UniProtKB - P23764 (GPX3_RAT)
Protein
Glutathione peroxidase 3
Gene
Gpx3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: RGD
- identical protein binding Source: UniProtKB
- peroxidase activity Source: GO_Central
- selenium binding Source: RGD
GO - Biological processi
- glutathione metabolic process Source: RGD
- hydrogen peroxide catabolic process Source: RGD
- response to corticosterone Source: RGD
- response to drug Source: RGD
- response to molecule of fungal origin Source: RGD
- response to organic cyclic compound Source: RGD
- response to organic substance Source: RGD
- response to oxidative stress Source: InterPro
- response to selenium ion Source: RGD
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3732, RnoGPx03 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione peroxidase 3 (EC:1.11.1.9)Short name: GPx-3 Short name: GSHPx-3 Alternative name(s): Plasma glutathione peroxidase Short name: GPx-P Short name: GSHPx-P |
Gene namesi | Name:Gpx3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69224, Gpx3 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000013064 | 25 – 226 | Glutathione peroxidase 3Add BLAST | 202 |
Proteomic databases
PRIDEi | P23764 |
PTM databases
iPTMneti | P23764 |
PhosphoSitePlusi | P23764 |
Expressioni
Tissue specificityi
Secreted in plasma.
Interactioni
Subunit structurei
Homotetramer.
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
InParanoidi | P23764 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | P23764 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P23764-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARILRASCL LSLLLAGFVP PGRGQEKSKT DCHGGMSGTI YEYGALTIDG
60 70 80 90 100
EEYIPFKQYA GKYILFVNVA SYUGLTDQYL ELNALQEELG PFGLVILGFP
110 120 130 140 150
CNQFGKQEPG ENSEILPSLK YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT
160 170 180 190 200
FLKNSCPPTA ELLGSPGRLF WEPMKIHDIR WNFEKFLVGP DGIPIMRWYH
210 220
RTTVSNVKMD ILSYMRRQAA LGARGK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K531 | A0A0G2K531_RAT | Glutathione peroxidase | Gpx3 | 225 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | A → S in BAA00587 (PubMed:1939013).Curated | 1 |
Non-standard residue
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-standard residuei | 73 | Selenocysteine | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00680 mRNA Translation: BAA00587.2 BC062227 mRNA Translation: AAH62227.1 |
PIRi | JX0176 |
RefSeqi | NP_071970.2, NM_022525.4 |
Genome annotation databases
GeneIDi | 64317 |
KEGGi | rno:64317 |
UCSCi | RGD:69224, rat |
Keywords - Coding sequence diversityi
SelenocysteineSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00680 mRNA Translation: BAA00587.2 BC062227 mRNA Translation: AAH62227.1 |
PIRi | JX0176 |
RefSeqi | NP_071970.2, NM_022525.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
PeroxiBasei | 3732, RnoGPx03 |
PTM databases
iPTMneti | P23764 |
PhosphoSitePlusi | P23764 |
Proteomic databases
PRIDEi | P23764 |
Genome annotation databases
GeneIDi | 64317 |
KEGGi | rno:64317 |
UCSCi | RGD:69224, rat |
Organism-specific databases
CTDi | 2878 |
RGDi | 69224, Gpx3 |
Phylogenomic databases
InParanoidi | P23764 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | P23764 |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
PROi | PR:P23764 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX3_RAT | |
Accessioni | P23764Primary (citable) accession number: P23764 Secondary accession number(s): Q6P6H2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families