UniProtKB - P23876 (FEPD_ECOLI)
Protein
Ferric enterobactin transport system permease protein FepD
Gene
fepD
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane.
GO - Molecular functioni
- ferric-enterobactin transmembrane transporter activity Source: EcoCyc
- transmembrane transporter activity Source: GO_Central
GO - Biological processi
- ferric-enterobactin import into cell Source: EcoCyc
- siderophore-dependent iron import into cell Source: GO_Central
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:FEPD-MONOMER MetaCyc:FEPD-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.14.2, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Ferric enterobactin transport system permease protein FepD |
Gene namesi | Name:fepD Ordered Locus Names:b0590, JW0582 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | PeriplasmicSequence analysis | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 63 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 85 – 92 | PeriplasmicSequence analysis | 8 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 120 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 142 – 151 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 152 – 172 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 173 – 192 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 193 – 213 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 214 – 241 | PeriplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 242 – 262 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 263 – 279 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 280 – 300 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 301 – 305 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 306 – 326 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 327 – 334 | CytoplasmicSequence analysis | 8 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060022 | 1 – 334 | Ferric enterobactin transport system permease protein FepDAdd BLAST | 334 |
Proteomic databases
PaxDbi | P23876 |
PRIDEi | P23876 |
Expressioni
Inductioni
Controlled in part by the amount of available iron. Induced by hydroxyurea (PubMed:20005847).1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261558, 236 interactors |
ComplexPortali | CPX-4404, Ferric-enterobactin ABC transporter complex |
STRINGi | 511145.b0590 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0609, Bacteria |
HOGENOMi | CLU_013016_1_0_6 |
InParanoidi | P23876 |
PhylomeDBi | P23876 |
Family and domain databases
Gene3Di | 1.10.3470.10, 1 hit |
InterProi | View protein in InterPro IPR037294, ABC_BtuC-like IPR000522, ABC_transptr_permease_BtuC |
PANTHERi | PTHR30472, PTHR30472, 1 hit |
Pfami | View protein in Pfam PF01032, FecCD, 1 hit |
SUPFAMi | SSF81345, SSF81345, 1 hit |
i Sequence
Sequence statusi: Complete.
P23876-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGSVAVTRA IAVPGLLLLL IIATALSLLI GAKSLPASVV LEAFSGTCQS
60 70 80 90 100
ADCTIVLDAR LPRTLAGLLA GGALGLAGAL MQTLTRNPLA DPGLLGVNAG
110 120 130 140 150
ASFAIVLGAA LFGYSSAQEQ LAMAFAGALV ASLIVAFTGS QGGGQLSPVR
160 170 180 190 200
LTLAGVALAA VLEGLTSGIA LLNPDVYDQL RFWQAGSLDI RNLHTLKVVL
210 220 230 240 250
IPVLIAGATA LLLSRALNSL SLGSDTATAL GSRVARTQLI GLLAITVLCG
260 270 280 290 300
SATAIVGPIA FIGLMMPHMA RWLVGADHRW SLPVTLLATP ALLLFADIIG
310 320 330
RVIVPGELRV SVVSAFIGAP VLIFLVRRKT RGGA
Sequence cautioni
The sequence AAB40789 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 233 – 234 | RV → AL in CAA42043 (PubMed:1787794).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57471 Genomic DNA Translation: CAA40707.1 X59402 Genomic DNA Translation: CAA42043.1 U82598 Genomic DNA Translation: AAB40789.1 Different initiation. U00096 Genomic DNA Translation: AAC73691.1 AP009048 Genomic DNA Translation: BAE76345.1 |
PIRi | S16296 |
RefSeqi | NP_415122.1, NC_000913.3 WP_000016947.1, NZ_SSZK01000032.1 |
Genome annotation databases
EnsemblBacteriai | AAC73691; AAC73691; b0590 BAE76345; BAE76345; BAE76345 |
GeneIDi | 57728859 945214 |
KEGGi | ecj:JW0582 eco:b0590 |
PATRICi | fig|1411691.4.peg.1679 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57471 Genomic DNA Translation: CAA40707.1 X59402 Genomic DNA Translation: CAA42043.1 U82598 Genomic DNA Translation: AAB40789.1 Different initiation. U00096 Genomic DNA Translation: AAC73691.1 AP009048 Genomic DNA Translation: BAE76345.1 |
PIRi | S16296 |
RefSeqi | NP_415122.1, NC_000913.3 WP_000016947.1, NZ_SSZK01000032.1 |
3D structure databases
SMRi | P23876 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261558, 236 interactors |
ComplexPortali | CPX-4404, Ferric-enterobactin ABC transporter complex |
STRINGi | 511145.b0590 |
Protein family/group databases
TCDBi | 3.A.1.14.2, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P23876 |
PRIDEi | P23876 |
Genome annotation databases
EnsemblBacteriai | AAC73691; AAC73691; b0590 BAE76345; BAE76345; BAE76345 |
GeneIDi | 57728859 945214 |
KEGGi | ecj:JW0582 eco:b0590 |
PATRICi | fig|1411691.4.peg.1679 |
Organism-specific databases
EchoBASEi | EB0292 |
Phylogenomic databases
eggNOGi | COG0609, Bacteria |
HOGENOMi | CLU_013016_1_0_6 |
InParanoidi | P23876 |
PhylomeDBi | P23876 |
Enzyme and pathway databases
BioCyci | EcoCyc:FEPD-MONOMER MetaCyc:FEPD-MONOMER |
Miscellaneous databases
PROi | PR:P23876 |
Family and domain databases
Gene3Di | 1.10.3470.10, 1 hit |
InterProi | View protein in InterPro IPR037294, ABC_BtuC-like IPR000522, ABC_transptr_permease_BtuC |
PANTHERi | PTHR30472, PTHR30472, 1 hit |
Pfami | View protein in Pfam PF01032, FecCD, 1 hit |
SUPFAMi | SSF81345, SSF81345, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FEPD_ECOLI | |
Accessioni | P23876Primary (citable) accession number: P23876 Secondary accession number(s): P77097, Q2MBL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 10, 2021 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families