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Entry version 138 (08 May 2019)
Sequence version 2 (26 May 2009)
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Protein

Transcriptional regulatory protein LevR

Gene

levR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in positive regulation of the levanase operon which comprises the levDEFG genes for a fructose PTS system, and sacA for levanase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi145 – 152ATPPROSITE-ProRule annotation8
Nucleotide bindingi215 – 224ATPPROSITE-ProRule annotation10

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU27080-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional regulatory protein LevR
Including the following 1 domains:
Putative phosphotransferase EIIA component (EC:2.7.1.-)
Alternative name(s):
Putative PTS system EIIA component
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:levR
Ordered Locus Names:BSU27080
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042501 – 935Transcriptional regulatory protein LevRAdd BLAST935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei503PhosphohistidinePROSITE-ProRule annotation1
Modified residuei582Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei866PhosphohistidinePROSITE-ProRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Possibly phosphorylated and inactivated by the PTS system.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23914

PRoteomics IDEntifications database

More...
PRIDEi
P23914

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU27080

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P23914

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini117 – 348Sigma-54 factor interactionPROSITE-ProRule annotationAdd BLAST232
Domaini468 – 573PRD 1PROSITE-ProRule annotationAdd BLAST106
Domaini574 – 711PTS EIIA type-4PROSITE-ProRule annotationAdd BLAST138
Domaini831 – 935PRD 2PROSITE-ProRule annotationAdd BLAST105

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PTS EIIA type-4 domain may serve a regulatory function, through its phosphorylation activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C1W Bacteria
COG1221 LUCA
COG3933 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261733

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMDHGTY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23914

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00006 PTS_IIA_man, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.510, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR011608 PRD
IPR036634 PRD_sf
IPR004701 PTS_EIIA_man-typ
IPR036662 PTS_EIIA_man-typ_sf
IPR033887 PTS_IIA_man
IPR002078 Sigma_54_int
IPR025943 Sigma_54_int_dom_ATP-bd_2
IPR001550 Transcrpt_antitermin_CS
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03610 EIIA-man, 1 hit
PF00874 PRD, 2 hits
PF00158 Sigma54_activat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
SSF53062 SSF53062, 1 hit
SSF63520 SSF63520, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00654 PRD_1, 1 hit
PS51372 PRD_2, 2 hits
PS51096 PTS_EIIA_TYPE_4, 1 hit
PS00676 SIGMA54_INTERACT_2, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23914-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRIDKIYHQ LKHNFHDSTL DHLLKIQGNS AKEIAEQLKM ERSNVSFELN
60 70 80 90 100
NLVRSKKVIK IKTFPVRYIP VEIAEKLFNK KWDTEMMEVK DLQAFSGNSK
110 120 130 140 150
QNHQHISTNP LELMIGAKGS LKKAISQAKA AVFYPPNGLH MLLLGPTGSG
160 170 180 190 200
KSLFANRIYQ FAIYSDILKA GAPFITFNCA DYYNNPQLLL SQLFGHKKGS
210 220 230 240 250
FTGAAEDKAG LVEQANGGIL FMDEIHRLPP EGQEMLFYFI DSGSYNRLGE
260 270 280 290 300
SEHKRTSNVL FICATTENPS SALLKTFLRR IPMTIHIPSL EERSLNERVD
310 320 330 340 350
LTTFLLGKEA ERIKKNLSVH IDVYNALIHS AKFGNVGQLK SNVQLVCAHG
360 370 380 390 400
FLHNLDRNEV IELTVRDLPD EIKQEWMSSS KNMQRSKAIS EYVNITTIIS
410 420 430 440 450
PIVEDETTKI DEDLSFNLYH LIEEKVKTLM KEGLSKKDIN QYILTDVHLH
460 470 480 490 500
VRSFFHHQAF QKDNLLTFVE DDVIQMTKQL KEIAEHELDC TFDRKFIYFL
510 520 530 540 550
SMHIDAFLKR GKQIDVLNTQ ETDEIRDTHV KEYRVAMIFK DKIQEYFKVA
560 570 580 590 600
IPEIEVIYLT MLIHSIKSLK ENKRVGIIVA AHGNSTASSM VEVATELLGS
610 620 630 640 650
TPIAAVDMPL TVSPSDILEC VAEKMKQVDE GEGVLMLVDM GSLAMLESRL
660 670 680 690 700
EEKTGISIKT ISNVTTSMVL DAVRKVNYLN LNLHAIYQSV TKDFIELWER
710 720 730 740 750
QPAASGKKKA LVSICTTGSG TAKKLEDILT TIVNKASDTP IHILTVSSIK
760 770 780 790 800
LANSIKEIEK EYEILATVGT KDPKINAPHV SLEVLIEGEG EKLIQQAITK
810 820 830 840 850
GSISLSNGLN EANIIVRELC EDSLKKYLVF LNPHHVIDML LEWLQTVQDE
860 870 880 890 900
LGVIFNNAVL IKVIMHTAFA FERVIKQNPI AFSEEEEIND QLKEMVYVTE
910 920 930
RTLAPYEEKL GLRISDDEKL FIAAIFAEEV HGQLF
Length:935
Mass (Da):105,833
Last modified:May 26, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E8C0BD28B2435C8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA22572 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA63460 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti883S → L in AAA22572 (PubMed:1900939).Curated1
Sequence conflicti883S → L in CAA63460 (PubMed:9141695).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60105 Genomic DNA Translation: AAA22572.1 Different initiation.
X92868 Genomic DNA Translation: CAA63460.1 Different initiation.
AL009126 Genomic DNA Translation: CAB14650.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A39160

NCBI Reference Sequences

More...
RefSeqi
NP_390586.2, NC_000964.3
WP_003229830.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14650; CAB14650; BSU27080

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937594

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU27080

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.2941

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60105 Genomic DNA Translation: AAA22572.1 Different initiation.
X92868 Genomic DNA Translation: CAA63460.1 Different initiation.
AL009126 Genomic DNA Translation: CAB14650.2
PIRiA39160
RefSeqiNP_390586.2, NC_000964.3
WP_003229830.1, NZ_JNCM01000036.1

3D structure databases

SMRiP23914
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU27080

Proteomic databases

PaxDbiP23914
PRIDEiP23914

Genome annotation databases

EnsemblBacteriaiCAB14650; CAB14650; BSU27080
GeneIDi937594
KEGGibsu:BSU27080
PATRICifig|224308.179.peg.2941

Phylogenomic databases

eggNOGiENOG4105C1W Bacteria
COG1221 LUCA
COG3933 LUCA
HOGENOMiHOG000261733
OMAiFMDHGTY
PhylomeDBiP23914

Enzyme and pathway databases

BioCyciBSUB:BSU27080-MONOMER

Family and domain databases

CDDicd00006 PTS_IIA_man, 1 hit
Gene3Di3.40.50.510, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR011608 PRD
IPR036634 PRD_sf
IPR004701 PTS_EIIA_man-typ
IPR036662 PTS_EIIA_man-typ_sf
IPR033887 PTS_IIA_man
IPR002078 Sigma_54_int
IPR025943 Sigma_54_int_dom_ATP-bd_2
IPR001550 Transcrpt_antitermin_CS
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF03610 EIIA-man, 1 hit
PF00874 PRD, 2 hits
PF00158 Sigma54_activat, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
SSF53062 SSF53062, 1 hit
SSF63520 SSF63520, 2 hits
PROSITEiView protein in PROSITE
PS00654 PRD_1, 1 hit
PS51372 PRD_2, 2 hits
PS51096 PTS_EIIA_TYPE_4, 1 hit
PS00676 SIGMA54_INTERACT_2, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEVR_BACSU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23914
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 26, 2009
Last modified: May 8, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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