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UniProtKB - P23890 (CADC_ECOLI)

Entry version 149 (11 Dec 2019)
Sequence version 1 (01 Nov 1991)
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Protein

Transcriptional activator CadC

Gene

cadC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for Pcad induction, a promoter upstream of cadBA that is responsible for the pH-regulated expression of CadA and CadB. Probably acts as an activating transcription factor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi3 – 102OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: EcoCyc
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:PD00436
ECOL316407:JW4094-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator CadC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cadC
Ordered Locus Names:b4133, JW4094
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei155 – 180HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Loss of Pcad activity.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi120 – 124PPPIP → AAAIS: Significantly reduced dependence on EF-P for translation, increased levels of protein in an efp-strain. 1 Publication5
Mutagenesisi121P → A: Reduced dependence on EF-P for translation, increased levels of protein in an efp- strain. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000813451 – 512Transcriptional activator CadCAdd BLAST512

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23890

PRoteomics IDEntifications database

More...PRIDEi		P23890

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induction requires low pH plus exogenous lysine as sensed by LysP as well as EF-P for translation. This requirement is reduced as the number of consecutive Pro residues in the protein is decreased.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P257372EBI-6401662,EBI-6401655

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4260781, 7 interactors
852945, 1 interactor

Database of interacting proteins

More...DIPi		DIP-9239N

Protein interaction database and analysis system

More...IntActi		P23890, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b4133

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23890

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23890

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi120 – 124Poly-Pro5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4108M3R Bacteria
COG3710 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000127085

KEGG Orthology (KO)

More...KOi		K03765

Family and domain databases

Conserved Domains Database

More...CDDi		cd00383 trans_reg_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040970 CadC_C1
IPR001867 OmpR/PhoB-type_DNA-bd
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR039420 WalR-like
IPR036388 WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR26402 PTHR26402, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18500 CadC_C1, 1 hit
PF00486 Trans_reg_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00862 Trans_reg_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46894 SSF46894, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51755 OMPR_PHOB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23890-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQPVVRVGE WLVTPSINQI SRNGRQLTLE PRLIDLLVFF AQHSGEVLSR 
        60         70         80         90        100
DELIDNVWKR SIVTNHVVTQ SISELRKSLK DNDEDSPVYI ATVPKRGYKL 
       110        120        130        140        150
MVPVIWYSEE EGEEIMLSSP PPIPEAVPAT DSPSHSLNIQ NTATPPEQSP 
       160        170        180        190        200
VKSKRFTTFW VWFFFLLSLG ICVALVAFSS LDTRLPMSKS RILLNPRDID 
       210        220        230        240        250
INMVNKSCNS WSSPYQLSYA IGVGDLVATS LNTFSTFMVH DKINYNIDEP 
       260        270        280        290        300
SSSGKTLSIA FVNQRQYRAQ QCFMSIKLVD NADGSTMLDK RYVITNGNQL 
       310        320        330        340        350
AIQNDLLESL SKALNQPWPQ RMQETLQKIL PHRGALLTNF YQAHDYLLHG 
       360        370        380        390        400
DDKSLNRASE LLGEIVQSSP EFTYARAEKA LVDIVRHSQH PLDEKQLAAL 
       410        420        430        440        450
NTEIDNIVTL PELNNLSIIY QIKAVSALVK GKTDESYQAI NTGIDLEMSW 
       460        470        480        490        500
LNYVLLGKVY EMKGMNREAA DAYLTAFNLR PGANTLYWIE NGIFQTSVPY 
       510 
VVPYLDKFLA SE
Length:512
Mass (Da):57,813
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA19F5E1D293ACCF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M67452 Genomic DNA Translation: AAA23531.1
U14003 Genomic DNA Translation: AAA97033.1
U00096 Genomic DNA Translation: AAC77094.1
AP009048 Genomic DNA Translation: BAE78136.1

Protein sequence database of the Protein Information Resource

More...PIRi		C41968

NCBI Reference Sequences

More...RefSeqi		NP_418557.1, NC_000913.3
WP_001187173.1, NZ_SSZK01000018.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77094; AAC77094; b4133
BAE78136; BAE78136; BAE78136

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948653

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4094
eco:b4133

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2566

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67452 Genomic DNA Translation: AAA23531.1
U14003 Genomic DNA Translation: AAA97033.1
U00096 Genomic DNA Translation: AAC77094.1
AP009048 Genomic DNA Translation: BAE78136.1
PIRiC41968
RefSeqiNP_418557.1, NC_000913.3
WP_001187173.1, NZ_SSZK01000018.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LY7X-ray1.80A188-512[»]
3LY8X-ray1.90A188-512[»]
3LY9X-ray2.20A188-512[»]
3LYAX-ray2.30A188-512[»]
5JU7X-ray2.05A2-107[»]
SMRiP23890
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4260781, 7 interactors
852945, 1 interactor
DIPiDIP-9239N
IntActiP23890, 1 interactor
STRINGi511145.b4133

Proteomic databases

PaxDbiP23890
PRIDEiP23890

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		948653

Genome annotation databases

EnsemblBacteriaiAAC77094; AAC77094; b4133
BAE78136; BAE78136; BAE78136
GeneIDi948653
KEGGiecj:JW4094
eco:b4133
PATRICifig|1411691.4.peg.2566

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB0131

Phylogenomic databases

eggNOGiENOG4108M3R Bacteria
COG3710 LUCA
HOGENOMiHOG000127085
KOiK03765

Enzyme and pathway databases

BioCyciEcoCyc:PD00436
ECOL316407:JW4094-MONOMER

Miscellaneous databases

EvolutionaryTraceiP23890

Protein Ontology

More...PROi		PR:P23890

Family and domain databases

CDDicd00383 trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR040970 CadC_C1
IPR001867 OmpR/PhoB-type_DNA-bd
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR039420 WalR-like
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR26402 PTHR26402, 1 hit
PfamiView protein in Pfam
PF18500 CadC_C1, 1 hit
PF00486 Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00862 Trans_reg_C, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
PROSITEiView protein in PROSITE
PS51755 OMPR_PHOB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23890
Secondary accession number(s): Q2M6H0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: December 11, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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