Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 106 (07 Oct 2020)
Sequence version 1 (01 Mar 1992)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic

Gene

EPSPS-1

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.By similarity

Miscellaneous

This enzyme is the target of the potent, broad-spectrum herbicide, glyphosate [n-(phosphonomethyl)glycine]. Overproduction of EPSP leads to glyphosate tolerance.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: chorismate biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107775732), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107817203), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107797958), Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic (DHAPS-1), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107809924), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107783854), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107796357), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107788249), Phospho-2-dehydro-3-deoxyheptonate aldolase (LOC107821084)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Shikimate dehydrogenase (LOC107791190), Shikimate dehydrogenase (LOC107767464), Shikimate dehydrogenase, bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 (LOC107767176), bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like (LOC107777512), 3-dehydroquinate dehydratase / shikimate dehydrogenase isoform 2, Shikimate dehydrogenase (LOC107793657), Shikimate dehydrogenase (LOC107767464), Shikimate dehydrogenase, Shikimate dehydrogenase (LOC107767464), Shikimate dehydrogenase (LOC107767464), Shikimate dehydrogenase (LOC107780015), Shikimate dehydrogenase (LOC107793657), Shikimate dehydrogenase (LOC107767464), Shikimate dehydrogenase (LOC107832188), Shikimate dehydrogenase (LOC107780015), bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X2 (LOC107767176)
  5. Shikimate kinase (SK), Shikimate kinase (LOC107818889), Shikimate kinase (LOC107767446)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (LOC107813883), 3-phosphoshikimate 1-carboxyvinyltransferase (LOC107815901), 3-phosphoshikimate 1-carboxyvinyltransferase (LOC107796782), 3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic (EPSPS-1), 3-phosphoshikimate 1-carboxyvinyltransferase (LOC107797655), 3-phosphoshikimate 1-carboxyvinyltransferase 2 (EPSPS-2)
  7. Chorismate synthase (LOC107769690), Chorismate synthase (CS1), Chorismate synthase (LOC107790266)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei102Shikimate-3-phosphateBy similarity1
Binding sitei205PhosphoenolpyruvateBy similarity1
Binding sitei280Shikimate-3-phosphateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei405Proton acceptorBy similarity1
Binding sitei432Shikimate-3-phosphateBy similarity1
Active sitei433Proton donorBy similarity1
Binding sitei436PhosphoenolpyruvateBy similarity1
Binding sitei478PhosphoenolpyruvateBy similarity1
Binding sitei503PhosphoenolpyruvateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00053;UER00089

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic (EC:2.5.1.19)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase 1
Short name:
EPSP synthase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPSPS-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNicotiana tabacum (Common tobacco)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4097 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000084051 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 74ChloroplastAdd BLAST74
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000229175 – 5183-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplasticAdd BLAST444

Proteomic databases

Protein Mass spectra EXtraction

More...
ProMEXi
P23981

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P23981

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni97 – 98Shikimate-3-phosphate bindingBy similarity2
Regioni173 – 176PhosphoenolpyruvateBy similarity4
Regioni252 – 254Shikimate-3-phosphate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EPSP synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K00800

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01556, EPSP_synthase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.65.10.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00210, EPSP_synth, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001986, Enolpyruvate_Tfrase_dom
IPR036968, Enolpyruvate_Tfrase_sf
IPR006264, EPSP_synthase
IPR023193, EPSP_synthase_CS
IPR013792, RNA3'P_cycl/enolpyr_Trfase_a/b

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00275, EPSP_synthase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55205, SSF55205, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01356, aroA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00104, EPSP_SYNTHASE_1, 1 hit
PS00885, EPSP_SYNTHASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P23981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQISSMGQG IRTPNLNSYL PKTQKVPLFS HSIFIGSKKI TQNSAKSLWV
60 70 80 90 100
SKEDSVLRVA KSPFRISASV VTAQKPNEIV LQPIKDISGT VKLPGSKSLS
110 120 130 140 150
NRILLLAALS KGRTVVDNLL SSDDIHYMLG ALKTLGLHVE DDNENQRAIV
160 170 180 190 200
EGCGGQFPVG KKSEEEIQLF LGNAGTAMRP LTAAVTVAGG HSRYVLDGVP
210 220 230 240 250
RMRERPIGDL VDGLKQLGAE VDCFLGTNCP PVRIVSKGGL PGGKVKLSGS
260 270 280 290 300
ISSQYLTALL MAAPLALGDV EIEIIDKLIS VPYVEMTLKL MERFGVSVEH
310 320 330 340 350
TSSWDKFLVR GGQKYKSPGK AYVEGDASSA SYFLAGAAVT GGTVTVEGCG
360 370 380 390 400
TSSLQGDVKF AEVLEKMGAE VTWTENSVTV KGPPRNSSGM KHLRAVDVNM
410 420 430 440 450
NKMPDVAMTL AVVALFADGP TAIRDVASWR VKETERMIAI CTELRKLGAT
460 470 480 490 500
VVEGSDYCII TPPEKLNVTE IDTYDDHRMA MAFSLAACAD VPVTIKDPGC
510
TRKTFPNYFD VLQQYSKH
Length:518
Mass (Da):55,711
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F03C514EAFE1681
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M61904 mRNA Translation: AAA34071.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S18353

NCBI Reference Sequences

More...
RefSeqi
NP_001312842.1, NM_001325913.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107813883

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nta:107813883

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61904 mRNA Translation: AAA34071.1
PIRiS18353
RefSeqiNP_001312842.1, NM_001325913.1

3D structure databases

SMRiP23981
ModBaseiSearch...

Proteomic databases

ProMEXiP23981

Genome annotation databases

GeneIDi107813883
KEGGinta:107813883

Phylogenomic databases

KOiK00800

Enzyme and pathway databases

UniPathwayiUPA00053;UER00089

Family and domain databases

CDDicd01556, EPSP_synthase, 1 hit
Gene3Di3.65.10.10, 2 hits
HAMAPiMF_00210, EPSP_synth, 1 hit
InterProiView protein in InterPro
IPR001986, Enolpyruvate_Tfrase_dom
IPR036968, Enolpyruvate_Tfrase_sf
IPR006264, EPSP_synthase
IPR023193, EPSP_synthase_CS
IPR013792, RNA3'P_cycl/enolpyr_Trfase_a/b
PfamiView protein in Pfam
PF00275, EPSP_synthase, 1 hit
SUPFAMiSSF55205, SSF55205, 1 hit
TIGRFAMsiTIGR01356, aroA, 1 hit
PROSITEiView protein in PROSITE
PS00104, EPSP_SYNTHASE_1, 1 hit
PS00885, EPSP_SYNTHASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAROA1_TOBAC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23981
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 7, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again