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Protein

Carnitine O-palmitoyltransferase 2, mitochondrial

Gene

CPT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei372Proton acceptorBy similarity1
Binding sitei486CarnitineBy similarity1
Binding sitei488CarnitineBy similarity1
Binding sitei499CarnitineBy similarity1

GO - Molecular functioni

GO - Biological processi

  • carnitine shuttle Source: Reactome
  • fatty acid beta-oxidation Source: GO_Central
  • positive regulation of cold-induced thermogenesis Source: YuBioLab
  • regulation of lipid metabolic process Source: Reactome

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS08187-MONOMER
BRENDAi2.3.1.21 2681
ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
UniPathwayi
UPA00659

Chemistry databases

SwissLipidsiSLP:000001044

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitine O-palmitoyltransferase 2, mitochondrial (EC:2.3.1.21)
Alternative name(s):
Carnitine palmitoyltransferase II
Short name:
CPT II
Gene namesi
Name:CPT2
Synonyms:CPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157184.5
HGNCiHGNC:2330 CPT2
MIMi600650 gene
neXtProtiNX_P23786

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 178Mitochondrial matrixBy similarityAdd BLAST153
Intramembranei179 – 208Note=Mitochondrial inner membraneBy similarityAdd BLAST30
Topological domaini209 – 658Mitochondrial matrixBy similarityAdd BLAST450

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Involvement in diseasei

Carnitine palmitoyltransferase 2 deficiency, myopathic, stress-induced (CPT2D)14 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation, characterized by recurrent myoglobinuria, episodes of muscle pain, stiffness, and rhabdomyolysis. These symptoms are exacerbated by prolonged exercise, fasting, cold, or viral infection. CPT2DM affects most frequently children or young adults, and severity of attacks is highly variable. Myoglobinuria can cause kidney failure and death.
See also OMIM:255110
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00139150P → H in CPT2D; muscular type. 2 PublicationsCorresponds to variant dbSNP:rs28936375EnsemblClinVar.1
Natural variantiVAR_001392113S → L in CPT2D; muscular form; frequent mutation. 4 PublicationsCorresponds to variant dbSNP:rs74315294EnsemblClinVar.1
Natural variantiVAR_020540151R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs515726177EnsemblClinVar.1
Natural variantiVAR_001393174E → K in CPT2D; muscular type. 1 PublicationCorresponds to variant dbSNP:rs28936674EnsemblClinVar.1
Natural variantiVAR_020541210Y → D in CPT2D. 1 Publication1
Natural variantiVAR_037976213D → G in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315300EnsemblClinVar.1
Natural variantiVAR_007966214M → T in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs515726174EnsemblClinVar.1
Natural variantiVAR_007967227P → L in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs74315298EnsemblClinVar.1
Natural variantiVAR_020542296R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs764849762Ensembl.1
Natural variantiVAR_001396383F → Y in CPT2D; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315295EnsemblClinVar.1
Natural variantiVAR_007968448F → L in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315297EnsemblClinVar.1
Natural variantiVAR_007969479Y → F in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs749895856EnsemblClinVar.1
Natural variantiVAR_007970503R → C in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315296EnsemblClinVar.1
Natural variantiVAR_007971549G → D in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs186044004EnsemblClinVar.1
Natural variantiVAR_020543550Q → R in CPT2D. 1 Publication1
Natural variantiVAR_001397553D → N in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs28936376EnsemblClinVar.1
Natural variantiVAR_020544600G → R in CPT2D. 1 Publication1
Natural variantiVAR_020545604P → S in CPT2D. 1 Publication1
Carnitine palmitoyltransferase 2 deficiency, infantile (CPT2DI)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation, characterized by hepatic or hepato-cardio-muscular manifestations with onset in infancy. Clinical features include hypoketotic hypoglycemia, lethargy, seizures, hepatomegaly, liver dysfunction, cardiomegaly and dilated cardiomyopathy.
See also OMIM:600649
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_001398628Y → S in CPT2DI; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673EnsemblClinVar.1
Natural variantiVAR_001399631R → C in CPT2DI; early-onset hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315293EnsemblClinVar.1
Carnitine palmitoyltransferase 2 deficiency, lethal neonatal (CPT2DLN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial long-chain fatty acid oxidation with fatal outcome, presenting shortly after birth. It is characterized by respiratory distress, seizures, altered mental status, hepatomegaly, cardiomegaly, cardiac arrhythmia, and, in many cases, dysmorphic features, renal dysgenesis, and migration defects. recessive.
See also OMIM:608836
Encephalopathy, acute, infection-induced, 4 (IIAE4)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. CPT2 polymorphic variants do not cause classical carnitine palmitoyltransferase 2 deficiency, and patients harboring any of them are asymptomatic most of the time. However, they are prone to viral infection (high fever)-related encephalopathy (PubMed:21697855).1 Publication
Disease descriptionA severe neurologic complication of an infection. It manifests within days in otherwise healthy children after common viral infections, without evidence of viral infection of the brain or inflammatory cell infiltration. In affected children, high-grade fever is accompanied within 12 to 48 hours by febrile convulsions, often leading to coma, multiple-organ failure, brain edema, and high morbidity and mortality. The infections are usually viral, particularly influenza, although other viruses and even mycoplasma have been found to cause the disorder.
See also OMIM:614212

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1376
GeneReviewsiCPT2
MalaCardsiCPT2
MIMi255110 phenotype
600649 phenotype
608836 phenotype
614212 phenotype
OpenTargetsiENSG00000157184
Orphaneti263524 Acute necrotizing encephalopathy of childhood
228302 Carnitine palmitoyl transferase II deficiency, myopathic form
228308 Carnitine palmitoyl transferase II deficiency, neonatal form
228305 Carnitine palmitoyl transferase II deficiency, severe infantile form
PharmGKBiPA26849

Chemistry databases

ChEMBLiCHEMBL3238
DrugBankiDB00583 L-Carnitine
DB01074 Perhexiline

Polymorphism and mutation databases

BioMutaiCPT2
DMDMi416836

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionAdd BLAST25
ChainiPRO_000000442426 – 658Carnitine O-palmitoyltransferase 2, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69N6-succinyllysineBy similarity1
Modified residuei79N6-acetyllysineBy similarity1
Modified residuei85N6-succinyllysineBy similarity1
Modified residuei239N6-acetyllysine; alternateBy similarity1
Modified residuei239N6-succinyllysine; alternateBy similarity1
Modified residuei305N6-acetyllysineBy similarity1
Modified residuei424N6-succinyllysineBy similarity1
Modified residuei439N6-succinyllysineBy similarity1
Modified residuei510N6-acetyllysine; alternateBy similarity1
Modified residuei510N6-succinyllysine; alternateBy similarity1
Modified residuei544N6-acetyllysine; alternateBy similarity1
Modified residuei544N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP23786
MaxQBiP23786
PaxDbiP23786
PeptideAtlasiP23786
PRIDEiP23786
ProteomicsDBi54164

2D gel databases

REPRODUCTION-2DPAGEiIPI00012912

PTM databases

iPTMnetiP23786
PhosphoSitePlusiP23786
SwissPalmiP23786

Expressioni

Gene expression databases

BgeeiENSG00000157184 Expressed in 204 organ(s), highest expression level in quadriceps femoris
CleanExiHS_CPT2
ExpressionAtlasiP23786 baseline and differential
GenevisibleiP23786 HS

Organism-specific databases

HPAiHPA028201
HPA028202
HPA028214

Interactioni

Protein-protein interaction databases

BioGridi107767, 36 interactors
IntActiP23786, 8 interactors
MINTiP23786
STRINGi9606.ENSP00000360541

Chemistry databases

BindingDBiP23786

Structurei

3D structure databases

ProteinModelPortaliP23786
SMRiP23786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni452 – 464Coenzyme A bindingBy similarityAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3719 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00550000074786
HOGENOMiHOG000007446
HOVERGENiHBG098001
InParanoidiP23786
KOiK08766
OrthoDBiEOG091G0697
PhylomeDBiP23786
TreeFamiTF315202

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR039551 Cho/carn_acyl_trans
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P23786-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPRLLLRAW PRGPAVGPGA PSRPLSAGSG PGQYLQRSIV PTMHYQDSLP
60 70 80 90 100
RLPIPKLEDT IRRYLSAQKP LLNDGQFRKT EQFCKSFENG IGKELHEQLV
110 120 130 140 150
ALDKQNKHTS YISGPWFDMY LSARDSVVLN FNPFMAFNPD PKSEYNDQLT
160 170 180 190 200
RATNMTVSAI RFLKTLRAGL LEPEVFHLNP AKSDTITFKR LIRFVPSSLS
210 220 230 240 250
WYGAYLVNAY PLDMSQYFRL FNSTRLPKPS RDELFTDDKA RHLLVLRKGN
260 270 280 290 300
FYIFDVLDQD GNIVSPSEIQ AHLKYILSDS SPAPEFPLAY LTSENRDIWA
310 320 330 340 350
ELRQKLMSSG NEESLRKVDS AVFCLCLDDF PIKDLVHLSH NMLHGDGTNR
360 370 380 390 400
WFDKSFNLII AKDGSTAVHF EHSWGDGVAV LRFFNEVFKD STQTPAVTPQ
410 420 430 440 450
SQPATTDSTV TVQKLNFELT DALKTGITAA KEKFDATMKT LTIDCVQFQR
460 470 480 490 500
GGKEFLKKQK LSPDAVAQLA FQMAFLRQYG QTVATYESCS TAAFKHGRTE
510 520 530 540 550
TIRPASVYTK RCSEAFVREP SRHSAGELQQ MMVECSKYHG QLTKEAAMGQ
560 570 580 590 600
GFDRHLFALR HLAAAKGIIL PELYLDPAYG QINHNVLSTS TLSSPAVNLG
610 620 630 640 650
GFAPVVSDGF GVGYAVHDNW IGCNVSSYPG RNAREFLQCV EKALEDMFDA

LEGKSIKS
Length:658
Mass (Da):73,777
Last modified:October 1, 1993 - v2
Checksum:i6444B75ACD57140F
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTB8A0A1B0GTB8_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
635Annotation score:
A0A1B0GVF3A0A1B0GVF3_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
670Annotation score:
A0A1B0GV75A0A1B0GV75_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
598Annotation score:
A0A1B0GWC0A0A1B0GWC0_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
647Annotation score:
A0A1B0GUD9A0A1B0GUD9_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
81Annotation score:
A0A1B0GTM0A0A1B0GTM0_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
223Annotation score:
A0A1B0GUB8A0A1B0GUB8_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
72Annotation score:
A0A1B0GTL9A0A1B0GTL9_HUMAN
Carnitine O-palmitoyltransferase 2,...
CPT2
54Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00139150P → H in CPT2D; muscular type. 2 PublicationsCorresponds to variant dbSNP:rs28936375EnsemblClinVar.1
Natural variantiVAR_001392113S → L in CPT2D; muscular form; frequent mutation. 4 PublicationsCorresponds to variant dbSNP:rs74315294EnsemblClinVar.1
Natural variantiVAR_020540151R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs515726177EnsemblClinVar.1
Natural variantiVAR_001393174E → K in CPT2D; muscular type. 1 PublicationCorresponds to variant dbSNP:rs28936674EnsemblClinVar.1
Natural variantiVAR_020541210Y → D in CPT2D. 1 Publication1
Natural variantiVAR_037976213D → G in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315300EnsemblClinVar.1
Natural variantiVAR_007966214M → T in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs515726174EnsemblClinVar.1
Natural variantiVAR_007967227P → L in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs74315298EnsemblClinVar.1
Natural variantiVAR_020542296R → Q in CPT2D. 2 PublicationsCorresponds to variant dbSNP:rs764849762Ensembl.1
Natural variantiVAR_001394352F → C Polymorphism associated with susceptibility to IIAE4; 3-fold decrease of affinity for L-carnitine; lower thermal stability compared to wild-type. 4 PublicationsCorresponds to variant dbSNP:rs2229291EnsemblClinVar.1
Natural variantiVAR_001395368V → I Common polymorphism associated with susceptibility to IIAE4; no effect on activity; does not affect affinity for L-carnitine; lower thermal stability compared to wild-type. 6 PublicationsCorresponds to variant dbSNP:rs1799821EnsemblClinVar.1
Natural variantiVAR_001396383F → Y in CPT2D; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315295EnsemblClinVar.1
Natural variantiVAR_007968448F → L in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315297EnsemblClinVar.1
Natural variantiVAR_007969479Y → F in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs749895856EnsemblClinVar.1
Natural variantiVAR_007970503R → C in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs74315296EnsemblClinVar.1
Natural variantiVAR_066567504P → L in a patient with IIAE4. 1 PublicationCorresponds to variant dbSNP:rs368311455Ensembl.1
Natural variantiVAR_007971549G → D in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs186044004EnsemblClinVar.1
Natural variantiVAR_020543550Q → R in CPT2D. 1 Publication1
Natural variantiVAR_001397553D → N in CPT2D. 1 PublicationCorresponds to variant dbSNP:rs28936376EnsemblClinVar.1
Natural variantiVAR_011741588S → C. Corresponds to variant dbSNP:rs1871748EnsemblClinVar.1
Natural variantiVAR_020544600G → R in CPT2D. 1 Publication1
Natural variantiVAR_020545604P → S in CPT2D. 1 Publication1
Natural variantiVAR_066568605V → L in a patient with IIAE4. 1 PublicationCorresponds to variant dbSNP:rs751557097Ensembl.1
Natural variantiVAR_001398628Y → S in CPT2DI; hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs28936673EnsemblClinVar.1
Natural variantiVAR_001399631R → C in CPT2DI; early-onset hepatocardiomuscular form. 1 PublicationCorresponds to variant dbSNP:rs74315293EnsemblClinVar.1
Natural variantiVAR_001400647M → V Common polymorphism; confirmed at protein level. 7 PublicationsCorresponds to variant dbSNP:rs1799822EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09648 mRNA Translation: AAB60383.1
M58581 mRNA Translation: AAB59462.1
U09646
, U09642, U09643, U09644, U09645 Genomic DNA Translation: AAB60382.1
AK312687 mRNA Translation: BAG35567.1
AL606760 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06753.1
BC002445 mRNA Translation: AAH02445.1
BC005172 mRNA Translation: AAH05172.1
CCDSiCCDS575.1
PIRiA39018
RefSeqiNP_000089.1, NM_000098.2
UniGeneiHs.713535

Genome annotation databases

EnsembliENST00000371486; ENSP00000360541; ENSG00000157184
GeneIDi1376
KEGGihsa:1376
UCSCiuc001cvb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09648 mRNA Translation: AAB60383.1
M58581 mRNA Translation: AAB59462.1
U09646
, U09642, U09643, U09644, U09645 Genomic DNA Translation: AAB60382.1
AK312687 mRNA Translation: BAG35567.1
AL606760 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06753.1
BC002445 mRNA Translation: AAH02445.1
BC005172 mRNA Translation: AAH05172.1
CCDSiCCDS575.1
PIRiA39018
RefSeqiNP_000089.1, NM_000098.2
UniGeneiHs.713535

3D structure databases

ProteinModelPortaliP23786
SMRiP23786
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107767, 36 interactors
IntActiP23786, 8 interactors
MINTiP23786
STRINGi9606.ENSP00000360541

Chemistry databases

BindingDBiP23786
ChEMBLiCHEMBL3238
DrugBankiDB00583 L-Carnitine
DB01074 Perhexiline
SwissLipidsiSLP:000001044

PTM databases

iPTMnetiP23786
PhosphoSitePlusiP23786
SwissPalmiP23786

Polymorphism and mutation databases

BioMutaiCPT2
DMDMi416836

2D gel databases

REPRODUCTION-2DPAGEiIPI00012912

Proteomic databases

EPDiP23786
MaxQBiP23786
PaxDbiP23786
PeptideAtlasiP23786
PRIDEiP23786
ProteomicsDBi54164

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371486; ENSP00000360541; ENSG00000157184
GeneIDi1376
KEGGihsa:1376
UCSCiuc001cvb.4 human

Organism-specific databases

CTDi1376
DisGeNETi1376
EuPathDBiHostDB:ENSG00000157184.5
GeneCardsiCPT2
GeneReviewsiCPT2
HGNCiHGNC:2330 CPT2
HPAiHPA028201
HPA028202
HPA028214
MalaCardsiCPT2
MIMi255110 phenotype
600649 phenotype
600650 gene
608836 phenotype
614212 phenotype
neXtProtiNX_P23786
OpenTargetsiENSG00000157184
Orphaneti263524 Acute necrotizing encephalopathy of childhood
228302 Carnitine palmitoyl transferase II deficiency, myopathic form
228308 Carnitine palmitoyl transferase II deficiency, neonatal form
228305 Carnitine palmitoyl transferase II deficiency, severe infantile form
PharmGKBiPA26849
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3719 Eukaryota
ENOG410XNZ9 LUCA
GeneTreeiENSGT00550000074786
HOGENOMiHOG000007446
HOVERGENiHBG098001
InParanoidiP23786
KOiK08766
OrthoDBiEOG091G0697
PhylomeDBiP23786
TreeFamiTF315202

Enzyme and pathway databases

UniPathwayi
UPA00659

BioCyciMetaCyc:HS08187-MONOMER
BRENDAi2.3.1.21 2681
ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Miscellaneous databases

ChiTaRSiCPT2 human
GeneWikiiCarnitine_palmitoyltransferase_II
GenomeRNAii1376
PROiPR:P23786
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157184 Expressed in 204 organ(s), highest expression level in quadriceps femoris
CleanExiHS_CPT2
ExpressionAtlasiP23786 baseline and differential
GenevisibleiP23786 HS

Family and domain databases

InterProiView protein in InterPro
IPR000542 Carn_acyl_trans
IPR039551 Cho/carn_acyl_trans
PANTHERiPTHR22589 PTHR22589, 1 hit
PfamiView protein in Pfam
PF00755 Carn_acyltransf, 1 hit
PROSITEiView protein in PROSITE
PS00439 ACYLTRANSF_C_1, 1 hit
PS00440 ACYLTRANSF_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPT2_HUMAN
AccessioniPrimary (citable) accession number: P23786
Secondary accession number(s): B2R6S0, Q5SW68, Q9BQ26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1993
Last modified: November 7, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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