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Protein

Periplasmic oligopeptide-binding protein

Gene

oppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.

GO - Molecular functioni

  • oligopeptide binding Source: EcoCyc

GO - Biological processi

  • chaperone-mediated protein folding Source: EcoCyc
  • oligopeptide transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW
  • response to heat Source: EcoCyc
  • transmembrane transport Source: InterPro

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:OPPA-MONOMER
MetaCyc:OPPA-MONOMER

Protein family/group databases

TCDBi3.A.1.5.41 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic oligopeptide-binding protein
Gene namesi
Name:oppA
Ordered Locus Names:b1243, JW1235
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10674 oppA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 263 PublicationsAdd BLAST26
ChainiPRO_000003179727 – 543Periplasmic oligopeptide-binding proteinAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi297 ↔ 443By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP23843
PaxDbiP23843
PRIDEiP23843

2D gel databases

SWISS-2DPAGEiP23843

Interactioni

Protein-protein interaction databases

BioGridi4263482, 672 interactors
DIPiDIP-10405N
IntActiP23843, 3 interactors
STRINGi316385.ECDH10B_1305

Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23843
SMRiP23843
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23843

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108J59 Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP23843
KOiK15580
OMAiYDFFTWE
PhylomeDBiP23843

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNITKRSLV AAGVLAALMA GNVALAADVP AGVTLAEKQT LVRNNGSEVQ
60 70 80 90 100
SLDPHKIEGV PESNISRDLF EGLLVSDLDG HPAPGVAESW DNKDAKVWTF
110 120 130 140 150
HLRKDAKWSD GTPVTAQDFV YSWQRSVDPN TASPYASYLQ YGHIAGIDEI
160 170 180 190 200
LEGKKPITDL GVKAIDDHTL EVTLSEPVPY FYKLLVHPST SPVPKAAIEK
210 220 230 240 250
FGEKWTQPGN IVTNGAYTLK DWVVNERIVL ERSPTYWNNA KTVINQVTYL
260 270 280 290 300
PIASEVTDVN RYRSGEIDMT NNSMPIELFQ KLKKEIPDEV HVDPYLCTYY
310 320 330 340 350
YEINNQKPPF NDVRVRTALK LGMDRDIIVN KVKAQGNMPA YGYTPPYTDG
360 370 380 390 400
AKLTQPEWFG WSQEKRNEEA KKLLAEAGYT ADKPLTINLL YNTSDLHKKL
410 420 430 440 450
AIAASSLWKK NIGVNVKLVN QEWKTFLDTR HQGTFDVARA GWCADYNEPT
460 470 480 490 500
SFLNTMLSNS SMNTAHYKSP AFDSIMAETL KVTDEAQRTA LYTKAEQQLD
510 520 530 540
KDSAIVPVYY YVNARLVKPW VGGYTGKDPL DNTYTRNMYI VKH
Length:543
Mass (Da):60,899
Last modified:October 1, 1994 - v2
Checksum:iBBEF9FEBD42254EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271N → Y in AAA21302 (Ref. 2) Curated1
Sequence conflicti314 – 315RV → LW in AAA21302 (Ref. 2) Curated2
Sequence conflicti487 – 488QR → HG in AAA21302 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05433 Genomic DNA Translation: AAA21302.1
M60918 Genomic DNA Translation: AAB00918.1
U00096 Genomic DNA Translation: AAC74325.1
AP009048 Genomic DNA Translation: BAA14775.1
X59501 Genomic DNA Translation: CAA42089.1
D83137 Genomic DNA Translation: BAA11814.1
PIRiF64871
RefSeqiNP_415759.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC74325; AAC74325; b1243
BAA14775; BAA14775; BAA14775
GeneIDi945830
KEGGiecj:JW1235
eco:b1243
PATRICifig|511145.12.peg.1293

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05433 Genomic DNA Translation: AAA21302.1
M60918 Genomic DNA Translation: AAB00918.1
U00096 Genomic DNA Translation: AAC74325.1
AP009048 Genomic DNA Translation: BAA14775.1
X59501 Genomic DNA Translation: CAA42089.1
D83137 Genomic DNA Translation: BAA11814.1
PIRiF64871
RefSeqiNP_415759.1, NC_000913.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TCFX-ray2.00A/B/C/D/E/F/G/H27-543[»]
3TCGX-ray2.00A/B/C/D/E/F/G/H27-543[»]
3TCHX-ray1.98A27-543[»]
ProteinModelPortaliP23843
SMRiP23843
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263482, 672 interactors
DIPiDIP-10405N
IntActiP23843, 3 interactors
STRINGi316385.ECDH10B_1305

Protein family/group databases

TCDBi3.A.1.5.41 the atp-binding cassette (abc) superfamily

2D gel databases

SWISS-2DPAGEiP23843

Proteomic databases

EPDiP23843
PaxDbiP23843
PRIDEiP23843

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74325; AAC74325; b1243
BAA14775; BAA14775; BAA14775
GeneIDi945830
KEGGiecj:JW1235
eco:b1243
PATRICifig|511145.12.peg.1293

Organism-specific databases

EchoBASEiEB0668
EcoGeneiEG10674 oppA

Phylogenomic databases

eggNOGiENOG4108J59 Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP23843
KOiK15580
OMAiYDFFTWE
PhylomeDBiP23843

Enzyme and pathway databases

BioCyciEcoCyc:OPPA-MONOMER
MetaCyc:OPPA-MONOMER

Miscellaneous databases

EvolutionaryTraceiP23843
PROiPR:P23843

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPPA_ECOLI
AccessioniPrimary (citable) accession number: P23843
Secondary accession number(s): P76829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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