nlpC

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	62	NucleophileBy similarity		1
Active siteⁱ	115	Proton acceptorBy similarity		1

GO - Molecular functionⁱ

cysteine-type peptidase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol protease

Molecular function

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11133-MONOMER

BioCycⁱ

EcoCyc:EG11133-MONOMER

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C40.A01

MEROPSⁱ

C40.A01

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable endopeptidase NlpC (EC:3.4.-.-) Alternative name(s): ORF-17 Probable lipoprotein NlpC
Gene namesⁱ	Name:nlpC Ordered Locus Names:b1708, JW1698
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG11133 nlpC

EcoGeneⁱ

EG11133 nlpC

Subcellular locationⁱ

Cell membrane Curated; Lipid-anchor Curated

GO - Cellular componentⁱ

plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 15	PROSITE-ProRule annotationAdd BLAST		15
ChainⁱPRO_0000019754	16 – 154	Probable endopeptidase NlpCAdd BLAST		139

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	16	N-palmitoyl cysteinePROSITE-ProRule annotation		1
Lipidationⁱ	16	S-diacylglycerol cysteinePROSITE-ProRule annotation		1

Keywords - PTMⁱ

Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P23898
PRIDEⁱ	P23898

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260300, 304 interactors
STRINGⁱ	316385.ECDH10B_1844

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23898
SMRⁱ	P23898
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase C40 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG4108QBX Bacteria COG0791 LUCA
HOGENOMⁱ	HOG000229978
InParanoidⁱ	P23898
KEGG Orthology (KO) More...KOⁱ	K13695
OMAⁱ	WKRAYWQ
PhylomeDBⁱ	P23898

Family and domain databases

InterProⁱ	View protein in InterPro IPR000064 NLP_P60_dom IPR038765 Papain_like_cys_pep_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00877 NLPC_P60, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P23898-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRFCLILITA LLLAGCSHHK APPPNARLSD SITVIAGLND QLQSWHGTPY 
        60         70         80         90        100
RYGGMTRRGV DCSGFVVVTM RDRFDLQLPR ETKQQASIGT QIDKDELLPG 
       110        120        130        140        150
DLVFFKTGSG QNGLHVGIYD TNNQFIHAST SKGVMRSSLD NVYWQKNFWQ 

ARRI

Length:154

Mass (Da):17,283

Last modified:November 1, 1991 - v1

Checksum:ⁱCCAD869AF624BC4D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14031 Genomic DNA Translation: AAA23529.1 U00096 Genomic DNA Translation: AAC74778.1 AP009048 Genomic DNA Translation: BAA15476.1
PIRⁱ	D64929
NCBI Reference Sequences More...RefSeqⁱ	NP_416223.1, NC_000913.3 WP_001209795.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC74778; AAC74778; b1708 BAA15476; BAA15476; BAA15476
GeneIDⁱ	946220
KEGGⁱ	ecj:JW1698 eco:b1708
PATRICⁱ	fig\|1411691.4.peg.549

Protein	Similar proteins		Species	Score	Length
P23898	NLPC_P60 domain containing protein		Escherichia coli NCCP15648		154
Putative peptidase, C40 clan, lipoprotein		uncultured bacterium Contig372		154
Probable lipoprotein nlpC		Klebsiella pneumoniae IS22		154
Endopeptidase		ECOLX		154
Endopeptidase		SHIBO		154
+33

Protein	Similar proteins		Species	Score	Length
P23898	NLPC_P60 domain containing protein		Escherichia coli NCCP15648		154
Putative peptidase, C40 clan, lipoprotein		uncultured bacterium Contig372		154
Probable lipoprotein nlpC		Klebsiella pneumoniae IS22		154
Endopeptidase		ECOLX		154
Endopeptidase		SHIBO		154
+308

Protein	Similar proteins		Species	Score	Length
P23898	NLPC_P60 domain containing protein		Escherichia coli NCCP15648		154
Putative peptidase, C40 clan, lipoprotein		uncultured bacterium Contig372		154
Probable lipoprotein nlpC		Klebsiella pneumoniae IS22		154
Endopeptidase		ECOLX		154
Endopeptidase		SHIBO		154
+802

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14031 Genomic DNA Translation: AAA23529.1 U00096 Genomic DNA Translation: AAC74778.1 AP009048 Genomic DNA Translation: BAA15476.1
PIRⁱ	D64929
NCBI Reference Sequences More...RefSeqⁱ	NP_416223.1, NC_000913.3 WP_001209795.1, NZ_LN832404.1

3D structure databases

ProteinModelPortalⁱ	P23898
SMRⁱ	P23898
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260300, 304 interactors
STRINGⁱ	316385.ECDH10B_1844

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	C40.A01

MEROPSⁱ

C40.A01

Proteomic databases

PaxDbⁱ	P23898
PRIDEⁱ	P23898

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74778; AAC74778; b1708 BAA15476; BAA15476; BAA15476
GeneIDⁱ	946220
KEGGⁱ	ecj:JW1698 eco:b1708
PATRICⁱ	fig\|1411691.4.peg.549

Organism-specific databases

EchoBASEⁱ	EB1123
EcoGeneⁱ	EG11133 nlpC

Phylogenomic databases

eggNOGⁱ	ENOG4108QBX Bacteria COG0791 LUCA
HOGENOMⁱ	HOG000229978
InParanoidⁱ	P23898
KEGG Orthology (KO) More...KOⁱ	K13695
OMAⁱ	WKRAYWQ
PhylomeDBⁱ	P23898

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG11133-MONOMER

BioCycⁱ

EcoCyc:EG11133-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P23898

PROⁱ

PR:P23898

Family and domain databases

InterProⁱ	View protein in InterPro IPR000064 NLP_P60_dom IPR038765 Papain_like_cys_pep_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00877 NLPC_P60, 1 hit
SUPFAMⁱ	SSF54001 SSF54001, 1 hit
PROSITEⁱ	View protein in PROSITE PS51257 PROKAR_LIPOPROTEIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NLPC_ECOLI
Accessionⁱ	P23898Primary (citable) accession number: P23898
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	November 1, 1991
	Last modified:	June 20, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
Peptidase families
Classification of peptidase families and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P23898 (NLPC_ECOLI)

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Probable endopeptidase NlpC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ