 ↔ 1466By similarity
Disulfide bondi1469 ↔ 1484By similarity
Disulfide bondi1471 ↔ 1494By similarity
Disulfide bondi1497 ↔ 1506By similarity
Disulfide bondi1509 ↔ 1524By similarity
Disulfide bondi1527 ↔ 1539By similarity
Disulfide bondi1529 ↔ 1546By similarity
Disulfide bondi1548 ↔ 1557By similarity
Disulfide bondi1560 ↔ 1571By similarity
Disulfide bondi1574InterchainCurated
Disulfide bondi1578InterchainCurated
Glycosylationi1597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1614N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1700N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1810N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1901N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1916N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1920N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2017N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2028N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2045N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2240N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2302 ↔ 2328By similarity
Glycosylationi2360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2478N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2495 ↔ 2521By similarity
Glycosylationi2551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2648N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi2683 ↔ 2710By similarity
Glycosylationi2868N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2893N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2909 ↔ 2934By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P24043

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P24043

PeptideAtlas

More...
PeptideAtlasi
P24043

PRoteomics IDEntifications database

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PRIDEi
P24043

ProteomicsDB human proteome resource

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ProteomicsDBi
54178

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1439

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24043

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P24043

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196569 Expressed in 221 organ(s), highest expression level in esophagus

CleanEx database of gene expression profiles

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CleanExi
HS_LAMA2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P24043 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P24043 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB040310
CAB078182

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-2 is a subunit of laminin-2 (laminin-211 or merosin), laminin-4 (laminin-221 or S-merosin) and laminin-12 (laminin-213). Interacts with FBLN1, FBLN2 and NID2.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110102, 5 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1771 Laminin-211 complex
CPX-1773 Laminin-221 complex
CPX-1781 Laminin-213 complex

Database of interacting proteins

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DIPi
DIP-42562N

Protein interaction database and analysis system

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IntActi
P24043, 7 interactors

Molecular INTeraction database

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MINTi
P24043

STRING: functional protein association networks

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STRINGi
9606.ENSP00000400365

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13122
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P24043

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P24043

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 286Laminin N-terminalPROSITE-ProRule annotationAdd BLAST252
Domaini287 – 343Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST57
Domaini344 – 413Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST70
Domaini414 – 468Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST55
Domaini469 – 517Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST49
Domaini518 – 527Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini531 – 723Laminin IV type A 1PROSITE-ProRule annotationAdd BLAST193
Domaini724 – 756Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST33
Domaini757 – 806Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST50
Domaini807 – 864Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST58
Domaini865 – 917Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST53
Domaini918 – 966Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST49
Domaini967 – 1013Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST47
Domaini1014 – 1059Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST46
Domaini1060 – 1105Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST46
Domaini1106 – 1165Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST60
Domaini1166 – 1175Laminin EGF-like 14; first partPROSITE-ProRule annotation10
Domaini1176 – 1379Laminin IV type A 2PROSITE-ProRule annotationAdd BLAST204
Domaini1380 – 1419Laminin EGF-like 14; second partPROSITE-ProRule annotationAdd BLAST40
Domaini1420 – 1468Laminin EGF-like 15PROSITE-ProRule annotationAdd BLAST49
Domaini1469 – 1526Laminin EGF-like 16PROSITE-ProRule annotationAdd BLAST58
Domaini1527 – 1573Laminin EGF-like 17PROSITE-ProRule annotationAdd BLAST47
Domaini2145 – 2328Laminin G-like 1PROSITE-ProRule annotationAdd BLAST184
Domaini2340 – 2521Laminin G-like 2PROSITE-ProRule annotationAdd BLAST182
Domaini2526 – 2710Laminin G-like 3PROSITE-ProRule annotationAdd BLAST185
Domaini2763 – 2934Laminin G-like 4PROSITE-ProRule annotationAdd BLAST172
Domaini2939 – 3110Laminin G-like 5PROSITE-ProRule annotationAdd BLAST172

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1574 – 2144Domain II and IAdd BLAST571

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1630 – 2150Sequence analysisAdd BLAST521

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI, IV and G are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155362

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293201

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052298

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24043

KEGG Orthology (KO)

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KOi
K05637

Identification of Orthologs from Complete Genome Data

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OMAi
IRHMAAP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G005L

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24043

TreeFam database of animal gene trees

More...
TreeFami
TF335359

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 2 hits
PF00053 Laminin_EGF, 16 hits
PF00054 Laminin_G_1, 4 hits
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 16 hits
SM00281 LamB, 2 hits
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 11 hits
PS01186 EGF_2, 3 hits
PS01248 EGF_LAM_1, 14 hits
PS50027 EGF_LAM_2, 15 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 2 hits
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P24043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGAAGVLLL LLLSGGLGGV QAQRPQQQRQ SQAHQQRGLF PAVLNLASNA
60 70 80 90 100
LITTNATCGE KGPEMYCKLV EHVPGQPVRN PQCRICNQNS SNPNQRHPIT
110 120 130 140 150
NAIDGKNTWW QSPSIKNGIE YHYVTITLDL QQVFQIAYVI VKAANSPRPG
160 170 180 190 200
NWILERSLDD VEYKPWQYHA VTDTECLTLY NIYPRTGPPS YAKDDEVICT
210 220 230 240 250
SFYSKIHPLE NGEIHISLIN GRPSADDPSP ELLEFTSARY IRLRFQRIRT
260 270 280 290 300
LNADLMMFAH KDPREIDPIV TRRYYYSVKD ISVGGMCICY GHARACPLDP
310 320 330 340 350
ATNKSRCECE HNTCGDSCDQ CCPGFHQKPW RAGTFLTKTE CEACNCHGKA
360 370 380 390 400
EECYYDENVA RRNLSLNIRG KYIGGGVCIN CTQNTAGINC ETCTDGFFRP
410 420 430 440 450
KGVSPNYPRP CQPCHCDPIG SLNEVCVKDE KHARRGLAPG SCHCKTGFGG
460 470 480 490 500
VSCDRCARGY TGYPDCKACN CSGLGSKNED PCFGPCICKE NVEGGDCSRC
510 520 530 540 550
KSGFFNLQED NWKGCDECFC SGVSNRCQSS YWTYGKIQDM SGWYLTDLPG
560 570 580 590 600
RIRVAPQQDD LDSPQQISIS NAEARQALPH SYYWSAPAPY LGNKLPAVGG
610 620 630 640 650
QLTFTISYDL EEEEEDTERV LQLMIILEGN DLSISTAQDE VYLHPSEEHT
660 670 680 690 700
NVLLLKEESF TIHGTHFPVR RKEFMTVLAN LKRVLLQITY SFGMDAIFRL
710 720 730 740 750
SSVNLESAVS YPTDGSIAAA VEVCQCPPGY TGSSCESCWP RHRRVNGTIF
760 770 780 790 800
GGICEPCQCF GHAESCDDVT GECLNCKDHT GGPYCDKCLP GFYGEPTKGT
810 820 830 840 850
SEDCQPCACP LNIPSNNFSP TCHLDRSLGL ICDGCPVGYT GPRCERCAEG
860 870 880 890 900
YFGQPSVPGG SCQPCQCNDN LDFSIPGSCD SLSGSCLICK PGTTGRYCEL
910 920 930 940 950
CADGYFGDAV DAKNCQPCRC NAGGSFSEVC HSQTGQCECR ANVQGQRCDK
960 970 980 990 1000
CKAGTFGLQS ARGCVPCNCN SFGSKSFDCE ESGQCWCQPG VTGKKCDRCA
1010 1020 1030 1040 1050
HGYFNFQEGG CTACECSHLG NNCDPKTGRC ICPPNTIGEK CSKCAPNTWG
1060 1070 1080 1090 1100
HSITTGCKAC NCSTVGSLDF QCNVNTGQCN CHPKFSGAKC TECSRGHWNY
1110 1120 1130 1140 1150
PRCNLCDCFL PGTDATTCDS ETKKCSCSDQ TGQCTCKVNV EGIHCDRCRP
1160 1170 1180 1190 1200
GKFGLDAKNP LGCSSCYCFG TTTQCSEAKG LIRTWVTLKA EQTILPLVDE
1210 1220 1230 1240 1250
ALQHTTTKGI VFQHPEIVAH MDLMREDLHL EPFYWKLPEQ FEGKKLMAYG
1260 1270 1280 1290 1300
GKLKYAIYFE AREETGFSTY NPQVIIRGGT PTHARIIVRH MAAPLIGQLT
1310 1320 1330 1340 1350
RHEIEMTEKE WKYYGDDPRV HRTVTREDFL DILYDIHYIL IKATYGNFMR
1360 1370 1380 1390 1400
QSRISEISME VAEQGRGTTM TPPADLIEKC DCPLGYSGLS CEACLPGFYR
1410 1420 1430 1440 1450
LRSQPGGRTP GPTLGTCVPC QCNGHSSLCD PETSICQNCQ HHTAGDFCER
1460 1470 1480 1490 1500
CALGYYGIVK GLPNDCQQCA CPLISSSNNF SPSCVAEGLD DYRCTACPRG
1510 1520 1530 1540 1550
YEGQYCERCA PGYTGSPGNP GGSCQECECD PYGSLPVPCD PVTGFCTCRP
1560 1570 1580 1590 1600
GATGRKCDGC KHWHAREGWE CVFCGDECTG LLLGDLARLE QMVMSINLTG
1610 1620 1630 1640 1650
PLPAPYKMLY GLENMTQELK HLLSPQRAPE RLIQLAEGNL NTLVTEMNEL
1660 1670 1680 1690 1700
LTRATKVTAD GEQTGQDAER TNTRAKSLGE FIKELARDAE AVNEKAIKLN
1710 1720 1730 1740 1750
ETLGTRDEAF ERNLEGLQKE IDQMIKELRR KNLETQKEIA EDELVAAEAL
1760 1770 1780 1790 1800
LKKVKKLFGE SRGENEEMEK DLREKLADYK NKVDDAWDLL REATDKIREA
1810 1820 1830 1840 1850
NRLFAVNQKN MTALEKKKEA VESGKRQIEN TLKEGNDILD EANRLADEIN
1860 1870 1880 1890 1900
SIIDYVEDIQ TKLPPMSEEL NDKIDDLSQE IKDRKLAEKV SQAESHAAQL
1910 1920 1930 1940 1950
NDSSAVLDGI LDEAKNISFN ATAAFKAYSN IKDYIDEAEK VAKEAKDLAH
1960 1970 1980 1990 2000
EATKLATGPR GLLKEDAKGC LQKSFRILNE AKKLANDVKE NEDHLNGLKT
2010 2020 2030 2040 2050
RIENADARNG DLLRTLNDTL GKLSAIPNDT AAKLQAVKDK ARQANDTAKD
2060 2070 2080 2090 2100
VLAQITELHQ NLDGLKKNYN KLADSVAKTN AVVKDPSKNK IIADADATVK
2110 2120 2130 2140 2150
NLEQEADRLI DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS
2160 2170 2180 2190 2200
GGDCIRTYKP EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR
2210 2220 2230 2240 2250
KGKVSFLWDV GSGVGRVEYP DLTIDDSYWY RIVASRTGRN GTISVRALDG
2260 2270 2280 2290 2300
PKASIVPSTH HSTSPPGYTI LDVDANAMLF VGGLTGKLKK ADAVRVITFT
2310 2320 2330 2340 2350
GCMGETYFDN KPIGLWNFRE KEGDCKGCTV SPQVEDSEGT IQFDGEGYAL
2360 2370 2380 2390 2400
VSRPIRWYPN ISTVMFKFRT FSSSALLMYL ATRDLRDFMS VELTDGHIKV
2410 2420 2430 2440 2450
SYDLGSGMAS VVSNQNHNDG KWKSFTLSRI QKQANISIVD IDTNQEENIA
2460 2470 2480 2490 2500
TSSSGNNFGL DLKADDKIYF GGLPTLRNLS MKARPEVNLK KYSGCLKDIE
2510 2520 2530 2540 2550
ISRTPYNILS SPDYVGVTKG CSLENVYTVS FPKPGFVELS PVPIDVGTEI
2560 2570 2580 2590 2600
NLSFSTKNES GIILLGSGGT PAPPRRKRRQ TGQAYYAILL NRGRLEVHLS
2610 2620 2630 2640 2650
TGARTMRKIV IRPEPNLFHD GREHSVHVER TRGIFTVQVD ENRRYMQNLT
2660 2670 2680 2690 2700
VEQPIEVKKL FVGGAPPEFQ PSPLRNIPPF EGCIWNLVIN SVPMDFARPV
2710 2720 2730 2740 2750
SFKNADIGRC AHQKLREDED GAAPAEIVIQ PEPVPTPAFP TPTPVLTHGP
2760 2770 2780 2790 2800
CAAESEPALL IGSKQFGLSR NSHIAIAFDD TKVKNRLTIE LEVRTEAESG
2810 2820 2830 2840 2850
LLFYMARINH ADFATVQLRN GLPYFSYDLG SGDTHTMIPT KINDGQWHKI
2860 2870 2880 2890 2900
KIMRSKQEGI LYVDGASNRT ISPKKADILD VVGMLYVGGL PINYTTRRIG
2910 2920 2930 2940 2950
PVTYSIDGCV RNLHMAEAPA DLEQPTSSFH VGTCFANAQR GTYFDGTGFA
2960 2970 2980 2990 3000
KAVGGFKVGL DLLVEFEFRT TTTTGVLLGI SSQKMDGMGI EMIDEKLMFH
3010 3020 3030 3040 3050
VDNGAGRFTA VYDAGVPGHL CDGQWHKVTA NKIKHRIELT VDGNQVEAQS
3060 3070 3080 3090 3100
PNPASTSADT NDPVFVGGFP DDLKQFGLTT SIPFRGCIRS LKLTKGTGKP
3110 3120
LEVNFAKALE LRGVQPVSCP AN
Length:3,122
Mass (Da):343,905
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2C13BD6FC1B7BAC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYF1A0A087WYF1_HUMAN
Laminin subunit alpha-2
LAMA2
3,118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX80A0A087WX80_HUMAN
Laminin subunit alpha-2
LAMA2
3,121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDM5A0A2R8YDM5_HUMAN
Laminin subunit alpha-2
LAMA2
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA63215 differs from that shown. Reason: Frameshift at position 3098.Curated
The sequence AAB18388 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA81394 differs from that shown. Reason: Frameshift at position 3098.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti588A → R in AAB18388 (PubMed:8910357).Curated1
Sequence conflicti1740A → D (PubMed:7535762).Curated1
Sequence conflicti1827Q → G (PubMed:7535762).Curated1
Sequence conflicti1981A → V in AAA63215 (PubMed:2185464).Curated1
Sequence conflicti2437S → Y in AAB18388 (PubMed:8910357).Curated1
Sequence conflicti2624H → R in AAA63215 (PubMed:2185464).Curated1
Sequence conflicti2807R → A in CAA81394 (PubMed:8294519).Curated1
Sequence conflicti2807R → A in AAB18388 (PubMed:8910357).Curated1
Sequence conflicti2969R → A in CAA81394 (PubMed:8294519).Curated1
Sequence conflicti2969R → A in AAB18388 (PubMed:8910357).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04771396R → S. Corresponds to variant dbSNP:rs34626728Ensembl.1
Natural variantiVAR_047714240Y → H. Corresponds to variant dbSNP:rs3778142Ensembl.1
Natural variantiVAR_015743527C → Y in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs121913574EnsemblClinVar.1
Natural variantiVAR_004165545L → Q1 PublicationCorresponds to variant dbSNP:rs118083923EnsemblClinVar.1
Natural variantiVAR_004166619R → H1 PublicationCorresponds to variant dbSNP:rs3816665EnsemblClinVar.1
Natural variantiVAR_047715644H → D. Corresponds to variant dbSNP:rs35879899EnsemblClinVar.1
Natural variantiVAR_015744862C → R in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs121913573EnsemblClinVar.1
Natural variantiVAR_004167919R → L1 PublicationCorresponds to variant dbSNP:rs35277491EnsemblClinVar.1
Natural variantiVAR_0477161138V → M. Corresponds to variant dbSNP:rs2306942EnsemblClinVar.1
Natural variantiVAR_0358191160P → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0477171205T → A. Corresponds to variant dbSNP:rs35889149EnsemblClinVar.1
Natural variantiVAR_0477181561K → Q. Corresponds to variant dbSNP:rs4143752Ensembl.1
Natural variantiVAR_0477191945A → T. Corresponds to variant dbSNP:rs3828736EnsemblClinVar.1
Natural variantiVAR_0157452564L → P in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs121913570EnsemblClinVar.1
Natural variantiVAR_0041682586Y → H1 Publication1
Natural variantiVAR_0477202587A → V3 PublicationsCorresponds to variant dbSNP:rs2229848Ensembl.1
Natural variantiVAR_0041692614E → K1 Publication1
Natural variantiVAR_0477212636T → A. Corresponds to variant dbSNP:rs2244008EnsemblClinVar.1
Natural variantiVAR_0765602889G → R in MDC1A. 1 PublicationCorresponds to variant dbSNP:rs886039896EnsemblClinVar.1
Natural variantiVAR_0477223029T → A. Corresponds to variant dbSNP:rs34551216Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z26653 mRNA Translation: CAA81394.1 Frameshift.
U66796
, U66733, U66734, U66735, U66736, U66737, U66738, U66739, U66740, U66741, U66742, U66743, U66745, U66746, U66747, U66748, U66749, U66750, U66751, U66752, U66753, U66754, U66755, U66756, U66757, U66758, U66759, U66760, U66761, U66762, U66763, U66764, U66765, U66766, U66768, U66769, U66770, U66771, U66772, U66773, U66774, U66775, U66776, U66777, U66778, U66779, U66780, U66781, U66782, U66783, U66784, U66785, U66786, U66787, U66788, U66789, U66790, U66791, U66792, U66793, U66794, U66795 Genomic DNA Translation: AAB18388.1 Sequence problems.
AL583853
, AL356124, AL445439, AL513527, AL590613, AL669984 Genomic DNA Translation: CAH70492.1
AL590613
, AL356124, AL445439, AL513527, AL583853, AL669984 Genomic DNA Translation: CAH70771.1
AL445439
, AL356124, AL513527, AL583853, AL590613, AL669984 Genomic DNA Translation: CAH72952.1
AL513527
, AL356124, AL445439, AL583853, AL590613, AL669984 Genomic DNA Translation: CAI15185.1
AL669984
, AL356124, AL445439, AL513527, AL583853, AL590613 Genomic DNA Translation: CAI16682.1
AL356124
, AL445439, AL513527, AL583853, AL590613, AL669984 Genomic DNA Translation: CAI22470.1
AL589927 Genomic DNA No translation available.
M59832 mRNA Translation: AAA63215.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS5138.1

Protein sequence database of the Protein Information Resource

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PIRi
PX0082 MMHUMH

NCBI Reference Sequences

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RefSeqi
NP_000417.2, NM_000426.3
NP_001073291.1, NM_001079823.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.200841

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000421865; ENSP00000400365; ENSG00000196569

Database of genes from NCBI RefSeq genomes

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GeneIDi
3908

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3908

UCSC genome browser

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UCSCi
uc063rgy.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26653 mRNA Translation: CAA81394.1 Frameshift.
U66796
, U66733, U66734, U66735, U66736, U66737, U66738, U66739, U66740, U66741, U66742, U66743, U66745, U66746, U66747, U66748, U66749, U66750, U66751, U66752, U66753, U66754, U66755, U66756, U66757, U66758, U66759, U66760, U66761, U66762, U66763, U66764, U66765, U66766, U66768, U66769, U66770, U66771, U66772, U66773, U66774, U66775, U66776, U66777, U66778, U66779, U66780, U66781, U66782, U66783, U66784, U66785, U66786, U66787, U66788, U66789, U66790, U66791, U66792, U66793, U66794, U66795 Genomic DNA Translation: AAB18388.1 Sequence problems.
AL583853
, AL356124, AL445439, AL513527, AL590613, AL669984 Genomic DNA Translation: CAH70492.1
AL590613
, AL356124, AL445439, AL513527, AL583853, AL669984 Genomic DNA Translation: CAH70771.1
AL445439
, AL356124, AL513527, AL583853, AL590613, AL669984 Genomic DNA Translation: CAH72952.1
AL513527
, AL356124, AL445439, AL583853, AL590613, AL669984 Genomic DNA Translation: CAI15185.1
AL669984
, AL356124, AL445439, AL513527, AL583853, AL590613 Genomic DNA Translation: CAI16682.1
AL356124
, AL445439, AL513527, AL583853, AL590613, AL669984 Genomic DNA Translation: CAI22470.1
AL589927 Genomic DNA No translation available.
M59832 mRNA Translation: AAA63215.1 Frameshift.
CCDSiCCDS5138.1
PIRiPX0082 MMHUMH
RefSeqiNP_000417.2, NM_000426.3
NP_001073291.1, NM_001079823.1
UniGeneiHs.200841

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YEPX-ray1.19A/B1181-1362[»]
4YEQX-ray3.20U1177-1379[»]
ProteinModelPortaliP24043
SMRiP24043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110102, 5 interactors
ComplexPortaliCPX-1771 Laminin-211 complex
CPX-1773 Laminin-221 complex
CPX-1781 Laminin-213 complex
DIPiDIP-42562N
IntActiP24043, 7 interactors
MINTiP24043
STRINGi9606.ENSP00000400365

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

GlyConnecti1439
iPTMnetiP24043
PhosphoSitePlusiP24043

Polymorphism and mutation databases

BioMutaiLAMA2
DMDMi215274259

Proteomic databases

EPDiP24043
PaxDbiP24043
PeptideAtlasiP24043
PRIDEiP24043
ProteomicsDBi54178

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3908
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421865; ENSP00000400365; ENSG00000196569
GeneIDi3908
KEGGihsa:3908
UCSCiuc063rgy.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3908
DisGeNETi3908
EuPathDBiHostDB:ENSG00000196569.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAMA2
GeneReviewsiLAMA2
HGNCiHGNC:6482 LAMA2
HPAiCAB040310
CAB078182
MalaCardsiLAMA2
MIMi156225 gene
607855 phenotype
neXtProtiNX_P24043
OpenTargetsiENSG00000196569
Orphaneti258 Congenital muscular dystrophy type 1A
PharmGKBiPA30271

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000155362
HOGENOMiHOG000293201
HOVERGENiHBG052298
InParanoidiP24043
KOiK05637
OMAiIRHMAAP
OrthoDBiEOG091G005L
PhylomeDBiP24043
TreeFamiTF335359

Enzyme and pathway databases

ReactomeiR-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-8874081 MET activates PTK2 signaling
SIGNORiP24043

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMA2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Laminin,_alpha_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3908

Protein Ontology

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PROi
PR:P24043

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196569 Expressed in 221 organ(s), highest expression level in esophagus
CleanExiHS_LAMA2
ExpressionAtlasiP24043 baseline and differential
GenevisibleiP24043 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000742 EGF-like_dom
IPR009254 Laminin_aI
IPR010307 Laminin_dom_II
IPR002049 Laminin_EGF
IPR001791 Laminin_G
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 2 hits
PF00053 Laminin_EGF, 16 hits
PF00054 Laminin_G_1, 4 hits
PF02210 Laminin_G_2, 1 hit
PF06008 Laminin_I, 1 hit
PF06009 Laminin_II, 1 hit
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 16 hits
SM00281 LamB, 2 hits
SM00282 LamG, 5 hits
SM00136 LamNT, 1 hit
SUPFAMiSSF49899 SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 11 hits
PS01186 EGF_2, 3 hits
PS01248 EGF_LAM_1, 14 hits
PS50027 EGF_LAM_2, 15 hits
PS50025 LAM_G_DOMAIN, 5 hits
PS51115 LAMININ_IVA, 2 hits
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24043
Secondary accession number(s): Q14736, Q5VUM2, Q93022
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 25, 2008
Last modified: December 5, 2018
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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