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UniProtKB - P23898 (NLPC_ECOLI)
Protein
Probable endopeptidase NlpC
Gene
nlpC
Organism
Escherichia coli (strain K12)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 62 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 115 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 127 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cysteine-type peptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11133-MONOMER |
Protein family/group databases
MEROPSi | C40.A01 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable endopeptidase NlpC (EC:3.4.-.-)Alternative name(s): ORF-17 Probable lipoprotein NlpC |
Gene namesi | Name:nlpC Ordered Locus Names:b1708, JW1698 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | PROSITE-ProRule annotationAdd BLAST | 15 | |
ChainiPRO_0000019754 | 16 – 154 | Probable endopeptidase NlpCAdd BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 16 | N-palmitoyl cysteinePROSITE-ProRule annotation | 1 | |
Lipidationi | 16 | S-diacylglycerol cysteinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
PaxDbi | P23898 |
PRIDEi | P23898 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260300, 304 interactors |
IntActi | P23898, 1 interactor |
STRINGi | 511145.b1708 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 154 | NlpC/P60PROSITE-ProRule annotationAdd BLAST | 123 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG0791, Bacteria |
HOGENOMi | CLU_016043_9_3_6 |
InParanoidi | P23898 |
OMAi | WKRAYWQ |
PhylomeDBi | P23898 |
Family and domain databases
InterProi | View protein in InterPro IPR000064, NLP_P60_dom IPR038765, Papain-like_cys_pep_sf |
Pfami | View protein in Pfam PF00877, NLPC_P60, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51935, NLPC_P60, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P23898-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFCLILITA LLLAGCSHHK APPPNARLSD SITVIAGLND QLQSWHGTPY
60 70 80 90 100
RYGGMTRRGV DCSGFVVVTM RDRFDLQLPR ETKQQASIGT QIDKDELLPG
110 120 130 140 150
DLVFFKTGSG QNGLHVGIYD TNNQFIHAST SKGVMRSSLD NVYWQKNFWQ
ARRI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14031 Genomic DNA Translation: AAA23529.1 U00096 Genomic DNA Translation: AAC74778.1 AP009048 Genomic DNA Translation: BAA15476.1 |
PIRi | D64929 |
RefSeqi | NP_416223.1, NC_000913.3 WP_001209795.1, NZ_STEB01000009.1 |
Genome annotation databases
EnsemblBacteriai | AAC74778; AAC74778; b1708 BAA15476; BAA15476; BAA15476 |
GeneIDi | 946220 |
KEGGi | ecj:JW1698 eco:b1708 |
PATRICi | fig|1411691.4.peg.549 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14031 Genomic DNA Translation: AAA23529.1 U00096 Genomic DNA Translation: AAC74778.1 AP009048 Genomic DNA Translation: BAA15476.1 |
PIRi | D64929 |
RefSeqi | NP_416223.1, NC_000913.3 WP_001209795.1, NZ_STEB01000009.1 |
3D structure databases
AlphaFoldDBi | P23898 |
SMRi | P23898 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260300, 304 interactors |
IntActi | P23898, 1 interactor |
STRINGi | 511145.b1708 |
Protein family/group databases
MEROPSi | C40.A01 |
Proteomic databases
PaxDbi | P23898 |
PRIDEi | P23898 |
Genome annotation databases
EnsemblBacteriai | AAC74778; AAC74778; b1708 BAA15476; BAA15476; BAA15476 |
GeneIDi | 946220 |
KEGGi | ecj:JW1698 eco:b1708 |
PATRICi | fig|1411691.4.peg.549 |
Organism-specific databases
EchoBASEi | EB1123 |
Phylogenomic databases
eggNOGi | COG0791, Bacteria |
HOGENOMi | CLU_016043_9_3_6 |
InParanoidi | P23898 |
OMAi | WKRAYWQ |
PhylomeDBi | P23898 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11133-MONOMER |
Miscellaneous databases
PROi | PR:P23898 |
Family and domain databases
InterProi | View protein in InterPro IPR000064, NLP_P60_dom IPR038765, Papain-like_cys_pep_sf |
Pfami | View protein in Pfam PF00877, NLPC_P60, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51935, NLPC_P60, 1 hit PS51257, PROKAR_LIPOPROTEIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NLPC_ECOLI | |
Accessioni | P23898Primary (citable) accession number: P23898 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families