UniProtKB - P23950 (TISB_MOUSE)
mRNA decay activator protein ZFP36L1
Zfp36l1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 114 – 142 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 152 – 180 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- mRNA 3'-UTR AU-rich region binding Source: UniProtKB
- mRNA binding Source: UniProtKB
GO - Biological processi
- 3'-UTR-mediated mRNA destabilization Source: UniProtKB
- apoptotic process Source: MGI
- cell population proliferation Source: MGI
- cellular response to cAMP Source: UniProtKB
- cellular response to epidermal growth factor stimulus Source: UniProtKB
- cellular response to fibroblast growth factor stimulus Source: UniProtKB
- cellular response to glucocorticoid stimulus Source: UniProtKB
- cellular response to hypoxia Source: UniProtKB
- cellular response to insulin stimulus Source: UniProtKB
- cellular response to peptide hormone stimulus Source: UniProtKB
- cellular response to raffinose Source: UniProtKB
- cellular response to salt stress Source: UniProtKB
- cellular response to transforming growth factor beta stimulus Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- chorio-allantoic fusion Source: MGI
- embryonic organ development Source: MGI
- ERK1 and ERK2 cascade Source: UniProtKB
- heart development Source: MGI
- MAPK cascade Source: UniProtKB
- mesendoderm development Source: UniProtKB
- mRNA catabolic process Source: MGI
- mRNA processing Source: UniProtKB-KW
- mRNA transport Source: UniProtKB
- multicellular organism growth Source: MGI
- negative regulation of erythrocyte differentiation Source: UniProtKB
- negative regulation of mitotic cell cycle phase transition Source: UniProtKB
- neural tube development Source: MGI
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: MGI
- nuclear-transcribed mRNA catabolic process, deadenylation-independent decay Source: UniProtKB
- p38MAPK cascade Source: UniProtKB
- phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of intracellular mRNA localization Source: UniProtKB
- positive regulation of monocyte differentiation Source: UniProtKB
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
- proepicardium development Source: MGI
- protein kinase B signaling Source: UniProtKB
- regulation of B cell differentiation Source: UniProtKB
- regulation of gene expression Source: UniProtKB
- regulation of keratinocyte apoptotic process Source: UniProtKB
- regulation of keratinocyte differentiation Source: UniProtKB
- regulation of keratinocyte proliferation Source: UniProtKB
- regulation of mRNA 3'-end processing Source: MGI
- regulation of mRNA stability Source: UniProtKB
- regulation of myoblast differentiation Source: UniProtKB
- regulation of stem cell proliferation Source: UniProtKB
- regulation of translation Source: MGI
- response to wounding Source: UniProtKB
- spongiotrophoblast layer development Source: MGI
- T cell differentiation in thymus Source: UniProtKB
- vasculogenesis Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding, Ribonucleoprotein, RNA-binding |
Biological process | mRNA processing, mRNA transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
Names & Taxonomyi
Protein namesi | Recommended name: mRNA decay activator protein ZFP36L1CuratedAlternative name(s): Butyrate response factor 1By similarity TPA-induced sequence 11b1 Publication Zinc finger protein 36, C3H1 type-like 1Imported Short name: ZFP36-like 1Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107946, Zfp36l1 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 3 Publications
- Cytoplasmic granule By similarity
- P-body By similarity
Note: Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (PubMed:11796723). Component of cytoplasmic stress granules (By similarity). Localizes in processing bodies (PBs) (By similarity).By similarity1 Publication
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- P-body Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089168 | 1 – 338 | mRNA decay activator protein ZFP36L1Add BLAST | 338 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 54 | Phosphoserine; by MAPKAPK2By similarity | 1 | |
Modified residuei | 90 | Phosphoserine; by PKB/AKT1By similarity | 1 | |
Modified residuei | 92 | Phosphoserine; by PKB/AKT1 and MAPKAPK2By similarity | 1 | |
Modified residuei | 203 | Phosphoserine; by PKB/AKT1 and MAPKAPK2By similarity | 1 | |
Modified residuei | 318 | PhosphoserineBy similarity | 1 | |
Modified residuei | 334 | Phosphoserine; by RPS6KA1By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P23950 |
PaxDbi | P23950 |
PeptideAtlasi | P23950 |
PRIDEi | P23950 |
PTM databases
iPTMneti | P23950 |
PhosphoSitePlusi | P23950 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000021127, Expressed in vas deferens and 354 other tissues |
ExpressionAtlasi | P23950, baseline and differential |
Genevisiblei | P23950, MM |
Interactioni
Subunit structurei
Associates with the cytoplasmic CCR4-NOT deadenylase and RNA exosome complexes to trigger ARE-containing mRNA deadenylation and decay processes.
Interacts with CNOT1.
Interacts (via N-terminus) with CNOT6.
Interacts with CNOT7; this interaction is inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner.
Interacts with DCP1A.
Interacts (via N-terminus) with DCP2.
Interacts (via N-terminus) with EXOSC2.
Interacts with XRN1.
Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (By similarity).
Interacts (via phosphorylated form) with YWHAZ; this interaction occurs in a p38 MAPK- and AKT-signaling pathways (PubMed:22701344).
By similarity1 PublicationGO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198385, 1 interactor |
IntActi | P23950, 1 interactor |
STRINGi | 10090.ENSMUSP00000021552 |
Miscellaneous databases
RNActi | P23950, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 111 | Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activationBy similarityAdd BLAST | 111 | |
Regioni | 185 – 338 | Necessary for mRNA decay activationBy similarityAdd BLAST | 154 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 307 – 316 | Poly-Ser | 10 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 114 – 142 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 152 – 180 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1677, Eukaryota |
GeneTreei | ENSGT00940000155076 |
HOGENOMi | CLU_033040_1_0_1 |
InParanoidi | P23950 |
OMAi | PMSESPN |
OrthoDBi | 1541140at2759 |
PhylomeDBi | P23950 |
TreeFami | TF315463 |
Family and domain databases
InterProi | View protein in InterPro IPR007635, Tis11B_N IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
Pfami | View protein in Pfam PF04553, Tis11B_N, 1 hit PF00642, zf-CCCH, 2 hits |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 2 hits |
SUPFAMi | SSF90229, SSF90229, 2 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP
60 70 80 90 100
RRHSVTLPSS KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP
110 120 130 140 150
TQKQPGSGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH
160 170 180 190 200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGGRD LSADRPRLQH
210 220 230 240 250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP
260 270 280 290 300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
310 320 330
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1W2P6I1 | A0A1W2P6I1_MOUSE | mRNA decay activator protein ZFP36L... | Zfp36l1 | 57 | Annotation score: | ||
A0A1W2P7G3 | A0A1W2P7G3_MOUSE | mRNA decay activator protein ZFP36L... | Zfp36l1 | 84 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58566 mRNA Translation: AAA72948.1 |
CCDSi | CCDS26010.1 |
PIRi | B39590 |
RefSeqi | NP_031590.1, NM_007564.5 |
Genome annotation databases
Ensembli | ENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127 ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127 |
GeneIDi | 12192 |
KEGGi | mmu:12192 |
UCSCi | uc007oal.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58566 mRNA Translation: AAA72948.1 |
CCDSi | CCDS26010.1 |
PIRi | B39590 |
RefSeqi | NP_031590.1, NM_007564.5 |
3D structure databases
SMRi | P23950 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198385, 1 interactor |
IntActi | P23950, 1 interactor |
STRINGi | 10090.ENSMUSP00000021552 |
PTM databases
iPTMneti | P23950 |
PhosphoSitePlusi | P23950 |
Proteomic databases
jPOSTi | P23950 |
PaxDbi | P23950 |
PeptideAtlasi | P23950 |
PRIDEi | P23950 |
Protocols and materials databases
Antibodypediai | 37, 352 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127 ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127 |
GeneIDi | 12192 |
KEGGi | mmu:12192 |
UCSCi | uc007oal.1, mouse |
Organism-specific databases
CTDi | 677 |
MGIi | MGI:107946, Zfp36l1 |
Phylogenomic databases
eggNOGi | KOG1677, Eukaryota |
GeneTreei | ENSGT00940000155076 |
HOGENOMi | CLU_033040_1_0_1 |
InParanoidi | P23950 |
OMAi | PMSESPN |
OrthoDBi | 1541140at2759 |
PhylomeDBi | P23950 |
TreeFami | TF315463 |
Enzyme and pathway databases
Reactomei | R-MMU-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
Miscellaneous databases
BioGRID-ORCSi | 12192, 0 hits in 17 CRISPR screens |
ChiTaRSi | Zfp36l1, mouse |
PROi | PR:P23950 |
RNActi | P23950, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021127, Expressed in vas deferens and 354 other tissues |
ExpressionAtlasi | P23950, baseline and differential |
Genevisiblei | P23950, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007635, Tis11B_N IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
Pfami | View protein in Pfam PF04553, Tis11B_N, 1 hit PF00642, zf-CCCH, 2 hits |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 2 hits |
SUPFAMi | SSF90229, SSF90229, 2 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TISB_MOUSE | |
Accessioni | P23950Primary (citable) accession number: P23950 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | March 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot