GATA2

Functionⁱ

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	295 – 319	GATA-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	349 – 373	GATA-type 2PROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

C2H2 zinc finger domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12483298
chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 19242469
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20206639
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
- 27780851
enhancer sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 19323994
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II distal enhancer sequence-specific DNA binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15016828
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure formation involved in morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
animal organ morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
blood coagulation Source: Reactome
cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation in hindbrain Source: Ensembl
cell fate determination Source: Ensembl
cell maturation Source: Ensembl
central nervous system neuron development Source: Ensembl
cochlea development Source: Ensembl
commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
definitive hemopoiesis Source: Ensembl
embryonic placenta development Source: Ensembl
eosinophil fate commitment
Source: BHF-UCL
Inferred from direct assayⁱ
- 12045236
GABAergic neuron differentiation Source: Ensembl
heart development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
homeostasis of number of cells within a tissue Source: Ensembl
inner ear morphogenesis Source: Ensembl
negative regulation of endothelial cell apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21788589
negative regulation of fat cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20705609
negative regulation of fat cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20705609
negative regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27780851
negative regulation of macrophage differentiation Source: Ensembl
negative regulation of neural precursor cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 16672344
negative regulation of Notch signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 16672344
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuron migration Source: Ensembl
phagocytosis Source: UniProtKB-KW
pituitary gland development Source: Ensembl
positive regulation of angiogenesis
Source: MGI
Inferred from direct assayⁱ
- 19242469
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27780851
positive regulation of cell migration involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27780851
positive regulation of cytosolic calcium ion concentration Source: Ensembl
positive regulation of erythrocyte differentiation Source: Ensembl
positive regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 27780851
positive regulation of mast cell degranulation Source: Ensembl
positive regulation of megakaryocyte differentiation Source: Ensembl
positive regulation of neuron differentiation Source: Ensembl
positive regulation of phagocytosis Source: UniProtKB
positive regulation of phagocytosis, engulfment Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 20206639
pri-miRNA transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 27780851
regulation of forebrain neuron differentiation Source: Ensembl
regulation of hematopoietic stem cell differentiation Source: Reactome
regulation of histone acetylation Source: Ensembl
regulation of primitive erythrocyte differentiation Source: Ensembl
response to lipid Source: Ensembl
semicircular canal development Source: Ensembl
somatic stem cell population maintenance Source: Ensembl
tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 16153155
urogenital system development Source: Ensembl
ventral spinal cord interneuron differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Phagocytosis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	P23769
SIGNORⁱ	P23769

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endothelial transcription factor GATA-2 Alternative name(s): GATA-binding protein 2
Gene namesⁱ	Name:GATA2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179348.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4171 GATA2
MIMⁱ	137295 gene
neXtProtⁱ	NX_P23769

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency 21 (IMD21)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn immunodeficiency disease characterized by profoundly decreased or absent monocytes, B-lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells, with little or no effect on T-cell numbers. Clinical features of DCML include susceptibility to disseminated non-tuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8. This syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_066405	254	P → L in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906630EnsemblClinVar.		1
Natural variantⁱVAR_066407	398	R → W in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906629EnsemblClinVar.		1

Lymphedema, primary, with myelodysplasia (LMPM)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA chronic disabling condition characterized by swelling of the extremities due to altered lymphatic flow, associated with myelodysplasia. Patients with lymphedema suffer from recurrent local infections, and physical impairment.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_066644	361	R → P in LMPM. 1 Publication		1
Natural variantⁱVAR_066645	373	C → R in LMPM. 1 PublicationCorresponds to variant dbSNP:rs387906633EnsemblClinVar.		1

Myelodysplastic syndrome (MDS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML).

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_066643	355	Missing in MDS. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2624
MalaCards human disease database More...MalaCardsⁱ	GATA2
MIMⁱ	614038 phenotype 614172 phenotype 614286 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000179348
Orphanetⁱ	3226 Deafness-lymphedema-leukemia syndrome 319465 Inherited acute myeloid leukemia 228423 Monocytopenia with susceptibility to infections 52688 Myelodysplastic syndrome
PharmGKBⁱ	PA28585

Polymorphism and mutation databases

BioMutaⁱ	GATA2
DMDMⁱ	229462971

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083403	1 – 480	Endothelial transcription factor GATA-2Add BLAST		480

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	73	PhosphoserineCombined sources	1
Modified residueⁱ	86	Asymmetric dimethylarginineCombined sources	1
Modified residueⁱ	192	PhosphoserineCombined sources	1
Cross-linkⁱ	389	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P23769
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P23769
PaxDbⁱ	P23769
PeptideAtlas More...PeptideAtlasⁱ	P23769
PRIDEⁱ	P23769
ProteomicsDBⁱ	54160 54161 [P23769-2]

PTM databases

iPTMnetⁱ	P23769
PhosphoSitePlusⁱ	P23769

Expressionⁱ

Tissue specificityⁱ

Endothelial cells.

Gene expression databases

Bgeeⁱ	ENSG00000179348 Expressed in 220 organ(s), highest expression level in endometrium
CleanExⁱ	HS_GATA2
ExpressionAtlasⁱ	P23769 baseline and differential
Genevisibleⁱ	P23769 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB024847 HPA005633

HPAⁱ

CAB024847
HPA005633

Interactionⁱ

Subunit structureⁱ

Interacts with BRD3 (By similarity). Interacts with AR and CCAR1.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ADAMTSL4	Q6UY14-3	3	EBI-2806671,EBI-10173507
FHL3	Q13643	3	EBI-2806671,EBI-741101
GOLGA2	Q08379	3	EBI-2806671,EBI-618309
KRT40	Q6A162	3	EBI-2806671,EBI-10171697
KRTAP10-9	P60411	3	EBI-2806671,EBI-10172052
Lmo2	P25801	3	EBI-2806671,EBI-3903256	From Mus musculus.
MDFI	Q99750	3	EBI-2806671,EBI-724076
NOTCH2NL	Q7Z3S9	3	EBI-2806671,EBI-945833
PRR20C	P86479	3	EBI-2806671,EBI-10172814
PSMA3	P25788	3	EBI-2806671,EBI-348380
SMAD4	Q13485	2	EBI-2806671,EBI-347263
SPI1	P17947	4	EBI-2806671,EBI-2293548
TRAF1	Q13077	3	EBI-2806671,EBI-359224
TRIM23	P36406	3	EBI-2806671,EBI-740098

GO - Molecular functionⁱ

C2H2 zinc finger domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12483298
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15016828

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108894, 44 interactors
Database of interacting proteins More...DIPⁱ	DIP-29711N
IntActⁱ	P23769, 29 interactors
STRINGⁱ	9606.ENSP00000345681

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23769
SMRⁱ	P23769
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	295 – 319	GATA-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	349 – 373	GATA-type 2PROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000047701
HOVERGENⁱ	HBG051705
InParanoidⁱ	P23769
KEGG Orthology (KO) More...KOⁱ	K17894
OMAⁱ	PRWMAHH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AUR
PhylomeDBⁱ	P23769
TreeFamⁱ	TF315391

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00202 ZnF_GATA, 2 hits
Gene3Dⁱ	3.30.50.10, 2 hits
InterProⁱ	View protein in InterPro IPR029522 GATA-2 IPR016374 TF_GATA-2/3 IPR039355 Transcription_factor_GATA IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit PTHR10071:SF149 PTHR10071:SF149, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00320 GATA, 2 hits
PIRSFⁱ	PIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00401 ZnF_GATA, 2 hits
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 2 hits PS50114 GATA_ZN_FINGER_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P23769-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN 
        60         70         80         90        100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG 
       110        120        130        140        150
GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG 
       160        170        180        190        200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG 
       210        220        230        240        250
SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP ATHHPIPTYP 
       260        270        280        290        300
SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
       310        320        330        340        350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA 
       360        370        380        390        400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM 
       410        420        430        440        450
SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG 
       460        470        480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG

Length:480

Mass (Da):50,500

Last modified:May 5, 2009 - v3

Checksum:ⁱC879CC932C355E6A

GO

Isoform 2 (identifier: P23769-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
340-353: Missing.

« Hide

        10         20         30         40         50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN 
        60         70         80         90        100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG 
       110        120        130        140        150
GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG 
       160        170        180        190        200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG 
       210        220        230        240        250
SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP ATHHPIPTYP 
       260        270        280        290        300
SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
       310        320        330        340        350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLT TTTTLWRRNA 
       360        370        380        390        400
NGDPVCNACG LYYKLHNVNR PLTMKKEGIQ TRNRKMSNKS KKSKKGAECF 
       410        420        430        440        450
EELSKCMQEK SSPFSAAALA GHMAPVGHLP PFSHSGHILP TPTPIHPSSS 
       460 
LSFGHPHPSS MVTAMG

Show »

Length:466

Mass (Da):49,106

Checksum:ⁱB074D2E927CE263B

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J965	C9J965_HUMAN	Endothelial transcription factor GA... Endothelial transcription factor GATA-2	GATA2	150	Annotation score:
A0A1D5RMQ8	A0A1D5RMQ8_HUMAN	Endothelial transcription factor GA... Endothelial transcription factor GATA-2	GATA2	8	Annotation score:

Sequence cautionⁱ

The sequence AAA35869 differs from that shown. Several sequencing errors.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	9	R → G in AAA35868 (PubMed:1714909).Curated	1
Sequence conflictⁱ	20 – 21	QH → HD in AAA35868 (PubMed:1714909).Curated	2
Sequence conflictⁱ	38 – 39	QL → HV in AAA35868 (PubMed:1714909).Curated	2
Sequence conflictⁱ	69	R → A in AAA35868 (PubMed:1714909).Curated	1
Sequence conflictⁱ	82	G → S in AAA35868 (PubMed:1714909).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055004	164	A → T3 PublicationsCorresponds to variant dbSNP:rs2335052EnsemblClinVar.	1
Natural variantⁱVAR_055005	235	T → N. Corresponds to variant dbSNP:rs35079193Ensembl.	1
Natural variantⁱVAR_066405	254	P → L in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906630EnsemblClinVar.	1
Natural variantⁱVAR_066406	354	T → M in IMD21 and MDS. 2 PublicationsCorresponds to variant dbSNP:rs387906631EnsemblClinVar.	1
Natural variantⁱVAR_066643	355	Missing in MDS. 1 Publication	1
Natural variantⁱVAR_066644	361	R → P in LMPM. 1 Publication	1
Natural variantⁱVAR_066645	373	C → R in LMPM. 1 PublicationCorresponds to variant dbSNP:rs387906633EnsemblClinVar.	1
Natural variantⁱVAR_066407	398	R → W in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906629EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041126	340 – 353	Missing in isoform 2. 1 PublicationAdd BLAST		14

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M68891 mRNA Translation: AAA35868.1 M77810 mRNA Translation: AAA35869.1 Sequence problems. BT006671 mRNA Translation: AAP35317.1 AK314826 mRNA Translation: BAG37347.1 AC080005 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79313.1 CH471052 Genomic DNA Translation: EAW79314.1 CH471052 Genomic DNA Translation: EAW79315.1 CH471052 Genomic DNA Translation: EAW79316.1 CH471052 Genomic DNA Translation: EAW79317.1 BC002557 mRNA Translation: AAH02557.1 BC015613 mRNA Translation: AAH15613.1 BC015577 mRNA Translation: AAH15577.1 BC018988 mRNA Translation: AAH18988.1 BC051272 mRNA Translation: AAH51272.1 BC051342 mRNA Translation: AAH51342.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3049.1 [P23769-1] CCDS46903.1 [P23769-2]
PIRⁱ	A40815 A41782
NCBI Reference Sequences More...RefSeqⁱ	NP_001139133.1, NM_001145661.1 [P23769-1] NP_001139134.1, NM_001145662.1 [P23769-2] NP_116027.2, NM_032638.4 [P23769-1]
UniGeneⁱ	Hs.367725

Genome annotation databases

Ensemblⁱ	ENST00000341105; ENSP00000345681; ENSG00000179348 [P23769-1] ENST00000430265; ENSP00000400259; ENSG00000179348 [P23769-2] ENST00000487848; ENSP00000417074; ENSG00000179348 [P23769-1]
GeneIDⁱ	2624
KEGGⁱ	hsa:2624
UCSC genome browser More...UCSCⁱ	uc003ekm.4 human [P23769-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23769	GATA binding protein 2		PANTR		480	UniRef100_P23769
GATA2 isoform 1		PONAB		480
Uncharacterized protein		PANPA		480
Uncharacterized protein		NOMLE		480
P23769-2	GATA2 isoform 3		PONAB		466	UniRef100_A0A2J8TVE4
GATA2 isoform 4		PANTR		466

Protein	Similar proteins		Species	Score	Length	Source
P23769	Endothelial transcription factor GATA-2		MOUSE		480	UniRef90_P23769
Endothelial transcription factor GATA-2		RAT		480
GATA binding protein 2		PANTR		480
GATA2 isoform 1		PONAB		480
Uncharacterized protein		PANPA		480
+112
P23769-2	Uncharacterized protein		RHIBE		468	UniRef90_A0A2K6M2B9
GATA2 isoform 3		PONAB		466
GATA2 isoform 4		PANTR		466
endothelial transcription factor GATA-2 isoform X2		ODORO		466
endothelial transcription factor GATA-2 isoform X2		LEPWE		466
+22

Protein	Similar proteins		Species	Score	Length	Source
P23769	Endothelial transcription factor GATA-2		RAT		480	UniRef50_P23769
Endothelial transcription factor GATA-2		MOUSE		480
GATA binding protein 2		PANTR		480
GATA2 isoform 1		PONAB		480
Uncharacterized protein		PANPA		480
+188

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M68891 mRNA Translation: AAA35868.1 M77810 mRNA Translation: AAA35869.1 Sequence problems. BT006671 mRNA Translation: AAP35317.1 AK314826 mRNA Translation: BAG37347.1 AC080005 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79313.1 CH471052 Genomic DNA Translation: EAW79314.1 CH471052 Genomic DNA Translation: EAW79315.1 CH471052 Genomic DNA Translation: EAW79316.1 CH471052 Genomic DNA Translation: EAW79317.1 BC002557 mRNA Translation: AAH02557.1 BC015613 mRNA Translation: AAH15613.1 BC015577 mRNA Translation: AAH15577.1 BC018988 mRNA Translation: AAH18988.1 BC051272 mRNA Translation: AAH51272.1 BC051342 mRNA Translation: AAH51342.1
CCDSⁱ	CCDS3049.1 [P23769-1] CCDS46903.1 [P23769-2]
PIRⁱ	A40815 A41782
RefSeqⁱ	NP_001139133.1, NM_001145661.1 [P23769-1] NP_001139134.1, NM_001145662.1 [P23769-2] NP_116027.2, NM_032638.4 [P23769-1]
UniGeneⁱ	Hs.367725

3D structure databases

ProteinModelPortalⁱ	P23769
SMRⁱ	P23769
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108894, 44 interactors
DIPⁱ	DIP-29711N
IntActⁱ	P23769, 29 interactors
STRINGⁱ	9606.ENSP00000345681

PTM databases

iPTMnetⁱ	P23769
PhosphoSitePlusⁱ	P23769

Polymorphism and mutation databases

BioMutaⁱ	GATA2
DMDMⁱ	229462971

Proteomic databases

EPDⁱ	P23769
MaxQBⁱ	P23769
PaxDbⁱ	P23769
PeptideAtlasⁱ	P23769
PRIDEⁱ	P23769
ProteomicsDBⁱ	54160 54161 [P23769-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2624
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000341105; ENSP00000345681; ENSG00000179348 [P23769-1] ENST00000430265; ENSP00000400259; ENSG00000179348 [P23769-2] ENST00000487848; ENSP00000417074; ENSG00000179348 [P23769-1]
GeneIDⁱ	2624
KEGGⁱ	hsa:2624
UCSCⁱ	uc003ekm.4 human [P23769-1]

Organism-specific databases

CTDⁱ	2624
DisGeNETⁱ	2624
EuPathDBⁱ	HostDB:ENSG00000179348.11
GeneCardsⁱ	GATA2
HGNCⁱ	HGNC:4171 GATA2
HPAⁱ	CAB024847 HPA005633
MalaCardsⁱ	GATA2
MIMⁱ	137295 gene 614038 phenotype 614172 phenotype 614286 phenotype
neXtProtⁱ	NX_P23769
OpenTargetsⁱ	ENSG00000179348
Orphanetⁱ	3226 Deafness-lymphedema-leukemia syndrome 319465 Inherited acute myeloid leukemia 228423 Monocytopenia with susceptibility to infections 52688 Myelodysplastic syndrome
PharmGKBⁱ	PA28585
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1601 Eukaryota COG5641 LUCA
GeneTreeⁱ	ENSGT00760000119221
HOGENOMⁱ	HOG000047701
HOVERGENⁱ	HBG051705
InParanoidⁱ	P23769
KOⁱ	K17894
OMAⁱ	PRWMAHH
OrthoDBⁱ	EOG091G0AUR
PhylomeDBⁱ	P23769
TreeFamⁱ	TF315391

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	P23769
SIGNORⁱ	P23769

Miscellaneous databases

ChiTaRSⁱ	GATA2 human
GeneWikiⁱ	GATA2
GenomeRNAiⁱ	2624
Protein Ontology More...PROⁱ	PR:P23769
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179348 Expressed in 220 organ(s), highest expression level in endometrium
CleanExⁱ	HS_GATA2
ExpressionAtlasⁱ	P23769 baseline and differential
Genevisibleⁱ	P23769 HS

Family and domain databases

CDDⁱ	cd00202 ZnF_GATA, 2 hits
Gene3Dⁱ	3.30.50.10, 2 hits
InterProⁱ	View protein in InterPro IPR029522 GATA-2 IPR016374 TF_GATA-2/3 IPR039355 Transcription_factor_GATA IPR000679 Znf_GATA IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR10071 PTHR10071, 1 hit PTHR10071:SF149 PTHR10071:SF149, 1 hit
Pfamⁱ	View protein in Pfam PF00320 GATA, 2 hits
PIRSFⁱ	PIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSⁱ	PR00619 GATAZNFINGER
SMARTⁱ	View protein in SMART SM00401 ZnF_GATA, 2 hits
PROSITEⁱ	View protein in PROSITE PS00344 GATA_ZN_FINGER_1, 2 hits PS50114 GATA_ZN_FINGER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GATA2_HUMAN
Accessionⁱ	P23769Primary (citable) accession number: P23769 Secondary accession number(s): D3DNB3 , Q53YE0, Q96BH0, Q96BH8, Q9BUJ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	May 5, 2009
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termⁱ

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Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P23769 (GATA2_HUMAN)

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Endothelial transcription factor GATA-2

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Functionⁱ

GO - Molecular functionⁱ

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Keywords - Diseaseⁱ

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