Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).
Entry version 182 (07 Apr 2021)
Sequence version 2 (01 Oct 1996)
Previous versions | rss
Add a publicationFeedback
Protein

Glycerol uptake/efflux facilitator protein

Gene

FPS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGlycerol metabolism, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-432030, Transport of glycerol from adipocytes to the liver by Aquaporins
R-SCE-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-SCE-432047, Passive transport by Aquaporins

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.8.5.1, the major intrinsic protein (mip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycerol uptake/efflux facilitator protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FPS1
Ordered Locus Names:YLL043W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000003966, FPS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YLL043W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 254ExtracellularSequence analysisAdd BLAST254
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 325CytoplasmicSequence analysisAdd BLAST50
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 369ExtracellularSequence analysisAdd BLAST23
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 446CytoplasmicSequence analysisAdd BLAST56
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 506ExtracellularSequence analysisAdd BLAST39
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 669CytoplasmicSequence analysisAdd BLAST142

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000640981 – 669Glycerol uptake/efflux facilitator proteinAdd BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei150PhosphoserineCombined sources1
Modified residuei168PhosphothreonineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P23900

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23900

PRoteomics IDEntifications database

More...
PRIDEi
P23900

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P23900

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31270, 369 interactors

Database of interacting proteins

More...
DIPi
DIP-3979N

Protein interaction database and analysis system

More...
IntActi
P23900, 7 interactors

Molecular INTeraction database

More...
MINTi
P23900

STRING: functional protein association networks

More...
STRINGi
4932.YLL043W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P23900, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi352 – 354NPA 13
Motifi480 – 482NPA 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 69Asn-richAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Leu-Ala/Ser (NPA).

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0224, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176604

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027014_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23900

Identification of Orthologs from Complete Genome Data

More...
OMAi
TMVMIIF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00333, MIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1080.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023271, Aquaporin-like
IPR000425, MIP
IPR022357, MIP_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00230, MIP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00783, MINTRINSICP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81338, SSF81338, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00861, MIP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00221, MIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23900-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNPQKALND FLSSESVHTH DSSRKQSNKQ SSDEGRSSSQ PSHHHSGGTN
60 70 80 90 100
NNNNNNNNNN NSNNNNNGND GGNDDDYDYE MQDYRPSPQS ARPTPTYVPQ
110 120 130 140 150
YSVESGTAFP IQEVIPSAYI NTQDINHKDN GPPSASSNRA FRPRGQTTVS
160 170 180 190 200
ANVLNIEDFY KNADDAHTIP ESHLSRRRSR SRATSNAGHS ANTGATNGRT
210 220 230 240 250
TGAQTNMESN ESPRNVPIMV KPKTLYQNPQ TPTVLPSTYH PINKWSSVKN
260 270 280 290 300
TYLKEFLAEF MGTMVMIIFG SAVVCQVNVA GKIQQDNFNV ALDNLNVTGS
310 320 330 340 350
SAETIDAMKS LTSLVSSVAG GTFDDVALGW AAAVVMGYFC AGGSAISGAH
360 370 380 390 400
LNPSITLANL VYRGFPLKKV PYYFAGQLIG AFTGALILFI WYKRVLQEAY
410 420 430 440 450
SDWWMNESVA GMFCVFPKPY LSSGRQFFSE FLCGAMLQAG TFALTDPYTC
460 470 480 490 500
LSSDVFPLMM FILIFIINAS MAYQTGTAMN LARDLGPRLA LYAVGFDHKM
510 520 530 540 550
LWVHHHHFFW VPMVGPFIGA LMGGLVYDVC IYQGHESPVN WSLPVYKEMI
560 570 580 590 600
MRAWFRRPGW KKRNRARRTS DLSDFSYNND DDEEFGERMA LQKTKTKSSI
610 620 630 640 650
SDNENEAGEK KVQFKSVQRG KRTFGGIPTI LEEEDSIETA SLGATTTDSI
660
GLSDTSSEDS HYGNAKKVT
Length:669
Mass (Da):73,877
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA9C78056A1251B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti640A → R in CAA38096 (PubMed:1648479).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54157 Genomic DNA Translation: CAA38096.1
Z73148 Genomic DNA Translation: CAA97494.1
BK006945 Genomic DNA Translation: DAA09279.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64795

NCBI Reference Sequences

More...
RefSeqi
NP_013057.1, NM_001181863.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLL043W_mRNA; YLL043W; YLL043W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850683

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLL043W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54157 Genomic DNA Translation: CAA38096.1
Z73148 Genomic DNA Translation: CAA97494.1
BK006945 Genomic DNA Translation: DAA09279.1
PIRiS64795
RefSeqiNP_013057.1, NM_001181863.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi31270, 369 interactors
DIPiDIP-3979N
IntActiP23900, 7 interactors
MINTiP23900
STRINGi4932.YLL043W

Protein family/group databases

TCDBi1.A.8.5.1, the major intrinsic protein (mip) family

PTM databases

iPTMnetiP23900

Proteomic databases

MaxQBiP23900
PaxDbiP23900
PRIDEiP23900

Genome annotation databases

EnsemblFungiiYLL043W_mRNA; YLL043W; YLL043W
GeneIDi850683
KEGGisce:YLL043W

Organism-specific databases

SGDiS000003966, FPS1
VEuPathDBiFungiDB:YLL043W

Phylogenomic databases

eggNOGiKOG0224, Eukaryota
GeneTreeiENSGT00940000176604
HOGENOMiCLU_027014_0_0_1
InParanoidiP23900
OMAiTMVMIIF

Enzyme and pathway databases

ReactomeiR-SCE-432030, Transport of glycerol from adipocytes to the liver by Aquaporins
R-SCE-432040, Vasopressin regulates renal water homeostasis via Aquaporins
R-SCE-432047, Passive transport by Aquaporins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23900
RNActiP23900, protein

Family and domain databases

CDDicd00333, MIP, 1 hit
Gene3Di1.20.1080.10, 2 hits
InterProiView protein in InterPro
IPR023271, Aquaporin-like
IPR000425, MIP
IPR022357, MIP_CS
PfamiView protein in Pfam
PF00230, MIP, 1 hit
PRINTSiPR00783, MINTRINSICP
SUPFAMiSSF81338, SSF81338, 1 hit
TIGRFAMsiTIGR00861, MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221, MIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFPS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23900
Secondary accession number(s): D6VXW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again