Irf2

Functionⁱ

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	5 – 113	IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST		109

GO - Molecular functionⁱ

DNA binding Source: MGI
DNA binding transcription factor activity Source: MGI
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation Source: InterPro
defense response to virus Source: MGI
positive regulation of transcription by RNA polymerase II Source: MGI
regulation of transcription, DNA-templated Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-933541 TRAF6 mediated IRF7 activation R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-MMU-933541 TRAF6 mediated IRF7 activation
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon regulatory factor 2 Short name: IRF-2
Gene namesⁱ	Name:Irf2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:96591 Irf2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000154550	1 – 349	Interferon regulatory factor 2Add BLAST		349

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	75	N6-acetyllysineBy similarity	1
Modified residueⁱ	78	N6-acetyllysineBy similarity	1
Cross-linkⁱ	137	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linkⁱ	137	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	166	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	225	PhosphoserineBy similarity	1
Cross-linkⁱ	260	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	293	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationⁱ

Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity (By similarity).By similarity

The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P23906
PeptideAtlas More...PeptideAtlasⁱ	P23906
PRIDEⁱ	P23906

PTM databases

iPTMnetⁱ	P23906
PhosphoSitePlusⁱ	P23906

Expressionⁱ

Inductionⁱ

By viruses and IFN.

Gene expression databases

Bgeeⁱ	ENSMUSG00000031627
CleanExⁱ	MM_IRF2
ExpressionAtlasⁱ	P23906 baseline and differential
Genevisibleⁱ	P23906 MM

Interactionⁱ

Subunit structureⁱ

Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	200785, 1 interactor
IntActⁱ	P23906, 1 interactor
Molecular INTeraction database More...MINTⁱ	P23906
STRINGⁱ	10090.ENSMUSP00000034041

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 17	Combined sources	10
Beta strandⁱ	25 – 28	Combined sources	4
Turnⁱ	29 – 32	Combined sources	4
Beta strandⁱ	33 – 37	Combined sources	5
Beta strandⁱ	43 – 47	Combined sources	5
Helixⁱ	48 – 51	Combined sources	4
Helixⁱ	53 – 61	Combined sources	9
Turnⁱ	67 – 69	Combined sources	3
Helixⁱ	74 – 87	Combined sources	14
Beta strandⁱ	91 – 93	Combined sources	3
Turnⁱ	95 – 97	Combined sources	3
Beta strandⁱ	98 – 100	Combined sources	3
Beta strandⁱ	106 – 111	Combined sources	6

3D structure databases

ProteinModelPortalⁱ	P23906
SMRⁱ	P23906
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P23906

EvolutionaryTraceⁱ

P23906

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IGY9 Eukaryota ENOG411152R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119093
HOGENOMⁱ	HOG000037937
HOVERGENⁱ	HBG003455
InParanoidⁱ	P23906
KEGG Orthology (KO) More...KOⁱ	K10153
OMAⁱ	SWPPFPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CB8
PhylomeDBⁱ	P23906
TreeFamⁱ	TF328512

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR017431 IRF1/IRF2 IPR031218 IRF2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 1 hit PTHR11949:SF22 PTHR11949:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit
PIRSFⁱ	PIRSF038196 IFN_RF1/2, 1 hit
PRINTSⁱ	PR00267 INTFRNREGFCT
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P23906-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK 
        60         70         80         90        100
DAPLFRNWAI HTGKHQPGID KPDPKTWKAN FRCAMNSLPD IEEVKDRSIK 
       110        120        130        140        150
KGNNAFRVYR MLPLSERPSK KGKKPKTEKE ERVKHIKQEP VESSLGLSNG 
       160        170        180        190        200
VSGFSPEYAV LTSAIKNEVD STVNIIVVGQ SHLDSNIEDQ EIVTNPPDIC 
       210        220        230        240        250
QVVEVTTESD DQPVSMSELY PLQISPVSSY AESETTDSVA SDEENAEGRP 
       260        270        280        290        300
HWRKRSIEGK QYLSNMGTRN TYLLPSMATF VTSNKPDLQV TIKEDSCPMP 
       310        320        330        340 
YNSSWPPFTD LPLPAPVTPT PSSSRPDRET RASVIKKTSD ITQARVKSC

Length:349

Mass (Da):39,453

Last modified:November 1, 1991 - v1

Checksum:ⁱ8738B082FB40FB11

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03168 mRNA Translation: AAA39333.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22295.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032417.3, NM_008391.4 XP_006509351.1, XM_006509288.3 XP_006509352.1, XM_006509289.3
UniGeneⁱ	Mm.1149

Genome annotation databases

Ensemblⁱ	ENSMUST00000034041; ENSMUSP00000034041; ENSMUSG00000031627
GeneIDⁱ	16363
KEGGⁱ	mmu:16363
UCSC genome browser More...UCSCⁱ	uc009lqo.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P23906	Interferon regulatory factor		MOUSE		349
UPI0005ABA032		MOUSE		377
Interferon regulatory factor 2 (Fragment)		MOUSE		113
Interferon regulatory factor 2 (Fragment)		MOUSE		118
Interferon regulatory factor 2 (Fragment)		MOUSE		180
+1

Protein	Similar proteins		Species	Score	Length
P23906	Interferon regulatory factor		MOUSE		349
interferon regulatory factor 2 isoform X1		MESAU		445
interferon regulatory factor 2 isoform X1		ODORO		372
Interferon regulatory factor 2		FELCA		371
UPI0004BDB9DC		EQUPR		370
+43

Protein	Similar proteins		Species	Score	Length
P23906	Interferon regulatory factor 2		HUMAN		349
Interferon regulatory factor		GORGO		349
Interferon regulatory factor 2		PIG		425
UPI000A314A85		MUSCR		354
UPI0004D0622E		GALVR		354
+237

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03168 mRNA Translation: AAA39333.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22295.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032417.3, NM_008391.4 XP_006509351.1, XM_006509288.3 XP_006509352.1, XM_006509289.3
UniGeneⁱ	Mm.1149

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IRF	NMR	-	A	2-113	[»]
	1IRG	NMR	-	A	2-113	[»]
	2IRF	X-ray	2.20	G/H/I/J/K/L	1-113	[»]
ProteinModelPortalⁱ	P23906
SMRⁱ	P23906
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200785, 1 interactor
IntActⁱ	P23906, 1 interactor
Molecular INTeraction database More...MINTⁱ	P23906
STRINGⁱ	10090.ENSMUSP00000034041

PTM databases

iPTMnetⁱ	P23906
PhosphoSitePlusⁱ	P23906

Proteomic databases

PaxDbⁱ	P23906
PeptideAtlas More...PeptideAtlasⁱ	P23906
PRIDEⁱ	P23906

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034041; ENSMUSP00000034041; ENSMUSG00000031627
GeneIDⁱ	16363
KEGGⁱ	mmu:16363
UCSC genome browser More...UCSCⁱ	uc009lqo.2 mouse

Organism-specific databases

CTDⁱ	3660
MGIⁱ	MGI:96591 Irf2

Phylogenomic databases

eggNOGⁱ	ENOG410IGY9 Eukaryota ENOG411152R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119093
HOGENOMⁱ	HOG000037937
HOVERGENⁱ	HBG003455
InParanoidⁱ	P23906
KEGG Orthology (KO) More...KOⁱ	K10153
OMAⁱ	SWPPFPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CB8
PhylomeDBⁱ	P23906
TreeFamⁱ	TF328512

Enzyme and pathway databases

Reactomeⁱ	R-MMU-933541 TRAF6 mediated IRF7 activation R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-MMU-933541 TRAF6 mediated IRF7 activation
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSⁱ	Irf2 mouse
EvolutionaryTraceⁱ	P23906
Protein Ontology More...PROⁱ	PR:P23906
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031627
CleanExⁱ	MM_IRF2
ExpressionAtlasⁱ	P23906 baseline and differential
Genevisibleⁱ	P23906 MM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR017431 IRF1/IRF2 IPR031218 IRF2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 1 hit PTHR11949:SF22 PTHR11949:SF22, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit
PIRSFⁱ	PIRSF038196 IFN_RF1/2, 1 hit
PRINTSⁱ	PR00267 INTFRNREGFCT
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IRF2_MOUSE
Accessionⁱ	P23906Primary (citable) accession number: P23906
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	November 1, 1991
	Last modified:	March 28, 2018
	This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - P23906 (IRF2_MOUSE)

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Interferon regulatory factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ