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Entry version 162 (08 May 2019)
Sequence version 1 (01 Nov 1991)
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Protein

Ecotin

Gene

eco

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei104 – 105Reactive bond2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: EcoCyc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10255-MONOMER
ECOL316407:JW2197-MONOMER

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I11.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ecotin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eco
Synonyms:eti
Ordered Locus Names:b2209, JW2197
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10255 eco

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02379 Beta-D-Glucose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 202 PublicationsAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000742321 – 162EcotinAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 107

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P23827

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P23827

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23827

PRoteomics IDEntifications database

More...
PRIDEi
P23827

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4262218, 13 interactors

Protein interaction database and analysis system

More...
IntActi
P23827, 6 interactors

Molecular INTeraction database

More...
MINTi
P23827

STRING: functional protein association networks

More...
STRINGi
511145.b2209

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZZX-ray2.30C/D21-162[»]
1ECYX-ray2.19A21-162[»]
1ECZX-ray2.68A/B21-162[»]
1EZSX-ray2.30A/B21-162[»]
1EZUX-ray2.40A/B21-162[»]
1FI8X-ray2.20C/E21-109[»]
D/F105-162[»]
1ID5X-ray2.50I21-162[»]
1IFGX-ray2.00A26-162[»]
1N8OX-ray2.00E21-162[»]
1P0SX-ray2.80E21-162[»]
1SLUX-ray1.80A21-162[»]
1SLVX-ray2.30A21-162[»]
1SLWX-ray2.00A21-162[»]
1SLXX-ray2.20A21-162[»]
1XX9X-ray2.20C/D21-162[»]
1XXDX-ray2.91C/D21-162[»]
1XXFX-ray2.60C/D21-162[»]
4IW4X-ray3.20C/D21-162[»]
4NIYX-ray2.84E/F/G/H21-162[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P23827

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P23827

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108QSZ Bacteria
COG4574 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263245

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23827

KEGG Orthology (KO)

More...
KOi
K08276

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P23827

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00242 Ecotin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1230.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00706 Ecotin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027438 Ecotin_C
IPR036198 Ecotin_sf
IPR005658 Prot_inh_ecotin
IPR023084 Prot_inh_ecotin_gammaproteobac

The PANTHER Classification System

More...
PANTHERi
PTHR35890 PTHR35890, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03974 Ecotin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006865 Prot_inh_ecotin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49772 SSF49772, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P23827-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTILPAVLF AAFATTSAWA AESVQPLEKI APYPQAEKGM KRQVIQLTPQ
60 70 80 90 100
EDESTLKVEL LIGQTLEVDC NLHRLGGKLE NKTLEGWGYD YYVFDKVSSP
110 120 130 140 150
VSTMMACPDG KKEKKFVTAY LGDAGMLRYN SKLPIVVYTP DNVDVKYRVW
160
KAEEKIDNAV VR
Length:162
Mass (Da):18,192
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE965383177B92ECD
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA16410 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60876 Genomic DNA Translation: AAA23719.1
X61951 Genomic DNA Translation: CAA43954.1
U00008 Genomic DNA Translation: AAA16410.1 Different initiation.
U00096 Genomic DNA Translation: AAC75269.1
AP009048 Genomic DNA Translation: BAA15992.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38742

NCBI Reference Sequences

More...
RefSeqi
NP_416713.1, NC_000913.3
WP_000849209.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC75269; AAC75269; b2209
BAA15992; BAA15992; BAA15992

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946700

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW2197
eco:b2209

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.26

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60876 Genomic DNA Translation: AAA23719.1
X61951 Genomic DNA Translation: CAA43954.1
U00008 Genomic DNA Translation: AAA16410.1 Different initiation.
U00096 Genomic DNA Translation: AAC75269.1
AP009048 Genomic DNA Translation: BAA15992.1
PIRiA38742
RefSeqiNP_416713.1, NC_000913.3
WP_000849209.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZZX-ray2.30C/D21-162[»]
1ECYX-ray2.19A21-162[»]
1ECZX-ray2.68A/B21-162[»]
1EZSX-ray2.30A/B21-162[»]
1EZUX-ray2.40A/B21-162[»]
1FI8X-ray2.20C/E21-109[»]
D/F105-162[»]
1ID5X-ray2.50I21-162[»]
1IFGX-ray2.00A26-162[»]
1N8OX-ray2.00E21-162[»]
1P0SX-ray2.80E21-162[»]
1SLUX-ray1.80A21-162[»]
1SLVX-ray2.30A21-162[»]
1SLWX-ray2.00A21-162[»]
1SLXX-ray2.20A21-162[»]
1XX9X-ray2.20C/D21-162[»]
1XXDX-ray2.91C/D21-162[»]
1XXFX-ray2.60C/D21-162[»]
4IW4X-ray3.20C/D21-162[»]
4NIYX-ray2.84E/F/G/H21-162[»]
SMRiP23827
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262218, 13 interactors
IntActiP23827, 6 interactors
MINTiP23827
STRINGi511145.b2209

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose

Protein family/group databases

MEROPSiI11.001

Proteomic databases

EPDiP23827
jPOSTiP23827
PaxDbiP23827
PRIDEiP23827

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75269; AAC75269; b2209
BAA15992; BAA15992; BAA15992
GeneIDi946700
KEGGiecj:JW2197
eco:b2209
PATRICifig|1411691.4.peg.26

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0251
EcoGeneiEG10255 eco

Phylogenomic databases

eggNOGiENOG4108QSZ Bacteria
COG4574 LUCA
HOGENOMiHOG000263245
InParanoidiP23827
KOiK08276
PhylomeDBiP23827

Enzyme and pathway databases

BioCyciEcoCyc:EG10255-MONOMER
ECOL316407:JW2197-MONOMER

Miscellaneous databases

EvolutionaryTraceiP23827

Protein Ontology

More...
PROi
PR:P23827

Family and domain databases

CDDicd00242 Ecotin, 1 hit
Gene3Di4.10.1230.10, 1 hit
HAMAPiMF_00706 Ecotin, 1 hit
InterProiView protein in InterPro
IPR027438 Ecotin_C
IPR036198 Ecotin_sf
IPR005658 Prot_inh_ecotin
IPR023084 Prot_inh_ecotin_gammaproteobac
PANTHERiPTHR35890 PTHR35890, 1 hit
PfamiView protein in Pfam
PF03974 Ecotin, 1 hit
PIRSFiPIRSF006865 Prot_inh_ecotin, 1 hit
SUPFAMiSSF49772 SSF49772, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECOT_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23827
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 8, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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