UniProtKB - P23908 (ARGE_ECOLI)
Protein
Acetylornithine deacetylase
Gene
argE
Organism
Escherichia coli (strain K12)
Status
Functioni
Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde.
Catalytic activityi
- EC:3.5.1.16
Cofactori
Protein has several cofactor binding sites:- Zn2+, Co2+Note: Binds 2 Zn2+ or Co2+ ions per subunit.
- glutathione
: L-arginine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).Proteins known to be involved in this subpathway in this organism are:
- Acetylornithine deacetylase (argE), Acetylornithine deacetylase (argE)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 80 | Cobalt or zinc 1By similarity | 1 | |
Active sitei | 82 | By similarity | 1 | |
Metal bindingi | 112 | Cobalt or zinc 1By similarity | 1 | |
Metal bindingi | 112 | Cobalt or zinc 2By similarity | 1 | |
Active sitei | 144 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 145 | Cobalt or zinc 2By similarity | 1 | |
Metal bindingi | 169 | Cobalt or zinc 1By similarity | 1 | |
Metal bindingi | 355 | Cobalt or zinc 2By similarity | 1 |
GO - Molecular functioni
- acetylornithine deacetylase activity Source: EcoliWiki
- cobalt ion binding Source: EcoCyc
- zinc ion binding Source: EcoCyc
GO - Biological processi
- arginine biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Hydrolase |
Biological process | Amino-acid biosynthesis, Arginine biosynthesis |
Ligand | Cobalt, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | EcoCyc:ACETYLORNDEACET-MONOMER MetaCyc:ACETYLORNDEACET-MONOMER |
BRENDAi | 3.5.1.16, 2026 |
UniPathwayi | UPA00068;UER00110 |
Protein family/group databases
MEROPSi | M20.974 |
Names & Taxonomyi
Protein namesi | Recommended name: Acetylornithine deacetylase (EC:3.5.1.16)Short name: AO Short name: Acetylornithinase Alternative name(s): N-acetylornithinase Short name: NAO |
Gene namesi | Name:argE Ordered Locus Names:b3957, JW3929 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185240 | 1 – 383 | Acetylornithine deacetylaseAdd BLAST | 383 |
Proteomic databases
jPOSTi | P23908 |
PaxDbi | P23908 |
PRIDEi | P23908 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGRIDi | 4259568, 71 interactors |
STRINGi | 511145.b3957 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0624, Bacteria |
HOGENOMi | CLU_021802_2_4_6 |
InParanoidi | P23908 |
PhylomeDBi | P23908 |
Family and domain databases
HAMAPi | MF_01108, ArgE, 1 hit |
InterProi | View protein in InterPro IPR010169, AcOrn-deacetyl IPR001261, ArgE/DapE_CS IPR036264, Bact_exopeptidase_dim_dom IPR002933, Peptidase_M20 IPR011650, Peptidase_M20_dimer |
PANTHERi | PTHR43808:SF1, PTHR43808:SF1, 1 hit |
Pfami | View protein in Pfam PF07687, M20_dimer, 1 hit PF01546, Peptidase_M20, 1 hit |
SUPFAMi | SSF55031, SSF55031, 1 hit |
TIGRFAMsi | TIGR01892, AcOrn-deacetyl, 1 hit |
PROSITEi | View protein in PROSITE PS00758, ARGE_DAPE_CPG2_1, 1 hit PS00759, ARGE_DAPE_CPG2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P23908-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASIGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHILQLR DNLKERYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP
310 320 330 340 350
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55417 Genomic DNA Translation: CAA39076.1 X62807 Genomic DNA Translation: CAA44625.1 AY330219 Genomic DNA Translation: AAP92671.1 AY331711 Genomic DNA Translation: AAP92815.1 U00006 Genomic DNA Translation: AAC43063.1 U00096 Genomic DNA Translation: AAC76939.1 AP009048 Genomic DNA Translation: BAE77354.1 J01587 Genomic DNA Translation: AAB59145.1 J01589 Genomic DNA Translation: AAA23484.2 |
PIRi | B42377 |
RefSeqi | NP_418392.1, NC_000913.3 WP_001298964.1, NZ_SSZK01000065.1 |
Genome annotation databases
EnsemblBacteriai | AAC76939; AAC76939; b3957 BAE77354; BAE77354; BAE77354 |
GeneIDi | 57732203 948456 |
KEGGi | ecj:JW3929 eco:b3957 |
PATRICi | fig|1411691.4.peg.2748 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55417 Genomic DNA Translation: CAA39076.1 X62807 Genomic DNA Translation: CAA44625.1 AY330219 Genomic DNA Translation: AAP92671.1 AY331711 Genomic DNA Translation: AAP92815.1 U00006 Genomic DNA Translation: AAC43063.1 U00096 Genomic DNA Translation: AAC76939.1 AP009048 Genomic DNA Translation: BAE77354.1 J01587 Genomic DNA Translation: AAB59145.1 J01589 Genomic DNA Translation: AAA23484.2 |
PIRi | B42377 |
RefSeqi | NP_418392.1, NC_000913.3 WP_001298964.1, NZ_SSZK01000065.1 |
3D structure databases
SMRi | P23908 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259568, 71 interactors |
STRINGi | 511145.b3957 |
Protein family/group databases
MEROPSi | M20.974 |
Proteomic databases
jPOSTi | P23908 |
PaxDbi | P23908 |
PRIDEi | P23908 |
Genome annotation databases
EnsemblBacteriai | AAC76939; AAC76939; b3957 BAE77354; BAE77354; BAE77354 |
GeneIDi | 57732203 948456 |
KEGGi | ecj:JW3929 eco:b3957 |
PATRICi | fig|1411691.4.peg.2748 |
Organism-specific databases
EchoBASEi | EB1263 |
Phylogenomic databases
eggNOGi | COG0624, Bacteria |
HOGENOMi | CLU_021802_2_4_6 |
InParanoidi | P23908 |
PhylomeDBi | P23908 |
Enzyme and pathway databases
UniPathwayi | UPA00068;UER00110 |
BioCyci | EcoCyc:ACETYLORNDEACET-MONOMER MetaCyc:ACETYLORNDEACET-MONOMER |
BRENDAi | 3.5.1.16, 2026 |
Miscellaneous databases
PROi | PR:P23908 |
Family and domain databases
HAMAPi | MF_01108, ArgE, 1 hit |
InterProi | View protein in InterPro IPR010169, AcOrn-deacetyl IPR001261, ArgE/DapE_CS IPR036264, Bact_exopeptidase_dim_dom IPR002933, Peptidase_M20 IPR011650, Peptidase_M20_dimer |
PANTHERi | PTHR43808:SF1, PTHR43808:SF1, 1 hit |
Pfami | View protein in Pfam PF07687, M20_dimer, 1 hit PF01546, Peptidase_M20, 1 hit |
SUPFAMi | SSF55031, SSF55031, 1 hit |
TIGRFAMsi | TIGR01892, AcOrn-deacetyl, 1 hit |
PROSITEi | View protein in PROSITE PS00758, ARGE_DAPE_CPG2_1, 1 hit PS00759, ARGE_DAPE_CPG2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARGE_ECOLI | |
Accessioni | P23908Primary (citable) accession number: P23908 Secondary accession number(s): Q2M8Q2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families