UniProtKB - P23975 (SC6A2_HUMAN)
Protein
Sodium-dependent noradrenaline transporter
Gene
SLC6A2
Organism
Homo sapiens (Human)
Status
Functioni
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication
Miscellaneous
This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 71 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 73 | Sodium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 74 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 78 | Sodium 2By similarity | 1 | |
Metal bindingi | 318 | Sodium 2By similarity | 1 | |
Metal bindingi | 350 | Sodium 2By similarity | 1 | |
Metal bindingi | 415 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 418 | Sodium 1By similarity | 1 | |
Metal bindingi | 419 | Sodium 1By similarity | 1 |
GO - Molecular functioni
- actin binding Source: ARUK-UCL
- alpha-tubulin binding Source: Ensembl
- beta-tubulin binding Source: Ensembl
- dopamine:sodium symporter activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- monoamine transmembrane transporter activity Source: MGI
- neurotransmitter:sodium symporter activity Source: InterPro
- neurotransmitter transmembrane transporter activity Source: ARUK-UCL
- norepinephrine:sodium symporter activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: ProtInc
- dopamine uptake involved in synaptic transmission Source: GO_Central
- monoamine transport Source: MGI
- neuron cellular homeostasis Source: ARUK-UCL
- neurotransmitter transport Source: ARUK-UCL
- norepinephrine transport Source: GO_Central
- norepinephrine uptake Source: ARUK-UCL
- response to drug Source: Ensembl
- response to pain Source: Ensembl
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Neurotransmitter transport, Symport, Transport |
Ligand | Metal-binding, Sodium |
Enzyme and pathway databases
PathwayCommonsi | P23975 |
Reactomei | R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters R-HSA-5619109, Defective SLC6A2 causes orthostatic intolerance (OI) |
SIGNORi | P23975 |
Protein family/group databases
TCDBi | 2.A.22.1.2, the neurotransmitter:sodium symporter (nss) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium-dependent noradrenaline transporterAlternative name(s): Norepinephrine transporter Short name: NET Solute carrier family 6 member 2 |
Gene namesi | Name:SLC6A2 Synonyms:NAT1, NET1, SLC6A5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11048, SLC6A2 |
MIMi | 163970, gene |
neXtProti | NX_P23975 |
VEuPathDBi | HostDB:ENSG00000103546.18 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- neuronal cell body membrane Source: GO_Central
- plasma membrane Source: Reactome
- presynaptic membrane Source: GO_Central
Other locations
- cell surface Source: Ensembl
- membrane Source: ProtInc
- membrane raft Source: Ensembl
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 62 | CytoplasmicBy similarityAdd BLAST | 62 | |
Transmembranei | 63 – 88 | Helical; Name=1By similarityAdd BLAST | 26 | |
Topological domaini | 89 – 92 | ExtracellularBy similarity | 4 | |
Transmembranei | 93 – 116 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 117 – 135 | CytoplasmicBy similarityAdd BLAST | 19 | |
Transmembranei | 136 – 166 | Helical; Name=3By similarityAdd BLAST | 31 | |
Topological domaini | 167 – 233 | ExtracellularBy similarityAdd BLAST | 67 | |
Transmembranei | 234 – 254 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 255 – 257 | CytoplasmicBy similarity | 3 | |
Transmembranei | 258 – 282 | Helical; Name=5By similarityAdd BLAST | 25 | |
Topological domaini | 283 – 306 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 307 – 332 | Helical; Name=6By similarityAdd BLAST | 26 | |
Topological domaini | 333 – 338 | CytoplasmicBy similarity | 6 | |
Transmembranei | 339 – 362 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 363 – 402 | ExtracellularBy similarityAdd BLAST | 40 | |
Transmembranei | 403 – 428 | Helical; Name=8By similarityAdd BLAST | 26 | |
Topological domaini | 429 – 443 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 444 – 464 | Helical; Name=9By similarityAdd BLAST | 21 | |
Topological domaini | 465 | ExtracellularBy similarity | 1 | |
Transmembranei | 466 – 492 | Helical; Name=10By similarityAdd BLAST | 27 | |
Topological domaini | 493 – 522 | CytoplasmicBy similarityAdd BLAST | 30 | |
Transmembranei | 523 – 545 | Helical; Name=11By similarityAdd BLAST | 23 | |
Topological domaini | 546 – 548 | ExtracellularBy similarity | 3 | |
Transmembranei | 549 – 569 | Helical; Name=12By similarityAdd BLAST | 21 | |
Topological domaini | 570 – 617 | CytoplasmicBy similarityAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Orthostatic intolerance (OI)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSyndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010022 | 457 | A → P in OI; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121918126EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6530 |
MalaCardsi | SLC6A2 |
MIMi | 604715, phenotype |
OpenTargetsi | ENSG00000103546 |
Orphaneti | 443236, Postural orthostatic tachycardia syndrome due to NET deficiency |
PharmGKBi | PA310 |
Miscellaneous databases
Pharosi | P23975, Tclin |
Chemistry databases
ChEMBLi | CHEMBL222 |
DrugBanki | DB04836, Amineptine DB05964, Amitifadine DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB00289, Atomoxetine DB00245, Benzatropine DB04889, Bicifadine DB01156, Bupropion DB01114, Chlorpheniramine DB01242, Clomipramine DB00907, Cocaine DB05688, CRx-119 DB00924, Cyclobenzaprine DB12305, Dasotraline DB05642, DDP-225 DB04840, Debrisoquine DB01151, Desipramine DB06700, Desvenlafaxine DB06701, Dexmethylphenidate DB01576, Dextroamphetamine DB00514, Dextromethorphan DB00937, Diethylpropion DB00988, Dopamine DB09167, Dosulepin DB01142, Doxepin DB06262, Droxidopa DB00476, Duloxetine DB01363, Ephedra sinica root DB01364, Ephedrine DB01175, Escitalopram DB09194, Etoperidone DB01381, Ginkgo biloba DB00226, Guanadrel DB01170, Guanethidine DB00458, Imipramine DB06704, Iobenguane DB09546, Iobenguane sulfate I-123 DB01221, Ketamine DB08918, Levomilnacipran DB00408, Loxapine DB00934, Maprotiline DB00579, Mazindol DB00454, Meperidine DB01577, Metamfetamine DB00422, Methylphenidate DB06148, Mianserin DB01454, Midomafetamine DB04896, Milnacipran DB01442, MMDA DB01149, Nefazodone DB13931, Netarsudil DB04821, Nomifensine DB00368, Norepinephrine DB00540, Nortriptyline DB01173, Orphenadrine DB00715, Paroxetine DB01579, Phendimetrazine DB00830, Phenmetrazine DB00191, Phentermine DB00721, Procaine DB00344, Protriptyline DB00852, Pseudoephedrine DB09363, Rauwolfia serpentina root DB00234, Reboxetine DB01104, Sertraline DB01105, Sibutramine DB14754, Solriamfetol DB06204, Tapentadol DB06156, Tesofensine DB00193, Tramadol DB00726, Trimipramine DB06333, Trodusquemine DB00285, Venlafaxine DB09185, Viloxazine DB09068, Vortioxetine DB05012, XEN2174 DB09225, Zotepine |
DrugCentrali | P23975 |
GuidetoPHARMACOLOGYi | 926 |
Genetic variation databases
BioMutai | SLC6A2 |
DMDMi | 128616 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214748 | 1 – 617 | Sodium-dependent noradrenaline transporterAdd BLAST | 617 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 176 ↔ 185 | By similarity | ||
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 198 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P23975 |
MaxQBi | P23975 |
PaxDbi | P23975 |
PeptideAtlasi | P23975 |
PRIDEi | P23975 |
ProteomicsDBi | 5409 54172 [P23975-1] 77077 |
PTM databases
GlyGeni | P23975, 3 sites |
iPTMneti | P23975 |
PhosphoSitePlusi | P23975 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103546, Expressed in chorionic villus and 109 other tissues |
ExpressionAtlasi | P23975, baseline and differential |
Genevisiblei | P23975, HS |
Organism-specific databases
HPAi | ENSG00000103546, Tissue enhanced (adrenal gland, placenta) |
Interactioni
Subunit structurei
Interacts with PRKCABP.
1 PublicationGO - Molecular functioni
- actin binding Source: ARUK-UCL
- alpha-tubulin binding Source: Ensembl
- beta-tubulin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112421, 3 interactors |
MINTi | P23975 |
STRINGi | 9606.ENSP00000219833 |
Chemistry databases
BindingDBi | P23975 |
Miscellaneous databases
RNActi | P23975, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000158960 |
HOGENOMi | CLU_006855_9_5_1 |
InParanoidi | P23975 |
OMAi | GWLDFIT |
OrthoDBi | 250396at2759 |
PhylomeDBi | P23975 |
TreeFami | TF343812 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002435, Na/ntran_symport_noradrenaline IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR00176, NANEUSMPORT PR01201, NORTRANSPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P23975-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD
60 70 80 90 100
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT
210 220 230 240 250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF
260 270 280 290 300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
310 320 330 340 350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN
360 370 380 390 400
CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG
410 420 430 440 450
STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT
460 470 480 490 500
FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
510 520 530 540 550
FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF
560 570 580 590 600
PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL
610
VAQRDIRQFQ LQHWLAI
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRE9 | H3BRE9_HUMAN | Transporter | SLC6A2 hCG_2025341 | 572 | Annotation score: | ||
H3BML6 | H3BML6_HUMAN | Transporter | SLC6A2 | 604 | Annotation score: | ||
H3BMY5 | H3BMY5_HUMAN | Transporter | SLC6A2 | 200 | Annotation score: | ||
H3BRS0 | H3BRS0_HUMAN | Transporter | SLC6A2 | 295 | Annotation score: | ||
H3BM11 | H3BM11_HUMAN | Transporter | SLC6A2 | 561 | Annotation score: | ||
I3L368 | I3L368_HUMAN | Sodium-dependent noradrenaline tran... | SLC6A2 | 58 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029157 | 7 | N → K. Corresponds to variant dbSNP:rs11568323Ensembl. | 1 | |
Natural variantiVAR_011756 | 69 | V → I. Corresponds to variant dbSNP:rs1805064Ensembl. | 1 | |
Natural variantiVAR_011757 | 99 | T → I. Corresponds to variant dbSNP:rs1805065EnsemblClinVar. | 1 | |
Natural variantiVAR_011758 | 245 | V → I. Corresponds to variant dbSNP:rs1805066EnsemblClinVar. | 1 | |
Natural variantiVAR_020048 | 283 | T → R. Corresponds to variant dbSNP:rs45564432EnsemblClinVar. | 1 | |
Natural variantiVAR_011759 | 292 | N → T. Corresponds to variant dbSNP:rs5563Ensembl. | 1 | |
Natural variantiVAR_011760 | 356 | V → L. Corresponds to variant dbSNP:rs5565Ensembl. | 1 | |
Natural variantiVAR_011761 | 369 | A → P. Corresponds to variant dbSNP:rs5566Ensembl. | 1 | |
Natural variantiVAR_011762 | 375 | N → S. Corresponds to variant dbSNP:rs5567Ensembl. | 1 | |
Natural variantiVAR_014800 | 449 | V → I. Corresponds to variant dbSNP:rs2234910Ensembl. | 1 | |
Natural variantiVAR_010022 | 457 | A → P in OI; loss of function. 1 PublicationCorresponds to variant dbSNP:rs121918126EnsemblClinVar. | 1 | |
Natural variantiVAR_011763 | 463 | K → R. Corresponds to variant dbSNP:rs5570Ensembl. | 1 | |
Natural variantiVAR_011764 | 478 | G → S. Corresponds to variant dbSNP:rs1805067Ensembl. | 1 | |
Natural variantiVAR_011765 | 528 | F → C. Corresponds to variant dbSNP:rs5558Ensembl. | 1 | |
Natural variantiVAR_011766 | 548 | Y → H. Corresponds to variant dbSNP:rs5559Ensembl. | 1 | |
Natural variantiVAR_021861 | 549 | I → T. Corresponds to variant dbSNP:rs3743788Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054119 | 1 – 135 | MLLAR…CPFFK → MGVQWWSHTQGEVAVGLGLG DSYLTPCPCP in isoform 3. 1 PublicationAdd BLAST | 135 | |
Alternative sequenceiVSP_044479 | 611 – 617 | LQHWLAI → MKTRQGRRRATNSCQISC in isoform 2. Curated | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65105 mRNA Translation: AAA59943.1 X91117 , X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA Translation: CAA62566.1 X91117 , X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA Translation: CAC39181.1 AK301811 mRNA Translation: BAG63260.1 AK312793 mRNA Translation: BAG35654.1 AC136621 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW82831.1 CH471092 Genomic DNA Translation: EAW82833.1 CH471092 Genomic DNA Translation: EAW82835.1 |
CCDSi | CCDS10754.1 [P23975-1] CCDS54011.1 [P23975-2] CCDS58463.1 [P23975-3] |
PIRi | S14278 |
RefSeqi | NP_001034.1, NM_001043.3 [P23975-1] NP_001165972.1, NM_001172501.1 [P23975-1] NP_001165973.1, NM_001172502.1 [P23975-3] NP_001165975.1, NM_001172504.1 [P23975-2] XP_006721326.1, XM_006721263.2 [P23975-2] XP_011521597.1, XM_011523295.1 [P23975-2] |
Genome annotation databases
Ensembli | ENST00000219833; ENSP00000219833; ENSG00000103546 [P23975-2] ENST00000379906; ENSP00000369237; ENSG00000103546 [P23975-1] ENST00000567238; ENSP00000457375; ENSG00000103546 [P23975-3] ENST00000568943; ENSP00000457473; ENSG00000103546 [P23975-1] |
GeneIDi | 6530 |
KEGGi | hsa:6530 |
UCSCi | uc002eif.4, human [P23975-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65105 mRNA Translation: AAA59943.1 X91117 , X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA Translation: CAA62566.1 X91117 , X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA Translation: CAC39181.1 AK301811 mRNA Translation: BAG63260.1 AK312793 mRNA Translation: BAG35654.1 AC136621 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW82831.1 CH471092 Genomic DNA Translation: EAW82833.1 CH471092 Genomic DNA Translation: EAW82835.1 |
CCDSi | CCDS10754.1 [P23975-1] CCDS54011.1 [P23975-2] CCDS58463.1 [P23975-3] |
PIRi | S14278 |
RefSeqi | NP_001034.1, NM_001043.3 [P23975-1] NP_001165972.1, NM_001172501.1 [P23975-1] NP_001165973.1, NM_001172502.1 [P23975-3] NP_001165975.1, NM_001172504.1 [P23975-2] XP_006721326.1, XM_006721263.2 [P23975-2] XP_011521597.1, XM_011523295.1 [P23975-2] |
3D structure databases
SMRi | P23975 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112421, 3 interactors |
MINTi | P23975 |
STRINGi | 9606.ENSP00000219833 |
Chemistry databases
BindingDBi | P23975 |
ChEMBLi | CHEMBL222 |
DrugBanki | DB04836, Amineptine DB05964, Amitifadine DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB00289, Atomoxetine DB00245, Benzatropine DB04889, Bicifadine DB01156, Bupropion DB01114, Chlorpheniramine DB01242, Clomipramine DB00907, Cocaine DB05688, CRx-119 DB00924, Cyclobenzaprine DB12305, Dasotraline DB05642, DDP-225 DB04840, Debrisoquine DB01151, Desipramine DB06700, Desvenlafaxine DB06701, Dexmethylphenidate DB01576, Dextroamphetamine DB00514, Dextromethorphan DB00937, Diethylpropion DB00988, Dopamine DB09167, Dosulepin DB01142, Doxepin DB06262, Droxidopa DB00476, Duloxetine DB01363, Ephedra sinica root DB01364, Ephedrine DB01175, Escitalopram DB09194, Etoperidone DB01381, Ginkgo biloba DB00226, Guanadrel DB01170, Guanethidine DB00458, Imipramine DB06704, Iobenguane DB09546, Iobenguane sulfate I-123 DB01221, Ketamine DB08918, Levomilnacipran DB00408, Loxapine DB00934, Maprotiline DB00579, Mazindol DB00454, Meperidine DB01577, Metamfetamine DB00422, Methylphenidate DB06148, Mianserin DB01454, Midomafetamine DB04896, Milnacipran DB01442, MMDA DB01149, Nefazodone DB13931, Netarsudil DB04821, Nomifensine DB00368, Norepinephrine DB00540, Nortriptyline DB01173, Orphenadrine DB00715, Paroxetine DB01579, Phendimetrazine DB00830, Phenmetrazine DB00191, Phentermine DB00721, Procaine DB00344, Protriptyline DB00852, Pseudoephedrine DB09363, Rauwolfia serpentina root DB00234, Reboxetine DB01104, Sertraline DB01105, Sibutramine DB14754, Solriamfetol DB06204, Tapentadol DB06156, Tesofensine DB00193, Tramadol DB00726, Trimipramine DB06333, Trodusquemine DB00285, Venlafaxine DB09185, Viloxazine DB09068, Vortioxetine DB05012, XEN2174 DB09225, Zotepine |
DrugCentrali | P23975 |
GuidetoPHARMACOLOGYi | 926 |
Protein family/group databases
TCDBi | 2.A.22.1.2, the neurotransmitter:sodium symporter (nss) family |
PTM databases
GlyGeni | P23975, 3 sites |
iPTMneti | P23975 |
PhosphoSitePlusi | P23975 |
Genetic variation databases
BioMutai | SLC6A2 |
DMDMi | 128616 |
Proteomic databases
MassIVEi | P23975 |
MaxQBi | P23975 |
PaxDbi | P23975 |
PeptideAtlasi | P23975 |
PRIDEi | P23975 |
ProteomicsDBi | 5409 54172 [P23975-1] 77077 |
Protocols and materials databases
Antibodypediai | 1363, 138 antibodies |
DNASUi | 6530 |
Genome annotation databases
Ensembli | ENST00000219833; ENSP00000219833; ENSG00000103546 [P23975-2] ENST00000379906; ENSP00000369237; ENSG00000103546 [P23975-1] ENST00000567238; ENSP00000457375; ENSG00000103546 [P23975-3] ENST00000568943; ENSP00000457473; ENSG00000103546 [P23975-1] |
GeneIDi | 6530 |
KEGGi | hsa:6530 |
UCSCi | uc002eif.4, human [P23975-1] |
Organism-specific databases
CTDi | 6530 |
DisGeNETi | 6530 |
GeneCardsi | SLC6A2 |
HGNCi | HGNC:11048, SLC6A2 |
HPAi | ENSG00000103546, Tissue enhanced (adrenal gland, placenta) |
MalaCardsi | SLC6A2 |
MIMi | 163970, gene 604715, phenotype |
neXtProti | NX_P23975 |
OpenTargetsi | ENSG00000103546 |
Orphaneti | 443236, Postural orthostatic tachycardia syndrome due to NET deficiency |
PharmGKBi | PA310 |
VEuPathDBi | HostDB:ENSG00000103546.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3659, Eukaryota |
GeneTreei | ENSGT00940000158960 |
HOGENOMi | CLU_006855_9_5_1 |
InParanoidi | P23975 |
OMAi | GWLDFIT |
OrthoDBi | 250396at2759 |
PhylomeDBi | P23975 |
TreeFami | TF343812 |
Enzyme and pathway databases
PathwayCommonsi | P23975 |
Reactomei | R-HSA-442660, Na+/Cl- dependent neurotransmitter transporters R-HSA-5619109, Defective SLC6A2 causes orthostatic intolerance (OI) |
SIGNORi | P23975 |
Miscellaneous databases
BioGRID-ORCSi | 6530, 3 hits in 982 CRISPR screens |
ChiTaRSi | SLC6A2, human |
GeneWikii | Norepinephrine_transporter |
GenomeRNAii | 6530 |
Pharosi | P23975, Tclin |
PROi | PR:P23975 |
RNActi | P23975, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103546, Expressed in chorionic villus and 109 other tissues |
ExpressionAtlasi | P23975, baseline and differential |
Genevisiblei | P23975, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002435, Na/ntran_symport_noradrenaline IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR00176, NANEUSMPORT PR01201, NORTRANSPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SC6A2_HUMAN | |
Accessioni | P23975Primary (citable) accession number: P23975 Secondary accession number(s): B2R707, B4DX48, Q96KH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families