Sodium-dependent dopamine transporter

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• dopamine:sodium symporter activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.3

    "Cloning and functional characterization of a cocaine-sensitive dopamine transporter."
    Giros B., el Mestikawy S., Bertrand L., Caron M.G.
    FEBS Lett. 295:149-154(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  • "Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats."
    Perry M.L., Leinninger G.M., Chen R., Luderman K.D., Yang H., Gnegy M.E., Myers M.G. Jr., Kennedy R.T.
    J. Neurochem. 114:666-674(2010) [PubMed] [Europe PMC] [Abstract]
• dopamine binding Source: RGDInferred from sequence orthologyⁱ
  • "Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm."
    Bailey A., Metaxas A., Yoo J.H., McGee T., Kitchen I.
    Eur. J. Neurosci. 28:759-770(2008) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: RGDInferred from direct assayⁱ
  • "Affinity labeling the dopamine transporter ligand binding site."
    Vaughan R.A., Parnas M.L., Gaffaney J.D., Lowe M.J., Wirtz S., Pham A., Reed B., Dutta S.M., Murray K.K., Justice J.B.
    J. Neurosci. Methods 143:33-40(2005) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• monoamine transmembrane transporter activity Source: RGDInferred from sequence orthologyⁱ
  • "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity."
    Jiang W., Prokopenko O., Wong L., Inouye M., Mirochnitchenko O.
    Mol. Cell. Biol. 25:6496-6508(2005) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter:sodium symporter activity Source: InterPro
• norepinephrine:sodium symporter activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Regulation of dopamine transporter activity by carboxypeptidase E."
    Zhang H., Li S., Wang M., Vukusic B., Pristupa Z.B., Liu F.
    Mol Brain 2:10-10(2009) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from direct assayⁱ
  • "Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism."
    Baucum A.J., Rau K.S., Riddle E.L., Hanson G.R., Fleckenstein A.E.
    J. Neurosci. 24:3436-3443(2004) [PubMed] [Europe PMC] [Abstract]
• protein N-terminus binding Source: RGDInferred from sequence orthologyⁱ
  • "Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3."
    Egana L.A., Cuevas R.A., Baust T.B., Parra L.A., Leak R.K., Hochendoner S., Pena K., Quiroz M., Hong W.C., Dorostkar M.M., Janz R., Sitte H.H., Torres G.E.
    J. Neurosci. 29:4592-4604(2009) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase 2A binding Source: RGDInferred from physical interactionⁱ
  • "Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats."
    Ramamoorthy S., Samuvel D.J., Balasubramaniam A., See R.E., Jayanthi L.D.
    Biochem. Biophys. Res. Commun. 391:1517-1521(2010) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade."
    du Bois T.M., Hsu C.W., Li Y., Tan Y.Y., Deng C., Huang X.F.
    Neurochem. Res. 33:1224-1231(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adenohypophysis development Source: RGDInferred from sequence orthologyⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Decreased plasma membrane expression of striatal dopamine transporter in aging."
    Salvatore M.F., Apparsundaram S., Gerhardt G.A.
    Neurobiol. Aging 24:1147-1154(2003) [PubMed] [Europe PMC] [Abstract]
• dopamine biosynthetic process Source: RGDInferred from sequence orthologyⁱ
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine catabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• dopamine transport Source: RGDInferred from direct assayⁱ
  • Ref.3

    "Cloning and functional characterization of a cocaine-sensitive dopamine transporter."
    Giros B., el Mestikawy S., Bertrand L., Caron M.G.
    FEBS Lett. 295:149-154(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  • "Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats."
    Perry M.L., Leinninger G.M., Chen R., Luderman K.D., Yang H., Gnegy M.E., Myers M.G. Jr., Kennedy R.T.
    J. Neurochem. 114:666-674(2010) [PubMed] [Europe PMC] [Abstract]
• dopamine uptake Source: RGDInferred from sequence orthologyⁱ
  • "The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking."
    Navaroli D.M., Stevens Z.H., Uzelac Z., Gabriel L., King M.J., Lifshitz L.M., Sitte H.H., Melikian H.E.
    J. Neurosci. 31:13758-13770(2011) [PubMed] [Europe PMC] [Abstract]
• dopamine uptake involved in synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• lactation Source: RGDInferred from sequence orthologyⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: RGDInferred from sequence orthologyⁱ
  • "Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists."
    Ralph R.J., Paulus M.P., Fumagalli F., Caron M.G., Geyer M.A.
    J. Neurosci. 21:305-313(2001) [PubMed] [Europe PMC] [Abstract]
• monoamine transport Source: RGDInferred from sequence orthologyⁱ
  • "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity."
    Jiang W., Prokopenko O., Wong L., Inouye M., Mirochnitchenko O.
    Mol. Cell. Biol. 25:6496-6508(2005) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter uptake Source: RGDInferred from sequence orthologyⁱ
  • "Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter."
    Giros B., Jaber M., Jones S.R., Wightman R.M., Caron M.G.
    Nature 379:606-612(1996) [PubMed] [Europe PMC] [Abstract]
• norepinephrine transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of multicellular organism growth Source: RGDInferred from sequence orthologyⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
• prepulse inhibition Source: RGDInferred from sequence orthologyⁱ
  • "Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists."
    Ralph R.J., Paulus M.P., Fumagalli F., Caron M.G., Geyer M.A.
    J. Neurosci. 21:305-313(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of dopamine metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter."
    Bosse R., Fumagalli F., Jaber M., Giros B., Gainetdinov R.R., Wetsel W.C., Missale C., Caron M.G.
    Neuron 19:127-138(1997) [PubMed] [Europe PMC] [Abstract]
  • "Profound neuronal plasticity in response to inactivation of the dopamine transporter."
    Jones S.R., Gainetdinov R.R., Jaber M., Giros B., Wightman R.M., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:4029-4034(1998) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: RGDInferred from direct assayⁱ
  • "The up-regulation of the striatal dopamine transporter's activity by cAMP is PKA-, CaMK II- and phosphatase-dependent."
    Page G., Barc-Pain S., Pontcharraud R., Cante A., Piriou A., Barrier L.
    Neurochem. Int. 45:627-632(2004) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGDInferred from sequence orthologyⁱ
  • "Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm."
    Bailey A., Metaxas A., Yoo J.H., McGee T., Kitchen I.
    Eur. J. Neurosci. 28:759-770(2008) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine."
    Owens W.A., Sevak R.J., Galici R., Chang X., Javors M.A., Galli A., France C.P., Daws L.C.
    J. Neurochem. 94:1402-1410(2005) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: RGDInferred from direct assayⁱ
  • "Acute ethanol decreases dopamine transporter velocity in rat striatum: in vivo and in vitro electrochemical measurements."
    Robinson D.L., Volz T.J., Schenk J.O., Wightman R.M.
    Alcohol. Clin. Exp. Res. 29:746-755(2005) [PubMed] [Europe PMC] [Abstract]
• response to iron ion Source: RGDInferred from expression patternⁱ
  • "Neonatal iron deficiency results in irreversible changes in dopamine function in rats."
    Beard J., Erikson K.M., Jones B.C.
    J. Nutr. 133:1174-1179(2003) [PubMed] [Europe PMC] [Abstract]
• response to nicotine Source: RGDInferred from expression patternⁱ
  • "Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain."
    Li S., Kim K.Y., Kim J.H., Kim J.H., Park M.S., Bahk J.Y., Kim M.O.
    Neurosci. Lett. 363:29-32(2004) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes."
    Salkovic-Petrisic M., Lackovic Z.
    J Neural Transm (Vienna) 110:15-29(2003) [PubMed] [Europe PMC] [Abstract]
• sensory perception of smell Source: RGDInferred from sequence orthologyⁱ
  • "Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopamine receptor."
    Tillerson J.L., Caudle W.M., Parent J.M., Gong C., Schallert T., Miller G.W.
    Behav. Brain Res. 172:97-105(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protease binding Source: RGDInferred from physical interactionⁱ
  • "Regulation of dopamine transporter activity by carboxypeptidase E."
    Zhang H., Li S., Wang M., Vukusic B., Pristupa Z.B., Liu F.
    Mol Brain 2:10-10(2009) [PubMed] [Europe PMC] [Abstract]
• protein N-terminus binding Source: RGDInferred from sequence orthologyⁱ
  • "Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3."
    Egana L.A., Cuevas R.A., Baust T.B., Parra L.A., Leak R.K., Hochendoner S., Pena K., Quiroz M., Hong W.C., Dorostkar M.M., Janz R., Sitte H.H., Torres G.E.
    J. Neurosci. 29:4592-4604(2009) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase 2A binding Source: RGDInferred from physical interactionⁱ
  • "Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats."
    Ramamoorthy S., Samuvel D.J., Balasubramaniam A., See R.E., Jayanthi L.D.
    Biochem. Biophys. Res. Commun. 391:1517-1521(2010) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade."
    du Bois T.M., Hsu C.W., Li Y., Tan Y.Y., Deng C., Huang X.F.
    Neurochem. Res. 33:1224-1231(2008) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSKSKCSVGP MSSVVAPAKE SNAVGPREVE LILVKEQNGV QLTNSTLINP 
        60         70         80         90        100
PQTPVEAQER ETWSKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV 
       110        120        130        140        150
PYLLFMVIAG MPLFYMELAL GQFNREGAAG VWKICPVLKG VGFTVILISF 
       160        170        180        190        200
YVGFFYNVII AWALHYFFSS FTMDLPWIHC NNTWNSPNCS DAHASNSSDG 
       210        220        230        240        250
LGLNDTFGTT PAAEYFERGV LHLHQSRGID DLGPPRWQLT ACLVLVIVLL 
       260        270        280        290        300
YFSLWKGVKT SGKVVWITAT MPYVVLTALL LRGVTLPGAM DGIRAYLSVD 
       310        320        330        340        350
FYRLCEASVW IDAATQVCFS LGVGFGVLIA FSSYNKFTNN CYRDAIITTS 
       360        370        380        390        400
INSLTSFSSG FVVFSFLGYM AQKHNVPIRD VATDGPGLIF IIYPEAIATL 
       410        420        430        440        450
PLSSAWAAVF FLMLLTLGID SAMGGMESVI TGLVDEFQLL HRHRELFTLG 
       460        470        480        490        500
IVLATFLLSL FCVTNGGIYV FTLLDHFAAG TSILFGVLIE AIGVAWFYGV 
       510        520        530        540        550
QQFSDDIKQM TGQRPNLYWR LCWKLVSPCF LLYVVVVSIV TFRPPHYGAY 
       560        570        580        590        600
IFPDWANALG WIIATSSMAM VPIYATYKFC SLPGSFREKL AYAITPEKDH 
       610 
QLVDRGEVRQ FTLRHWLLL                                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families