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Protein

Homeobox protein Hox-D12

Gene

Hoxd12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi200 – 259HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • embryonic digit morphogenesis Source: MGI
  • pattern specification process Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro
  • skeletal system development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12
Alternative name(s):
Homeobox protein Hox-4.7
Homeobox protein Hox-5.6
Gene namesi
Name:Hoxd12
Synonyms:Hox-4.7, Hoxd-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96204 Hoxd12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002391 – 268Homeobox protein Hox-D12Add BLAST268

Proteomic databases

MaxQBiP23812
PaxDbiP23812
PRIDEiP23812

PTM databases

iPTMnetiP23812
PhosphoSitePlusiP23812

Expressioni

Developmental stagei

Expressed during development of the posterior part of the body.

Gene expression databases

BgeeiENSMUSG00000001823 Expressed in 74 organ(s), highest expression level in thymus
CleanExiMM_HOXD12
GenevisibleiP23812 MM

Interactioni

Protein-protein interaction databases

BioGridi200394, 9 interactors
IntActiP23812, 1 interactor
STRINGi10090.ENSMUSP00000001878

Structurei

3D structure databases

ProteinModelPortaliP23812
SMRiP23812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiP23812
KOiK09297
OMAiKFYAPEA
OrthoDBiEOG091G0P35
PhylomeDBiP23812
TreeFamiTF351604

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23812-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP
60 70 80 90 100
WATTPASCTP AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF
110 120 130 140 150
YTPDAPTASE ERSRTRPPFA PESSLVHSAL KGTKYDYAGV GRTAPGSATL
160 170 180 190 200
LQGAPCASSF KEDTKGPLNL NMAVQVAGVA SCLRSSLPDG LPWGAAPGRA
210 220 230 240 250
RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS DQQVKIWFQN
260
RRMKKKRVVQ REQALALY
Length:268
Mass (Da):29,198
Last modified:September 22, 2009 - v2
Checksum:i5EA04C2B59336AC4
GO

Sequence cautioni

The sequence CAA41654 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58849 Genomic DNA Translation: CAA41654.1 Sequence problems.
AK031206 mRNA Translation: BAC27299.1
AL928644 Genomic DNA Translation: CAM20526.1
CH466519 Genomic DNA Translation: EDL27169.1
BC145656 mRNA Translation: AAI45657.1
CCDSiCCDS38147.1
PIRiS16317
RefSeqiNP_032300.2, NM_008274.3
UniGeneiMm.57124

Genome annotation databases

EnsembliENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823
GeneIDi15432
KEGGimmu:15432
UCSCiuc008kdv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58849 Genomic DNA Translation: CAA41654.1 Sequence problems.
AK031206 mRNA Translation: BAC27299.1
AL928644 Genomic DNA Translation: CAM20526.1
CH466519 Genomic DNA Translation: EDL27169.1
BC145656 mRNA Translation: AAI45657.1
CCDSiCCDS38147.1
PIRiS16317
RefSeqiNP_032300.2, NM_008274.3
UniGeneiMm.57124

3D structure databases

ProteinModelPortaliP23812
SMRiP23812
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200394, 9 interactors
IntActiP23812, 1 interactor
STRINGi10090.ENSMUSP00000001878

PTM databases

iPTMnetiP23812
PhosphoSitePlusiP23812

Proteomic databases

MaxQBiP23812
PaxDbiP23812
PRIDEiP23812

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001878; ENSMUSP00000001878; ENSMUSG00000001823
GeneIDi15432
KEGGimmu:15432
UCSCiuc008kdv.2 mouse

Organism-specific databases

CTDi3238
MGIiMGI:96204 Hoxd12

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231177
HOVERGENiHBG052050
InParanoidiP23812
KOiK09297
OMAiKFYAPEA
OrthoDBiEOG091G0P35
PhylomeDBiP23812
TreeFamiTF351604

Miscellaneous databases

PROiPR:P23812
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001823 Expressed in 74 organ(s), highest expression level in thymus
CleanExiMM_HOXD12
GenevisibleiP23812 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD12_MOUSE
AccessioniPrimary (citable) accession number: P23812
Secondary accession number(s): Q8BSN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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