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Entry version 153 (05 Jun 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Ferric enterobactin transport system permease protein FepG

Gene

fepG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ferric-enterobactin transmembrane transporter activity Source: EcoCyc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:FEPG-MONOMER
ECOL316407:JW0581-MONOMER
MetaCyc:FEPG-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.14.2 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ferric enterobactin transport system permease protein FepG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fepG
Ordered Locus Names:b0589, JW0581
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10298 fepG

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7PeriplasmicSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 62CytoplasmicSequence analysisAdd BLAST34
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 92PeriplasmicSequence analysis9
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 117CytoplasmicSequence analysis4
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 146PeriplasmicSequence analysis8
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 190CytoplasmicSequence analysisAdd BLAST23
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 235PeriplasmicSequence analysisAdd BLAST24
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 275CytoplasmicSequence analysisAdd BLAST19
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 303PeriplasmicSequence analysis7
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 330CytoplasmicSequence analysis6

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000600231 – 330Ferric enterobactin transport system permease protein FepGAdd BLAST330

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23877

PRoteomics IDEntifications database

More...
PRIDEi
P23877

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Controlled in part by the amount of available iron. Induced 1.4-fold by hydroxyurea (PubMed:20005847).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
4261377, 423 interactors

Database of interacting proteins

More...
DIPi
DIP-9597N

STRING: functional protein association networks

More...
STRINGi
511145.b0589

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P23877

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105TVJ Bacteria
COG4779 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045409

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P23877

KEGG Orthology (KO)

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KOi
K23187

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.3470.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037294 ABC_BtuC-like
IPR000522 ABC_transptr_permease_BtuC

The PANTHER Classification System

More...
PANTHERi
PTHR30472 PTHR30472, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01032 FecCD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81345 SSF81345, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYVSRRLLI TCLLLVSACV VAGIWGLRSG AVTLETSQVF AALMGDAPRS
60 70 80 90 100
MTMVVTEWRL PRVLMALLIG AALGVSGAIF QSLMRNPLGS PDVMGFNTGA
110 120 130 140 150
WSGVLVAMVL FGQDLTAIAL SAMVGGIVTS LLVWLLAWRN GIDTFRLIII
160 170 180 190 200
GIGVRAMLVA FNTWLLLKAS LETALTAGLW NAGSLNGLTW AKTSPSAPII
210 220 230 240 250
ILMLIAAALL VRRMRLLEMG DDTACALGVS VERSRLLMML VAVVLTAAAT
260 270 280 290 300
ALAGPISFIA LVAPHIARRI SGTARWGLTQ AALCGALLLL AADLCAQQLF
310 320 330
MPYQLPVGVV TVSLGGIYLI VLLIQESRKK
Length:330
Mass (Da):34,910
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA67FA9513733D3CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230 – 231SV → RL in CAA40708 (PubMed:1838574).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X57471 Genomic DNA Translation: CAA40708.1
U82598 Genomic DNA Translation: AAB40788.1
U00096 Genomic DNA Translation: AAC73690.1
AP009048 Genomic DNA Translation: BAE76344.1

Protein sequence database of the Protein Information Resource

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PIRi
C64792

NCBI Reference Sequences

More...
RefSeqi
NP_415121.1, NC_000913.3
WP_000640988.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC73690; AAC73690; b0589
BAE76344; BAE76344; BAE76344

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW0581
eco:b0589

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.1680

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA Translation: CAA40708.1
U82598 Genomic DNA Translation: AAB40788.1
U00096 Genomic DNA Translation: AAC73690.1
AP009048 Genomic DNA Translation: BAE76344.1
PIRiC64792
RefSeqiNP_415121.1, NC_000913.3
WP_000640988.1, NZ_LN832404.1

3D structure databases

SMRiP23877
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4261377, 423 interactors
DIPiDIP-9597N
STRINGi511145.b0589

Protein family/group databases

TCDBi3.A.1.14.2 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP23877
PRIDEiP23877

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73690; AAC73690; b0589
BAE76344; BAE76344; BAE76344
GeneIDi945209
KEGGiecj:JW0581
eco:b0589
PATRICifig|1411691.4.peg.1680

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0294
EcoGeneiEG10298 fepG

Phylogenomic databases

eggNOGiENOG4105TVJ Bacteria
COG4779 LUCA
HOGENOMiHOG000045409
InParanoidiP23877
KOiK23187
PhylomeDBiP23877

Enzyme and pathway databases

BioCyciEcoCyc:FEPG-MONOMER
ECOL316407:JW0581-MONOMER
MetaCyc:FEPG-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23877

Family and domain databases

Gene3Di1.10.3470.10, 1 hit
InterProiView protein in InterPro
IPR037294 ABC_BtuC-like
IPR000522 ABC_transptr_permease_BtuC
PANTHERiPTHR30472 PTHR30472, 1 hit
PfamiView protein in Pfam
PF01032 FecCD, 1 hit
SUPFAMiSSF81345 SSF81345, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFEPG_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23877
Secondary accession number(s): P77587, Q2MBL2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: June 5, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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