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Protein

V-type proton ATPase subunit c''

Gene

VMA16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei108Essential for proton translocation1

GO - Molecular functioni

  • proton-exporting ATPase activity, phosphorylative mechanism Source: MGI
  • proton-transporting ATPase activity, rotational mechanism Source: SGD

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31086-MONOMER
ReactomeiR-SCE-1222556 ROS, RNS production in phagocytes
R-SCE-77387 Insulin receptor recycling
R-SCE-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.3 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit c''
Short name:
V-ATPase subunit c''
Alternative name(s):
V-ATPase 22 kDa proteolipid subunit
Vacuolar proton pump c'' subunit
Gene namesi
Name:VMA16
Synonyms:PPA1
Ordered Locus Names:YHR026W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiFungiDB:YHR026W
SGDiS000001068 VMA16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 61ExtracellularSequence analysisAdd BLAST26
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 100CytoplasmicSequence analysisAdd BLAST18
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 145ExtracellularSequence analysisAdd BLAST24
Transmembranei146 – 167HelicalSequence analysisAdd BLAST22
Topological domaini168 – 179CytoplasmicSequence analysisAdd BLAST12
Transmembranei180 – 205HelicalSequence analysisAdd BLAST26
Topological domaini206 – 213ExtracellularSequence analysis8

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi108E → D: Partial inactivation. 1 Publication1
Mutagenesisi108E → L, Q or V: Inactivation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717801 – 213V-type proton ATPase subunit c''Add BLAST213

Proteomic databases

PaxDbiP23968
PRIDEiP23968

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d and e). The proteolipid components c, c' and c'' are present as a hexameric ring that forms the proton-conducting pore.

Protein-protein interaction databases

BioGridi36457, 60 interactors
ComplexPortaliCPX-1192 Vacuolar proton translocating ATPase complex, Golgi variant
CPX-1193 Vacuolar proton translocating ATPase complex, vacuole variant
DIPiDIP-4054N
IntActiP23968, 8 interactors
MINTiP23968
STRINGi4932.YHR026W

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23968
SMRiP23968
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075120
HOGENOMiHOG000056522
KOiK03661
OMAiTSPYMWS
OrthoDBiEOG092C5DS5

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits

Sequencei

Sequence statusi: Complete.

P23968-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKESKDDDM SLGKFSFSHF LYYLVLIVVI VYGLYKLFTG HGSDINFGKF
60 70 80 90 100
LLRTSPYMWA NLGIALCVGL SVVGAAWGIF ITGSSMIGAG VRAPRITTKN
110 120 130 140 150
LISIIFCEVV AIYGLIIAIV FSSKLTVATA ENMYSKSNLY TGYSLFWAGI
160 170 180 190 200
TVGASNLICG IAVGITGATA AISDAADSAL FVKILVIEIF GSILGLLGLI
210
VGLLMAGKAS EFQ
Length:213
Mass (Da):22,596
Last modified:March 1, 1992 - v1
Checksum:i033FF5A516B97F8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35294 Genomic DNA Translation: AAA34892.1
U10399 Genomic DNA Translation: AAB68881.1
AY692797 Genomic DNA Translation: AAT92816.1
BK006934 Genomic DNA Translation: DAA06717.1
PIRiA34633
RefSeqiNP_011891.1, NM_001179156.1

Genome annotation databases

EnsemblFungiiYHR026W; YHR026W; YHR026W
GeneIDi856421
KEGGisce:YHR026W

Similar proteinsi

Entry informationi

Entry nameiVATO_YEAST
AccessioniPrimary (citable) accession number: P23968
Secondary accession number(s): D3DKX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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