Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - P24014 (SLIT_DROME)

Entry version 218 (07 Apr 2021)
Sequence version 2 (28 Feb 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Protein slit

Gene

sli

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-376176, Signaling by ROBO receptors
R-DME-428890, Role of ABL in ROBO-SLIT signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein slit
Short name:
dSlit
Cleaved into the following 2 chains:
Protein slit N-product
Protein slit C-product
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sli
ORF Names:CG43758
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0264089, sli

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies lacking sli exhibit disruption of the developing midline cells and the commissural axon pathways.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Add BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000771937 – 1504Protein slitAdd BLAST1468
ChainiPRO_000000772037 – 1135Protein slit N-productBy similarityAdd BLAST1099
ChainiPRO_00000077211136 – 1504Protein slit C-productBy similarityAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi543 ↔ 5491 Publication
Disulfide bondi547 ↔ 5561 Publication
Disulfide bondi657 ↔ 7331 Publication
Disulfide bondi681 ↔ 7041 Publication
Disulfide bondi683 ↔ 7251 Publication
Glycosylationi807N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi812N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi935 ↔ 946By similarity
Disulfide bondi940 ↔ 956By similarity
Disulfide bondi958 ↔ 967By similarity
Disulfide bondi974 ↔ 985By similarity
Disulfide bondi979 ↔ 995By similarity
Glycosylationi982N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi997 ↔ 1006By similarity
Disulfide bondi1013 ↔ 1025By similarity
Disulfide bondi1019 ↔ 1034By similarity
Glycosylationi1022N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1036 ↔ 1045By similarity
Disulfide bondi1052 ↔ 1065By similarity
Disulfide bondi1059 ↔ 1074By similarity
Disulfide bondi1076 ↔ 1085By similarity
Glycosylationi1084N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1092 ↔ 1103By similarity
Disulfide bondi1097 ↔ 1112By similarity
Disulfide bondi1114 ↔ 1123By similarity
Disulfide bondi1139 ↔ 1149By similarity
Disulfide bondi1144 ↔ 1161By similarity
Disulfide bondi1163 ↔ 1172By similarity
Glycosylationi1183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1323 ↔ 1349By similarity
Disulfide bondi1381 ↔ 1392By similarity
Disulfide bondi1386 ↔ 1404By similarity
Disulfide bondi1406 ↔ 1415By similarity
Disulfide bondi1433 ↔ 1467By similarity
Disulfide bondi1447 ↔ 1481By similarity
Disulfide bondi1458 ↔ 1497By similarity
Disulfide bondi1462 ↔ 1499By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1135 – 1136CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P24014

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In embryos, highest expression occurs around the midline glia and low expression is observed around CNS axons lateral to the midline. Expression can be seen on the commissural axons traversing the glial cells but it is absent from the cell bodies of these neurons.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0264089, Expressed in central nervous system and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24014, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24014, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with robo.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		62473, 41 interactors

Protein interaction database and analysis system

More...IntActi		P24014, 7 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0303575

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24014

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P24014

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 100LRRNT 1Add BLAST37
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati101 – 122LRR 1Add BLAST22
Repeati125 – 146LRR 2Add BLAST22
Repeati149 – 170LRR 3Add BLAST22
Repeati173 – 194LRR 4Add BLAST22
Repeati197 – 218LRR 5Add BLAST22
Repeati221 – 242LRR 6Add BLAST22
Domaini254 – 304LRRCT 1Add BLAST51
Domaini310 – 346LRRNT 2Add BLAST37
Repeati347 – 368LRR 7Add BLAST22
Repeati371 – 392LRR 8Add BLAST22
Repeati395 – 416LRR 9Add BLAST22
Repeati419 – 440LRR 10Add BLAST22
Repeati443 – 464LRR 11Add BLAST22
Domaini476 – 526LRRCT 2Add BLAST51
Domaini534 – 570LRRNT 3Add BLAST37
Repeati571 – 592LRR 12Add BLAST22
Repeati596 – 617LRR 13Add BLAST22
Repeati620 – 641LRR 14Add BLAST22
Repeati644 – 665LRR 15Add BLAST22
Domaini677 – 727LRRCT 3Add BLAST51
Domaini730 – 766LRRNT 4Add BLAST37
Repeati767 – 788LRR 16Add BLAST22
Repeati791 – 812LRR 17Add BLAST22
Repeati815 – 836LRR 18Add BLAST22
Repeati839 – 860LRR 19Add BLAST22
Domaini872 – 922LRRCT 4Add BLAST51
Domaini931 – 968EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini970 – 1007EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini1009 – 1046EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini1048 – 1086EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1088 – 1124EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1135 – 1173EGF-like 6PROSITE-ProRule annotationAdd BLAST39
Domaini1176 – 1349Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1377 – 1416EGF-like 7PROSITE-ProRule annotationAdd BLAST40
Domaini1433 – 1504CTCKPROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4237, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167217

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24014

Identification of Orthologs from Complete Genome Data

More...OMAi		HKIDACY

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24014

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000483, Cys-rich_flank_reg_C
IPR006207, Cys_knot_C
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00008, EGF, 4 hits
PF12661, hEGF, 1 hit
PF00054, Laminin_G_1, 1 hit
PF13855, LRR_8, 6 hits
PF01463, LRRCT, 4 hits
PF01462, LRRNT, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00041, CT, 1 hit
SM00181, EGF, 7 hits
SM00179, EGF_CA, 6 hits
SM00282, LamG, 1 hit
SM00369, LRR_TYP, 16 hits
SM00082, LRRCT, 4 hits
SM00013, LRRNT, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 2 hits
PS50025, LAM_G_DOMAIN, 1 hit
PS51450, LRR, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform C (identifier: P24014-1) [UniParc]FASTAAdd to basket
Also known as: E

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPSRTTLM PPPFRLQLRL LILPILLLLR HDAVHAEPYS GGFGSSAVSS 
        60         70         80         90        100
GGLGSVGIHI PGGGVGVITE ARCPRVCSCT GLNVDCSHRG LTSVPRKISA 
       110        120        130        140        150
DVERLELQGN NLTVIYETDF QRLTKLRMLQ LTDNQIHTIE RNSFQDLVSL 
       160        170        180        190        200
ERLRLNNNRL KAIPENFVTS SASLLRLDIS NNVITTVGRR VFKGAQSLRS 
       210        220        230        240        250
LQLDNNQITC LDEHAFKGLV ELEILTLNNN NLTSLPHNIF GGLGRLRALR 
       260        270        280        290        300
LSDNPFACDC HLSWLSRFLR SATRLAPYTR CQSPSQLKGQ NVADLHDQEF 
       310        320        330        340        350
KCSGLTEHAP MECGAENSCP HPCRCADGIV DCREKSLTSV PVTLPDDTTE 
       360        370        380        390        400
LRLEQNFITE LPPKSFSSFR RLRRIDLSNN NISRIAHDAL SGLKQLTTLV 
       410        420        430        440        450
LYGNKIKDLP SGVFKGLGSL QLLLLNANEI SCIRKDAFRD LHSLSLLSLY 
       460        470        480        490        500
DNNIQSLANG TFDAMKSIKT VHLAKNPFIC DCNLRWLADY LHKNPIETSG 
       510        520        530        540        550
ARCESPKRMH RRRIESLREE KFKCSWDELR MKLSGECRMD SDCPAMCHCE 
       560        570        580        590        600
GTTVDCTGRG LKEIPRDIPL HTTELLLNDN ELGRISSDGL FGRLPHLVKL 
       610        620        630        640        650
ELKRNQLTGI EPNAFEGASH IQELQLGENK IKEISNKMFL GLHQLKTLNL 
       660        670        680        690        700
YDNQISCVMP GSFEHLNSLT SLNLASNPFN CNCHLAWFAE WLRKKSLNGG 
       710        720        730        740        750
AARCGAPSKV RDVQIKDLPH SEFKCSSENS EGCLGDGYCP PSCTCTGTVV 
       760        770        780        790        800
RCSRNQLKEI PRGIPAETSE LYLESNEIEQ IHYERIRHLR SLTRLDLSNN 
       810        820        830        840        850
QITILSNYTF ANLTKLSTLI ISYNKLQCLQ RHALSGLNNL RVLSLHGNRI 
       860        870        880        890        900
SMLPEGSFED LKSLTHIALG SNPLYCDCGL KWFSDWIKLD YVEPGIARCA 
       910        920        930        940        950
EPEQMKDKLI LSTPSSSFVC RGRVRNDILA KCNACFEQPC QNQAQCVALP 
       960        970        980        990       1000
QREYQCLCQP GYHGKHCEFM IDACYGNPCR NNATCTVLEE GRFSCQCAPG 
      1010       1020       1030       1040       1050
YTGARCETNI DDCLGEIKCQ NNATCIDGVE SYKCECQPGF SGEFCDTKIQ 
      1060       1070       1080       1090       1100
FCSPEFNPCA NGAKCMDHFT HYSCDCQAGF HGTNCTDNID DCQNHMCQNG 
      1110       1120       1130       1140       1150
GTCVDGINDY QCRCPDDYTG KYCEGHNMIS MMYPQTSPCQ NHECKHGVCF 
      1160       1170       1180       1190       1200
QPNAQGSDYL CRCHPGYTGK WCEYLTSISF VHNNSFVELE PLRTRPEANV 
      1210       1220       1230       1240       1250
TIVFSSAEQN GILMYDGQDA HLAVELFNGR IRVSYDVGNH PVSTMYSFEM 
      1260       1270       1280       1290       1300
VADGKYHAVE LLAIKKNFTL RVDRGLARSI INEGSNDYLK LTTPMFLGGL 
      1310       1320       1330       1340       1350
PVDPAQQAYK NWQIRNLTSF KGCMKEVWIN HKLVDFGNAQ RQQKITPGCA 
      1360       1370       1380       1390       1400
LLEGEQQEEE DDEQDFMDET PHIKEEPVDP CLENKCRRGS RCVPNSNARD 
      1410       1420       1430       1440       1450
GYQCKCKHGQ RGRYCDQGEG STEPPTVTAA STCRKEQVRE YYTENDCRSR 
      1460       1470       1480       1490       1500
QPLKYAKCVG GCGNQCCAAK IVRRRKVRMV CSNNRKYIKN LDIVRKCGCT 

KKCY
Length:1,504
Mass (Da):168,599
Last modified:February 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i836A3F5022BF234F
GO
Isoform A (identifier: P24014-2) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     152-175: Missing.

Show »
Length:1,480
Mass (Da):165,890
Checksum:iF456BC617D8453ED
GO
Isoform B (identifier: P24014-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-175: Missing.
     1418-1428: Missing.

Show »
Length:1,469
Mass (Da):164,834
Checksum:i14DBA99CE1DAEAC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4KES0A0A0B4KES0_DROME
Slit, isoform F
sli CG33464, CG8355, CT21700, CT37068, Dmel\CG43758
2,157Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA72722 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350 – 351EL → DV in CAA37910 (PubMed:2176636).Curated2
Sequence conflicti350 – 351EL → DV in AAD26567 (PubMed:10102267).Curated2
Sequence conflicti421Q → R in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti468I → M in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti527D → G in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti560G → R in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti691 – 692WL → CV in CAA37910 (PubMed:2176636).Curated2
Sequence conflicti751R → A in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti843L → V in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti1207 – 1208AE → G in AAA72722 (PubMed:3144436).Curated2
Sequence conflicti1429 – 1435AASTCRK → GTYIYHA in AAA72722 (PubMed:3144436).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001408152 – 175Missing in isoform A and isoform B. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0014091418 – 1428Missing in isoform B. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X53959 mRNA Translation: CAA37910.1
AF126540 mRNA Translation: AAD26567.1
AE013599 Genomic DNA Translation: AAF58097.1
AE013599 Genomic DNA Translation: AAF58098.1
AE013599 Genomic DNA Translation: AAM70966.1
AE013599 Genomic DNA Translation: ABV53816.1
AE013599 Genomic DNA Translation: ABV53817.1
M23543 Genomic DNA Translation: AAA72722.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		A36665
B36665

NCBI Reference Sequences

More...RefSeqi		NP_001097333.1, NM_001103863.3 [P24014-2]
NP_001097334.1, NM_001103864.3 [P24014-1]
NP_476727.1, NM_057379.4 [P24014-1]
NP_476728.1, NM_057380.4 [P24014-2]
NP_476729.1, NM_057381.4 [P24014-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0330729; FBpp0303573; FBgn0264089 [P24014-2]
FBtr0330730; FBpp0303574; FBgn0264089 [P24014-3]
FBtr0330731; FBpp0303575; FBgn0264089 [P24014-1]
FBtr0330732; FBpp0303576; FBgn0264089 [P24014-2]
FBtr0330733; FBpp0303577; FBgn0264089 [P24014-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36746

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG43758

UCSC genome browser

More...UCSCi		CG8355-RD, d. melanogaster
CG8355-RE, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53959 mRNA Translation: CAA37910.1
AF126540 mRNA Translation: AAD26567.1
AE013599 Genomic DNA Translation: AAF58097.1
AE013599 Genomic DNA Translation: AAF58098.1
AE013599 Genomic DNA Translation: AAM70966.1
AE013599 Genomic DNA Translation: ABV53816.1
AE013599 Genomic DNA Translation: ABV53817.1
M23543 Genomic DNA Translation: AAA72722.1 Different initiation.
PIRiA36665
B36665
RefSeqiNP_001097333.1, NM_001103863.3 [P24014-2]
NP_001097334.1, NM_001103864.3 [P24014-1]
NP_476727.1, NM_057379.4 [P24014-1]
NP_476728.1, NM_057380.4 [P24014-2]
NP_476729.1, NM_057381.4 [P24014-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W8AX-ray2.80A542-733[»]
SMRiP24014
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi62473, 41 interactors
IntActiP24014, 7 interactors
STRINGi7227.FBpp0303575

Proteomic databases

PaxDbiP24014

Genome annotation databases

EnsemblMetazoaiFBtr0330729; FBpp0303573; FBgn0264089 [P24014-2]
FBtr0330730; FBpp0303574; FBgn0264089 [P24014-3]
FBtr0330731; FBpp0303575; FBgn0264089 [P24014-1]
FBtr0330732; FBpp0303576; FBgn0264089 [P24014-2]
FBtr0330733; FBpp0303577; FBgn0264089 [P24014-1]
GeneIDi36746
KEGGidme:Dmel_CG43758
UCSCiCG8355-RD, d. melanogaster
CG8355-RE, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		36746
FlyBaseiFBgn0264089, sli

Phylogenomic databases

eggNOGiKOG4237, Eukaryota
GeneTreeiENSGT00940000167217
InParanoidiP24014
OMAiHKIDACY
PhylomeDBiP24014

Enzyme and pathway databases

ReactomeiR-DME-376176, Signaling by ROBO receptors
R-DME-428890, Role of ABL in ROBO-SLIT signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36746, 0 hits in 3 CRISPR screens
EvolutionaryTraceiP24014

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36746

Protein Ontology

More...PROi		PR:P24014

Gene expression databases

BgeeiFBgn0264089, Expressed in central nervous system and 21 other tissues
ExpressionAtlasiP24014, baseline and differential
GenevisibleiP24014, DM

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000483, Cys-rich_flank_reg_C
IPR006207, Cys_knot_C
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
PfamiView protein in Pfam
PF00008, EGF, 4 hits
PF12661, hEGF, 1 hit
PF00054, Laminin_G_1, 1 hit
PF13855, LRR_8, 6 hits
PF01463, LRRCT, 4 hits
PF01462, LRRNT, 4 hits
SMARTiView protein in SMART
SM00041, CT, 1 hit
SM00181, EGF, 7 hits
SM00179, EGF_CA, 6 hits
SM00282, LamG, 1 hit
SM00369, LRR_TYP, 16 hits
SM00082, LRRCT, 4 hits
SM00013, LRRNT, 4 hits
SUPFAMiSSF49899, SSF49899, 1 hit
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 3 hits
PS01185, CTCK_1, 1 hit
PS01225, CTCK_2, 1 hit
PS00022, EGF_1, 7 hits
PS01186, EGF_2, 5 hits
PS50026, EGF_3, 7 hits
PS01187, EGF_CA, 2 hits
PS50025, LAM_G_DOMAIN, 1 hit
PS51450, LRR, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIT_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24014
Secondary accession number(s): A8DYF5
, A8DYF6, Q24526, Q8MLB9, Q9V7F8, Q9V7F9, Q9XYV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: February 28, 2003
Last modified: April 7, 2021
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again