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Protein

Trk system potassium uptake protein TrkG

Gene

trkG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA. Requires TrkE (sapD) for maximal transport activity, low activity is seen in its absence; no further stimulation is seen with SapF (PubMed:11700350). Transport in the absence of SapD is dependent on a high membrane potential and a high cytoplasmic ATP concentration, suggesting this protein may be able to interact with other ATP-binding proteins (PubMed:11700350). Can transport potassium and rubidium (PubMed:7896723).4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 mM for K+1 Publication
  2. KM=0.4 mM for Rb+1 Publication
  1. Vmax=300 µmol/min/g enzyme with K+ as substrate1 Publication
  2. Vmax=17 µmol/min/g enzyme with Rb+ as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi114Potassium; via carbonyl oxygenBy similarity1
Metal bindingi115Potassium; via carbonyl oxygenBy similarity1
Metal bindingi223Potassium; via carbonyl oxygenBy similarity1
Metal bindingi224Potassium; via carbonyl oxygenBy similarity1
Metal bindingi320Potassium; via carbonyl oxygenBy similarity1
Metal bindingi321Potassium; via carbonyl oxygenBy similarity1
Metal bindingi437Potassium; via carbonyl oxygenBy similarity1
Metal bindingi438Potassium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Potassium transport, Transport
LigandMetal-binding, Potassium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:TRKG-MONOMER
MetaCyc:TRKG-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.38.1.6 the k(+) transporter (trk) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trk system potassium uptake protein TrkG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trkG
Ordered Locus Names:b1363, JW1358
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG11020 trkG

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini? – 485CytoplasmicBy similarity1 Publication
Topological domaini? – 391CytoplasmicBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei? – 302By similarity
Topological domaini? – 276CytoplasmicBy similarity
Intramembranei? – 100By similarity
Topological domaini1 – 5CytoplasmicBy similarity5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 32HelicalBy similarityAdd BLAST27
Topological domaini33 – 38PeriplasmicBy similarity6
Transmembranei39 – 60HelicalBy similarityAdd BLAST22
Topological domaini61 – 68CytoplasmicBy similarity8
Transmembranei69 – 93HelicalBy similarityAdd BLAST25
Topological domaini94 – ?PeriplasmicBy similarity
Intramembranei101 – 112Helical; Pore-formingBy similarityAdd BLAST12
Intramembranei113 – 118By similarity6
Topological domaini119 – 127PeriplasmicBy similarity9
Transmembranei128 – 153HelicalBy similarityAdd BLAST26
Topological domaini154 – 180CytoplasmicBy similarityAdd BLAST27
Transmembranei181 – 205HelicalBy similarityAdd BLAST25
Topological domaini206 – 208PeriplasmicBy similarity3
Intramembranei209By similarity1
Intramembranei210 – 221Helical; Pore-formingBy similarityAdd BLAST12
Intramembranei222 – 227By similarity6
Topological domaini228 – 237PeriplasmicBy similarity10
Intramembranei238 – 253HelicalBy similarityAdd BLAST16
Intramembranei254 – ?By similarity
Transmembranei277 – 297HelicalBy similarityAdd BLAST21
Topological domaini298 – ?PeriplasmicBy similarity
Intramembranei303 – 318Helical; Pore-formingBy similarityAdd BLAST16
Intramembranei319 – 324By similarity6
Topological domaini325 – 332PeriplasmicBy similarity8
Intramembranei333 – 344HelicalBy similarityAdd BLAST12
Intramembranei345 – 357Note=Loop between two helicesBy similarityAdd BLAST13
Intramembranei358 – ?HelicalBy similarity
Transmembranei392 – 419HelicalBy similarityAdd BLAST28
Topological domaini420 – 421PeriplasmicBy similarity2
Intramembranei422 – 423By similarity2
Intramembranei424 – 434Helical; Pore-formingBy similarityAdd BLAST11
Intramembranei435 – 441By similarity7
Topological domaini442 – 453PeriplasmicBy similarityAdd BLAST12
Intramembranei454 – 465HelicalBy similarityAdd BLAST12
Intramembranei466 – ?By similarity

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000704741 – 485Trk system potassium uptake protein TrkGAdd BLAST485

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23849

PRoteomics IDEntifications database

More...
PRIDEi
P23849

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260161, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-11029N

Protein interaction database and analysis system

More...
IntActi
P23849, 1 interactor

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_1486

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P23849

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni113 – 118Selectivity filter part 1By similarity6
Regioni222 – 227Selectivity filter part 2By similarity6
Regioni319 – 324Selectivity filter part 3By similarity6
Regioni436 – 441Selectivity filter part 4By similarity6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TrkH potassium transport family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D37 Bacteria
COG0168 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000225541

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23849

KEGG Orthology (KO)

More...
KOi
K03498

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23849

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003445 Cat_transpt
IPR004772 TrkH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02386 TrkH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006247 TrkH, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00933 2a38, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23849-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTSHVRVVT HMCGFLVWLY SLSMLPPMVV ALFYKEKSLF VFFITFVIFF
60 70 80 90 100
CIGGGAWYTT KKSGIQLRTR DGFIIIVMFW ILFSVISAFP LWIDSELNLT
110 120 130 140 150
FIDALFEGVS GITTTGATVI DDVSSLPRAY LYYRSQLNFI GGLGVIVLAV
160 170 180 190 200
AVLPLLGIGG AKLYQSEMPG PFKDDKLTPR LADTSRTLWI TYSLLGIACI
210 220 230 240 250
VCYRLAGMPL FDAICHGIST VSLGGFSTHS ESIGYFNNYL VELVAGSFSL
260 270 280 290 300
LSAFNFTLWY IVISRKTIKP LIRDIELRFF LLIALGVIIV TSFQVWHIGM
310 320 330 340 350
YDLHGSFIHS FFLASSMLTD NGLATQDYAS WPTHTIVFLL LSSFFGGCIG
360 370 380 390 400
STCGGIKSLR FLILFKQSKH EINQLSHPRA LLSVNVGGKI VTDRVMRSVW
410 420 430 440 450
SFFFLYTLFT VFFILVLNGM GYDFLTSFAT VAACINNMGL GFGATASSFG
460 470 480
VLNDIAKCLM CIAMILGRLE IYPVIILFSG FFWRS
Length:485
Mass (Da):53,944
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87E19BEC3B50B458
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56783 Genomic DNA Translation: CAA40103.1
U00096 Genomic DNA Translation: AAC74445.1
AP009048 Genomic DNA Translation: BAA14960.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A39408

NCBI Reference Sequences

More...
RefSeqi
NP_415881.1, NC_000913.3
WP_001097895.1, NZ_CP014272.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74445; AAC74445; b1363
BAA14960; BAA14960; BAA14960

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1358
eco:b1363

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.1422

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56783 Genomic DNA Translation: CAA40103.1
U00096 Genomic DNA Translation: AAC74445.1
AP009048 Genomic DNA Translation: BAA14960.1
PIRiA39408
RefSeqiNP_415881.1, NC_000913.3
WP_001097895.1, NZ_CP014272.1

3D structure databases

ProteinModelPortaliP23849
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260161, 11 interactors
DIPiDIP-11029N
IntActiP23849, 1 interactor
STRINGi316385.ECDH10B_1486

Protein family/group databases

TCDBi2.A.38.1.6 the k(+) transporter (trk) family

Proteomic databases

PaxDbiP23849
PRIDEiP23849

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74445; AAC74445; b1363
BAA14960; BAA14960; BAA14960
GeneIDi945932
KEGGiecj:JW1358
eco:b1363
PATRICifig|511145.12.peg.1422

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1013
EcoGeneiEG11020 trkG

Phylogenomic databases

eggNOGiENOG4105D37 Bacteria
COG0168 LUCA
HOGENOMiHOG000225541
InParanoidiP23849
KOiK03498
PhylomeDBiP23849

Enzyme and pathway databases

BioCyciEcoCyc:TRKG-MONOMER
MetaCyc:TRKG-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23849

Family and domain databases

InterProiView protein in InterPro
IPR003445 Cat_transpt
IPR004772 TrkH
PfamiView protein in Pfam
PF02386 TrkH, 1 hit
PIRSFiPIRSF006247 TrkH, 1 hit
TIGRFAMsiTIGR00933 2a38, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRKG_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23849
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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