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Protein

Proteasome subunit beta type-6

Gene

PRE7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

  • proteasomal ubiquitin-independent protein catabolic process Source: SGD
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciYEAST:G3O-28942-MONOMER
ReactomeiR-SCE-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SCE-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SCE-187577 SCF(Skp2)-mediated degradation of p27/p21
R-SCE-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-SCE-382556 ABC-family proteins mediated transport
R-SCE-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SCE-5668541 TNFR2 non-canonical NF-kB pathway
R-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-5689880 Ub-specific processing proteases
R-SCE-6798695 Neutrophil degranulation
R-SCE-68949 Orc1 removal from chromatin
R-SCE-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SCE-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SCE-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SCE-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.A12

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-6 (EC:3.4.25.1)
Alternative name(s):
Multicatalytic endopeptidase complex subunit C5
Proteasome component C5
Gene namesi
Name:PRE7
Synonyms:PRS3, PTS1
Ordered Locus Names:YBL041W
ORF Names:YBL0407
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL041W
SGDiS000000137 PRE7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4904

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003314891 – 19Add BLAST19
ChainiPRO_000014804220 – 241Proteasome subunit beta type-6Add BLAST222

Proteomic databases

MaxQBiP23724
PaxDbiP23724
PRIDEiP23724

2D gel databases

UCD-2DPAGEiP23724

PTM databases

iPTMnetiP23724

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32656, 399 interactors
ComplexPortaliCPX-2262 26S Proteasome complex
DIPiDIP-2821N
IntActiP23724, 27 interactors
MINTiP23724
STRINGi4932.YBL041W

Chemistry databases

BindingDBiP23724

Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi40 – 45Combined sources6
Beta strandi48 – 50Combined sources3
Beta strandi53 – 57Combined sources5
Beta strandi62 – 64Combined sources3
Beta strandi70 – 76Combined sources7
Helixi77 – 97Combined sources21
Turni98 – 100Combined sources3
Helixi105 – 117Combined sources13
Turni118 – 121Combined sources4
Beta strandi126 – 133Combined sources8
Beta strandi139 – 144Combined sources6
Beta strandi146 – 148Combined sources3
Beta strandi150 – 159Combined sources10
Helixi162 – 172Combined sources11
Turni181 – 183Combined sources3
Beta strandi186 – 188Combined sources3
Helixi196 – 213Combined sources18
Beta strandi214 – 217Combined sources4
Beta strandi219 – 227Combined sources9
Beta strandi230 – 237Combined sources8

3D structure databases

ProteinModelPortaliP23724
SMRiP23724
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23724

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075035
HOGENOMiHOG000091081
InParanoidiP23724
KOiK02732
OMAiEHRFNPY
OrthoDBiEOG092C4IM8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR035202 Proteasome_beta1
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF59 PTHR11599:SF59, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIASEYSS EASNTPIEHQ FNPYGDNGGT ILGIAGEDFA VLAGDTRNIT
60 70 80 90 100
DYSINSRYEP KVFDCGDNIV MSANGFAADG DALVKRFKNS VKWYHFDHND
110 120 130 140 150
KKLSINSAAR NIQHLLYGKR FFPYYVHTII AGLDEDGKGA VYSFDPVGSY
160 170 180 190 200
EREQCRAGGA AASLIMPFLD NQVNFKNQYE PGTNGKVKKP LKYLSVEEVI
210 220 230 240
KLVRDSFTSA TERHIQVGDG LEILIVTKDG VRKEFYELKR D
Length:241
Mass (Da):26,871
Last modified:November 1, 1991 - v1
Checksum:i770A4DF1DF0A0F0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34777 Genomic DNA Translation: AAA68908.1
D00845 Genomic DNA Translation: BAA00725.1
X78214 Genomic DNA Translation: CAA55053.1
Z35802 Genomic DNA Translation: CAA84861.1
AY558462 Genomic DNA Translation: AAS56788.1
BK006936 Genomic DNA Translation: DAA07077.1
PIRiS42436
RefSeqiNP_009512.1, NM_001178281.1

Genome annotation databases

EnsemblFungiiYBL041W; YBL041W; YBL041W
GeneIDi852239
KEGGisce:YBL041W

Similar proteinsi

Entry informationi

Entry nameiPSB6_YEAST
AccessioniPrimary (citable) accession number: P23724
Secondary accession number(s): D6VPV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: July 18, 2018
This is version 199 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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