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UniProtKB - P23842 (PDEA_ECOLI)
Protein
Probable cyclic di-GMP phosphodiesterase PdeA
Gene
pdeA
Organism
Escherichia coli (strain K12)
Status
Functioni
Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
By similarityCatalytic activityi
- EC:3.1.4.52By similarity
GO - Molecular functioni
- cyclic-guanylate-specific phosphodiesterase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase |
Ligand | c-di-GMP |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11145-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pdeA1 Publication Synonyms:yfeA Ordered Locus Names:b2395, JW5391 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 37 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 41 – 61 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169216 | 1 – 729 | Probable cyclic di-GMP phosphodiesterase PdeAAdd BLAST | 729 |
Proteomic databases
jPOSTi | P23842 |
PaxDbi | P23842 |
PRIDEi | P23842 |
Expressioni
Inductioni
Expressed during exponential and post-exponential growth at both 28 and 37 degrees Celsius. Repressed by RpoS.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259186, 204 interactors |
DIPi | DIP-12011N |
IntActi | P23842, 1 interactor |
STRINGi | 511145.b2395 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 348 – 476 | GGDEFPROSITE-ProRule annotationAdd BLAST | 129 | |
Domaini | 488 – 729 | EALPROSITE-ProRule annotationAdd BLAST | 242 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2199, Bacteria COG2200, Bacteria |
HOGENOMi | CLU_023566_2_0_6 |
InParanoidi | P23842 |
OMAi | IRIFWRR |
PhylomeDBi | P23842 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit 3.30.70.270, 1 hit |
InterProi | View protein in InterPro IPR001633, EAL_dom IPR035919, EAL_sf IPR000160, GGDEF_dom IPR007895, MASE1 IPR029787, Nucleotide_cyclase IPR043128, Rev_trsase/Diguanyl_cyclase |
Pfami | View protein in Pfam PF00563, EAL, 1 hit PF05231, MASE1, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit SM00267, GGDEF, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit PS50887, GGDEF, 1 hit |
i Sequence
Sequence statusi: Complete.
P23842-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFVEHNLIKN IKIFTLAFTL TVVLIQLSRF ISPLAIIHSS YIFLAWMPLC
60 70 80 90 100
VMLSILFIFG WRGVVPVLCG MFCTNLWNFH LSFLQTAVML GSQTFVVLCA
110 120 130 140 150
CAILRWQLGT RWRYGLTSRY VWQRLFWLGL VTPIGIKCSM YLVGSFFDFP
160 170 180 190 200
LKISTFFGDA DAIFTVVDLL SLFTAVLIYN MLFYYLTRMI VSPHFAQILW
210 220 230 240 250
RRDIAPSLGK EKRAFTLSWL AALSVLLLLL CTPYENDFIA GYLVPVFFII
260 270 280 290 300
FTLGVGKLRY PFLNLTWAVS TLCLLNYNQN FLQGVETEYS LAFILAVLIS
310 320 330 340 350
FSVCLLYMVR IYHRSEWLNR RWHLQALTDP LTLLPNFRAL EQAPEQEAGK
360 370 380 390 400
SFCCLRIDNL EFMSRHYGLM MRVHCIRSIC RTLLPLMQEN EKLYQLPGSE
410 420 430 440 450
LLLVLSGPET EGRLQHMVNI LNSRQIHWNN TGLDMGYGAA WGRFDGNQET
460 470 480 490 500
LQPLLGQLSW LAEQSCAHHH VLALDSREEM VSGQTTKQVL LLNTIRTALD
510 520 530 540 550
QGDLLLYAQP IRNKEGEGYD EILARLKYDG GIMTPDKFLP LIAQFNLSAR
560 570 580 590 600
FDLQVLESLL KWLATHPCDK KGPRFSVNLM PLTLLQKNIA GRIIRLFKRY
610 620 630 640 650
HISPQAVILE ITEEQAFSNA ESSMYNIEQL HKFGFRIAID DFGTGYANYE
660 670 680 690 700
RLKRLQADII KIDGVFVKDI VTNTLDAMIV RSITDLAKAK SLSVVAEFVE
710 720
TQQQQALLHK LGVQYLQGYL IGRPQPLAD
Sequence cautioni
The sequence AAA65719 differs from that shown. Reason: Frameshift.Curated
The sequence AAA65719 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAA45395 differs from that shown. Reason: Frameshift.Curated
The sequence CAA45395 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75454.2 AP009048 Genomic DNA Translation: BAA16267.2 M13687 Genomic DNA Translation: AAA65719.1 Sequence problems. X63976 Genomic DNA Translation: CAA45395.1 Sequence problems. |
PIRi | H65013 S11411 |
RefSeqi | NP_416896.4, NC_000913.3 WP_000497400.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75454; AAC75454; b2395 BAA16267; BAA16267; BAA16267 |
GeneIDi | 66673736 946864 |
KEGGi | ecj:JW5391 eco:b2395 |
PATRICi | fig|1411691.4.peg.4333 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC75454.2 AP009048 Genomic DNA Translation: BAA16267.2 M13687 Genomic DNA Translation: AAA65719.1 Sequence problems. X63976 Genomic DNA Translation: CAA45395.1 Sequence problems. |
PIRi | H65013 S11411 |
RefSeqi | NP_416896.4, NC_000913.3 WP_000497400.1, NZ_LN832404.1 |
3D structure databases
AlphaFoldDBi | P23842 |
SMRi | P23842 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259186, 204 interactors |
DIPi | DIP-12011N |
IntActi | P23842, 1 interactor |
STRINGi | 511145.b2395 |
Proteomic databases
jPOSTi | P23842 |
PaxDbi | P23842 |
PRIDEi | P23842 |
Genome annotation databases
EnsemblBacteriai | AAC75454; AAC75454; b2395 BAA16267; BAA16267; BAA16267 |
GeneIDi | 66673736 946864 |
KEGGi | ecj:JW5391 eco:b2395 |
PATRICi | fig|1411691.4.peg.4333 |
Organism-specific databases
EchoBASEi | EB1135 |
Phylogenomic databases
eggNOGi | COG2199, Bacteria COG2200, Bacteria |
HOGENOMi | CLU_023566_2_0_6 |
InParanoidi | P23842 |
OMAi | IRIFWRR |
PhylomeDBi | P23842 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11145-MONOMER |
Miscellaneous databases
PROi | PR:P23842 |
Family and domain databases
CDDi | cd01948, EAL, 1 hit |
Gene3Di | 3.20.20.450, 1 hit 3.30.70.270, 1 hit |
InterProi | View protein in InterPro IPR001633, EAL_dom IPR035919, EAL_sf IPR000160, GGDEF_dom IPR007895, MASE1 IPR029787, Nucleotide_cyclase IPR043128, Rev_trsase/Diguanyl_cyclase |
Pfami | View protein in Pfam PF00563, EAL, 1 hit PF05231, MASE1, 1 hit |
SMARTi | View protein in SMART SM00052, EAL, 1 hit SM00267, GGDEF, 1 hit |
SUPFAMi | SSF141868, SSF141868, 1 hit SSF55073, SSF55073, 1 hit |
PROSITEi | View protein in PROSITE PS50883, EAL, 1 hit PS50887, GGDEF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PDEA_ECOLI | |
Accessioni | P23842Primary (citable) accession number: P23842 Secondary accession number(s): P76529, P76954 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | April 27, 2001 | |
Last modified: | May 25, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |