PAX7

Functionⁱ

Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	217 – 276	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 9339373
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding Source: Ensembl
transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 9339373
cartilage development Source: Ensembl
chromatin remodeling Source: Ensembl
dorsal/ventral neural tube patterning Source: Ensembl
embryonic skeletal system development Source: Ensembl
muscle tissue morphogenesis Source: Ensembl
negative regulation of apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 10871843
neuron fate commitment Source: Ensembl
positive regulation of histone methylation Source: Ensembl
positive regulation of myoblast proliferation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of cell fate commitment Source: Ensembl
regulation of protein binding Source: Ensembl
skeletal muscle satellite cell commitment Source: Ensembl
skeletal muscle tissue regeneration Source: Ensembl
spinal cord association neuron differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P23759

SIGNORⁱ

P23759

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Paired box protein Pax-7 Alternative name(s): HuP1
Gene namesⁱ	Name:PAX7 Synonyms:HUP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000009709.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8621 PAX7
MIMⁱ	167410 gene
neXtProtⁱ	NX_P23759

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Rhabdomyosarcoma 2 (RMS2)1 Publication

The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.1 Publication

Disease descriptionA form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5081
MalaCards human disease database More...MalaCardsⁱ	PAX7
MIMⁱ	268220 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000009709
Orphanetⁱ	99756 Alveolar rhabdomyosarcoma
PharmGKBⁱ	PA32961

Polymorphism and mutation databases

BioMutaⁱ	PAX7
DMDMⁱ	8247951

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050194	1 – 505	Paired box protein Pax-7Add BLAST		505

Proteomic databases

PaxDbⁱ	P23759
PeptideAtlas More...PeptideAtlasⁱ	P23759
PRIDEⁱ	P23759
ProteomicsDBⁱ	54148 54149 [P23759-2]

PTM databases

iPTMnetⁱ	P23759
PhosphoSitePlusⁱ	P23759

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000009709 Expressed in 33 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_PAX7
Genevisibleⁱ	P23759 HS

Interactionⁱ

Subunit structureⁱ

Can bind to DNA as a heterodimer with PAX3. Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex (By similarity). Interacts with DAXX (PubMed:10393185).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	111115, 6 interactors
IntActⁱ	P23759, 14 interactors
Molecular INTeraction database More...MINTⁱ	P23759
STRINGⁱ	9606.ENSP00000364524

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23759
SMRⁱ	P23759
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	34 – 163	PairedPROSITE-ProRule annotationAdd BLAST		130

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	27 – 210	Sufficient to mediate interaction with PAXBP1By similarityAdd BLAST		184

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	479 – 491	OARPROSITE-ProRule annotationAdd BLAST		13

Sequence similaritiesⁱ

Belongs to the paired homeobox family.Curated

Keywords - Domainⁱ

Homeobox, Paired box

Phylogenomic databases

eggNOGⁱ	KOG0849 Eukaryota ENOG410XS01 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00680000099553
HOGENOMⁱ	HOG000230939
HOVERGENⁱ	HBG009115
InParanoidⁱ	P23759
KEGG Orthology (KO) More...KOⁱ	K09381
OMAⁱ	GTVPRMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0S4E
TreeFamⁱ	TF351610

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit cd00131 PAX, 1 hit
Gene3Dⁱ	1.10.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom IPR001523 Paired_dom IPR022106 Pax7_C IPR036388 WH-like_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00292 PAX, 1 hit PF12360 Pax7, 1 hit
PRINTSⁱ	PR00027 PAIREDBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00351 PAX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit PS00034 PAIRED_1, 1 hit PS51057 PAIRED_2, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 3 (identifier: P23759-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALPGTVPR MMRPAPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP 
        60         70         80         90        100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA 
       110        120        130        140        150
IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS 
       160        170        180        190        200
GLVSSISRVL RIKFGKKEEE DEADKKEDDG EKKAKHSIDG ILGDKGNRLD 
       210        220        230        240        250
EGSDVESEPD LPLKRKQRRS RTTFTAEQLE ELEKAFERTH YPDIYTREEL 
       260        270        280        290        300
AQRTKLTEAR VQVWFSNRRA RWRKQAGANQ LAAFNHLLPG GFPPTGMPTL 
       310        320        330        340        350
PPYQLPDSTY PTTTISQDGG STVHRPQPLP PSTMHQGGLA AAAAAADTSS 
       360        370        380        390        400
AYGARHSFSS YSDSFMNPAA PSNHMNPVSN GLSPQVMSIL GNPSAVPPQP 
       410        420        430        440        450
QADFSISPLH GGLDSATSIS ASCSQRADSI KPGDSLPTSQ AYCPPTYSTT 
       460        470        480        490        500
GYSVDPVAGY QYGQYGQTAV DYLAKNVSLS TQRRMKLGEH SAVLGLLPVE 

TGQAY

Length:505

Mass (Da):55,119

Last modified:June 24, 2015 - v4

Checksum:ⁱE51CF8B3E8D4C3D9

GO

Isoform 1 (identifier: P23759-1) [UniParc]FASTA Add to basket

Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
468-505: TAVDYLAKNV...LLPVETGQAY → SECLVPWASP...LKSSQMEQFT

« Hide

        10         20         30         40         50
MAALPGTVPR MMRPAPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP 
        60         70         80         90        100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA 
       110        120        130        140        150
IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS 
       160        170        180        190        200
GLVSSISRVL RIKFGKKEEE DEADKKEDDG EKKAKHSIDG ILGDKGNRLD 
       210        220        230        240        250
EGSDVESEPD LPLKRKQRRS RTTFTAEQLE ELEKAFERTH YPDIYTREEL 
       260        270        280        290        300
AQRTKLTEAR VQVWFSNRRA RWRKQAGANQ LAAFNHLLPG GFPPTGMPTL 
       310        320        330        340        350
PPYQLPDSTY PTTTISQDGG STVHRPQPLP PSTMHQGGLA AAAAAADTSS 
       360        370        380        390        400
AYGARHSFSS YSDSFMNPAA PSNHMNPVSN GLSPQVMSIL GNPSAVPPQP 
       410        420        430        440        450
QADFSISPLH GGLDSATSIS ASCSQRADSI KPGDSLPTSQ AYCPPTYSTT 
       460        470        480        490        500
GYSVDPVAGY QYGQYGQSEC LVPWASPVPI PSPTPRASCL FMESYKVVSG 
       510        520
WGMSISQMEK LKSSQMEQFT

Show »

Length:520

Mass (Da):56,896

Checksum:ⁱ3B0F8CC99D65699C

GO

Isoform 2 (identifier: P23759-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
151-152: Missing.
468-505: TAVDYLAKNV...LLPVETGQAY → SECLVPWASP...LKSSQMEQFT

« Hide

        10         20         30         40         50
MAALPGTVPR MMRPAPGQNY PRTGFPLEVS TPLGQGRVNQ LGGVFINGRP 
        60         70         80         90        100
LPNHIRHKIV EMAHHGIRPC VISRQLRVSH GCVSKILCRY QETGSIRPGA 
       110        120        130        140        150
IGGSKPRQVA TPDVEKKIEE YKRENPGMFS WEIRDRLLKD GHCDRSTVPS 
       160        170        180        190        200
VSSISRVLRI KFGKKEEEDE ADKKEDDGEK KAKHSIDGIL GDKGNRLDEG 
       210        220        230        240        250
SDVESEPDLP LKRKQRRSRT TFTAEQLEEL EKAFERTHYP DIYTREELAQ 
       260        270        280        290        300
RTKLTEARVQ VWFSNRRARW RKQAGANQLA AFNHLLPGGF PPTGMPTLPP 
       310        320        330        340        350
YQLPDSTYPT TTISQDGGST VHRPQPLPPS TMHQGGLAAA AAAADTSSAY 
       360        370        380        390        400
GARHSFSSYS DSFMNPAAPS NHMNPVSNGL SPQVMSILGN PSAVPPQPQA 
       410        420        430        440        450
DFSISPLHGG LDSATSISAS CSQRADSIKP GDSLPTSQAY CPPTYSTTGY 
       460        470        480        490        500
SVDPVAGYQY GQYGQSECLV PWASPVPIPS PTPRASCLFM ESYKVVSGWG 
       510 
MSISQMEKLK SSQMEQFT

Show »

Length:518

Mass (Da):56,726

Checksum:ⁱ5400E4AF04F4023C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	468	T → S in ABC48797 (PubMed:16830101).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057678	151 – 152	Missing in isoform 2. 1 Publication		2
Alternative sequenceⁱVSP_057679	468 – 505	TAVDY…TGQAY → SECLVPWASPVPIPSPTPRA SCLFMESYKVVSGWGMSISQ MEKLKSSQMEQFT in isoform 1 and isoform 2. 2 PublicationsAdd BLAST		38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X96743 mRNA Translation: CAA65520.1 X96744 X96748 Genomic DNA Translation: CAA65521.1 X96744 X96748 Genomic DNA Translation: CAA65522.1 DQ322591 mRNA Translation: ABC48797.1 AL021528 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94853.1 BC121165 mRNA Translation: AAI21166.1 BC121166 mRNA Translation: AAI21167.1 Z35141 mRNA Translation: CAA84513.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS186.1 [P23759-1] CCDS44074.1 [P23759-3] CCDS44075.1 [P23759-2]
PIRⁱ	S78502
NCBI Reference Sequences More...RefSeqⁱ	NP_001128726.1, NM_001135254.1 [P23759-3] NP_002575.1, NM_002584.2 [P23759-1] NP_039236.1, NM_013945.2 [P23759-2]
UniGeneⁱ	Hs.113253

Genome annotation databases

Ensemblⁱ	ENST00000375375; ENSP00000364524; ENSG00000009709 [P23759-1] ENST00000400661; ENSP00000383502; ENSG00000009709 [P23759-2] ENST00000420770; ENSP00000403389; ENSG00000009709 [P23759-3]
GeneIDⁱ	5081
KEGGⁱ	hsa:5081
UCSC genome browser More...UCSCⁱ	uc001bay.3 human [P23759-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23759	PAX7 isoform 2		PANTR		505	UniRef100_P23759
Paired box 7		GORGO		505

Protein	Similar proteins		Species	Score	Length	Source
P23759	Paired box protein Pax-7		MOUSE		503	UniRef90_P47239
Paired box 7		BOVIN		505
paired box protein Pax-7 isoform X2		Florida manatee		505
Uncharacterized protein		RHIRO		505
Uncharacterized protein		RHIBE		505
+210
P23759-1	Uncharacterized protein		Cebus capucinus imitator		520	UniRef90_P23759-1
PAX7 isoform 1		PONAB		520
PAX7 (Fragment)		PONPY		189
PAX7 isoform 1		PANTR		520
Uncharacterized protein		CHLSB		520
+44
P23759-2	Isoform 1 of Paired box protein Pax-7		HUMAN		520	UniRef90_P23759-1
Uncharacterized protein		Cebus capucinus imitator		520
PAX7 isoform 1		PONAB		520
PAX7 (Fragment)		PONPY		189
PAX7 isoform 1		PANTR		520
+44

Protein	Similar proteins		Species	Score	Length	Source
P23759	Paired box protein Pax-7		MOUSE		503	UniRef50_P47239
paired box protein Pax-7 isoform X1		DELLE		505
paired box protein Pax-7 isoform X1		LIPVE		505
paired box protein Pax-7 isoform X1		DIPOR		505
paired box protein Pax-7 isoform X1		MESAU		505
+342
P23759-1	Uncharacterized protein		CHLSB		520	UniRef50_P23759-1
Paired box 7		GORGO		520
PAX7 (Fragment)		western gorilla		109
Uncharacterized protein		Cebus capucinus imitator		520
PAX7 isoform 1		PANTR		520
+422
P23759-2	Isoform 1 of Paired box protein Pax-7		HUMAN		520	UniRef50_P23759-1
Uncharacterized protein		CHLSB		520
Paired box 7		GORGO		520
PAX7 (Fragment)		western gorilla		109
Uncharacterized protein		Cebus capucinus imitator		520
+422

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X96743 mRNA Translation: CAA65520.1 X96744 X96748 Genomic DNA Translation: CAA65521.1 X96744 X96748 Genomic DNA Translation: CAA65522.1 DQ322591 mRNA Translation: ABC48797.1 AL021528 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW94853.1 BC121165 mRNA Translation: AAI21166.1 BC121166 mRNA Translation: AAI21167.1 Z35141 mRNA Translation: CAA84513.1
CCDSⁱ	CCDS186.1 [P23759-1] CCDS44074.1 [P23759-3] CCDS44075.1 [P23759-2]
PIRⁱ	S78502
RefSeqⁱ	NP_001128726.1, NM_001135254.1 [P23759-3] NP_002575.1, NM_002584.2 [P23759-1] NP_039236.1, NM_013945.2 [P23759-2]
UniGeneⁱ	Hs.113253

3D structure databases

ProteinModelPortalⁱ	P23759
SMRⁱ	P23759
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111115, 6 interactors
IntActⁱ	P23759, 14 interactors
MINTⁱ	P23759
STRINGⁱ	9606.ENSP00000364524

PTM databases

iPTMnetⁱ	P23759
PhosphoSitePlusⁱ	P23759

Polymorphism and mutation databases

BioMutaⁱ	PAX7
DMDMⁱ	8247951

Proteomic databases

PaxDbⁱ	P23759
PeptideAtlasⁱ	P23759
PRIDEⁱ	P23759
ProteomicsDBⁱ	54148 54149 [P23759-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000375375; ENSP00000364524; ENSG00000009709 [P23759-1] ENST00000400661; ENSP00000383502; ENSG00000009709 [P23759-2] ENST00000420770; ENSP00000403389; ENSG00000009709 [P23759-3]
GeneIDⁱ	5081
KEGGⁱ	hsa:5081
UCSCⁱ	uc001bay.3 human [P23759-3]

Organism-specific databases

CTDⁱ	5081
DisGeNETⁱ	5081
EuPathDBⁱ	HostDB:ENSG00000009709.11
GeneCardsⁱ	PAX7
HGNCⁱ	HGNC:8621 PAX7
MalaCardsⁱ	PAX7
MIMⁱ	167410 gene 268220 phenotype
neXtProtⁱ	NX_P23759
OpenTargetsⁱ	ENSG00000009709
Orphanetⁱ	99756 Alveolar rhabdomyosarcoma
PharmGKBⁱ	PA32961
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0849 Eukaryota ENOG410XS01 LUCA
GeneTreeⁱ	ENSGT00680000099553
HOGENOMⁱ	HOG000230939
HOVERGENⁱ	HBG009115
InParanoidⁱ	P23759
KOⁱ	K09381
OMAⁱ	GTVPRMV
OrthoDBⁱ	EOG091G0S4E
TreeFamⁱ	TF351610

Enzyme and pathway databases

SIGNORⁱ	P23759

SIGNORⁱ

P23759

Miscellaneous databases

ChiTaRSⁱ	PAX7 human
GeneWikiⁱ	PAX7
GenomeRNAiⁱ	5081
Protein Ontology More...PROⁱ	PR:P23759
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000009709 Expressed in 33 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_PAX7
Genevisibleⁱ	P23759 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit cd00131 PAX, 1 hit
Gene3Dⁱ	1.10.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom IPR001523 Paired_dom IPR022106 Pax7_C IPR036388 WH-like_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00292 PAX, 1 hit PF12360 Pax7, 1 hit
PRINTSⁱ	PR00027 PAIREDBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00351 PAX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit PS00034 PAIRED_1, 1 hit PS51057 PAIRED_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PAX7_HUMAN
Accessionⁱ	P23759Primary (citable) accession number: P23759 Secondary accession number(s): E9PFV9, Q0VA99, Q2PJS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	June 24, 2015
	Last modified:	September 12, 2018
	This is version 188 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P23759 (PAX7_HUMAN)

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Paired box protein Pax-7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ