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Protein

Sodium-dependent noradrenaline transporter

Gene

SLC6A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi73Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi74Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi78Sodium 2By similarity1
Metal bindingi318Sodium 2By similarity1
Metal bindingi350Sodium 2By similarity1
Metal bindingi415Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi418Sodium 1By similarity1
Metal bindingi419Sodium 1By similarity1

GO - Molecular functioni

  • actin binding Source: ARUK-UCL
  • alpha-tubulin binding Source: Ensembl
  • beta-tubulin binding Source: Ensembl
  • dopamine:sodium symporter activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • monoamine transmembrane transporter activity Source: MGI
  • neurotransmitter:sodium symporter activity Source: InterPro
  • norepinephrine:sodium symporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport
LigandMetal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI)

Protein family/group databases

TCDBi2.A.22.1.2 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:SLC6A2
Synonyms:NAT1, NET1, SLC6A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103546.18
HGNCiHGNC:11048 SLC6A2
MIMi163970 gene
neXtProtiNX_P23975

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicBy similarityAdd BLAST62
Transmembranei63 – 88Helical; Name=1By similarityAdd BLAST26
Topological domaini89 – 92ExtracellularBy similarity4
Transmembranei93 – 116Helical; Name=2By similarityAdd BLAST24
Topological domaini117 – 135CytoplasmicBy similarityAdd BLAST19
Transmembranei136 – 166Helical; Name=3By similarityAdd BLAST31
Topological domaini167 – 233ExtracellularBy similarityAdd BLAST67
Transmembranei234 – 254Helical; Name=4By similarityAdd BLAST21
Topological domaini255 – 257CytoplasmicBy similarity3
Transmembranei258 – 282Helical; Name=5By similarityAdd BLAST25
Topological domaini283 – 306ExtracellularBy similarityAdd BLAST24
Transmembranei307 – 332Helical; Name=6By similarityAdd BLAST26
Topological domaini333 – 338CytoplasmicBy similarity6
Transmembranei339 – 362Helical; Name=7By similarityAdd BLAST24
Topological domaini363 – 402ExtracellularBy similarityAdd BLAST40
Transmembranei403 – 428Helical; Name=8By similarityAdd BLAST26
Topological domaini429 – 443CytoplasmicBy similarityAdd BLAST15
Transmembranei444 – 464Helical; Name=9By similarityAdd BLAST21
Topological domaini465ExtracellularBy similarity1
Transmembranei466 – 492Helical; Name=10By similarityAdd BLAST27
Topological domaini493 – 522CytoplasmicBy similarityAdd BLAST30
Transmembranei523 – 545Helical; Name=11By similarityAdd BLAST23
Topological domaini546 – 548ExtracellularBy similarity3
Transmembranei549 – 569Helical; Name=12By similarityAdd BLAST21
Topological domaini570 – 617CytoplasmicBy similarityAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Orthostatic intolerance (OI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSyndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
See also OMIM:604715
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010022457A → P in OI; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121918126EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6530
MalaCardsiSLC6A2
MIMi604715 phenotype
OpenTargetsiENSG00000103546
Orphaneti443236 Orthostatic intolerance due to NET deficiency
PharmGKBiPA310

Chemistry databases

ChEMBLiCHEMBL222
DrugBankiDB04836 Amineptine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00289 Atomoxetine
DB04889 Bicifadine
DB01156 Bupropion
DB01114 Chlorphenamine
DB00215 Citalopram
DB01242 Clomipramine
DB00907 Cocaine
DB05688 CRx-119
DB04840 Debrisoquin
DB01151 Desipramine
DB06700 Desvenlafaxine
DB06701 Dexmethylphenidate
DB01576 Dextroamphetamine
DB00514 Dextromethorphan
DB00937 Diethylpropion
DB00988 Dopamine
DB01142 Doxepin
DB06262 Droxidopa
DB00476 Duloxetine
DB01363 Ephedra
DB01364 Ephedrine
DB00696 Ergotamine
DB01175 Escitalopram
DB01381 Ginkgo biloba
DB00226 Guanadrel
DB01170 Guanethidine
DB00458 Imipramine
DB06704 Iobenguane
DB01221 Ketamine
DB08918 Levomilnacipran
DB00408 Loxapine
DB00934 Maprotiline
DB00579 Mazindol
DB01577 Methamphetamine
DB00422 Methylphenidate
DB06148 Mianserin
DB04896 Milnacipran
DB00370 Mirtazapine
DB01442 MMDA
DB01149 Nefazodone
DB04821 Nomifensine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB01173 Orphenadrine
DB00715 Paroxetine
DB00454 Pethidine
DB01579 Phendimetrazine
DB00830 Phenmetrazine
DB00191 Phentermine
DB00344 Protriptyline
DB00852 Pseudoephedrine
DB00234 Reboxetine
DB01105 Sibutramine
DB06204 Tapentadol
DB00193 Tramadol
DB00726 Trimipramine
DB00285 Venlafaxine
DB05012 XEN2174
GuidetoPHARMACOLOGYi926

Polymorphism and mutation databases

BioMutaiSLC6A2
DMDMi128616

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147481 – 617Sodium-dependent noradrenaline transporterAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi176 ↔ 185By similarity
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP23975
PaxDbiP23975
PeptideAtlasiP23975
PRIDEiP23975
ProteomicsDBi54172

PTM databases

iPTMnetiP23975
PhosphoSitePlusiP23975

Expressioni

Gene expression databases

BgeeiENSG00000103546 Expressed in 94 organ(s), highest expression level in chorionic villus
CleanExiHS_NAT1
HS_NET1
HS_SLC6A2
HS_SLC6A5
ExpressionAtlasiP23975 baseline and differential
GenevisibleiP23975 HS

Organism-specific databases

HPAiCAB078195
HPA004057
HPA076311

Interactioni

Subunit structurei

Interacts with PRKCABP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112421, 3 interactors
MINTiP23975
STRINGi9606.ENSP00000219833

Chemistry databases

BindingDBiP23975

Structurei

3D structure databases

ProteinModelPortaliP23975
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP23975
KOiK05035
OMAiAYCITPE
OrthoDBiEOG091G08PX
PhylomeDBiP23975
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002435 Na/ntran_symport_noradrenaline
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01201 NORTRANSPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P23975-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD
60 70 80 90 100
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT
210 220 230 240 250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF
260 270 280 290 300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
310 320 330 340 350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN
360 370 380 390 400
CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG
410 420 430 440 450
STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT
460 470 480 490 500
FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
510 520 530 540 550
FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF
560 570 580 590 600
PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL
610
VAQRDIRQFQ LQHWLAI
Length:617
Mass (Da):69,332
Last modified:March 1, 1992 - v1
Checksum:iBDC6DF31316907BB
GO
Isoform 2 (identifier: P23975-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-617: LQHWLAI → MKTRQGRRRATNSCQISC

Show »
Length:628
Mass (Da):70,548
Checksum:i4CF79AD92F272587
GO
Isoform 3 (identifier: P23975-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MLLARMNPQV...TVWKICPFFK → MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP

Show »
Length:512
Mass (Da):57,370
Checksum:iB25C836CA8BA912F
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRE9H3BRE9_HUMAN
Transporter
SLC6A2 hCG_2025341
572Annotation score:
H3BMY5H3BMY5_HUMAN
Transporter
SLC6A2
200Annotation score:
H3BML6H3BML6_HUMAN
Transporter
SLC6A2
604Annotation score:
H3BM11H3BM11_HUMAN
Transporter
SLC6A2
561Annotation score:
H3BRS0H3BRS0_HUMAN
Transporter
SLC6A2
295Annotation score:
I3L368I3L368_HUMAN
Sodium-dependent noradrenaline tran...
SLC6A2
58Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0291577N → K. Corresponds to variant dbSNP:rs11568323EnsemblClinVar.1
Natural variantiVAR_01175669V → I. Corresponds to variant dbSNP:rs1805064Ensembl.1
Natural variantiVAR_01175799T → I. Corresponds to variant dbSNP:rs1805065Ensembl.1
Natural variantiVAR_011758245V → I. Corresponds to variant dbSNP:rs1805066Ensembl.1
Natural variantiVAR_020048283T → R. Corresponds to variant dbSNP:rs45564432EnsemblClinVar.1
Natural variantiVAR_011759292N → T. Corresponds to variant dbSNP:rs5563Ensembl.1
Natural variantiVAR_011760356V → L. Corresponds to variant dbSNP:rs5565Ensembl.1
Natural variantiVAR_011761369A → P. Corresponds to variant dbSNP:rs5566Ensembl.1
Natural variantiVAR_011762375N → S. Corresponds to variant dbSNP:rs5567Ensembl.1
Natural variantiVAR_014800449V → I. Corresponds to variant dbSNP:rs2234910Ensembl.1
Natural variantiVAR_010022457A → P in OI; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121918126EnsemblClinVar.1
Natural variantiVAR_011763463K → R. Corresponds to variant dbSNP:rs5570Ensembl.1
Natural variantiVAR_011764478G → S. Corresponds to variant dbSNP:rs1805067Ensembl.1
Natural variantiVAR_011765528F → C. Corresponds to variant dbSNP:rs5558Ensembl.1
Natural variantiVAR_011766548Y → H. Corresponds to variant dbSNP:rs5559Ensembl.1
Natural variantiVAR_021861549I → T. Corresponds to variant dbSNP:rs3743788EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541191 – 135MLLAR…CPFFK → MGVQWWSHTQGEVAVGLGLG DSYLTPCPCP in isoform 3. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_044479611 – 617LQHWLAI → MKTRQGRRRATNSCQISC in isoform 2. Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65105 mRNA Translation: AAA59943.1
X91117
, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA Translation: CAA62566.1
X91117
, X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA Translation: CAC39181.1
AK301811 mRNA Translation: BAG63260.1
AK312793 mRNA Translation: BAG35654.1
AC136621 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82831.1
CH471092 Genomic DNA Translation: EAW82833.1
CH471092 Genomic DNA Translation: EAW82835.1
CCDSiCCDS10754.1 [P23975-1]
CCDS54011.1 [P23975-2]
CCDS58463.1 [P23975-3]
PIRiS14278
RefSeqiNP_001034.1, NM_001043.3 [P23975-1]
NP_001165972.1, NM_001172501.1 [P23975-1]
NP_001165973.1, NM_001172502.1 [P23975-3]
NP_001165975.1, NM_001172504.1 [P23975-2]
XP_006721326.1, XM_006721263.2 [P23975-2]
XP_011521597.1, XM_011523295.1 [P23975-2]
UniGeneiHs.78036

Genome annotation databases

EnsembliENST00000219833; ENSP00000219833; ENSG00000103546 [P23975-2]
ENST00000379906; ENSP00000369237; ENSG00000103546 [P23975-1]
ENST00000567238; ENSP00000457375; ENSG00000103546 [P23975-3]
ENST00000568943; ENSP00000457473; ENSG00000103546 [P23975-1]
GeneIDi6530
KEGGihsa:6530
UCSCiuc002eif.4 human [P23975-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65105 mRNA Translation: AAA59943.1
X91117
, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA Translation: CAA62566.1
X91117
, X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA Translation: CAC39181.1
AK301811 mRNA Translation: BAG63260.1
AK312793 mRNA Translation: BAG35654.1
AC136621 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82831.1
CH471092 Genomic DNA Translation: EAW82833.1
CH471092 Genomic DNA Translation: EAW82835.1
CCDSiCCDS10754.1 [P23975-1]
CCDS54011.1 [P23975-2]
CCDS58463.1 [P23975-3]
PIRiS14278
RefSeqiNP_001034.1, NM_001043.3 [P23975-1]
NP_001165972.1, NM_001172501.1 [P23975-1]
NP_001165973.1, NM_001172502.1 [P23975-3]
NP_001165975.1, NM_001172504.1 [P23975-2]
XP_006721326.1, XM_006721263.2 [P23975-2]
XP_011521597.1, XM_011523295.1 [P23975-2]
UniGeneiHs.78036

3D structure databases

ProteinModelPortaliP23975
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112421, 3 interactors
MINTiP23975
STRINGi9606.ENSP00000219833

Chemistry databases

BindingDBiP23975
ChEMBLiCHEMBL222
DrugBankiDB04836 Amineptine
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB00289 Atomoxetine
DB04889 Bicifadine
DB01156 Bupropion
DB01114 Chlorphenamine
DB00215 Citalopram
DB01242 Clomipramine
DB00907 Cocaine
DB05688 CRx-119
DB04840 Debrisoquin
DB01151 Desipramine
DB06700 Desvenlafaxine
DB06701 Dexmethylphenidate
DB01576 Dextroamphetamine
DB00514 Dextromethorphan
DB00937 Diethylpropion
DB00988 Dopamine
DB01142 Doxepin
DB06262 Droxidopa
DB00476 Duloxetine
DB01363 Ephedra
DB01364 Ephedrine
DB00696 Ergotamine
DB01175 Escitalopram
DB01381 Ginkgo biloba
DB00226 Guanadrel
DB01170 Guanethidine
DB00458 Imipramine
DB06704 Iobenguane
DB01221 Ketamine
DB08918 Levomilnacipran
DB00408 Loxapine
DB00934 Maprotiline
DB00579 Mazindol
DB01577 Methamphetamine
DB00422 Methylphenidate
DB06148 Mianserin
DB04896 Milnacipran
DB00370 Mirtazapine
DB01442 MMDA
DB01149 Nefazodone
DB04821 Nomifensine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB01173 Orphenadrine
DB00715 Paroxetine
DB00454 Pethidine
DB01579 Phendimetrazine
DB00830 Phenmetrazine
DB00191 Phentermine
DB00344 Protriptyline
DB00852 Pseudoephedrine
DB00234 Reboxetine
DB01105 Sibutramine
DB06204 Tapentadol
DB00193 Tramadol
DB00726 Trimipramine
DB00285 Venlafaxine
DB05012 XEN2174
GuidetoPHARMACOLOGYi926

Protein family/group databases

TCDBi2.A.22.1.2 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiP23975
PhosphoSitePlusiP23975

Polymorphism and mutation databases

BioMutaiSLC6A2
DMDMi128616

Proteomic databases

MaxQBiP23975
PaxDbiP23975
PeptideAtlasiP23975
PRIDEiP23975
ProteomicsDBi54172

Protocols and materials databases

DNASUi6530
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219833; ENSP00000219833; ENSG00000103546 [P23975-2]
ENST00000379906; ENSP00000369237; ENSG00000103546 [P23975-1]
ENST00000567238; ENSP00000457375; ENSG00000103546 [P23975-3]
ENST00000568943; ENSP00000457473; ENSG00000103546 [P23975-1]
GeneIDi6530
KEGGihsa:6530
UCSCiuc002eif.4 human [P23975-1]

Organism-specific databases

CTDi6530
DisGeNETi6530
EuPathDBiHostDB:ENSG00000103546.18
GeneCardsiSLC6A2
HGNCiHGNC:11048 SLC6A2
HPAiCAB078195
HPA004057
HPA076311
MalaCardsiSLC6A2
MIMi163970 gene
604715 phenotype
neXtProtiNX_P23975
OpenTargetsiENSG00000103546
Orphaneti443236 Orthostatic intolerance due to NET deficiency
PharmGKBiPA310
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP23975
KOiK05035
OMAiAYCITPE
OrthoDBiEOG091G08PX
PhylomeDBiP23975
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI)

Miscellaneous databases

ChiTaRSiSLC6A2 human
GeneWikiiNorepinephrine_transporter
GenomeRNAii6530
PROiPR:P23975
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103546 Expressed in 94 organ(s), highest expression level in chorionic villus
CleanExiHS_NAT1
HS_NET1
HS_SLC6A2
HS_SLC6A5
ExpressionAtlasiP23975 baseline and differential
GenevisibleiP23975 HS

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002435 Na/ntran_symport_noradrenaline
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01201 NORTRANSPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A2_HUMAN
AccessioniPrimary (citable) accession number: P23975
Secondary accession number(s): B2R707, B4DX48, Q96KH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 7, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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