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Entry version 145 (11 Dec 2019)
Sequence version 2 (01 Oct 1994)
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Protein

Periplasmic oligopeptide-binding protein

Gene

oppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:OPPA-MONOMER
ECOL316407:JW1235-MONOMER
MetaCyc:OPPA-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.5.41 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Periplasmic oligopeptide-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:oppA
Ordered Locus Names:b1243, JW1235
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 263 PublicationsAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003179727 – 543Periplasmic oligopeptide-binding proteinAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi297 ↔ 443By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P23843

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P23843

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23843

PRoteomics IDEntifications database

More...
PRIDEi
P23843

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P23843

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4263482, 672 interactors
850197, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4344 Oligopeptide ABC transporter complex

Database of interacting proteins

More...
DIPi
DIP-10405N

Protein interaction database and analysis system

More...
IntActi
P23843, 3 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1243

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P23843

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P23843

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108J59 Bacteria
COG4166 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000179191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23843

KEGG Orthology (KO)

More...
KOi
K15580

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23843

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR30290 PTHR30290, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00496 SBP_bac_5, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002741 MppA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P23843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNITKRSLV AAGVLAALMA GNVALAADVP AGVTLAEKQT LVRNNGSEVQ
60 70 80 90 100
SLDPHKIEGV PESNISRDLF EGLLVSDLDG HPAPGVAESW DNKDAKVWTF
110 120 130 140 150
HLRKDAKWSD GTPVTAQDFV YSWQRSVDPN TASPYASYLQ YGHIAGIDEI
160 170 180 190 200
LEGKKPITDL GVKAIDDHTL EVTLSEPVPY FYKLLVHPST SPVPKAAIEK
210 220 230 240 250
FGEKWTQPGN IVTNGAYTLK DWVVNERIVL ERSPTYWNNA KTVINQVTYL
260 270 280 290 300
PIASEVTDVN RYRSGEIDMT NNSMPIELFQ KLKKEIPDEV HVDPYLCTYY
310 320 330 340 350
YEINNQKPPF NDVRVRTALK LGMDRDIIVN KVKAQGNMPA YGYTPPYTDG
360 370 380 390 400
AKLTQPEWFG WSQEKRNEEA KKLLAEAGYT ADKPLTINLL YNTSDLHKKL
410 420 430 440 450
AIAASSLWKK NIGVNVKLVN QEWKTFLDTR HQGTFDVARA GWCADYNEPT
460 470 480 490 500
SFLNTMLSNS SMNTAHYKSP AFDSIMAETL KVTDEAQRTA LYTKAEQQLD
510 520 530 540
KDSAIVPVYY YVNARLVKPW VGGYTGKDPL DNTYTRNMYI VKH
Length:543
Mass (Da):60,899
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBEF9FEBD42254EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271N → Y in AAA21302 (Ref. 2) Curated1
Sequence conflicti314 – 315RV → LW in AAA21302 (Ref. 2) Curated2
Sequence conflicti487 – 488QR → HG in AAA21302 (Ref. 2) Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05433 Genomic DNA Translation: AAA21302.1
M60918 Genomic DNA Translation: AAB00918.1
U00096 Genomic DNA Translation: AAC74325.1
AP009048 Genomic DNA Translation: BAA14775.1
X59501 Genomic DNA Translation: CAA42089.1
D83137 Genomic DNA Translation: BAA11814.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F64871

NCBI Reference Sequences

More...
RefSeqi
NP_415759.1, NC_000913.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74325; AAC74325; b1243
BAA14775; BAA14775; BAA14775

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1235
eco:b1243

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.1293

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05433 Genomic DNA Translation: AAA21302.1
M60918 Genomic DNA Translation: AAB00918.1
U00096 Genomic DNA Translation: AAC74325.1
AP009048 Genomic DNA Translation: BAA14775.1
X59501 Genomic DNA Translation: CAA42089.1
D83137 Genomic DNA Translation: BAA11814.1
PIRiF64871
RefSeqiNP_415759.1, NC_000913.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TCFX-ray2.00A/B/C/D/E/F/G/H27-543[»]
3TCGX-ray2.00A/B/C/D/E/F/G/H27-543[»]
3TCHX-ray1.98A27-543[»]
SMRiP23843
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi4263482, 672 interactors
850197, 1 interactor
ComplexPortaliCPX-4344 Oligopeptide ABC transporter complex
DIPiDIP-10405N
IntActiP23843, 3 interactors
STRINGi511145.b1243

Protein family/group databases

TCDBi3.A.1.5.41 the atp-binding cassette (abc) superfamily

2D gel databases

SWISS-2DPAGEiP23843

Proteomic databases

EPDiP23843
jPOSTiP23843
PaxDbiP23843
PRIDEiP23843

Genome annotation databases

EnsemblBacteriaiAAC74325; AAC74325; b1243
BAA14775; BAA14775; BAA14775
GeneIDi945830
KEGGiecj:JW1235
eco:b1243
PATRICifig|511145.12.peg.1293

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0668

Phylogenomic databases

eggNOGiENOG4108J59 Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP23843
KOiK15580
PhylomeDBiP23843

Enzyme and pathway databases

BioCyciEcoCyc:OPPA-MONOMER
ECOL316407:JW1235-MONOMER
MetaCyc:OPPA-MONOMER

Miscellaneous databases

EvolutionaryTraceiP23843

Protein Ontology

More...
PROi
PR:P23843

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR039424 SBP_5
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PANTHERiPTHR30290 PTHR30290, 1 hit
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOPPA_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23843
Secondary accession number(s): P76829
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1994
Last modified: December 11, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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