SLC6A2

Functionⁱ

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	71	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	73	Sodium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	74	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	78	Sodium 2By similarity	1
Metal bindingⁱ	318	Sodium 2By similarity	1
Metal bindingⁱ	350	Sodium 2By similarity	1
Metal bindingⁱ	415	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	418	Sodium 1By similarity	1
Metal bindingⁱ	419	Sodium 1By similarity	1

GO - Molecular functionⁱ

actin binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 18331289
alpha-tubulin binding Source: Ensembl
beta-tubulin binding Source: Ensembl
dopamine:sodium symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
monoamine transmembrane transporter activity
Source: MGI
Inferred from direct assayⁱ
- 16024787
neurotransmitter:sodium symporter activity Source: InterPro
norepinephrine:sodium symporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 2008212
dopamine uptake involved in synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
monoamine transport
Source: MGI
Inferred from direct assayⁱ
- 16024787
neuron cellular homeostasis
Source: ARUK-UCL
Traceable author statementⁱ
- 18331289
norepinephrine transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to pain Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurotransmitter transport, Symport, Transport
Ligand	Metal-binding, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI)

Reactomeⁱ

R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI)

Protein family/group databases

TCDBⁱ	2.A.22.1.2 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.1.2 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium-dependent noradrenaline transporter Alternative name(s): Norepinephrine transporter Short name: NET Solute carrier family 6 member 2
Gene namesⁱ	Name:SLC6A2 Synonyms:NAT1, NET1, SLC6A5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103546.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11048 SLC6A2
MIMⁱ	163970 gene
neXtProtⁱ	NX_P23975

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 62	CytoplasmicBy similarityAdd BLAST	62
Transmembraneⁱ	63 – 88	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	89 – 92	ExtracellularBy similarity	4
Transmembraneⁱ	93 – 116	Helical; Name=2By similarityAdd BLAST	24
Topological domainⁱ	117 – 135	CytoplasmicBy similarityAdd BLAST	19
Transmembraneⁱ	136 – 166	Helical; Name=3By similarityAdd BLAST	31
Topological domainⁱ	167 – 233	ExtracellularBy similarityAdd BLAST	67
Transmembraneⁱ	234 – 254	Helical; Name=4By similarityAdd BLAST	21
Topological domainⁱ	255 – 257	CytoplasmicBy similarity	3
Transmembraneⁱ	258 – 282	Helical; Name=5By similarityAdd BLAST	25
Topological domainⁱ	283 – 306	ExtracellularBy similarityAdd BLAST	24
Transmembraneⁱ	307 – 332	Helical; Name=6By similarityAdd BLAST	26
Topological domainⁱ	333 – 338	CytoplasmicBy similarity	6
Transmembraneⁱ	339 – 362	Helical; Name=7By similarityAdd BLAST	24
Topological domainⁱ	363 – 402	ExtracellularBy similarityAdd BLAST	40
Transmembraneⁱ	403 – 428	Helical; Name=8By similarityAdd BLAST	26
Topological domainⁱ	429 – 443	CytoplasmicBy similarityAdd BLAST	15
Transmembraneⁱ	444 – 464	Helical; Name=9By similarityAdd BLAST	21
Topological domainⁱ	465	ExtracellularBy similarity	1
Transmembraneⁱ	466 – 492	Helical; Name=10By similarityAdd BLAST	27
Topological domainⁱ	493 – 522	CytoplasmicBy similarityAdd BLAST	30
Transmembraneⁱ	523 – 545	Helical; Name=11By similarityAdd BLAST	23
Topological domainⁱ	546 – 548	ExtracellularBy similarity	3
Transmembraneⁱ	549 – 569	Helical; Name=12By similarityAdd BLAST	21
Topological domainⁱ	570 – 617	CytoplasmicBy similarityAdd BLAST	48

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Orthostatic intolerance (OI)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionSyndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010022	457	A → P in OI; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121918126EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6530
MalaCards human disease database More...MalaCardsⁱ	SLC6A2
MIMⁱ	604715 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000103546
Orphanetⁱ	443236 Orthostatic intolerance due to NET deficiency
PharmGKBⁱ	PA310

Chemistry databases

ChEMBLⁱ	CHEMBL222
Drug and drug target database More...DrugBankⁱ	DB04836 Amineptine DB00321 Amitriptyline DB00543 Amoxapine DB00182 Amphetamine DB00289 Atomoxetine DB04889 Bicifadine DB01156 Bupropion DB01114 Chlorphenamine DB00215 Citalopram DB01242 Clomipramine DB00907 Cocaine DB05688 CRx-119 DB04840 Debrisoquin DB01151 Desipramine DB06700 Desvenlafaxine DB06701 Dexmethylphenidate DB01576 Dextroamphetamine DB00514 Dextromethorphan DB00937 Diethylpropion DB00988 Dopamine DB01142 Doxepin DB06262 Droxidopa DB00476 Duloxetine DB01363 Ephedra DB01364 Ephedrine DB00696 Ergotamine DB01175 Escitalopram DB01381 Ginkgo biloba DB00226 Guanadrel DB01170 Guanethidine DB00458 Imipramine DB06704 Iobenguane DB01221 Ketamine DB08918 Levomilnacipran DB00408 Loxapine DB00934 Maprotiline DB00579 Mazindol DB01577 Methamphetamine DB00422 Methylphenidate DB06148 Mianserin DB04896 Milnacipran DB00370 Mirtazapine DB01442 MMDA DB01149 Nefazodone DB04821 Nomifensine DB00368 Norepinephrine DB00540 Nortriptyline DB01173 Orphenadrine DB00715 Paroxetine DB00454 Pethidine DB01579 Phendimetrazine DB00830 Phenmetrazine DB00191 Phentermine DB00344 Protriptyline DB00852 Pseudoephedrine DB00234 Reboxetine DB01105 Sibutramine DB06204 Tapentadol DB00193 Tramadol DB00726 Trimipramine DB00285 Venlafaxine DB05012 XEN2174
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	926

Polymorphism and mutation databases

BioMutaⁱ	SLC6A2
DMDMⁱ	128616

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214748	1 – 617	Sodium-dependent noradrenaline transporterAdd BLAST		617

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	176 ↔ 185	By similarity
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	192	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P23975
PaxDbⁱ	P23975
PeptideAtlas More...PeptideAtlasⁱ	P23975
PRIDEⁱ	P23975
ProteomicsDBⁱ	54172

PTM databases

iPTMnetⁱ	P23975
PhosphoSitePlusⁱ	P23975

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000103546 Expressed in 94 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_NAT1 HS_NET1 HS_SLC6A2 HS_SLC6A5
ExpressionAtlasⁱ	P23975 baseline and differential
Genevisibleⁱ	P23975 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB078195 HPA004057 HPA076311

HPAⁱ

CAB078195
HPA004057
HPA076311

Interactionⁱ

Subunit structureⁱ

Interacts with PRKCABP.1 Publication

GO - Molecular functionⁱ

actin binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 18331289
alpha-tubulin binding Source: Ensembl
beta-tubulin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112421, 3 interactors
Molecular INTeraction database More...MINTⁱ	P23975
STRINGⁱ	9606.ENSP00000219833

Chemistry databases

BindingDBⁱ

P23975

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23975
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	P23975
KEGG Orthology (KO) More...KOⁱ	K05035
OMAⁱ	AYCITPE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	P23975
TreeFamⁱ	TF343812

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002435 Na/ntran_symport_noradrenaline IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT PR01201 NORTRANSPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P23975-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD 
        60         70         80         90        100
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 
       110        120        130        140        150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 
       160        170        180        190        200
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT 
       210        220        230        240        250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF 
       260        270        280        290        300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 
       310        320        330        340        350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN 
       360        370        380        390        400
CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 
       410        420        430        440        450
STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT 
       460        470        480        490        500
FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 
       510        520        530        540        550
FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF 
       560        570        580        590        600
PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL 
       610 
VAQRDIRQFQ LQHWLAI

Length:617

Mass (Da):69,332

Last modified:March 1, 1992 - v1

Checksum:ⁱBDC6DF31316907BB

GO

Isoform 2 (identifier: P23975-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
611-617: LQHWLAI → MKTRQGRRRATNSCQISC

« Hide

        10         20         30         40         50
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD 
        60         70         80         90        100
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 
       110        120        130        140        150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 
       160        170        180        190        200
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT 
       210        220        230        240        250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF 
       260        270        280        290        300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 
       310        320        330        340        350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN 
       360        370        380        390        400
CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 
       410        420        430        440        450
STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT 
       460        470        480        490        500
FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 
       510        520        530        540        550
FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF 
       560        570        580        590        600
PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL 
       610        620 
VAQRDIRQFQ MKTRQGRRRA TNSCQISC

Show »

Length:628

Mass (Da):70,548

Checksum:ⁱ4CF79AD92F272587

GO

Isoform 3 (identifier: P23975-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-135: MLLARMNPQV...TVWKICPFFK → MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP

« Hide

        10         20         30         40         50
MGVQWWSHTQ GEVAVGLGLG DSYLTPCPCP GVGYAVILIA LYVGFYYNVI 
        60         70         80         90        100
IAWSLYYLFS SFTLNLPWTD CGHTWNSPNC TDPKLLNGSV LGNHTKYSKY 
       110        120        130        140        150
KFTPAAEFYE RGVLHLHESS GIHDIGLPQW QLLLCLMVVV IVLYFSLWKG 
       160        170        180        190        200
VKTSGKVVWI TATLPYFVLF VLLVHGVTLP GASNGINAYL HIDFYRLKEA 
       210        220        230        240        250
TVWIDAATQI FFSLGAGFGV LIAFASYNKF DNNCYRDALL TSSINCITSF 
       260        270        280        290        300
VSGFAIFSIL GYMAHEHKVN IEDVATEGAG LVFILYPEAI STLSGSTFWA 
       310        320        330        340        350
VVFFVMLLAL GLDSSMGGME AVITGLADDF QVLKRHRKLF TFGVTFSTFL 
       360        370        380        390        400
LALFCITKGG IYVLTLLDTF AAGTSILFAV LMEAIGVSWF YGVDRFSNDI 
       410        420        430        440        450
QQMMGFRPGL YWRLCWKFVS PAFLLFVVVV SIINFKPLTY DDYIFPPWAN 
       460        470        480        490        500
WVGWGIALSS MVLVPIYVIY KFLSTQGSLW ERLAYGITPE NEHHLVAQRD 
       510 
IRQFQLQHWL AI

Show »

Length:512

Mass (Da):57,370

Checksum:ⁱB25C836CA8BA912F

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BRE9	H3BRE9_HUMAN	Transporter Transporter	SLC6A2 hCG_2025341	572	Annotation score:
H3BMY5	H3BMY5_HUMAN	Transporter Transporter	SLC6A2	200	Annotation score:
H3BML6	H3BML6_HUMAN	Transporter Transporter	SLC6A2	604	Annotation score:
H3BM11	H3BM11_HUMAN	Transporter Transporter	SLC6A2	561	Annotation score:
H3BRS0	H3BRS0_HUMAN	Transporter Transporter	SLC6A2	295	Annotation score:
I3L368	I3L368_HUMAN	Sodium-dependent noradrenaline tran... Sodium-dependent noradrenaline transporter	SLC6A2	58	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029157	7	N → K. Corresponds to variant dbSNP:rs11568323EnsemblClinVar.	1
Natural variantⁱVAR_011756	69	V → I. Corresponds to variant dbSNP:rs1805064Ensembl.	1
Natural variantⁱVAR_011757	99	T → I. Corresponds to variant dbSNP:rs1805065Ensembl.	1
Natural variantⁱVAR_011758	245	V → I. Corresponds to variant dbSNP:rs1805066Ensembl.	1
Natural variantⁱVAR_020048	283	T → R. Corresponds to variant dbSNP:rs45564432EnsemblClinVar.	1
Natural variantⁱVAR_011759	292	N → T. Corresponds to variant dbSNP:rs5563Ensembl.	1
Natural variantⁱVAR_011760	356	V → L. Corresponds to variant dbSNP:rs5565Ensembl.	1
Natural variantⁱVAR_011761	369	A → P. Corresponds to variant dbSNP:rs5566Ensembl.	1
Natural variantⁱVAR_011762	375	N → S. Corresponds to variant dbSNP:rs5567Ensembl.	1
Natural variantⁱVAR_014800	449	V → I. Corresponds to variant dbSNP:rs2234910Ensembl.	1
Natural variantⁱVAR_010022	457	A → P in OI; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121918126EnsemblClinVar.	1
Natural variantⁱVAR_011763	463	K → R. Corresponds to variant dbSNP:rs5570Ensembl.	1
Natural variantⁱVAR_011764	478	G → S. Corresponds to variant dbSNP:rs1805067Ensembl.	1
Natural variantⁱVAR_011765	528	F → C. Corresponds to variant dbSNP:rs5558Ensembl.	1
Natural variantⁱVAR_011766	548	Y → H. Corresponds to variant dbSNP:rs5559Ensembl.	1
Natural variantⁱVAR_021861	549	I → T. Corresponds to variant dbSNP:rs3743788EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054119	1 – 135	MLLAR…CPFFK → MGVQWWSHTQGEVAVGLGLG DSYLTPCPCP in isoform 3. 1 PublicationAdd BLAST		135
Alternative sequenceⁱVSP_044479	611 – 617	LQHWLAI → MKTRQGRRRATNSCQISC in isoform 2. Curated		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65105 mRNA Translation: AAA59943.1 X91117 X91119 Genomic DNA Translation: CAA62566.1 X91117 X91127 Genomic DNA Translation: CAC39181.1 AK301811 mRNA Translation: BAG63260.1 AK312793 mRNA Translation: BAG35654.1 AC136621 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW82831.1 CH471092 Genomic DNA Translation: EAW82833.1 CH471092 Genomic DNA Translation: EAW82835.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10754.1 [P23975-1] CCDS54011.1 [P23975-2] CCDS58463.1 [P23975-3]
PIRⁱ	S14278
NCBI Reference Sequences More...RefSeqⁱ	NP_001034.1, NM_001043.3 [P23975-1] NP_001165972.1, NM_001172501.1 [P23975-1] NP_001165973.1, NM_001172502.1 [P23975-3] NP_001165975.1, NM_001172504.1 [P23975-2] XP_006721326.1, XM_006721263.2 [P23975-2] XP_011521597.1, XM_011523295.1 [P23975-2]
UniGeneⁱ	Hs.78036

Genome annotation databases

Ensemblⁱ	ENST00000219833; ENSP00000219833; ENSG00000103546 [P23975-2] ENST00000379906; ENSP00000369237; ENSG00000103546 [P23975-1] ENST00000567238; ENSP00000457375; ENSG00000103546 [P23975-3] ENST00000568943; ENSP00000457473; ENSG00000103546 [P23975-1]
GeneIDⁱ	6530
KEGGⁱ	hsa:6530
UCSC genome browser More...UCSCⁱ	uc002eif.4 human [P23975-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23975	Transporter		HUMAN		617	UniRef100_P23975
Norepinephrine transporter isoform 1 (Fragment)		HUMAN		42
UPI0000D4A481		HUMAN		376
P23975-2	Transporter (Fragment)		HUMAN		200	UniRef100_P23975-2

Protein	Similar proteins		Species	Score	Length	Source
P23975	Sodium-dependent noradrenaline transporter		MOUSE		617	UniRef90_P23975
Transporter		HUMAN		617
Transporter		CRIGR		625
Transporter		HETGA		623
Transporter		PONAB		617
+62
P23975-2	Transporter (Fragment)		HUMAN		200	UniRef90_P23975-2
Transporter		Yangtze finless porpoise		782
Transporter		TURTR		617
Transporter		DELLE		763
sodium-dependent noradrenaline transporter isoform X1		BALAS		645
+42
P23975-3	Uncharacterized protein		PANPA		595	UniRef90_P23975-3
SLC6A2 isoform 4		PANTR		512
SLC6A2 isoform 9		PONAB		512
Solute carrier family 6 member 2		SAIBB		511
Uncharacterized protein		CALJA		511
+2

Protein	Similar proteins		Species	Score	Length	Source
P23975	Sodium-dependent dopamine transporter		HUMAN		620	UniRef50_Q01959
Sodium-dependent dopamine transporter		MACFA		620
Sodium-dependent dopamine transporter		RAT		619
Sodium-dependent dopamine transporter		MOUSE		619
Sodium-dependent noradrenaline transporter		BOVIN		615
+241
P23975-3	Uncharacterized protein		PANPA		595	UniRef50_P23975-3
SLC6A2 isoform 9		PONAB		512
SLC6A2 isoform 4		PANTR		512
Uncharacterized protein		CALJA		511
Uncharacterized protein		Cebus capucinus imitator		511
+265

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M65105 mRNA Translation: AAA59943.1 X91117 X91119 Genomic DNA Translation: CAA62566.1 X91117 X91127 Genomic DNA Translation: CAC39181.1 AK301811 mRNA Translation: BAG63260.1 AK312793 mRNA Translation: BAG35654.1 AC136621 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW82831.1 CH471092 Genomic DNA Translation: EAW82833.1 CH471092 Genomic DNA Translation: EAW82835.1
CCDSⁱ	CCDS10754.1 [P23975-1] CCDS54011.1 [P23975-2] CCDS58463.1 [P23975-3]
PIRⁱ	S14278
RefSeqⁱ	NP_001034.1, NM_001043.3 [P23975-1] NP_001165972.1, NM_001172501.1 [P23975-1] NP_001165973.1, NM_001172502.1 [P23975-3] NP_001165975.1, NM_001172504.1 [P23975-2] XP_006721326.1, XM_006721263.2 [P23975-2] XP_011521597.1, XM_011523295.1 [P23975-2]
UniGeneⁱ	Hs.78036

3D structure databases

ProteinModelPortalⁱ	P23975
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112421, 3 interactors
MINTⁱ	P23975
STRINGⁱ	9606.ENSP00000219833

Chemistry databases

BindingDBⁱ	P23975
ChEMBLⁱ	CHEMBL222
DrugBankⁱ	DB04836 Amineptine DB00321 Amitriptyline DB00543 Amoxapine DB00182 Amphetamine DB00289 Atomoxetine DB04889 Bicifadine DB01156 Bupropion DB01114 Chlorphenamine DB00215 Citalopram DB01242 Clomipramine DB00907 Cocaine DB05688 CRx-119 DB04840 Debrisoquin DB01151 Desipramine DB06700 Desvenlafaxine DB06701 Dexmethylphenidate DB01576 Dextroamphetamine DB00514 Dextromethorphan DB00937 Diethylpropion DB00988 Dopamine DB01142 Doxepin DB06262 Droxidopa DB00476 Duloxetine DB01363 Ephedra DB01364 Ephedrine DB00696 Ergotamine DB01175 Escitalopram DB01381 Ginkgo biloba DB00226 Guanadrel DB01170 Guanethidine DB00458 Imipramine DB06704 Iobenguane DB01221 Ketamine DB08918 Levomilnacipran DB00408 Loxapine DB00934 Maprotiline DB00579 Mazindol DB01577 Methamphetamine DB00422 Methylphenidate DB06148 Mianserin DB04896 Milnacipran DB00370 Mirtazapine DB01442 MMDA DB01149 Nefazodone DB04821 Nomifensine DB00368 Norepinephrine DB00540 Nortriptyline DB01173 Orphenadrine DB00715 Paroxetine DB00454 Pethidine DB01579 Phendimetrazine DB00830 Phenmetrazine DB00191 Phentermine DB00344 Protriptyline DB00852 Pseudoephedrine DB00234 Reboxetine DB01105 Sibutramine DB06204 Tapentadol DB00193 Tramadol DB00726 Trimipramine DB00285 Venlafaxine DB05012 XEN2174
GuidetoPHARMACOLOGYⁱ	926

Protein family/group databases

TCDBⁱ	2.A.22.1.2 the neurotransmitter:sodium symporter (nss) family

TCDBⁱ

2.A.22.1.2 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetⁱ	P23975
PhosphoSitePlusⁱ	P23975

Polymorphism and mutation databases

BioMutaⁱ	SLC6A2
DMDMⁱ	128616

Proteomic databases

MaxQBⁱ	P23975
PaxDbⁱ	P23975
PeptideAtlasⁱ	P23975
PRIDEⁱ	P23975
ProteomicsDBⁱ	54172

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6530
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000219833; ENSP00000219833; ENSG00000103546 [P23975-2] ENST00000379906; ENSP00000369237; ENSG00000103546 [P23975-1] ENST00000567238; ENSP00000457375; ENSG00000103546 [P23975-3] ENST00000568943; ENSP00000457473; ENSG00000103546 [P23975-1]
GeneIDⁱ	6530
KEGGⁱ	hsa:6530
UCSCⁱ	uc002eif.4 human [P23975-1]

Organism-specific databases

CTDⁱ	6530
DisGeNETⁱ	6530
EuPathDBⁱ	HostDB:ENSG00000103546.18
GeneCardsⁱ	SLC6A2
HGNCⁱ	HGNC:11048 SLC6A2
HPAⁱ	CAB078195 HPA004057 HPA076311
MalaCardsⁱ	SLC6A2
MIMⁱ	163970 gene 604715 phenotype
neXtProtⁱ	NX_P23975
OpenTargetsⁱ	ENSG00000103546
Orphanetⁱ	443236 Orthostatic intolerance due to NET deficiency
PharmGKBⁱ	PA310
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3659 Eukaryota COG0733 LUCA
GeneTreeⁱ	ENSGT00760000118857
HOGENOMⁱ	HOG000116406
HOVERGENⁱ	HBG071421
InParanoidⁱ	P23975
KOⁱ	K05035
OMAⁱ	AYCITPE
OrthoDBⁱ	EOG091G08PX
PhylomeDBⁱ	P23975
TreeFamⁱ	TF343812

Enzyme and pathway databases

Reactomeⁱ	R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI)

Reactomeⁱ

R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-5619109 Defective SLC6A2 causes orthostatic intolerance (OI)

Miscellaneous databases

ChiTaRSⁱ	SLC6A2 human
GeneWikiⁱ	Norepinephrine_transporter
GenomeRNAiⁱ	6530
Protein Ontology More...PROⁱ	PR:P23975
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103546 Expressed in 94 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_NAT1 HS_NET1 HS_SLC6A2 HS_SLC6A5
ExpressionAtlasⁱ	P23975 baseline and differential
Genevisibleⁱ	P23975 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000175 Na/ntran_symport IPR002435 Na/ntran_symport_noradrenaline IPR037272 SNS_sf
PANTHERⁱ	PTHR11616 PTHR11616, 1 hit
Pfamⁱ	View protein in Pfam PF00209 SNF, 1 hit
PRINTSⁱ	PR00176 NANEUSMPORT PR01201 NORTRANSPORT
SUPFAMⁱ	SSF161070 SSF161070, 1 hit
PROSITEⁱ	View protein in PROSITE PS00610 NA_NEUROTRAN_SYMP_1, 1 hit PS00754 NA_NEUROTRAN_SYMP_2, 1 hit PS50267 NA_NEUROTRAN_SYMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC6A2_HUMAN
Accessionⁱ	P23975Primary (citable) accession number: P23975 Secondary accession number(s): B2R707, B4DX48, Q96KH8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P23975 (SC6A2_HUMAN)

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Sodium-dependent noradrenaline transporter

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ