UniProtKB - P23769 (GATA2_HUMAN)
Protein
Endothelial transcription factor GATA-2
Gene
GATA2
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 295 – 319 | GATA-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 349 – 373 | GATA-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: BHF-UCL
- chromatin binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: BHF-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- blood coagulation Source: Reactome
- cell differentiation in hindbrain Source: Ensembl
- cell fate commitment Source: GO_Central
- cell fate determination Source: Ensembl
- cell maturation Source: Ensembl
- central nervous system neuron development Source: Ensembl
- cochlea development Source: Ensembl
- commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
- definitive hemopoiesis Source: Ensembl
- embryonic placenta development Source: Ensembl
- eosinophil fate commitment Source: BHF-UCL
- GABAergic neuron differentiation Source: Ensembl
- homeostasis of number of cells within a tissue Source: Ensembl
- inner ear morphogenesis Source: Ensembl
- negative regulation of endothelial cell apoptotic process Source: BHF-UCL
- negative regulation of fat cell differentiation Source: UniProtKB
- negative regulation of fat cell proliferation Source: UniProtKB
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of macrophage differentiation Source: Ensembl
- negative regulation of neural precursor cell proliferation Source: MGI
- negative regulation of Notch signaling pathway Source: MGI
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neuron migration Source: Ensembl
- phagocytosis Source: UniProtKB-KW
- pituitary gland development Source: Ensembl
- positive regulation of angiogenesis Source: MGI
- positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of erythrocyte differentiation Source: Ensembl
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of mast cell degranulation Source: Ensembl
- positive regulation of megakaryocyte differentiation Source: Ensembl
- positive regulation of neuron differentiation Source: Ensembl
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of phagocytosis, engulfment Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of forebrain neuron differentiation Source: Ensembl
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of histone acetylation Source: Ensembl
- regulation of primitive erythrocyte differentiation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to lipid Source: Ensembl
- semicircular canal development Source: Ensembl
- somatic stem cell population maintenance Source: Ensembl
- urogenital system development Source: Ensembl
- vascular wound healing Source: BHF-UCL
- ventral spinal cord interneuron differentiation Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Phagocytosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P23769 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P23769 |
SIGNORi | P23769 |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelial transcription factor GATA-2Alternative name(s): GATA-binding protein 2 |
Gene namesi | Name:GATA2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4171, GATA2 |
MIMi | 137295, gene |
neXtProti | NX_P23769 |
VEuPathDBi | HostDB:ENSG00000179348.11 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- cytoplasm Source: BHF-UCL
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency 21 (IMD21)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn immunodeficiency disease characterized by profoundly decreased or absent monocytes, B-lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells, with little or no effect on T-cell numbers. Clinical features of DCML include susceptibility to disseminated non-tuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8. This syndrome links susceptibility to mycobacterial, viral, and fungal infections with malignancy and can be transmitted in an autosomal dominant pattern.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066405 | 254 | P → L in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906630EnsemblClinVar. | 1 | |
Natural variantiVAR_066406 | 354 | T → M in IMD21 and MDS. 2 PublicationsCorresponds to variant dbSNP:rs387906631EnsemblClinVar. | 1 | |
Natural variantiVAR_066407 | 398 | R → W in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906629EnsemblClinVar. | 1 |
Lymphedema, primary, with myelodysplasia (LMPM)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA chronic disabling condition characterized by swelling of the extremities due to altered lymphatic flow, associated with myelodysplasia. Patients with lymphedema suffer from recurrent local infections, and physical impairment.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066644 | 361 | R → P in LMPM. 1 Publication | 1 | |
Natural variantiVAR_066645 | 373 | C → R in LMPM. 1 PublicationCorresponds to variant dbSNP:rs387906633EnsemblClinVar. | 1 |
Myelodysplastic syndrome (MDS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML).
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066406 | 354 | T → M in IMD21 and MDS. 2 PublicationsCorresponds to variant dbSNP:rs387906631EnsemblClinVar. | 1 | |
Natural variantiVAR_066643 | 355 | Missing in MDS. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 2624 |
MalaCardsi | GATA2 |
MIMi | 614038, phenotype 614172, phenotype 614286, phenotype |
OpenTargetsi | ENSG00000179348 |
Orphaneti | 3226, Deafness-lymphedema-leukemia syndrome 319465, Inherited acute myeloid leukemia 228423, Monocytopenia with susceptibility to infections 52688, Myelodysplastic syndrome |
PharmGKBi | PA28585 |
Miscellaneous databases
Pharosi | P23769, Tbio |
Genetic variation databases
BioMutai | GATA2 |
DMDMi | 229462971 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083403 | 1 – 480 | Endothelial transcription factor GATA-2Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 73 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 192 | PhosphoserineCombined sources | 1 | |
Cross-linki | 389 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P23769 |
jPOSTi | P23769 |
MassIVEi | P23769 |
MaxQBi | P23769 |
PaxDbi | P23769 |
PeptideAtlasi | P23769 |
PRIDEi | P23769 |
ProteomicsDBi | 54160 [P23769-1] 54161 [P23769-2] |
PTM databases
iPTMneti | P23769 |
PhosphoSitePlusi | P23769 |
Expressioni
Tissue specificityi
Endothelial cells.
Gene expression databases
Bgeei | ENSG00000179348, Expressed in endometrium and 233 other tissues |
ExpressionAtlasi | P23769, baseline and differential |
Genevisiblei | P23769, HS |
Organism-specific databases
HPAi | ENSG00000179348, Tissue enhanced (blood, ductus deferens, seminal vesicle) |
Interactioni
Subunit structurei
Interacts with BRD3 (By similarity).
Interacts with AR and CCAR1.
By similarity1 PublicationBinary interactionsi
Hide detailsP23769
Isoform 2 [P23769-2]
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108894, 60 interactors |
DIPi | DIP-29711N |
IntActi | P23769, 40 interactors |
STRINGi | 9606.ENSP00000345681 |
Miscellaneous databases
RNActi | P23769, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P23769 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 295 – 319 | GATA-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 349 – 373 | GATA-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000156315 |
HOGENOMi | CLU_027524_1_0_1 |
InParanoidi | P23769 |
OMAi | SHMAHMG |
OrthoDBi | 1240204at2759 |
PhylomeDBi | P23769 |
TreeFami | TF315391 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR029522, GATA-2 IPR016374, TF_GATA-2/3 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit PTHR10071:SF149, PTHR10071:SF149, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits |
PIRSFi | PIRSF003027, TF_GATA-1/2/3, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P23769-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG
110 120 130 140 150
GKAALSAAAA HHHNPWTVSP FSKTPLHPSA AGGPGGPLSV YPGAGGGSGG
160 170 180 190 200
GSGSSVASLT PTAAHSGSHL FGFPPTPPKE VSPDPSTTGA ASPASSSAGG
210 220 230 240 250
SAARGEDKDG VKYQVSLTES MKMESGSPLR PGLATMGTQP ATHHPIPTYP
260 270 280 290 300
SYVPAAAHDY SSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
310 320 330 340 350
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA
360 370 380 390 400
NCQTTTTTLW RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM
410 420 430 440 450
SNKSKKSKKG AECFEELSKC MQEKSSPFSA AALAGHMAPV GHLPPFSHSG
460 470 480
HILPTPTPIH PSSSLSFGHP HPSSMVTAMG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J965 | C9J965_HUMAN | Endothelial transcription factor GA... | GATA2 | 150 | Annotation score: | ||
A0A1D5RMQ8 | A0A1D5RMQ8_HUMAN | Endothelial transcription factor GA... | GATA2 | 8 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | R → G in AAA35868 (PubMed:1714909).Curated | 1 | |
Sequence conflicti | 20 – 21 | QH → HD in AAA35868 (PubMed:1714909).Curated | 2 | |
Sequence conflicti | 38 – 39 | QL → HV in AAA35868 (PubMed:1714909).Curated | 2 | |
Sequence conflicti | 69 | R → A in AAA35868 (PubMed:1714909).Curated | 1 | |
Sequence conflicti | 82 | G → S in AAA35868 (PubMed:1714909).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055004 | 164 | A → T3 PublicationsCorresponds to variant dbSNP:rs2335052EnsemblClinVar. | 1 | |
Natural variantiVAR_055005 | 235 | T → N. Corresponds to variant dbSNP:rs35079193Ensembl. | 1 | |
Natural variantiVAR_066405 | 254 | P → L in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906630EnsemblClinVar. | 1 | |
Natural variantiVAR_066406 | 354 | T → M in IMD21 and MDS. 2 PublicationsCorresponds to variant dbSNP:rs387906631EnsemblClinVar. | 1 | |
Natural variantiVAR_066643 | 355 | Missing in MDS. 1 Publication | 1 | |
Natural variantiVAR_066644 | 361 | R → P in LMPM. 1 Publication | 1 | |
Natural variantiVAR_066645 | 373 | C → R in LMPM. 1 PublicationCorresponds to variant dbSNP:rs387906633EnsemblClinVar. | 1 | |
Natural variantiVAR_066407 | 398 | R → W in IMD21. 1 PublicationCorresponds to variant dbSNP:rs387906629EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041126 | 340 – 353 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68891 mRNA Translation: AAA35868.1 M77810 mRNA Translation: AAA35869.1 Sequence problems. BT006671 mRNA Translation: AAP35317.1 AK314826 mRNA Translation: BAG37347.1 AC080005 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79313.1 CH471052 Genomic DNA Translation: EAW79314.1 CH471052 Genomic DNA Translation: EAW79315.1 CH471052 Genomic DNA Translation: EAW79316.1 CH471052 Genomic DNA Translation: EAW79317.1 BC002557 mRNA Translation: AAH02557.1 BC015613 mRNA Translation: AAH15613.1 BC015577 mRNA Translation: AAH15577.1 BC018988 mRNA Translation: AAH18988.1 BC051272 mRNA Translation: AAH51272.1 BC051342 mRNA Translation: AAH51342.1 |
CCDSi | CCDS3049.1 [P23769-1] CCDS46903.1 [P23769-2] |
PIRi | A40815 A41782 |
RefSeqi | NP_001139133.1, NM_001145661.1 [P23769-1] NP_001139134.1, NM_001145662.1 [P23769-2] NP_116027.2, NM_032638.4 [P23769-1] |
Genome annotation databases
Ensembli | ENST00000341105; ENSP00000345681; ENSG00000179348 [P23769-1] ENST00000430265; ENSP00000400259; ENSG00000179348 [P23769-2] ENST00000487848; ENSP00000417074; ENSG00000179348 [P23769-1] |
GeneIDi | 2624 |
KEGGi | hsa:2624 |
UCSCi | uc003ekm.4, human [P23769-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M68891 mRNA Translation: AAA35868.1 M77810 mRNA Translation: AAA35869.1 Sequence problems. BT006671 mRNA Translation: AAP35317.1 AK314826 mRNA Translation: BAG37347.1 AC080005 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79313.1 CH471052 Genomic DNA Translation: EAW79314.1 CH471052 Genomic DNA Translation: EAW79315.1 CH471052 Genomic DNA Translation: EAW79316.1 CH471052 Genomic DNA Translation: EAW79317.1 BC002557 mRNA Translation: AAH02557.1 BC015613 mRNA Translation: AAH15613.1 BC015577 mRNA Translation: AAH15577.1 BC018988 mRNA Translation: AAH18988.1 BC051272 mRNA Translation: AAH51272.1 BC051342 mRNA Translation: AAH51342.1 |
CCDSi | CCDS3049.1 [P23769-1] CCDS46903.1 [P23769-2] |
PIRi | A40815 A41782 |
RefSeqi | NP_001139133.1, NM_001145661.1 [P23769-1] NP_001139134.1, NM_001145662.1 [P23769-2] NP_116027.2, NM_032638.4 [P23769-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5O9B | NMR | - | A | 343-391 | [»] | |
SMRi | P23769 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108894, 60 interactors |
DIPi | DIP-29711N |
IntActi | P23769, 40 interactors |
STRINGi | 9606.ENSP00000345681 |
PTM databases
iPTMneti | P23769 |
PhosphoSitePlusi | P23769 |
Genetic variation databases
BioMutai | GATA2 |
DMDMi | 229462971 |
Proteomic databases
EPDi | P23769 |
jPOSTi | P23769 |
MassIVEi | P23769 |
MaxQBi | P23769 |
PaxDbi | P23769 |
PeptideAtlasi | P23769 |
PRIDEi | P23769 |
ProteomicsDBi | 54160 [P23769-1] 54161 [P23769-2] |
Protocols and materials databases
Antibodypediai | 788, 479 antibodies |
DNASUi | 2624 |
Genome annotation databases
Ensembli | ENST00000341105; ENSP00000345681; ENSG00000179348 [P23769-1] ENST00000430265; ENSP00000400259; ENSG00000179348 [P23769-2] ENST00000487848; ENSP00000417074; ENSG00000179348 [P23769-1] |
GeneIDi | 2624 |
KEGGi | hsa:2624 |
UCSCi | uc003ekm.4, human [P23769-1] |
Organism-specific databases
CTDi | 2624 |
DisGeNETi | 2624 |
GeneCardsi | GATA2 |
HGNCi | HGNC:4171, GATA2 |
HPAi | ENSG00000179348, Tissue enhanced (blood, ductus deferens, seminal vesicle) |
MalaCardsi | GATA2 |
MIMi | 137295, gene 614038, phenotype 614172, phenotype 614286, phenotype |
neXtProti | NX_P23769 |
OpenTargetsi | ENSG00000179348 |
Orphaneti | 3226, Deafness-lymphedema-leukemia syndrome 319465, Inherited acute myeloid leukemia 228423, Monocytopenia with susceptibility to infections 52688, Myelodysplastic syndrome |
PharmGKBi | PA28585 |
VEuPathDBi | HostDB:ENSG00000179348.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1601, Eukaryota |
GeneTreei | ENSGT00940000156315 |
HOGENOMi | CLU_027524_1_0_1 |
InParanoidi | P23769 |
OMAi | SHMAHMG |
OrthoDBi | 1240204at2759 |
PhylomeDBi | P23769 |
TreeFami | TF315391 |
Enzyme and pathway databases
PathwayCommonsi | P23769 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9616222, Transcriptional regulation of granulopoiesis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P23769 |
SIGNORi | P23769 |
Miscellaneous databases
BioGRID-ORCSi | 2624, 27 hits in 1026 CRISPR screens |
ChiTaRSi | GATA2, human |
GeneWikii | GATA2 |
GenomeRNAii | 2624 |
Pharosi | P23769, Tbio |
PROi | PR:P23769 |
RNActi | P23769, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179348, Expressed in endometrium and 233 other tissues |
ExpressionAtlasi | P23769, baseline and differential |
Genevisiblei | P23769, HS |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 2 hits |
Gene3Di | 3.30.50.10, 2 hits |
InterProi | View protein in InterPro IPR029522, GATA-2 IPR016374, TF_GATA-2/3 IPR039355, Transcription_factor_GATA IPR000679, Znf_GATA IPR013088, Znf_NHR/GATA |
PANTHERi | PTHR10071, PTHR10071, 1 hit PTHR10071:SF149, PTHR10071:SF149, 1 hit |
Pfami | View protein in Pfam PF00320, GATA, 2 hits |
PIRSFi | PIRSF003027, TF_GATA-1/2/3, 1 hit |
PRINTSi | PR00619, GATAZNFINGER |
SMARTi | View protein in SMART SM00401, ZnF_GATA, 2 hits |
PROSITEi | View protein in PROSITE PS00344, GATA_ZN_FINGER_1, 2 hits PS50114, GATA_ZN_FINGER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GATA2_HUMAN | |
Accessioni | P23769Primary (citable) accession number: P23769 Secondary accession number(s): D3DNB3 Q9BUJ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | May 5, 2009 | |
Last modified: | April 7, 2021 | |
This is version 195 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references