We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P23971 (MENE_BACSU)
Protein
2-succinylbenzoate--CoA ligase
Gene
menE
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).
UniRule annotationCatalytic activityi
- EC:6.2.1.26UniRule annotation
: 1,4-dihydroxy-2-naphthoate biosynthesis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.
Pathwayi: menaquinone biosynthesis
This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationView all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- CoA-ligase activity Source: GO_Central
- o-succinylbenzoate-CoA ligase activity Source: UniProtKB-UniRule
GO - Biological processi
- menaquinone biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ligase |
Biological process | Menaquinone biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BSUB:BSU30790-MONOMER |
BRENDAi | 6.2.1.26, 658 |
UniPathwayi | UPA00079 UPA01057;UER00166 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-succinylbenzoate--CoA ligaseUniRule annotation (EC:6.2.1.26UniRule annotation)Alternative name(s): o-succinylbenzoyl-CoA synthetaseUniRule annotation Short name: OSB-CoA synthetaseUniRule annotation |
Gene namesi | Name:menEUniRule annotation Ordered Locus Names:BSU30790 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193159 | 1 – 486 | 2-succinylbenzoate--CoA ligaseAdd BLAST | 486 |
Proteomic databases
PaxDbi | P23971 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P23971 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0318, Bacteria |
InParanoidi | P23971 |
OMAi | WCAHVQN |
PhylomeDBi | P23971 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_00731, MenE, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR010192, MenE |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR01923, menE, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
P23971-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTEQPNWLM QRAQLTPERI ALIYEDQTVT FAELFAASKR MAEQLAAHSV
60 70 80 90 100
RKGDTAAILL QNRAEMVYAV HACFLLGVKA VLLNTKLSTH ERLFQLEDSG
110 120 130 140 150
SGFLLTDSSF EKKEYEHIVQ TIDVDELMKE AAEEIEIEAY MQMDATATLM
160 170 180 190 200
YTSGTTGKPK GVQQTFGNHY FSAVSSALNL GITEQDRWLI ALPLFHISGL
210 220 230 240 250
SALFKSVIYG MTVVLHQRFS VSDVLHSINR HEVTMISAVQ TMLASLLEET
260 270 280 290 300
NRCPESIRCI LLGGGPAPLP LLEECREKGF PVFQSYGMTE TCSQIVTLSP
310 320 330 340 350
EFSMEKLGSA GKPLFSCEIK IERDGQVCEP YEHGEIMVKG PNVMKSYFNR
360 370 380 390 400
ESANEASFQN GWLKTGDLGY LDNEGFLYVL DRRSDLIISG GENIYPAEVE
410 420 430 440 450
SVLLSHPAVA EAGVSGAEDK KWGKVPHAYL VLHKPVSAGE LTDYCKERLA
460 470 480
KYKIPAKFFV LDRLPRNASN KLLRNQLKDA RKGELL
Sequence cautioni
The sequence AAA50402 differs from that shown. Reason: Frameshift.Curated
The sequence AAC37017 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 174 – 180 | VSSALNL → CRPLLF in AAA50402 (PubMed:1629163).Curated | 7 | |
Sequence conflicti | 174 – 180 | VSSALNL → CRPLLF in AAC37017 (PubMed:8566759).Curated | 7 | |
Sequence conflicti | 187 – 195 | RWLIALPLF → AGLCIAAL in AAA50402 (PubMed:1629163).Curated | 9 | |
Sequence conflicti | 187 – 195 | RWLIALPLF → AGLCIAAL in AAC37017 (PubMed:8566759).Curated | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74521 Genomic DNA Translation: AAA50402.1 Frameshift. M74538 Genomic DNA Translation: AAC37017.1 Frameshift. AF008220 Genomic DNA Translation: AAC00227.1 AL009126 Genomic DNA Translation: CAB15057.1 |
PIRi | H69656 |
RefSeqi | NP_390957.1, NC_000964.3 WP_003229056.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB15057; CAB15057; BSU_30790 |
GeneIDi | 937132 |
KEGGi | bsu:BSU30790 |
PATRICi | fig|224308.179.peg.3337 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74521 Genomic DNA Translation: AAA50402.1 Frameshift. M74538 Genomic DNA Translation: AAC37017.1 Frameshift. AF008220 Genomic DNA Translation: AAC00227.1 AL009126 Genomic DNA Translation: CAB15057.1 |
PIRi | H69656 |
RefSeqi | NP_390957.1, NC_000964.3 WP_003229056.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5BUQ | X-ray | 1.98 | A/B | 1-486 | [»] | |
5BUR | X-ray | 2.82 | A/B | 1-486 | [»] | |
5BUS | X-ray | 2.60 | A/B | 1-486 | [»] | |
5GTD | X-ray | 2.69 | A/B | 1-486 | [»] | |
5X8F | X-ray | 1.76 | A/B/C/D | 2-486 | [»] | |
5X8G | X-ray | 1.90 | A/B/C/D | 2-486 | [»] | |
SMRi | P23971 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU30790 |
Proteomic databases
PaxDbi | P23971 |
Genome annotation databases
EnsemblBacteriai | CAB15057; CAB15057; BSU_30790 |
GeneIDi | 937132 |
KEGGi | bsu:BSU30790 |
PATRICi | fig|224308.179.peg.3337 |
Phylogenomic databases
eggNOGi | COG0318, Bacteria |
InParanoidi | P23971 |
OMAi | WCAHVQN |
PhylomeDBi | P23971 |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA01057;UER00166 |
BioCyci | BSUB:BSU30790-MONOMER |
BRENDAi | 6.2.1.26, 658 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
HAMAPi | MF_00731, MenE, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR010192, MenE |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
TIGRFAMsi | TIGR01923, menE, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MENE_BACSU | |
Accessioni | P23971Primary (citable) accession number: P23971 Secondary accession number(s): O34837 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | February 11, 2002 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families