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UniProtKB - P24001 (IL32_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 3 (12 Dec 2006)
Previous versions | rss
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Protein

Interleukin-32

Gene

IL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P24001

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-449836, Other interleukin signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P24001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-32
Short name:
IL-32
Alternative name(s):
Natural killer cells protein 4
Tumor necrosis factor alpha-inducing factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL32
Synonyms:NK4, TAIF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16830, IL32

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606001, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P24001

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000008517.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9235

Open Targets

More...OpenTargetsi		ENSG00000008517

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128395754

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P24001, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL32

Domain mapping of disease mutations (DMDM)

More...DMDMi		119364597

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002148731 – 234Interleukin-32Add BLAST204

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P24001

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P24001

MaxQB - The MaxQuant DataBase

More...MaxQBi		P24001

PeptideAtlas

More...PeptideAtlasi		P24001

PRoteomics IDEntifications database

More...PRIDEi		P24001

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1618
54173 [P24001-1]
54174 [P24001-2]
54175 [P24001-3]
54176 [P24001-4]
54177 [P24001-5]
7283

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P24001

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P24001

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P24001

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000008517, Expressed in right lobe of liver and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P24001, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P24001, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000008517, Tissue enhanced (blood, liver, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114664, 16 interactors

Database of interacting proteins

More...DIPi		DIP-61119N

Protein interaction database and analysis system

More...IntActi		P24001, 6 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P24001, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P24001

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167201

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P24001

Database of Orthologous Groups

More...OrthoDBi		1509659at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P24001

TreeFam database of animal gene trees

More...TreeFami		TF341753

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028067, IL-32

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15225, IL32, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P24001-1) [UniParc]FASTAAdd to basket
Also known as: Gamma

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCFPKVLSDD MKKLKARMVM LLPTSAQGLG AWVSACDTED TVGHLGPWRD 
        60         70         80         90        100
KDPALWCQLC LSSQHQAIER FYDKMQNAES GRGQVMSSLA ELEDDFKEGY 
       110        120        130        140        150
LETVAAYYEE QHPELTPLLE KERDGLRCRG NRSPVPDVED PATEEPGESF 
       160        170        180        190        200
CDKVMRWFQA MLQRLQTWWH GVLAWVKEKV VALVHAVQAL WKQFQSFCCS 
       210        220        230 
LSELFMSSFQ SYGAPRGDKE ELTPQKCSEP QSSK
Length:234
Mass (Da):26,676
Last modified:December 12, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F339FE2D348A761
GO
Isoform 2 (identifier: P24001-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.

Show »
Length:188
Mass (Da):21,737
Checksum:i601340225A3BB1CD
GO
Isoform 3 (identifier: P24001-3) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     19-64: Missing.

Show »
Length:178
Mass (Da):20,600
Checksum:i0B04D770664399C4
GO
Isoform 4 (identifier: P24001-4) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     154-210: Missing.

Show »
Length:131
Mass (Da):14,909
Checksum:iA31708A3A25CFF6F
GO
Isoform 5 (identifier: P24001-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     65-84: Missing.

Show »
Length:168
Mass (Da):19,389
Checksum:i5998CF072214C612
GO
Isoform 6 (identifier: P24001-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     85-93: Missing.

Show »
Length:179
Mass (Da):20,777
Checksum:iDE570457CCC5F59F
GO
Isoform 7 (identifier: P24001-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-84: Missing.
     94-113: Missing.

Show »
Length:148
Mass (Da):17,003
Checksum:i5384285DC256FD2B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C6GKH1C6GKH1_HUMAN
Interleukin-32
IL32
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1V1F8W1V1_HUMAN
Interleukin-32
IL32
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVN4F8VVN4_HUMAN
Interleukin-32
IL32
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIV2E9PIV2_HUMAN
Interleukin-32
IL32
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK07E9PK07_HUMAN
Interleukin-32
IL32
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSD2F8VSD2_HUMAN
Interleukin-32
IL32
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti233S → L in BM825040 (PubMed:16341674).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_005506152D → N1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0220051 – 10Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_04785519 – 84Missing in isoform 7. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_02200619 – 64Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST46
Alternative sequenceiVSP_04331865 – 84Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04578585 – 93Missing in isoform 6. 1 Publication9
Alternative sequenceiVSP_04785694 – 113Missing in isoform 7. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_022007154 – 210Missing in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M59807 mRNA Translation: AAA36367.2
AY495331 mRNA Translation: AAS80143.1
AY495332 mRNA Translation: AAS80144.1
AY495333 mRNA Translation: AAS80145.1
AY495334 Genomic DNA Translation: AAS80146.1
AY495334 Genomic DNA Translation: AAS80147.1
AY495334 Genomic DNA Translation: AAS80148.1
EU339107 mRNA Translation: ACA50721.1
AK296143 mRNA Translation: BAG58883.1
BM825040 mRNA No translation available.
AC108134 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85405.1
CH471112 Genomic DNA Translation: EAW85406.1
CH471112 Genomic DNA Translation: EAW85407.1
CH471112 Genomic DNA Translation: EAW85408.1
CH471112 Genomic DNA Translation: EAW85409.1
CH471112 Genomic DNA Translation: EAW85410.1
BC009401 mRNA Translation: AAH09401.1
BC018782 mRNA Translation: AAH18782.1
BC105602 mRNA Translation: AAI05603.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32377.1 [P24001-2]
CCDS32378.1 [P24001-4]
CCDS32379.1 [P24001-6]
CCDS45394.1 [P24001-5]
CCDS76811.1 [P24001-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I56140

NCBI Reference Sequences

More...RefSeqi		NP_001012649.1, NM_001012631.1 [P24001-2]
NP_001012650.1, NM_001012632.1 [P24001-2]
NP_001012651.1, NM_001012633.1 [P24001-4]
NP_001012652.1, NM_001012634.1 [P24001-5]
NP_001012653.1, NM_001012635.1 [P24001-5]
NP_001012654.1, NM_001012636.1 [P24001-6]
NP_001012736.1, NM_001012718.1 [P24001-2]
NP_001295007.1, NM_001308078.1 [P24001-1]
NP_004212.4, NM_004221.4 [P24001-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000008180; ENSP00000008180; ENSG00000008517 [P24001-5]
ENST00000325568; ENSP00000324742; ENSG00000008517 [P24001-2]
ENST00000382213; ENSP00000371648; ENSG00000008517 [P24001-6]
ENST00000396887; ENSP00000380096; ENSG00000008517 [P24001-4]
ENST00000396890; ENSP00000380099; ENSG00000008517 [P24001-1]
ENST00000440815; ENSP00000405063; ENSG00000008517 [P24001-2]
ENST00000444393; ENSP00000411958; ENSG00000008517 [P24001-2]
ENST00000525643; ENSP00000432218; ENSG00000008517 [P24001-2]
ENST00000526464; ENSP00000450364; ENSG00000008517 [P24001-2]
ENST00000528163; ENSP00000432850; ENSG00000008517 [P24001-2]
ENST00000529550; ENSP00000437020; ENSG00000008517 [P24001-2]
ENST00000530538; ENSP00000436929; ENSG00000008517 [P24001-2]
ENST00000530890; ENSP00000433747; ENSG00000008517 [P24001-5]
ENST00000531965; ENSP00000433177; ENSG00000008517 [P24001-3]
ENST00000533097; ENSP00000432917; ENSG00000008517 [P24001-2]
ENST00000534507; ENSP00000431775; ENSG00000008517 [P24001-1]
ENST00000548246; ENSP00000447979; ENSG00000008517 [P24001-7]
ENST00000548476; ENSP00000449483; ENSG00000008517 [P24001-1]
ENST00000548652; ENSP00000446624; ENSG00000008517 [P24001-6]
ENST00000549213; ENSP00000447812; ENSG00000008517 [P24001-4]
ENST00000551122; ENSP00000447496; ENSG00000008517 [P24001-4]
ENST00000552356; ENSP00000446978; ENSG00000008517 [P24001-5]
ENST00000552664; ENSP00000448683; ENSG00000008517 [P24001-2]
ENST00000675975; ENSP00000501913; ENSG00000008517 [P24001-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9235

UCSC genome browser

More...UCSCi		uc002ctk.4, human [P24001-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59807 mRNA Translation: AAA36367.2
AY495331 mRNA Translation: AAS80143.1
AY495332 mRNA Translation: AAS80144.1
AY495333 mRNA Translation: AAS80145.1
AY495334 Genomic DNA Translation: AAS80146.1
AY495334 Genomic DNA Translation: AAS80147.1
AY495334 Genomic DNA Translation: AAS80148.1
EU339107 mRNA Translation: ACA50721.1
AK296143 mRNA Translation: BAG58883.1
BM825040 mRNA No translation available.
AC108134 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85405.1
CH471112 Genomic DNA Translation: EAW85406.1
CH471112 Genomic DNA Translation: EAW85407.1
CH471112 Genomic DNA Translation: EAW85408.1
CH471112 Genomic DNA Translation: EAW85409.1
CH471112 Genomic DNA Translation: EAW85410.1
BC009401 mRNA Translation: AAH09401.1
BC018782 mRNA Translation: AAH18782.1
BC105602 mRNA Translation: AAI05603.1
CCDSiCCDS32377.1 [P24001-2]
CCDS32378.1 [P24001-4]
CCDS32379.1 [P24001-6]
CCDS45394.1 [P24001-5]
CCDS76811.1 [P24001-1]
PIRiI56140
RefSeqiNP_001012649.1, NM_001012631.1 [P24001-2]
NP_001012650.1, NM_001012632.1 [P24001-2]
NP_001012651.1, NM_001012633.1 [P24001-4]
NP_001012652.1, NM_001012634.1 [P24001-5]
NP_001012653.1, NM_001012635.1 [P24001-5]
NP_001012654.1, NM_001012636.1 [P24001-6]
NP_001012736.1, NM_001012718.1 [P24001-2]
NP_001295007.1, NM_001308078.1 [P24001-1]
NP_004212.4, NM_004221.4 [P24001-2]

3D structure databases

SMRiP24001
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114664, 16 interactors
DIPiDIP-61119N
IntActiP24001, 6 interactors

PTM databases

iPTMnetiP24001
PhosphoSitePlusiP24001
SwissPalmiP24001

Genetic variation databases

BioMutaiIL32
DMDMi119364597

Proteomic databases

jPOSTiP24001
MassIVEiP24001
MaxQBiP24001
PeptideAtlasiP24001
PRIDEiP24001
ProteomicsDBi1618
54173 [P24001-1]
54174 [P24001-2]
54175 [P24001-3]
54176 [P24001-4]
54177 [P24001-5]
7283

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10701, 585 antibodies

Genome annotation databases

EnsembliENST00000008180; ENSP00000008180; ENSG00000008517 [P24001-5]
ENST00000325568; ENSP00000324742; ENSG00000008517 [P24001-2]
ENST00000382213; ENSP00000371648; ENSG00000008517 [P24001-6]
ENST00000396887; ENSP00000380096; ENSG00000008517 [P24001-4]
ENST00000396890; ENSP00000380099; ENSG00000008517 [P24001-1]
ENST00000440815; ENSP00000405063; ENSG00000008517 [P24001-2]
ENST00000444393; ENSP00000411958; ENSG00000008517 [P24001-2]
ENST00000525643; ENSP00000432218; ENSG00000008517 [P24001-2]
ENST00000526464; ENSP00000450364; ENSG00000008517 [P24001-2]
ENST00000528163; ENSP00000432850; ENSG00000008517 [P24001-2]
ENST00000529550; ENSP00000437020; ENSG00000008517 [P24001-2]
ENST00000530538; ENSP00000436929; ENSG00000008517 [P24001-2]
ENST00000530890; ENSP00000433747; ENSG00000008517 [P24001-5]
ENST00000531965; ENSP00000433177; ENSG00000008517 [P24001-3]
ENST00000533097; ENSP00000432917; ENSG00000008517 [P24001-2]
ENST00000534507; ENSP00000431775; ENSG00000008517 [P24001-1]
ENST00000548246; ENSP00000447979; ENSG00000008517 [P24001-7]
ENST00000548476; ENSP00000449483; ENSG00000008517 [P24001-1]
ENST00000548652; ENSP00000446624; ENSG00000008517 [P24001-6]
ENST00000549213; ENSP00000447812; ENSG00000008517 [P24001-4]
ENST00000551122; ENSP00000447496; ENSG00000008517 [P24001-4]
ENST00000552356; ENSP00000446978; ENSG00000008517 [P24001-5]
ENST00000552664; ENSP00000448683; ENSG00000008517 [P24001-2]
ENST00000675975; ENSP00000501913; ENSG00000008517 [P24001-2]
GeneIDi9235
KEGGihsa:9235
UCSCiuc002ctk.4, human [P24001-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9235
DisGeNETi9235

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL32
HGNCiHGNC:16830, IL32
HPAiENSG00000008517, Tissue enhanced (blood, liver, pancreas)
MIMi606001, gene
neXtProtiNX_P24001
OpenTargetsiENSG00000008517
PharmGKBiPA128395754
VEuPathDBiHostDB:ENSG00000008517.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000167201
InParanoidiP24001
OrthoDBi1509659at2759
PhylomeDBiP24001
TreeFamiTF341753

Enzyme and pathway databases

PathwayCommonsiP24001
ReactomeiR-HSA-449836, Other interleukin signaling
SIGNORiP24001

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9235, 5 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL32, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9235
PharosiP24001, Tbio

Protein Ontology

More...PROi		PR:P24001
RNActiP24001, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000008517, Expressed in right lobe of liver and 187 other tissues
ExpressionAtlasiP24001, baseline and differential
GenevisibleiP24001, HS

Family and domain databases

InterProiView protein in InterPro
IPR028067, IL-32
PfamiView protein in Pfam
PF15225, IL32, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL32_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24001
Secondary accession number(s): A6NNM0
, A8MPX0, B4DJM1, B8Q191, D3DUB0, D3DUB2, Q5VFH7, Q5VFH8, Q8WV38, Q96GK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 12, 2006
Last modified: February 10, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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