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Protein

Homeobox protein Hox-D11

Gene

Hoxd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi251 – 310HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11
Alternative name(s):
Homeobox protein Hox-4.6
Homeobox protein Hox-5.5
Gene namesi
Name:Hoxd11
Synonyms:Hox-4.6, Hoxd-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96203 Hoxd11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002321 – 323Homeobox protein Hox-D11Add BLAST323

Proteomic databases

PaxDbiP23813
PRIDEiP23813

PTM databases

iPTMnetiP23813
PhosphoSitePlusiP23813

Expressioni

Developmental stagei

Expressed during development of the posterior part of the body.

Gene expression databases

CleanExiMM_HOXD11

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122582

Structurei

3D structure databases

ProteinModelPortaliP23813
SMRiP23813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi64 – 87Poly-GlyAdd BLAST24
Compositional biasi93 – 105Poly-AlaAdd BLAST13

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
HOVERGENiHBG052048
InParanoidiP23813
KOiK09296

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 2 hits
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P23813-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF
60 70 80 90 100
RDYGLERAKW PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA
110 120 130 140 150
AAAAAEEAAM QRDLLPPAGR RPDVLFKAPE PVCGAPGPPH GPAAAASNFY
160 170 180 190 200
SAVGRNGILP QGFDQFYEAA PGPPFAGPQP QPAPAPPQPE GAADKGDPKP
210 220 230 240 250
GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE KSGGTVAPQR
260 270 280 290 300
SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ
310 320
NRRMKEKKLN RDRLQYFTGN PLF
Length:323
Mass (Da):33,546
Last modified:December 1, 1992 - v2
Checksum:iB003D1347F5FE771
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ASM7A2ASM7_MOUSE
Homeo box D11
Hoxd11 mCG_50911
336Annotation score:

Sequence cautioni

The sequence CAA42943 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60761, X60762 Genomic DNA Translation: CAA43173.1
X71422 Genomic DNA Translation: CAA50553.1
X60395 Genomic DNA Translation: CAA42943.1 Different initiation.
PIRiS16318
RefSeqiNP_032299.1, NM_008273.2
UniGeneiMm.207763

Genome annotation databases

GeneIDi15431
KEGGimmu:15431

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60761, X60762 Genomic DNA Translation: CAA43173.1
X71422 Genomic DNA Translation: CAA50553.1
X60395 Genomic DNA Translation: CAA42943.1 Different initiation.
PIRiS16318
RefSeqiNP_032299.1, NM_008273.2
UniGeneiMm.207763

3D structure databases

ProteinModelPortaliP23813
SMRiP23813
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122582

PTM databases

iPTMnetiP23813
PhosphoSitePlusiP23813

Proteomic databases

PaxDbiP23813
PRIDEiP23813

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15431
KEGGimmu:15431

Organism-specific databases

CTDi3237
MGIiMGI:96203 Hoxd11

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
HOVERGENiHBG052048
InParanoidiP23813
KOiK09296

Miscellaneous databases

PROiPR:P23813
SOURCEiSearch...

Gene expression databases

CleanExiMM_HOXD11

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 2 hits
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD11_MOUSE
AccessioniPrimary (citable) accession number: P23813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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