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Protein

Secretin receptor

Gene

Sctr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • peptide binding Source: RGD
  • secretin receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Secretin receptor
Short name:
SCT-R
Gene namesi
Name:Sctr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621342 Sctr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 143ExtracellularSequence analysisAdd BLAST118
Transmembranei144 – 167Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini168 – 174CytoplasmicSequence analysis7
Transmembranei175 – 194Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini195 – 216ExtracellularSequence analysisAdd BLAST22
Transmembranei217 – 240Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini241 – 254CytoplasmicSequence analysisAdd BLAST14
Transmembranei255 – 276Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini277 – 294ExtracellularSequence analysisAdd BLAST18
Transmembranei295 – 317Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini318 – 343CytoplasmicSequence analysisAdd BLAST26
Transmembranei344 – 362Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini363 – 369ExtracellularSequence analysis7
Transmembranei370 – 392Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini393 – 449CytoplasmicSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi252

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001285426 – 449Secretin receptorAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP23811
PRIDEiP23811

PTM databases

PhosphoSitePlusiP23811

Interactioni

Protein-protein interaction databases

BioGridi249651, 1 interactor
STRINGi10116.ENSRNOP00000064579

Structurei

3D structure databases

ProteinModelPortaliP23811
SMRiP23811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOVERGENiHBG008318
InParanoidiP23811
KOiK04588
PhylomeDBiP23811

Family and domain databases

CDDicd15275 7tmB1_secretin, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR002144 GPCR_2_secretin_rcpt
PANTHERiPTHR12011:SF29 PTHR12011:SF29, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00490 SECRETINR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P23811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSTMRPRLS LLLLRLLLLT KAAHTVGVPP RLCDVRRVLL EERAHCLQQL
60 70 80 90 100
SKEKKGALGP ETASGCEGLW DNMSCWPSSA PARTVEVQCP KFLLMLSNKN
110 120 130 140 150
GSLFRNCTQD GWSETFPRPD LACGVNINNS FNERRHAYLL KLKVMYTVGY
160 170 180 190 200
SSSLAMLLVA LSILCSFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF
210 220 230 240 250
SSDDVTYCDA HKVGCKLVMI FFQYCIMANY AWLLVEGLYL HTLLAISFFS
260 270 280 290 300
ERKYLQAFVL LGWGSPAIFV ALWAITRHFL ENTGCWDINA NASVWWVIRG
310 320 330 340 350
PVILSILINF IFFINILRIL MRKLRTQETR GSETNHYKRL AKSTLLLIPL
360 370 380 390 400
FGIHYIVFAF SPEDAMEVQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ
410 420 430 440
KKWRQWHLQE FPLRPVAFNN SFSNATNGPT HSTKASTEQS RSIPRASII
Length:449
Mass (Da):51,234
Last modified:November 1, 1991 - v1
Checksum:iE70D05B5D061480D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R5B5M0R5B5_RAT
Secretin receptor
Sctr
448Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59132 mRNA Translation: CAA41849.1
BC081781 mRNA Translation: AAH81781.1
PIRiS16319
RefSeqiNP_112377.1, NM_031115.1
UniGeneiRn.32256

Genome annotation databases

GeneIDi81779
KEGGirno:81779

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59132 mRNA Translation: CAA41849.1
BC081781 mRNA Translation: AAH81781.1
PIRiS16319
RefSeqiNP_112377.1, NM_031115.1
UniGeneiRn.32256

3D structure databases

ProteinModelPortaliP23811
SMRiP23811
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249651, 1 interactor
STRINGi10116.ENSRNOP00000064579

Chemistry databases

GuidetoPHARMACOLOGYi252

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP23811

Proteomic databases

PaxDbiP23811
PRIDEiP23811

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81779
KEGGirno:81779

Organism-specific databases

CTDi6344
RGDi621342 Sctr

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOVERGENiHBG008318
InParanoidiP23811
KOiK04588
PhylomeDBiP23811

Miscellaneous databases

PROiPR:P23811

Family and domain databases

CDDicd15275 7tmB1_secretin, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR002144 GPCR_2_secretin_rcpt
PANTHERiPTHR12011:SF29 PTHR12011:SF29, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR00490 SECRETINR
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCTR_RAT
AccessioniPrimary (citable) accession number: P23811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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