UniProtKB - P24014 (SLIT_DROME)
Protein slit
sli
Functioni
A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.
4 PublicationsGO - Molecular functioni
- calcium ion binding Source: InterPro
- heparin binding Source: FlyBase
- Roundabout binding Source: FlyBase
GO - Biological processi
- axon guidance Source: FlyBase
- axon midline choice point recognition Source: FlyBase
- dendrite morphogenesis Source: FlyBase
- digestive tract mesoderm development Source: FlyBase
- embryonic heart tube development Source: FlyBase
- epithelial cell migration, open tracheal system Source: FlyBase
- glial cell migration Source: UniProtKB
- gonad development Source: FlyBase
- induction of negative chemotaxis Source: UniProtKB
- mesodermal cell migration Source: FlyBase
- mesoderm migration involved in gastrulation Source: UniProtKB
- neuron differentiation Source: FlyBase
- neuron migration Source: FlyBase
- outflow tract morphogenesis Source: FlyBase
- positive regulation of cell-cell adhesion Source: FlyBase
- positive regulation of cell migration Source: FlyBase
- regulation of epithelial cell migration Source: FlyBase
- regulation of epithelial cell migration, open tracheal system Source: FlyBase
- Roundabout signaling pathway Source: FlyBase
- salivary gland boundary specification Source: FlyBase
- synaptic target inhibition Source: FlyBase
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
Reactomei | R-DME-376176, Signaling by ROBO receptors R-DME-428890, Role of ABL in ROBO-SLIT signaling |
SignaLinki | P24014 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein slitShort name: dSlit Cleaved into the following 2 chains: |
Gene namesi | Name:sli ORF Names:CG43758 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0264089, sli |
VEuPathDBi | VectorBase:FBgn0264089 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- axon Source: FlyBase
- cell surface Source: FlyBase
- Slit-Robo signaling complex Source: FlyBase
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 36 | Add BLAST | 36 | |
ChainiPRO_0000007719 | 37 – 1504 | Protein slitAdd BLAST | 1468 | |
ChainiPRO_0000007720 | 37 – 1135 | Protein slit N-productBy similarityAdd BLAST | 1099 | |
ChainiPRO_0000007721 | 1136 – 1504 | Protein slit C-productBy similarityAdd BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 111 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 231 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 381 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 459 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 543 ↔ 549 | 1 Publication | ||
Disulfide bondi | 547 ↔ 556 | 1 Publication | ||
Disulfide bondi | 657 ↔ 733 | 1 Publication | ||
Disulfide bondi | 681 ↔ 704 | 1 Publication | ||
Disulfide bondi | 683 ↔ 725 | 1 Publication | ||
Glycosylationi | 807 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 812 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 935 ↔ 946 | By similarity | ||
Disulfide bondi | 940 ↔ 956 | By similarity | ||
Disulfide bondi | 958 ↔ 967 | By similarity | ||
Disulfide bondi | 974 ↔ 985 | By similarity | ||
Disulfide bondi | 979 ↔ 995 | By similarity | ||
Glycosylationi | 982 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 997 ↔ 1006 | By similarity | ||
Disulfide bondi | 1013 ↔ 1025 | By similarity | ||
Disulfide bondi | 1019 ↔ 1034 | By similarity | ||
Glycosylationi | 1022 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1036 ↔ 1045 | By similarity | ||
Disulfide bondi | 1052 ↔ 1065 | By similarity | ||
Disulfide bondi | 1059 ↔ 1074 | By similarity | ||
Disulfide bondi | 1076 ↔ 1085 | By similarity | ||
Glycosylationi | 1084 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1092 ↔ 1103 | By similarity | ||
Disulfide bondi | 1097 ↔ 1112 | By similarity | ||
Disulfide bondi | 1114 ↔ 1123 | By similarity | ||
Disulfide bondi | 1139 ↔ 1149 | By similarity | ||
Disulfide bondi | 1144 ↔ 1161 | By similarity | ||
Disulfide bondi | 1163 ↔ 1172 | By similarity | ||
Glycosylationi | 1183 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1267 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1316 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1323 ↔ 1349 | By similarity | ||
Disulfide bondi | 1381 ↔ 1392 | By similarity | ||
Disulfide bondi | 1386 ↔ 1404 | By similarity | ||
Disulfide bondi | 1406 ↔ 1415 | By similarity | ||
Disulfide bondi | 1433 ↔ 1467 | By similarity | ||
Disulfide bondi | 1447 ↔ 1481 | By similarity | ||
Disulfide bondi | 1458 ↔ 1497 | By similarity | ||
Disulfide bondi | 1462 ↔ 1499 | By similarity |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1135 – 1136 | CleavageBy similarity | 2 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P24014 |
PTM databases
GlyGeni | P24014, 13 sites |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | FBgn0264089, Expressed in central nervous system and 21 other tissues |
ExpressionAtlasi | P24014, baseline and differential |
Genevisiblei | P24014, DM |
Interactioni
Subunit structurei
Interacts with robo.
1 PublicationGO - Molecular functioni
- Roundabout binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 62473, 41 interactors |
IntActi | P24014, 7 interactors |
STRINGi | 7227.FBpp0303575 |
Structurei
Secondary structure
3D structure databases
SMRi | P24014 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P24014 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 100 | LRRNT 1Add BLAST | 37 | |
Repeati | 101 – 122 | LRR 1Add BLAST | 22 | |
Repeati | 125 – 146 | LRR 2Add BLAST | 22 | |
Repeati | 149 – 170 | LRR 3Add BLAST | 22 | |
Repeati | 173 – 194 | LRR 4Add BLAST | 22 | |
Repeati | 197 – 218 | LRR 5Add BLAST | 22 | |
Repeati | 221 – 242 | LRR 6Add BLAST | 22 | |
Domaini | 254 – 304 | LRRCT 1Add BLAST | 51 | |
Domaini | 310 – 346 | LRRNT 2Add BLAST | 37 | |
Repeati | 347 – 368 | LRR 7Add BLAST | 22 | |
Repeati | 371 – 392 | LRR 8Add BLAST | 22 | |
Repeati | 395 – 416 | LRR 9Add BLAST | 22 | |
Repeati | 419 – 440 | LRR 10Add BLAST | 22 | |
Repeati | 443 – 464 | LRR 11Add BLAST | 22 | |
Domaini | 476 – 526 | LRRCT 2Add BLAST | 51 | |
Domaini | 534 – 570 | LRRNT 3Add BLAST | 37 | |
Repeati | 571 – 592 | LRR 12Add BLAST | 22 | |
Repeati | 596 – 617 | LRR 13Add BLAST | 22 | |
Repeati | 620 – 641 | LRR 14Add BLAST | 22 | |
Repeati | 644 – 665 | LRR 15Add BLAST | 22 | |
Domaini | 677 – 727 | LRRCT 3Add BLAST | 51 | |
Domaini | 730 – 766 | LRRNT 4Add BLAST | 37 | |
Repeati | 767 – 788 | LRR 16Add BLAST | 22 | |
Repeati | 791 – 812 | LRR 17Add BLAST | 22 | |
Repeati | 815 – 836 | LRR 18Add BLAST | 22 | |
Repeati | 839 – 860 | LRR 19Add BLAST | 22 | |
Domaini | 872 – 922 | LRRCT 4Add BLAST | 51 | |
Domaini | 931 – 968 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 970 – 1007 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1009 – 1046 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1048 – 1086 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1088 – 1124 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1135 – 1173 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1176 – 1349 | Laminin G-likePROSITE-ProRule annotationAdd BLAST | 174 | |
Domaini | 1377 – 1416 | EGF-like 7PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 1433 – 1504 | CTCKPROSITE-ProRule annotationAdd BLAST | 72 |
Keywords - Domaini
EGF-like domain, Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG4237, Eukaryota |
GeneTreei | ENSGT00940000167217 |
InParanoidi | P24014 |
OMAi | ETKCQNN |
PhylomeDBi | P24014 |
Family and domain databases
CDDi | cd00110, LamG, 1 hit |
Gene3Di | 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000483, Cys-rich_flank_reg_C IPR006207, Cys_knot_C IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR001791, Laminin_G IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF00008, EGF, 4 hits PF12661, hEGF, 1 hit PF00054, Laminin_G_1, 1 hit PF13855, LRR_8, 6 hits PF01463, LRRCT, 4 hits PF01462, LRRNT, 4 hits |
SMARTi | View protein in SMART SM00041, CT, 1 hit SM00181, EGF, 7 hits SM00179, EGF_CA, 6 hits SM00282, LamG, 1 hit SM00369, LRR_TYP, 16 hits SM00082, LRRCT, 4 hits SM00013, LRRNT, 4 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS00022, EGF_1, 7 hits PS01186, EGF_2, 5 hits PS50026, EGF_3, 7 hits PS01187, EGF_CA, 2 hits PS50025, LAM_G_DOMAIN, 1 hit PS51450, LRR, 20 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPSRTTLM PPPFRLQLRL LILPILLLLR HDAVHAEPYS GGFGSSAVSS
60 70 80 90 100
GGLGSVGIHI PGGGVGVITE ARCPRVCSCT GLNVDCSHRG LTSVPRKISA
110 120 130 140 150
DVERLELQGN NLTVIYETDF QRLTKLRMLQ LTDNQIHTIE RNSFQDLVSL
160 170 180 190 200
ERLRLNNNRL KAIPENFVTS SASLLRLDIS NNVITTVGRR VFKGAQSLRS
210 220 230 240 250
LQLDNNQITC LDEHAFKGLV ELEILTLNNN NLTSLPHNIF GGLGRLRALR
260 270 280 290 300
LSDNPFACDC HLSWLSRFLR SATRLAPYTR CQSPSQLKGQ NVADLHDQEF
310 320 330 340 350
KCSGLTEHAP MECGAENSCP HPCRCADGIV DCREKSLTSV PVTLPDDTTE
360 370 380 390 400
LRLEQNFITE LPPKSFSSFR RLRRIDLSNN NISRIAHDAL SGLKQLTTLV
410 420 430 440 450
LYGNKIKDLP SGVFKGLGSL QLLLLNANEI SCIRKDAFRD LHSLSLLSLY
460 470 480 490 500
DNNIQSLANG TFDAMKSIKT VHLAKNPFIC DCNLRWLADY LHKNPIETSG
510 520 530 540 550
ARCESPKRMH RRRIESLREE KFKCSWDELR MKLSGECRMD SDCPAMCHCE
560 570 580 590 600
GTTVDCTGRG LKEIPRDIPL HTTELLLNDN ELGRISSDGL FGRLPHLVKL
610 620 630 640 650
ELKRNQLTGI EPNAFEGASH IQELQLGENK IKEISNKMFL GLHQLKTLNL
660 670 680 690 700
YDNQISCVMP GSFEHLNSLT SLNLASNPFN CNCHLAWFAE WLRKKSLNGG
710 720 730 740 750
AARCGAPSKV RDVQIKDLPH SEFKCSSENS EGCLGDGYCP PSCTCTGTVV
760 770 780 790 800
RCSRNQLKEI PRGIPAETSE LYLESNEIEQ IHYERIRHLR SLTRLDLSNN
810 820 830 840 850
QITILSNYTF ANLTKLSTLI ISYNKLQCLQ RHALSGLNNL RVLSLHGNRI
860 870 880 890 900
SMLPEGSFED LKSLTHIALG SNPLYCDCGL KWFSDWIKLD YVEPGIARCA
910 920 930 940 950
EPEQMKDKLI LSTPSSSFVC RGRVRNDILA KCNACFEQPC QNQAQCVALP
960 970 980 990 1000
QREYQCLCQP GYHGKHCEFM IDACYGNPCR NNATCTVLEE GRFSCQCAPG
1010 1020 1030 1040 1050
YTGARCETNI DDCLGEIKCQ NNATCIDGVE SYKCECQPGF SGEFCDTKIQ
1060 1070 1080 1090 1100
FCSPEFNPCA NGAKCMDHFT HYSCDCQAGF HGTNCTDNID DCQNHMCQNG
1110 1120 1130 1140 1150
GTCVDGINDY QCRCPDDYTG KYCEGHNMIS MMYPQTSPCQ NHECKHGVCF
1160 1170 1180 1190 1200
QPNAQGSDYL CRCHPGYTGK WCEYLTSISF VHNNSFVELE PLRTRPEANV
1210 1220 1230 1240 1250
TIVFSSAEQN GILMYDGQDA HLAVELFNGR IRVSYDVGNH PVSTMYSFEM
1260 1270 1280 1290 1300
VADGKYHAVE LLAIKKNFTL RVDRGLARSI INEGSNDYLK LTTPMFLGGL
1310 1320 1330 1340 1350
PVDPAQQAYK NWQIRNLTSF KGCMKEVWIN HKLVDFGNAQ RQQKITPGCA
1360 1370 1380 1390 1400
LLEGEQQEEE DDEQDFMDET PHIKEEPVDP CLENKCRRGS RCVPNSNARD
1410 1420 1430 1440 1450
GYQCKCKHGQ RGRYCDQGEG STEPPTVTAA STCRKEQVRE YYTENDCRSR
1460 1470 1480 1490 1500
QPLKYAKCVG GCGNQCCAAK IVRRRKVRMV CSNNRKYIKN LDIVRKCGCT
KKCY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KES0 | A0A0B4KES0_DROME | Slit, isoform F | sli CG33464, CG8355, CT21700, CT37068, Dmel\CG43758 | 2,157 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 350 – 351 | EL → DV in CAA37910 (PubMed:2176636).Curated | 2 | |
Sequence conflicti | 350 – 351 | EL → DV in AAD26567 (PubMed:10102267).Curated | 2 | |
Sequence conflicti | 421 | Q → R in CAA37910 (PubMed:2176636).Curated | 1 | |
Sequence conflicti | 468 | I → M in CAA37910 (PubMed:2176636).Curated | 1 | |
Sequence conflicti | 527 | D → G in CAA37910 (PubMed:2176636).Curated | 1 | |
Sequence conflicti | 560 | G → R in CAA37910 (PubMed:2176636).Curated | 1 | |
Sequence conflicti | 691 – 692 | WL → CV in CAA37910 (PubMed:2176636).Curated | 2 | |
Sequence conflicti | 751 | R → A in CAA37910 (PubMed:2176636).Curated | 1 | |
Sequence conflicti | 843 | L → V in CAA37910 (PubMed:2176636).Curated | 1 | |
Sequence conflicti | 1207 – 1208 | AE → G in AAA72722 (PubMed:3144436).Curated | 2 | |
Sequence conflicti | 1429 – 1435 | AASTCRK → GTYIYHA in AAA72722 (PubMed:3144436).Curated | 7 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001408 | 152 – 175 | Missing in isoform A and isoform B. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_001409 | 1418 – 1428 | Missing in isoform B. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53959 mRNA Translation: CAA37910.1 AF126540 mRNA Translation: AAD26567.1 AE013599 Genomic DNA Translation: AAF58097.1 AE013599 Genomic DNA Translation: AAF58098.1 AE013599 Genomic DNA Translation: AAM70966.1 AE013599 Genomic DNA Translation: ABV53816.1 AE013599 Genomic DNA Translation: ABV53817.1 M23543 Genomic DNA Translation: AAA72722.1 Different initiation. |
PIRi | A36665 B36665 |
RefSeqi | NP_001097333.1, NM_001103863.3 [P24014-2] NP_001097334.1, NM_001103864.3 [P24014-1] NP_476727.1, NM_057379.4 [P24014-1] NP_476728.1, NM_057380.4 [P24014-2] NP_476729.1, NM_057381.4 [P24014-3] |
Genome annotation databases
EnsemblMetazoai | FBtr0330729; FBpp0303573; FBgn0264089 [P24014-2] FBtr0330730; FBpp0303574; FBgn0264089 [P24014-3] FBtr0330731; FBpp0303575; FBgn0264089 [P24014-1] FBtr0330732; FBpp0303576; FBgn0264089 [P24014-2] FBtr0330733; FBpp0303577; FBgn0264089 [P24014-1] |
GeneIDi | 36746 |
KEGGi | dme:Dmel_CG43758 |
UCSCi | CG8355-RD, d. melanogaster CG8355-RE, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53959 mRNA Translation: CAA37910.1 AF126540 mRNA Translation: AAD26567.1 AE013599 Genomic DNA Translation: AAF58097.1 AE013599 Genomic DNA Translation: AAF58098.1 AE013599 Genomic DNA Translation: AAM70966.1 AE013599 Genomic DNA Translation: ABV53816.1 AE013599 Genomic DNA Translation: ABV53817.1 M23543 Genomic DNA Translation: AAA72722.1 Different initiation. |
PIRi | A36665 B36665 |
RefSeqi | NP_001097333.1, NM_001103863.3 [P24014-2] NP_001097334.1, NM_001103864.3 [P24014-1] NP_476727.1, NM_057379.4 [P24014-1] NP_476728.1, NM_057380.4 [P24014-2] NP_476729.1, NM_057381.4 [P24014-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1W8A | X-ray | 2.80 | A | 542-733 | [»] | |
SMRi | P24014 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 62473, 41 interactors |
IntActi | P24014, 7 interactors |
STRINGi | 7227.FBpp0303575 |
PTM databases
GlyGeni | P24014, 13 sites |
Proteomic databases
PaxDbi | P24014 |
Genome annotation databases
EnsemblMetazoai | FBtr0330729; FBpp0303573; FBgn0264089 [P24014-2] FBtr0330730; FBpp0303574; FBgn0264089 [P24014-3] FBtr0330731; FBpp0303575; FBgn0264089 [P24014-1] FBtr0330732; FBpp0303576; FBgn0264089 [P24014-2] FBtr0330733; FBpp0303577; FBgn0264089 [P24014-1] |
GeneIDi | 36746 |
KEGGi | dme:Dmel_CG43758 |
UCSCi | CG8355-RD, d. melanogaster CG8355-RE, d. melanogaster |
Organism-specific databases
CTDi | 36746 |
FlyBasei | FBgn0264089, sli |
VEuPathDBi | VectorBase:FBgn0264089 |
Phylogenomic databases
eggNOGi | KOG4237, Eukaryota |
GeneTreei | ENSGT00940000167217 |
InParanoidi | P24014 |
OMAi | ETKCQNN |
PhylomeDBi | P24014 |
Enzyme and pathway databases
Reactomei | R-DME-376176, Signaling by ROBO receptors R-DME-428890, Role of ABL in ROBO-SLIT signaling |
SignaLinki | P24014 |
Miscellaneous databases
BioGRID-ORCSi | 36746, 0 hits in 3 CRISPR screens |
EvolutionaryTracei | P24014 |
GenomeRNAii | 36746 |
PROi | PR:P24014 |
Gene expression databases
Bgeei | FBgn0264089, Expressed in central nervous system and 21 other tissues |
ExpressionAtlasi | P24014, baseline and differential |
Genevisiblei | P24014, DM |
Family and domain databases
CDDi | cd00110, LamG, 1 hit |
Gene3Di | 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000483, Cys-rich_flank_reg_C IPR006207, Cys_knot_C IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR001791, Laminin_G IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF00008, EGF, 4 hits PF12661, hEGF, 1 hit PF00054, Laminin_G_1, 1 hit PF13855, LRR_8, 6 hits PF01463, LRRCT, 4 hits PF01462, LRRNT, 4 hits |
SMARTi | View protein in SMART SM00041, CT, 1 hit SM00181, EGF, 7 hits SM00179, EGF_CA, 6 hits SM00282, LamG, 1 hit SM00369, LRR_TYP, 16 hits SM00082, LRRCT, 4 hits SM00013, LRRNT, 4 hits |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 3 hits PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS00022, EGF_1, 7 hits PS01186, EGF_2, 5 hits PS50026, EGF_3, 7 hits PS01187, EGF_CA, 2 hits PS50025, LAM_G_DOMAIN, 1 hit PS51450, LRR, 20 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SLIT_DROME | |
Accessioni | P24014Primary (citable) accession number: P24014 Secondary accession number(s): A8DYF5 Q9XYV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | February 28, 2003 | |
Last modified: | February 23, 2022 | |
This is version 221 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references