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Protein

Histidine decarboxylase

Gene

Hdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of histamine from histidine.By similarity

Catalytic activityi

L-histidine = histamine + CO2.

Cofactori

Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (Hdc)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88Substrate; via amide nitrogenBy similarity1
Binding sitei201SubstrateBy similarity1

GO - Molecular functioni

  • amino acid binding Source: MGI
  • histidine decarboxylase activity Source: MGI
  • protein homodimerization activity Source: MGI
  • pyridoxal phosphate binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.22 3474
ReactomeiR-MMU-70921 Histidine catabolism
UniPathwayi
UPA00822;UER00786

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:Hdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96062 Hdc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469511 – 662Histidine decarboxylaseAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei312N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP23738
PRIDEiP23738

PTM databases

PhosphoSitePlusiP23738

Expressioni

Gene expression databases

BgeeiENSMUSG00000027360 Expressed in 176 organ(s), highest expression level in zone of skin
CleanExiMM_HDC
GenevisibleiP23738 MM

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200264, 1 interactor
STRINGi10090.ENSMUSP00000028838

Structurei

3D structure databases

ProteinModelPortaliP23738
SMRiP23738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiP23738
KOiK01590
OMAiPVYLRHE
OrthoDBiEOG091G03KI
TreeFamiTF313863

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequencei

Sequence statusi: Complete.

P23738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEPCEYREY REYYRARGKE MVDYISQYLS TVRERQVTPN VQPGYLRAQL
60 70 80 90 100
PASAPEEPDS WDSIFGDIER VIMPGVVHWQ SPHMHAYYPA LTSWPSLLGD
110 120 130 140 150
MLADAINCLG FTWASSPACT ELEMNIMDWL AKMLGLPEYF LHHHPSSRGG
160 170 180 190 200
GVLQSTVSES TLIALLAARK NKILAMKACE PDANESSLNA RLVAYTSDQA
210 220 230 240 250
HSSVEKAGLI SLVKIRFLPV DDNFSLRGEA LQKAIEEDKQ QGLVPVFVCA
260 270 280 290 300
TLGTTGVCAF DRLSELGPIC ASEGLWLHVD AAYAGTAFLC PELRGFLEGI
310 320 330 340 350
EYADSFTFNP SKWMMVHFDC TGFWVKDKYK LQQTFSVNPI YLRHANSGAA
360 370 380 390 400
TDFMHWQIPL SRRFRSIKLW FVIRSFGVKN LQAHVRHGTE MAKYFESLVR
410 420 430 440 450
SDPSFEIPAK RHLGLVVFRL KGPNCLTESV LKEIAKAGQL FLIPATIQDK
460 470 480 490 500
LIIRFTVTSQ FTTKEDILRD WHLIQEAANL VLSQHCTSQP SPRAKNVIPP
510 520 530 540 550
PPGTRGLSLE SVSEGGDDPA QARKIIKQPG ASLARREGGS DLETMPDPFD
560 570 580 590 600
DCFSEEAPNT TKHKLSSFLF SYLSVQNRRK TTRSLSCNSV PMSAQKSLPA
610 620 630 640 650
DASLKNGGSF RARIFSGFPE QMMMMKKGAF KKLIKFYSVP SFPECSSQCA
660
RQLPCCPLEA MV
Length:662
Mass (Da):74,045
Last modified:July 27, 2011 - v2
Checksum:iF4CBC771DD437E77
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177K → T in CAA40685 (PubMed:2125007).Curated1
Sequence conflicti177K → T AA sequence (PubMed:8268224).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57437 mRNA Translation: CAA40685.1
AF109137 mRNA Translation: AAC95389.1
AK088545 mRNA Translation: BAC40415.1
AK133455 mRNA Translation: BAE21666.1
AK150168 mRNA Translation: BAE29356.1
AK153104 mRNA Translation: BAE31724.1
AL844555 Genomic DNA Translation: CAM18696.1
CH466519 Genomic DNA Translation: EDL28158.1
S67000 Genomic DNA Translation: AAB29093.1
CCDSiCCDS16684.1
PIRiS12989
RefSeqiNP_032256.3, NM_008230.6
UniGeneiMm.18603

Genome annotation databases

EnsembliENSMUST00000028838; ENSMUSP00000028838; ENSMUSG00000027360
GeneIDi15186
KEGGimmu:15186
UCSCiuc008mdr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57437 mRNA Translation: CAA40685.1
AF109137 mRNA Translation: AAC95389.1
AK088545 mRNA Translation: BAC40415.1
AK133455 mRNA Translation: BAE21666.1
AK150168 mRNA Translation: BAE29356.1
AK153104 mRNA Translation: BAE31724.1
AL844555 Genomic DNA Translation: CAM18696.1
CH466519 Genomic DNA Translation: EDL28158.1
S67000 Genomic DNA Translation: AAB29093.1
CCDSiCCDS16684.1
PIRiS12989
RefSeqiNP_032256.3, NM_008230.6
UniGeneiMm.18603

3D structure databases

ProteinModelPortaliP23738
SMRiP23738
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200264, 1 interactor
STRINGi10090.ENSMUSP00000028838

PTM databases

PhosphoSitePlusiP23738

Proteomic databases

PaxDbiP23738
PRIDEiP23738

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028838; ENSMUSP00000028838; ENSMUSG00000027360
GeneIDi15186
KEGGimmu:15186
UCSCiuc008mdr.2 mouse

Organism-specific databases

CTDi3067
MGIiMGI:96062 Hdc

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiP23738
KOiK01590
OMAiPVYLRHE
OrthoDBiEOG091G03KI
TreeFamiTF313863

Enzyme and pathway databases

UniPathwayi
UPA00822;UER00786

BRENDAi4.1.1.22 3474
ReactomeiR-MMU-70921 Histidine catabolism

Miscellaneous databases

ChiTaRSiHdc mouse
PROiPR:P23738
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027360 Expressed in 176 organ(s), highest expression level in zone of skin
CleanExiMM_HDC
GenevisibleiP23738 MM

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCHS_MOUSE
AccessioniPrimary (citable) accession number: P23738
Secondary accession number(s): Q9QWU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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