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Protein

Polycomb group RING finger protein 2

Gene

Pcgf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor (PubMed:8521824). Binds specifically to the DNA sequence 5'-GACTNGACT-3' (PubMed:8521824). Has tumor suppressor activity (PubMed:8521824). May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1(PubMed:15728456). Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (PubMed:8625838, PubMed:15183898). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity).By similarityCurated5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • promoter-specific chromatin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 2
Alternative name(s):
DNA-binding protein Mel-18
Melanoma nuclear protein 18
RING finger protein 110
Zinc finger protein 144
Short name:
Zfp-144
Gene namesi
Name:Pcgf2
Synonyms:Mel-18, Mel18, Rnf110, Zfp144, Znf144
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99161 Pcgf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Probably related to tumorigenesis since it is expressed strongly in most tumor cell lines.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559851 – 342Polycomb group RING finger protein 2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei237Phosphothreonine; by PKASequence analysis1
Modified residuei334Phosphothreonine; by PKASequence analysis1

Post-translational modificationi

Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP23798
PaxDbiP23798
PeptideAtlasiP23798
PRIDEiP23798

PTM databases

iPTMnetiP23798
PhosphoSitePlusiP23798

Expressioni

Tissue specificityi

Expressed in embryonic stem cells (PubMed:22226355). Expressed in a variety of tumor cells and in neural tissues (PubMed:2246278).2 Publications

Developmental stagei

Developmentally regulated.1 Publication

Gene expression databases

BgeeiENSMUSG00000018537 Expressed in 241 organ(s), highest expression level in frontal cortex
CleanExiMM_PCGF2
ExpressionAtlasiP23798 baseline and differential
GenevisibleiP23798 MM

Interactioni

Subunit structurei

Exists as both a monomer and homodimer (PubMed:12480532). Component of a PRC1-like complex. Interacts with CBX8, RING1 AND RNF2 (By similarity). Interacts with CBX7 (PubMed:22226355). Interacts with PHC2 (PubMed:16024804).By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi204639, 13 interactors
CORUMiP23798
DIPiDIP-37645N
IntActiP23798, 14 interactors
MINTiP23798
STRINGi10090.ENSMUSP00000018681

Structurei

3D structure databases

ProteinModelPortaliP23798
SMRiP23798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 95Nuclear localization signalSequence analysisAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 342Pro/Ser-richAdd BLAST101

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231945
HOVERGENiHBG052826
InParanoidiP23798
KOiK11460
OMAiFYEWRRT
OrthoDBiEOG091G09IB
PhylomeDBiP23798
TreeFamiTF324206

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039642 E3_Ub_ligase/polycomb_RING
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825 PTHR10825, 1 hit
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P23798-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN
60 70 80 90 100
KYCPMCDVQV HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA
110 120 130 140 150
YPLTEVPNGS NEDRGEVLEQ EKGALGDDEI VSLSIEFYEG VRDREEKKNL
160 170 180 190 200
TENGDGDKEK TGVRFLRCPA AMTVMHLAKF LRNKMDVPSK YKVEILYEDE
210 220 230 240 250
PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLPT VPTPSEGTNT
260 270 280 290 300
SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP
310 320 330 340
TPPSTAAGTT TATNGGTSNC LQTPSSTSRG RKMTVNGAPC PP
Length:342
Mass (Da):37,723
Last modified:May 1, 1992 - v2
Checksum:iC23031B8B9E30108
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AR14B1AR14_MOUSE
Polycomb group RING finger protein ...
Pcgf2
158Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90085 mRNA Translation: BAA14122.1
AF483502 mRNA Translation: AAL90776.1
AF483503 mRNA Translation: AAL90777.1
BC016419 mRNA Translation: AAH16419.1
CCDSiCCDS25327.1
PIRiA37991
RefSeqiNP_001156779.1, NM_001163307.1
NP_001156780.1, NM_001163308.1
NP_033571.1, NM_009545.2
XP_011247274.1, XM_011248972.2
XP_011247275.1, XM_011248973.2
XP_011247277.1, XM_011248975.2
XP_017169992.1, XM_017314503.1
UniGeneiMm.2418

Genome annotation databases

EnsembliENSMUST00000018681; ENSMUSP00000018681; ENSMUSG00000018537
ENSMUST00000103148; ENSMUSP00000099437; ENSMUSG00000018537
ENSMUST00000169807; ENSMUSP00000126967; ENSMUSG00000018537
ENSMUST00000179765; ENSMUSP00000137517; ENSMUSG00000018537
GeneIDi22658
KEGGimmu:22658
UCSCiuc007lel.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90085 mRNA Translation: BAA14122.1
AF483502 mRNA Translation: AAL90776.1
AF483503 mRNA Translation: AAL90777.1
BC016419 mRNA Translation: AAH16419.1
CCDSiCCDS25327.1
PIRiA37991
RefSeqiNP_001156779.1, NM_001163307.1
NP_001156780.1, NM_001163308.1
NP_033571.1, NM_009545.2
XP_011247274.1, XM_011248972.2
XP_011247275.1, XM_011248973.2
XP_011247277.1, XM_011248975.2
XP_017169992.1, XM_017314503.1
UniGeneiMm.2418

3D structure databases

ProteinModelPortaliP23798
SMRiP23798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204639, 13 interactors
CORUMiP23798
DIPiDIP-37645N
IntActiP23798, 14 interactors
MINTiP23798
STRINGi10090.ENSMUSP00000018681

PTM databases

iPTMnetiP23798
PhosphoSitePlusiP23798

Proteomic databases

MaxQBiP23798
PaxDbiP23798
PeptideAtlasiP23798
PRIDEiP23798

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018681; ENSMUSP00000018681; ENSMUSG00000018537
ENSMUST00000103148; ENSMUSP00000099437; ENSMUSG00000018537
ENSMUST00000169807; ENSMUSP00000126967; ENSMUSG00000018537
ENSMUST00000179765; ENSMUSP00000137517; ENSMUSG00000018537
GeneIDi22658
KEGGimmu:22658
UCSCiuc007lel.2 mouse

Organism-specific databases

CTDi7703
MGIiMGI:99161 Pcgf2

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231945
HOVERGENiHBG052826
InParanoidiP23798
KOiK11460
OMAiFYEWRRT
OrthoDBiEOG091G09IB
PhylomeDBiP23798
TreeFamiTF324206

Enzyme and pathway databases

ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-4551638 SUMOylation of chromatin organization proteins
R-MMU-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRSiPcgf2 mouse
PROiPR:P23798
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018537 Expressed in 241 organ(s), highest expression level in frontal cortex
CleanExiMM_PCGF2
ExpressionAtlasiP23798 baseline and differential
GenevisibleiP23798 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039642 E3_Ub_ligase/polycomb_RING
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825 PTHR10825, 1 hit
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCGF2_MOUSE
AccessioniPrimary (citable) accession number: P23798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: May 1, 1992
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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