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UniProtKB - P23830 (PSS_ECOLI)
Protein
CDP-diacylglycerol--serine O-phosphatidyltransferase
Gene
pssA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:2.7.8.8
GO - Molecular functioni
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Source: InterPro
- CDP-diacylglycerol-serine O-phosphatidyltransferase activity Source: EcoCyc
- phospholipid binding Source: EcoCyc
GO - Biological processi
- cardiolipin biosynthetic process Source: InterPro
- phospholipid biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:PHOSPHASERSYN-MONOMER |
BRENDAi | 2.7.8.8, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: CDP-diacylglycerol--serine O-phosphatidyltransferase (EC:2.7.8.8)Alternative name(s): Phosphatidylserine synthase |
Gene namesi | Name:pssA Synonyms:pss Ordered Locus Names:b2585, JW2569 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Cytoplasm and Cytosol
Cytosol
- cytosol Source: EcoCyc
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056824 | 1 – 451 | CDP-diacylglycerol--serine O-phosphatidyltransferaseAdd BLAST | 451 |
Proteomic databases
jPOSTi | P23830 |
PaxDbi | P23830 |
PRIDEi | P23830 |
Interactioni
Subunit structurei
Multimeric.
Interacts with ACP, YbgC and PlsB, forming altogether a complex at the inner membrane.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4259429, 210 interactors |
DIPi | DIP-10593N |
IntActi | P23830, 35 interactors |
STRINGi | 511145.b2585 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 159 | PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST | 27 | |
Domaini | 352 – 379 | PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 154 | HydrophobicAdd BLAST | 36 | |
Regioni | 239 – 284 | HydrophobicAdd BLAST | 46 |
Sequence similaritiesi
Belongs to the CDP-alcohol phosphatidyltransferase class-II family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | COG1502, Bacteria |
HOGENOMi | CLU_051350_1_0_6 |
InParanoidi | P23830 |
PhylomeDBi | P23830 |
Family and domain databases
InterProi | View protein in InterPro IPR016270, PGS1 IPR025202, PLD-like_dom IPR001736, PLipase_D/transphosphatidylase |
PANTHERi | PTHR12586, PTHR12586, 1 hit |
Pfami | View protein in Pfam PF13091, PLDc_2, 2 hits |
SMARTi | View protein in SMART SM00155, PLDc, 2 hits |
PROSITEi | View protein in PROSITE PS50035, PLD, 2 hits |
i Sequence
Sequence statusi: Complete.
P23830-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSKFKRNKH QQHLAQLPKI SQSVDDVDFF YAPADFRETL LEKIASAKQR
60 70 80 90 100
ICIVALYLEQ DDGGKGILNA LYEAKRQRPE LDVRVLVDWH RAQRGRIGAA
110 120 130 140 150
ASNTNADWYC RMAQENPGVD VPVYGVPINT REALGVLHFK GFIIDDSVLY
160 170 180 190 200
SGASLNDVYL HQHDKYRYDR YHLIRNRKMS DIMFEWVTQN IMNGRGVNRL
210 220 230 240 250
DDVNRPKSPE IKNDIRLFRQ ELRDAAYHFQ GDADNDQLSV TPLVGLGKSS
260 270 280 290 300
LLNKTIFHLM PCAEQKLTIC TPYFNLPAIL VRNIIQLLRE GKKVEIIVGD
310 320 330 340 350
KTANDFYIPE DEPFKIIGAL PYLYEINLRR FLSRLQYYVN TDQLVVRLWK
360 370 380 390 400
DDDNTYHLKG MWVDDKWMLI TGNNLNPRAW RLDLENAILI HDPQLELAPQ
410 420 430 440 450
REKELELIRE HTTIVKHYRD LQSIADYPVK VRKLIRRLRR IRIDRLISRI
L
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | A → R in AAA97504 (PubMed:2002065).Curated | 1 | |
Sequence conflicti | 78 | R → DD in AAA97504 (PubMed:2002065).Curated | 1 | |
Sequence conflicti | 165 – 167 | KYR → NIA in AAA97504 (PubMed:2002065).Curated | 3 | |
Sequence conflicti | 287 – 288 | LL → FV in AAA97504 (PubMed:2002065).Curated | 2 | |
Sequence conflicti | 309 | P → S in AAA97504 (PubMed:2002065).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58699 Genomic DNA Translation: AAA97504.1 U00096 Genomic DNA Translation: AAC75638.2 AP009048 Genomic DNA Translation: BAA16470.2 |
RefSeqi | NP_417080.4, NC_000913.3 WP_000949265.1, NZ_STEB01000011.1 |
Genome annotation databases
EnsemblBacteriai | AAC75638; AAC75638; b2585 BAA16470; BAA16470; BAA16470 |
GeneIDi | 66673525 947059 |
KEGGi | ecj:JW2569 eco:b2585 |
PATRICi | fig|1411691.4.peg.4149 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58699 Genomic DNA Translation: AAA97504.1 U00096 Genomic DNA Translation: AAC75638.2 AP009048 Genomic DNA Translation: BAA16470.2 |
RefSeqi | NP_417080.4, NC_000913.3 WP_000949265.1, NZ_STEB01000011.1 |
3D structure databases
SMRi | P23830 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259429, 210 interactors |
DIPi | DIP-10593N |
IntActi | P23830, 35 interactors |
STRINGi | 511145.b2585 |
Proteomic databases
jPOSTi | P23830 |
PaxDbi | P23830 |
PRIDEi | P23830 |
Genome annotation databases
EnsemblBacteriai | AAC75638; AAC75638; b2585 BAA16470; BAA16470; BAA16470 |
GeneIDi | 66673525 947059 |
KEGGi | ecj:JW2569 eco:b2585 |
PATRICi | fig|1411691.4.peg.4149 |
Organism-specific databases
EchoBASEi | EB0774 |
Phylogenomic databases
eggNOGi | COG1502, Bacteria |
HOGENOMi | CLU_051350_1_0_6 |
InParanoidi | P23830 |
PhylomeDBi | P23830 |
Enzyme and pathway databases
BioCyci | EcoCyc:PHOSPHASERSYN-MONOMER |
BRENDAi | 2.7.8.8, 2026 |
Miscellaneous databases
PROi | PR:P23830 |
Family and domain databases
InterProi | View protein in InterPro IPR016270, PGS1 IPR025202, PLD-like_dom IPR001736, PLipase_D/transphosphatidylase |
PANTHERi | PTHR12586, PTHR12586, 1 hit |
Pfami | View protein in Pfam PF13091, PLDc_2, 2 hits |
SMARTi | View protein in SMART SM00155, PLDc, 2 hits |
PROSITEi | View protein in PROSITE PS50035, PLD, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PSS_ECOLI | |
Accessioni | P23830Primary (citable) accession number: P23830 Secondary accession number(s): P78100, P78256 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families