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Protein

Carbohydrate-binding protein AQN-3

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AQN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. AQN proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease-inhibitor-binding capability.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate-binding protein AQN-3
Alternative name(s):
Spermadhesin AQN-3
Zona pellucida-binding protein AQN-3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002214541 – 116Carbohydrate-binding protein AQN-3Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 30PROSITE-ProRule annotation1 Publication
Glycosylationi50N-linked (GlcNAc...) asparagine1
Disulfide bondi53 ↔ 74PROSITE-ProRule annotation1 Publication
Modified residuei85Methylhistidine1 Publication1

Post-translational modificationi

The residue at position 85 was identified as a methylhistidine by mass spectrometry.

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation

Proteomic databases

PaxDbiP24020
PRIDEiP24020

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003222

Structurei

3D structure databases

ProteinModelPortaliP24020
SMRiP24020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 110CUBPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the spermadhesin family.Curated

Phylogenomic databases

eggNOGiENOG410JGFV Eukaryota
ENOG41118AQ LUCA
HOVERGENiHBG004277

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR000124 Spermadhesin
PfamiView protein in Pfam
PF00431 CUB, 1 hit
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00985 SPERMADHESIN_1, 1 hit
PS00986 SPERMADHESIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P24020-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AQNKGSDDCG GFLKNYSGWI SYYKALTTNC VWTIEMKPGH KIILQILPLN
60 70 80 90 100
LTCGKEYLEV RDQRAGPDNF LKVCGGTGFV YQSSHNVATV KYSRDSHHPA
110
SSFNVYFYGI PQGAKA
Length:116
Mass (Da):12,885
Last modified:March 1, 1992 - v1
Checksum:iEC83E07A811D9FD3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79F → T AA sequence (PubMed:8603690).Curated1
Sequence conflicti85H → S AA sequence (PubMed:8269963).Curated1

Sequence databases

PIRiS17567
S39434

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiS17567
S39434

3D structure databases

ProteinModelPortaliP24020
SMRiP24020
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000003222

Proteomic databases

PaxDbiP24020
PRIDEiP24020

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410JGFV Eukaryota
ENOG41118AQ LUCA
HOVERGENiHBG004277

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR000124 Spermadhesin
PfamiView protein in Pfam
PF00431 CUB, 1 hit
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00985 SPERMADHESIN_1, 1 hit
PS00986 SPERMADHESIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAQN3_PIG
AccessioniPrimary (citable) accession number: P24020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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