UniProtKB - P24001 (IL32_HUMAN)
Protein
Interleukin-32
Gene
IL32
Organism
Homo sapiens (Human)
Status
Functioni
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.1 Publication
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: ProtInc
- cytokine-mediated signaling pathway Source: Reactome
- defense response Source: ProtInc
- immune response Source: ProtInc
- negative regulation of viral life cycle Source: ARUK-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: ARUK-UCL
- positive regulation of type III interferon production Source: ARUK-UCL
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
PathwayCommonsi | P24001 |
Reactomei | R-HSA-449836, Other interleukin signaling |
SIGNORi | P24001 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-32Short name: IL-32 Alternative name(s): Natural killer cells protein 4 Tumor necrosis factor alpha-inducing factor |
Gene namesi | Name:IL32 Synonyms:NK4, TAIF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16830, IL32 |
MIMi | 606001, gene |
neXtProti | NX_P24001 |
VEuPathDBi | HostDB:ENSG00000008517.16 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular space Source: ProtInc
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 9235 |
OpenTargetsi | ENSG00000008517 |
PharmGKBi | PA128395754 |
Miscellaneous databases
Pharosi | P24001, Tbio |
Genetic variation databases
BioMutai | IL32 |
DMDMi | 119364597 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000021487 | 31 – 234 | Interleukin-32Add BLAST | 204 |
Proteomic databases
jPOSTi | P24001 |
MassIVEi | P24001 |
MaxQBi | P24001 |
PeptideAtlasi | P24001 |
PRIDEi | P24001 |
ProteomicsDBi | 1618 54173 [P24001-1] 54174 [P24001-2] 54175 [P24001-3] 54176 [P24001-4] 54177 [P24001-5] 7283 |
PTM databases
iPTMneti | P24001 |
PhosphoSitePlusi | P24001 |
SwissPalmi | P24001 |
Expressioni
Tissue specificityi
Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.1 Publication
Inductioni
Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2.1 Publication
Gene expression databases
Bgeei | ENSG00000008517, Expressed in right lobe of liver and 187 other tissues |
ExpressionAtlasi | P24001, baseline and differential |
Genevisiblei | P24001, HS |
Organism-specific databases
HPAi | ENSG00000008517, Tissue enhanced (blood, liver, pancreas) |
Interactioni
Binary interactionsi
Hide detailsP24001
With | #Exp. | IntAct |
---|---|---|
RHBDD2 - isoform 3 [Q6NTF9-3] | 3 | EBI-2866752,EBI-17589229 |
IL32 - isoform 2 [P24001-2]
With | #Exp. | IntAct |
---|---|---|
CEBPA [P49715] | 7 | EBI-8800907,EBI-1172054 |
PRKCD [Q05655] | 7 | EBI-8800907,EBI-704279 |
Isoform 3 [P24001-3]
With | #Exp. | IntAct |
---|---|---|
IL32 - isoform 2 [P24001-2] | 2 | EBI-8800897,EBI-8800907 |
Isoform 4 [P24001-4]
With | #Exp. | IntAct |
---|---|---|
PRTN3 [P24158] | 3 | EBI-15570379,EBI-465028 |
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 114664, 16 interactors |
DIPi | DIP-61119N |
IntActi | P24001, 6 interactors |
Miscellaneous databases
RNActi | P24001, protein |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
GeneTreei | ENSGT00940000167201 |
InParanoidi | P24001 |
OrthoDBi | 1509659at2759 |
PhylomeDBi | P24001 |
TreeFami | TF341753 |
Family and domain databases
InterProi | View protein in InterPro IPR028067, IL-32 |
Pfami | View protein in Pfam PF15225, IL32, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P24001-1) [UniParc]FASTAAdd to basket
Also known as: Gamma
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCFPKVLSDD MKKLKARMVM LLPTSAQGLG AWVSACDTED TVGHLGPWRD
60 70 80 90 100
KDPALWCQLC LSSQHQAIER FYDKMQNAES GRGQVMSSLA ELEDDFKEGY
110 120 130 140 150
LETVAAYYEE QHPELTPLLE KERDGLRCRG NRSPVPDVED PATEEPGESF
160 170 180 190 200
CDKVMRWFQA MLQRLQTWWH GVLAWVKEKV VALVHAVQAL WKQFQSFCCS
210 220 230
LSELFMSSFQ SYGAPRGDKE ELTPQKCSEP QSSK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC6GKH1 | C6GKH1_HUMAN | Interleukin-32 | IL32 | 168 | Annotation score: | ||
F8W1V1 | F8W1V1_HUMAN | Interleukin-32 | IL32 | 212 | Annotation score: | ||
F8VVN4 | F8VVN4_HUMAN | Interleukin-32 | IL32 | 225 | Annotation score: | ||
E9PIV2 | E9PIV2_HUMAN | Interleukin-32 | IL32 | 221 | Annotation score: | ||
E9PK07 | E9PK07_HUMAN | Interleukin-32 | IL32 | 131 | Annotation score: | ||
F8VSD2 | F8VSD2_HUMAN | Interleukin-32 | IL32 | 225 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 233 | S → L in BM825040 (PubMed:16341674).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_005506 | 152 | D → N1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022005 | 1 – 10 | Missing in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_047855 | 19 – 84 | Missing in isoform 7. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_022006 | 19 – 64 | Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_043318 | 65 – 84 | Missing in isoform 5. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_045785 | 85 – 93 | Missing in isoform 6. 1 Publication | 9 | |
Alternative sequenceiVSP_047856 | 94 – 113 | Missing in isoform 7. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_022007 | 154 – 210 | Missing in isoform 4. 1 PublicationAdd BLAST | 57 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | P24001 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114664, 16 interactors |
DIPi | DIP-61119N |
IntActi | P24001, 6 interactors |
PTM databases
iPTMneti | P24001 |
PhosphoSitePlusi | P24001 |
SwissPalmi | P24001 |
Genetic variation databases
BioMutai | IL32 |
DMDMi | 119364597 |
Proteomic databases
jPOSTi | P24001 |
MassIVEi | P24001 |
MaxQBi | P24001 |
PeptideAtlasi | P24001 |
PRIDEi | P24001 |
ProteomicsDBi | 1618 54173 [P24001-1] 54174 [P24001-2] 54175 [P24001-3] 54176 [P24001-4] 54177 [P24001-5] 7283 |
Protocols and materials databases
Antibodypediai | 10701, 585 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 9235 |
DisGeNETi | 9235 |
GeneCardsi | IL32 |
HGNCi | HGNC:16830, IL32 |
HPAi | ENSG00000008517, Tissue enhanced (blood, liver, pancreas) |
MIMi | 606001, gene |
neXtProti | NX_P24001 |
OpenTargetsi | ENSG00000008517 |
PharmGKBi | PA128395754 |
VEuPathDBi | HostDB:ENSG00000008517.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000167201 |
InParanoidi | P24001 |
OrthoDBi | 1509659at2759 |
PhylomeDBi | P24001 |
TreeFami | TF341753 |
Enzyme and pathway databases
PathwayCommonsi | P24001 |
Reactomei | R-HSA-449836, Other interleukin signaling |
SIGNORi | P24001 |
Miscellaneous databases
BioGRID-ORCSi | 9235, 5 hits in 878 CRISPR screens |
ChiTaRSi | IL32, human |
GenomeRNAii | 9235 |
Pharosi | P24001, Tbio |
PROi | PR:P24001 |
RNActi | P24001, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000008517, Expressed in right lobe of liver and 187 other tissues |
ExpressionAtlasi | P24001, baseline and differential |
Genevisiblei | P24001, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028067, IL-32 |
Pfami | View protein in Pfam PF15225, IL32, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL32_HUMAN | |
Accessioni | P24001Primary (citable) accession number: P24001 Secondary accession number(s): A6NNM0 Q96GK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | December 12, 2006 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot