Zfp36l1

Functionⁱ

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22701344, PubMed:24700863, PubMed:24733888, PubMed:27102483). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylating complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:22701344, PubMed:24700863, PubMed:24733888). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (By similarity). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (By similarity). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (PubMed:24733888). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (By similarity). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (PubMed:27102483). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (By similarity). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in vasculogenesis and endocardial development (PubMed:15226444, PubMed:17013884). Involved in the regulation of keratinocyte proliferation, differentiation and apoptosis (By similarity). Plays a role in myoblast cell differentiation (PubMed:17889962).By similarity8 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	114 – 142	C3H1-type 1PROSITE-ProRule annotationAdd BLAST		29
Zinc fingerⁱ	152 – 180	C3H1-type 2PROSITE-ProRule annotationAdd BLAST		29

GO - Molecular functionⁱ

14-3-3 protein binding Source: UniProtKB
AU-rich element binding Source: MGI
DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
mRNA 3'-UTR AU-rich region binding
Source: UniProtKB
Inferred from direct assayⁱ
mRNA 3'-UTR binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24700863

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

3'-UTR-mediated mRNA destabilization
Source: UniProtKB
Inferred from direct assayⁱ
apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
cellular response to cAMP
Source: UniProtKB
Inferred from direct assayⁱ
- 19179481
cellular response to epidermal growth factor stimulus Source: UniProtKB
cellular response to fibroblast growth factor stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 24733888
cellular response to glucocorticoid stimulus Source: UniProtKB
cellular response to hypoxia Source: UniProtKB
cellular response to insulin stimulus Source: UniProtKB
cellular response to peptide hormone stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 19179481
cellular response to raffinose
Source: UniProtKB
Inferred from direct assayⁱ
- 24700863
cellular response to salt stress
Source: UniProtKB
Inferred from direct assayⁱ
- 24700863
cellular response to transforming growth factor beta stimulus Source: UniProtKB
cellular response to tumor necrosis factor Source: UniProtKB
chorio-allantoic fusion
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
embryonic organ development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
ERK1 and ERK2 cascade Source: UniProtKB
heart development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 24733888
mesendoderm development
Source: UniProtKB
Inferred from direct assayⁱ
- 24733888
mRNA catabolic process
Source: MGI
Inferred from sequence orthologyⁱ
- 10751406
mRNA processing Source: UniProtKB-KW
mRNA transport Source: UniProtKB
multicellular organism growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
negative regulation of erythrocyte differentiation Source: UniProtKB
negative regulation of mitotic cell cycle phase transition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27102483
neural tube development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Source: MGI
Inferred from direct assayⁱ
- 15814898
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay Source: UniProtKB
p38MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 17889962
phosphatidylinositol 3-kinase signaling Source: UniProtKB
positive regulation of fat cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 22701344
positive regulation of intracellular mRNA localization Source: UniProtKB
positive regulation of monocyte differentiation Source: UniProtKB
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
proepicardium development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
protein kinase B signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22701344
regulation of B cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27102483
regulation of gene expression Source: UniProtKB
regulation of keratinocyte apoptotic process Source: UniProtKB
regulation of keratinocyte differentiation Source: UniProtKB
regulation of keratinocyte proliferation Source: UniProtKB
regulation of mRNA 3'-end processing Source: MGI
regulation of mRNA stability
Source: UniProtKB
Inferred from direct assayⁱ
regulation of myoblast differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17889962
regulation of stem cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 24733888
regulation of translation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17013884
response to wounding Source: UniProtKB
spongiotrophoblast layer development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15226444
T cell differentiation in thymus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20622884
vasculogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 17013884

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA transport, Transport
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

Reactomeⁱ

R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: mRNA decay activator protein ZFP36L1Curated Alternative name(s): Butyrate response factor 1By similarity TPA-induced sequence 11b1 Publication Zinc finger protein 36, C3H1 type-like 1Imported Short name: ZFP36-like 1Imported
Gene namesⁱ	Name:Zfp36l1Imported Synonyms:Brf1By similarity, Tis11b1 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:107946 Zfp36l1

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Embryos die in utero at 11 dpc (PubMed:15226444, PubMed:17013884). Exhibit extraembryonic, intraembryonic, vascular and neural tube defects and cardiac abnormalities at 9.5 dpc (PubMed:17013884). Show a reduced number of circulating blood cells (PubMed:17013884). Show failure of chorioallantoic fusion (PubMed:15226444). Exhibited increased level of VEGFA protein level in embryonic fibroblasts under both normoxic and hypoxic conditions (PubMed:17013884). Knockout mice lacking both ZFP36L1 and ZFP36L2 during thymopoiesis lead to aberrant T cell development and subsequently develop a T-cell acute lymphoblastic leukemia (T-ALL) (PubMed:20622884). Show also higher levels of NOTCH1 protein and mRNA in thymocytes (PubMed:20622884). Conditional knockout mice of both ZFP36L1 and ZFP36L2 in pro-B cells display reduced B lymphocyte number and delayed variable-diversity-joining (VDJ) recombination (PubMed:27102483). Exhibit also increased protein and ARE-containing mRNA expressions of several factors implicated in cell cycle progression in late pre-B cells (PubMed:27102483).4 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000089168	1 – 338	mRNA decay activator protein ZFP36L1Add BLAST		338

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	54	Phosphoserine; by MAPKAPK2By similarity	1
Modified residueⁱ	90	Phosphoserine; by PKB/AKT1By similarity	1
Modified residueⁱ	92	Phosphoserine; by PKB/AKT1 and MAPKAPK2By similarity	1
Modified residueⁱ	203	Phosphoserine; by PKB/AKT1 and MAPKAPK2By similarity	1
Modified residueⁱ	318	PhosphoserineBy similarity	1
Modified residueⁱ	334	Phosphoserine; by RPS6KA1By similarity	1

Post-translational modificationⁱ

Phosphorylated (PubMed:19179481). Phosphorylated by RPS6KA1 at Ser-334 upon phorbol 12-myristate 13-acetate (PMA) treatment; this phosphorylation results in dissociation of the CCR4-NOT deadenylase complex and induces p38 MAPK-mediated stabilization of the low-density lipoprotein receptor LDLR mRNA. Phosphorylated by protein kinase AKT1 at Ser-92 and Ser-203 in response to insulin; these phosphorylations stabilize ZFP36L1, increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization. AKT1-mediated phosphorylation at Ser-92 does not impair ARE-containing RNA-binding. Phosphorylated at Ser-54, Ser-92 and Ser-203 by MAPKAPK2; these phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization in a protein kinase AKT1-independent manner. MAPKAPK2-mediated phosphorylations at Ser-54, Ser-92 and Ser-203 do not impair ARE-containing RNA-binding (By similarity). Phosphorylations increase the association with 14-3-3 proteins and mediate ARE-containing mRNA stabilization during early adipogenesis in a p38 MAPK- and AKT-dependent manner (PubMed:22701344).By similarity2 Publications

Ubiquitinated. Ubiquitination leads to proteasomal degradation, a process inhibited by phosphorylations at Ser-90, Ser-92 and Ser-203.By similarity

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P23950
PeptideAtlas More...PeptideAtlasⁱ	P23950
PRIDEⁱ	P23950

PTM databases

iPTMnetⁱ	P23950
PhosphoSitePlusⁱ	P23950

Expressionⁱ

Tissue specificityⁱ

Expressed in preadipocytes and adipocytes (PubMed:22701344). Expressed in the proximal and distal tubules in the renal cortex (at protein level) (PubMed:24700863). Expressed in ovary, heart, kidney, lung, spleen and thymus (PubMed:15226444). Weakly expressed in brain, liver and testis (PubMed:15226444). Expressed in osteoblasts (PubMed:15465005). Expressed in embryonic stem cells (ESCs) (PubMed:24733888). Expressed through B lymphocyte development (PubMed:27102483).6 Publications

Developmental stageⁱ

Expressed in embryos at 8 dpc, onward (PubMed:15226444). Expressed in the allantois and throughout the neuroectoderm and paraxial mesoderm at 8 dpc (PubMed:15226444). Expressed in the chorion and blood vessels at 8.5 dpc (PubMed:17013884). Expressed in the neural tube, paraxial mesoderm, heart, brain, otic vesicle and yolk sac at 9.5 dpc (PubMed:17013884). Expressed in embryonic stem cells (ESC) (PubMed:15226444).2 Publications

Inductionⁱ

Up-regulated during myogenic differentiation in a p38 MAPK-dependent manner (PubMed:17889962). Up-regulated in response to fibroblast growth factor FGF4 in embryonic stem cells (ESCs) in a p38 MAPK-dependent manner (PubMed:24733888). Up-regulated during high sodium diet-fed in the renal tubules (PubMed:24700863). Up-regulated upon hypertonic stress condition with raffinose (at protein level) (PubMed:24700863). Up-regulated by parathyroid hormone (PTH) in calvarial osteoblasts (PubMed:15465005). Up-regulated in response to adrenocorticotropic hormone (ACTH) (PubMed:19179481). Up-regulated in response to cAMP (PubMed:19179481). Down-regulated by bone morphogenetic protein BMP2 treatment in calvarial osteoblasts (PubMed:15465005). Down-regulated during the conversion from quiescence to activated satellite cells upon muscle injury (PubMed:23046558, PubMed:25815583).7 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000021127 Expressed in 339 organ(s), highest expression level in vas deferens
CleanExⁱ	MM_ZFP36L1
ExpressionAtlasⁱ	P23950 baseline and differential
Genevisibleⁱ	P23950 MM

Interactionⁱ

Subunit structureⁱ

Associates with the cytoplasmic CCR4-NOT deadenylase and RNA exosome complexes to trigger ARE-containing mRNA deadenylation and decay processes. Interacts with CNOT1. Interacts (via N-terminus) with CNOT6. Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner. Interacts with DCP1A. Interacts (via N-terminus) with DCP2. Interacts (via N-terminus) with EXOSC2. Interacts with XRN1. Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity). Interacts (via phosphorylated form) with YWHAZ; this interaction occurs in a p38 MAPK- and AKT-signaling pathways (PubMed:22701344).By similarity1 Publication

GO - Molecular functionⁱ

14-3-3 protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198385, 1 interactor
IntActⁱ	P23950, 1 interactor
STRINGⁱ	10090.ENSMUSP00000021552

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23950
SMRⁱ	P23950
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 111	Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activationBy similarityAdd BLAST		111
Regionⁱ	185 – 338	Necessary for mRNA decay activationBy similarityAdd BLAST		154

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	307 – 316	Poly-Ser		10

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	114 – 142	C3H1-type 1PROSITE-ProRule annotationAdd BLAST		29
Zinc fingerⁱ	152 – 180	C3H1-type 2PROSITE-ProRule annotationAdd BLAST		29

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1677 Eukaryota COG5063 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063262
HOGENOMⁱ	HOG000233479
HOVERGENⁱ	HBG008483
InParanoidⁱ	P23950
KEGG Orthology (KO) More...KOⁱ	K18753
OMAⁱ	LQHSYSF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0957
PhylomeDBⁱ	P23950
TreeFamⁱ	TF315463

Family and domain databases

InterProⁱ	View protein in InterPro IPR007635 Tis11B_N IPR000571 Znf_CCCH IPR036855 Znf_CCCH_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04553 Tis11B_N, 1 hit PF00642 zf-CCCH, 2 hits
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 2 hits
SUPFAMⁱ	SSF90229 SSF90229, 2 hits
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P23950-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP 
        60         70         80         90        100
RRHSVTLPSS KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP 
       110        120        130        140        150
TQKQPGSGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH 
       160        170        180        190        200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGGRD LSADRPRLQH 
       210        220        230        240        250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP 
       260        270        280        290        300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
       310        320        330 
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

Length:338

Mass (Da):36,385

Last modified:March 1, 1992 - v1

Checksum:ⁱA28F2C8BF476496C

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W2P7G3	A0A1W2P7G3_MOUSE	mRNA decay activator protein ZFP36L... mRNA decay activator protein ZFP36L1	Zfp36l1	84	Annotation score:
A0A1W2P6I1	A0A1W2P6I1_MOUSE	mRNA decay activator protein ZFP36L... mRNA decay activator protein ZFP36L1	Zfp36l1	57	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M58566 mRNA Translation: AAA72948.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS26010.1
PIRⁱ	B39590
NCBI Reference Sequences More...RefSeqⁱ	NP_031590.1, NM_007564.5
UniGeneⁱ	Mm.235132

Genome annotation databases

Ensemblⁱ	ENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127 ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127
GeneIDⁱ	12192
KEGGⁱ	mmu:12192
UCSC genome browser More...UCSCⁱ	uc007oal.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23950	Zinc finger protein 36, C3H type-like 1		MOUSE		338	UniRef100_P23950
mRNA decay activator protein ZFP36L1		MOUSE		57

Protein	Similar proteins		Species	Score	Length	Source
P23950	mRNA decay activator protein ZFP36L1	)	HUMAN		338	UniRef90_Q07352
mRNA decay activator protein ZFP36L1		RAT		338
ZFP36 ring finger protein like 1		GORGO		338
zinc finger protein 36, C3H1 type-like 1-like		LIPVE		226
Zinc finger protein 36, C3H type-like 1 (Fragment)		MUSPF		339
+121

Protein	Similar proteins		Species	Score	Length	Source
P23950	mRNA decay activator protein ZFP36L1	)	HUMAN		338	UniRef50_Q07352
mRNA decay activator protein ZFP36L1		RAT		338
ZFP36 ring finger protein like 1		GORGO		338
zinc finger protein 36, C3H1 type-like 1-like		LIPVE		226
Zinc finger protein 36, C3H type-like 1 (Fragment)		MUSPF		339
+276

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M58566 mRNA Translation: AAA72948.1
CCDSⁱ	CCDS26010.1
PIRⁱ	B39590
RefSeqⁱ	NP_031590.1, NM_007564.5
UniGeneⁱ	Mm.235132

3D structure databases

ProteinModelPortalⁱ	P23950
SMRⁱ	P23950
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198385, 1 interactor
IntActⁱ	P23950, 1 interactor
STRINGⁱ	10090.ENSMUSP00000021552

PTM databases

iPTMnetⁱ	P23950
PhosphoSitePlusⁱ	P23950

Proteomic databases

PaxDbⁱ	P23950
PeptideAtlasⁱ	P23950
PRIDEⁱ	P23950

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127 ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127
GeneIDⁱ	12192
KEGGⁱ	mmu:12192
UCSCⁱ	uc007oal.1 mouse

Organism-specific databases

CTDⁱ	677
MGIⁱ	MGI:107946 Zfp36l1

Phylogenomic databases

eggNOGⁱ	KOG1677 Eukaryota COG5063 LUCA
GeneTreeⁱ	ENSGT00530000063262
HOGENOMⁱ	HOG000233479
HOVERGENⁱ	HBG008483
InParanoidⁱ	P23950
KOⁱ	K18753
OMAⁱ	LQHSYSF
OrthoDBⁱ	EOG091G0957
PhylomeDBⁱ	P23950
TreeFamⁱ	TF315463

Enzyme and pathway databases

Reactomeⁱ	R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

Reactomeⁱ

R-MMU-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

Miscellaneous databases

ChiTaRSⁱ	Zfp36l1 mouse
Protein Ontology More...PROⁱ	PR:P23950
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021127 Expressed in 339 organ(s), highest expression level in vas deferens
CleanExⁱ	MM_ZFP36L1
ExpressionAtlasⁱ	P23950 baseline and differential
Genevisibleⁱ	P23950 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR007635 Tis11B_N IPR000571 Znf_CCCH IPR036855 Znf_CCCH_sf
Pfamⁱ	View protein in Pfam PF04553 Tis11B_N, 1 hit PF00642 zf-CCCH, 2 hits
SMARTⁱ	View protein in SMART SM00356 ZnF_C3H1, 2 hits
SUPFAMⁱ	SSF90229 SSF90229, 2 hits
PROSITEⁱ	View protein in PROSITE PS50103 ZF_C3H1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TISB_MOUSE
Accessionⁱ	P23950Primary (citable) accession number: P23950
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
	Last sequence update:	March 1, 1992
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P23950 (TISB_MOUSE)

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mRNA decay activator protein ZFP36L1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ