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Protein

Alpha-1D adrenergic receptor

Gene

Adra1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
RA42
Gene namesi
Name:Adra1d
Synonyms:Adra1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62064 Adra1d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90ExtracellularBy similarityAdd BLAST90
Transmembranei91 – 115Helical; Name=1By similarityAdd BLAST25
Topological domaini116 – 127CytoplasmicBy similarityAdd BLAST12
Transmembranei128 – 153Helical; Name=2By similarityAdd BLAST26
Topological domaini154 – 163ExtracellularBy similarity10
Transmembranei164 – 186Helical; Name=3By similarityAdd BLAST23
Topological domaini187 – 207CytoplasmicBy similarityAdd BLAST21
Transmembranei208 – 232Helical; Name=4By similarityAdd BLAST25
Topological domaini233 – 245ExtracellularBy similarityAdd BLAST13
Transmembranei246 – 269Helical; Name=5By similarityAdd BLAST24
Topological domaini270 – 342CytoplasmicBy similarityAdd BLAST73
Transmembranei343 – 367Helical; Name=6By similarityAdd BLAST25
Topological domaini368 – 374ExtracellularBy similarity7
Transmembranei375 – 399Helical; Name=7By similarityAdd BLAST25
Topological domaini400 – 561CytoplasmicBy similarityAdd BLAST162

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL326
GuidetoPHARMACOLOGYi24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690771 – 561Alpha-1D adrenergic receptorAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi413S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23944
PRIDEiP23944

PTM databases

PhosphoSitePlusiP23944

Expressioni

Tissue specificityi

Vas deferens, hippocampus, cerebral cortex, aorta, brain stem, heart and spleen.

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028877

Chemistry databases

BindingDBiP23944

Structurei

3D structure databases

ProteinModelPortaliP23944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 57Gly-richAdd BLAST37
Compositional biasi416 – 421Poly-Arg6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP23944
KOiK04137
PhylomeDBiP23944

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000363 ADRA1D_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF14 PTHR24248:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00240 ADRENRGCA1DR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P23944-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTFRDILSVT FEGPRSSSST GGSGAGGGAG TVGPEGGAVG GVPGATGGGA
60 70 80 90 100
VVGTGSGEDN QSSTGEPGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF
110 120 130 140 150
ILTAVAGNLL VILSVACNRH LQTVTNYFIV NLAVADLLLS AAVLPFSATM
160 170 180 190 200
EVLGFWAFGR TFCDVWAAVD VLCCTASILS LCTISVDRYV GVRHSLKYPA
210 220 230 240 250
IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC GITEEVGYAI
260 270 280 290 300
FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI
310 320 330 340 350
HCRGAATSAK GYPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV
360 370 380 390 400
FVLCWFPFFF VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS
410 420 430 440 450
REFKRAFLRL LRCQCRRRRR RLWAVYGHHW RASTGDARSD CAPSPRIAPP
460 470 480 490 500
GAPLALTAHP GAGSADTPET QDSVSSSRKP ASALREWRLL GPLQRPTTQL
510 520 530 540 550
RAKVSSLSHK IRSGARRAET ACALRSEVEA VSLNVPQDGA EAVICQAYEP
560
GDYSNLRETD I
Length:561
Mass (Da):59,354
Last modified:November 1, 1995 - v2
Checksum:iB6537DCAD4F7BE27
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8W0G3V8W0_RAT
Adrenergic receptor, alpha 1d
Adra1d rCG_26550
562Annotation score:

Sequence cautioni

The sequence AAA63477 differs from that shown. Reason: Frameshift at positions 424 and 483.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60654 mRNA Translation: AAA63477.1 Frameshift.
L31771 mRNA Translation: AAB59704.1
AF071014 Genomic DNA Translation: AAC25396.1
PIRiA38731
RefSeqiNP_077809.1, NM_024483.1
UniGeneiRn.11314

Genome annotation databases

GeneIDi29413
KEGGirno:29413
UCSCiRGD:62064 rat

Similar proteinsi

Entry informationi

Entry nameiADA1D_RAT
AccessioniPrimary (citable) accession number: P23944
Secondary accession number(s): Q71UM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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