We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P23813 (HXD11_MOUSE)
Protein
Homeobox protein Hox-D11
Gene
Hoxd11
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 251 – 310 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- anatomical structure development Source: GO_Central
- anterior/posterior pattern specification Source: MGI
- branching involved in ureteric bud morphogenesis Source: MGI
- cartilage development involved in endochondral bone morphogenesis Source: MGI
- developmental growth Source: MGI
- dorsal/ventral pattern formation Source: MGI
- embryonic digit morphogenesis Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- embryonic skeletal joint morphogenesis Source: MGI
- metanephros development Source: MGI
- organ induction Source: MGI
- pattern specification process Source: MGI
- positive regulation of cell development Source: MGI
- positive regulation of chondrocyte differentiation Source: MGI
- proximal/distal pattern formation Source: MGI
- regulation of chondrocyte differentiation Source: MGI
- regulation of gene expression Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- single fertilization Source: MGI
- skeletal system development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-D11Alternative name(s): Homeobox protein Hox-4.6 Homeobox protein Hox-5.5 |
Gene namesi | Name:Hoxd11 Synonyms:Hox-4.6, Hoxd-11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96203, Hoxd11 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200232 | 1 – 323 | Homeobox protein Hox-D11Add BLAST | 323 |
Proteomic databases
PaxDbi | P23813 |
PRIDEi | P23813 |
ProteomicsDBi | 273330 |
PTM databases
iPTMneti | P23813 |
PhosphoSitePlusi | P23813 |
Expressioni
Developmental stagei
Expressed during development of the posterior part of the body.
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000122582 |
Miscellaneous databases
RNActi | P23813, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 164 – 255 | DisorderedSequence analysisAdd BLAST | 92 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 173 – 193 | Pro residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
InParanoidi | P23813 |
OrthoDBi | 976319at2759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR021918, DUF3528 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF12045, DUF3528, 2 hits PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P23813-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF
60 70 80 90 100
RDYGLERAKW PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA
110 120 130 140 150
AAAAAEEAAM QRDLLPPAGR RPDVLFKAPE PVCGAPGPPH GPAAAASNFY
160 170 180 190 200
SAVGRNGILP QGFDQFYEAA PGPPFAGPQP QPAPAPPQPE GAADKGDPKP
210 220 230 240 250
GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE KSGGTVAPQR
260 270 280 290 300
SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ
310 320
NRRMKEKKLN RDRLQYFTGN PLF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2ASM7 | A2ASM7_MOUSE | Homeo box D11 | Hoxd11 | 336 | Annotation score: |
Sequence cautioni
The sequence CAA42943 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60761, X60762 Genomic DNA Translation: CAA43173.1 X71422 Genomic DNA Translation: CAA50553.1 X60395 Genomic DNA Translation: CAA42943.1 Different initiation. |
PIRi | S16318 |
RefSeqi | NP_032299.1, NM_008273.2 |
Genome annotation databases
GeneIDi | 15431 |
KEGGi | mmu:15431 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60761, X60762 Genomic DNA Translation: CAA43173.1 X71422 Genomic DNA Translation: CAA50553.1 X60395 Genomic DNA Translation: CAA42943.1 Different initiation. |
PIRi | S16318 |
RefSeqi | NP_032299.1, NM_008273.2 |
3D structure databases
SMRi | P23813 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000122582 |
PTM databases
iPTMneti | P23813 |
PhosphoSitePlusi | P23813 |
Proteomic databases
PaxDbi | P23813 |
PRIDEi | P23813 |
ProteomicsDBi | 273330 |
Protocols and materials databases
DNASUi | 15431 |
Genome annotation databases
GeneIDi | 15431 |
KEGGi | mmu:15431 |
Organism-specific databases
CTDi | 3237 |
MGIi | MGI:96203, Hoxd11 |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
InParanoidi | P23813 |
OrthoDBi | 976319at2759 |
Miscellaneous databases
BioGRID-ORCSi | 15431, 0 hits in 64 CRISPR screens |
PROi | PR:P23813 |
RNActi | P23813, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR021918, DUF3528 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF12045, DUF3528, 2 hits PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HXD11_MOUSE | |
Accessioni | P23813Primary (citable) accession number: P23813 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families