UniProtKB - P23878 (FEPC_ECOLI)
Protein
Ferric enterobactin transport ATP-binding protein FepC
Gene
fepC
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 47 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: EcoCyc
- ferric-enterobactin transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- ferric-enterobactin import into cell Source: EcoCyc
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | ATP-binding, Iron, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:FEPC-MONOMER MetaCyc:FEPC-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.14.2, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Ferric enterobactin transport ATP-binding protein FepC |
Gene namesi | Name:fepC Ordered Locus Names:b0588, JW0580 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Peripheral membrane protein Curated
Plasma Membrane
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092325 | 1 – 271 | Ferric enterobactin transport ATP-binding protein FepCAdd BLAST | 271 |
Proteomic databases
PaxDbi | P23878 |
PRIDEi | P23878 |
Expressioni
Inductioni
Induced 1.5-fold by hydroxyurea.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259899, 380 interactors 849587, 2 interactors |
ComplexPortali | CPX-4404, Ferric-enterobactin ABC transporter complex |
IntActi | P23878, 14 interactors |
STRINGi | 511145.b0588 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 244 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 237 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Phylogenomic databases
eggNOGi | COG1120, Bacteria |
HOGENOMi | CLU_000604_1_11_6 |
InParanoidi | P23878 |
PhylomeDBi | P23878 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P23878-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTESVARLRG EQLTLGYGKY TVAENLTVEI PDGHFTAIIG PNGCGKSTLL
60 70 80 90 100
RTLSRLMTPA HGHVWLDGEH IQHYASKEVA RRIGLLAQNA TTPGDITVQE
110 120 130 140 150
LVARGRYPHQ PLFTRWRKED EEAVTKAMQA TGITHLADQS VDTLSGGQRQ
160 170 180 190 200
RAWIAMVLAQ ETAIMLLDEP TTWLDISHQI DLLELLSELN REKGYTLAAV
210 220 230 240 250
LHDLNQACRY ASHLIALREG KIVAQGAPKE IVTAELIERI YGLRCMIIDD
260 270
PVAGTPLVVP LGRTAPSTAN S
Sequence cautioni
The sequence AAB40787 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 227 | A → R in CAA40709 (PubMed:1838574).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57471 Genomic DNA Translation: CAA40709.1 U82598 Genomic DNA Translation: AAB40787.1 Different initiation. U00096 Genomic DNA Translation: AAC73689.1 AP009048 Genomic DNA Translation: BAE76343.1 |
PIRi | B64792 |
RefSeqi | NP_415120.1, NC_000913.3 WP_000140647.1, NZ_STEB01000047.1 |
Genome annotation databases
EnsemblBacteriai | AAC73689; AAC73689; b0588 BAE76343; BAE76343; BAE76343 |
GeneIDi | 58390986 945201 |
KEGGi | ecj:JW0580 eco:b0588 |
PATRICi | fig|1411691.4.peg.1681 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57471 Genomic DNA Translation: CAA40709.1 U82598 Genomic DNA Translation: AAB40787.1 Different initiation. U00096 Genomic DNA Translation: AAC73689.1 AP009048 Genomic DNA Translation: BAE76343.1 |
PIRi | B64792 |
RefSeqi | NP_415120.1, NC_000913.3 WP_000140647.1, NZ_STEB01000047.1 |
3D structure databases
SMRi | P23878 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259899, 380 interactors 849587, 2 interactors |
ComplexPortali | CPX-4404, Ferric-enterobactin ABC transporter complex |
IntActi | P23878, 14 interactors |
STRINGi | 511145.b0588 |
Protein family/group databases
TCDBi | 3.A.1.14.2, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P23878 |
PRIDEi | P23878 |
Genome annotation databases
EnsemblBacteriai | AAC73689; AAC73689; b0588 BAE76343; BAE76343; BAE76343 |
GeneIDi | 58390986 945201 |
KEGGi | ecj:JW0580 eco:b0588 |
PATRICi | fig|1411691.4.peg.1681 |
Organism-specific databases
EchoBASEi | EB0291 |
Phylogenomic databases
eggNOGi | COG1120, Bacteria |
HOGENOMi | CLU_000604_1_11_6 |
InParanoidi | P23878 |
PhylomeDBi | P23878 |
Enzyme and pathway databases
BioCyci | EcoCyc:FEPC-MONOMER MetaCyc:FEPC-MONOMER |
Miscellaneous databases
PROi | PR:P23878 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FEPC_ECOLI | |
Accessioni | P23878Primary (citable) accession number: P23878 Secondary accession number(s): P75724, P77096, Q2MBL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families