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UniProtKB - P23702 (LTXB_AGGAC)
Protein
Leukotoxin export ATP-binding protein LtxB
Gene
ltxB
Organism
Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Status
Functioni
Involved in the export of the LtxA leukotoxin.
1 PublicationCaution
Leu-9 is present instead of the conserved Cys which is expected to be the active site residue of peptidase C39. Thus they are presumed to be without peptidase activity.Curated
Catalytic activityi
- ATP + H(2)O + protein(Side 1) = ADP + phosphate + protein(Side 2).By similarity EC:7.4.2.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 83 | PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 502 – 509 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type peptide transporter activity Source: UniProtKB-EC
- ABC-type protein transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- peptidase activity Source: InterPro
GO - Biological processi
- protein secretion by the type I secretion system Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
TCDBi | 3.A.1.109.8, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ltxB1 Publication Synonyms:AaLtb1 Publication, lktB1 Publication |
Organismi | Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) |
Taxonomic identifieri | 714 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Aggregatibacter |
Subcellular locationi
Plasma membrane
- Cell inner membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- type I protein secretion system complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 295 – 315 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 387 – 407 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutation has no effect on the levels of leukotoxin mRNA, but mutants have significantly less total leukotoxin than the parent strain.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092377 | 1 – 707 | Leukotoxin export ATP-binding protein LtxBAdd BLAST | 707 |
Expressioni
Inductioni
Levels of toxin expression vary greatly among strains. Highly leukotoxic strains (JP2-type strains) produce more LtxA protein and ltx mRNA than minimally leukotoxic strains (652-type strains). Variations are probably due to different types of promoters.1 Publication
Interactioni
Subunit structurei
Probably part of a complex composed of LtxB, LtxD and TdeA, which forms a single transport channel across the two membranes.
1 PublicationProtein-protein interaction databases
STRINGi | 714.ACT75_09610 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 125 | Peptidase C39PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 158 – 436 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 279 | |
Domaini | 468 – 703 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 236 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2274, Bacteria |
Family and domain databases
CDDi | cd02417, Peptidase_C39_likeA, 1 hit |
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR010132, ATPase_T1SS_HlyB IPR027417, P-loop_NTPase IPR005074, Peptidase_C39 IPR039395, Peptidase_C39-like_A IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF03412, Peptidase_C39, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR01846, type_I_sec_HlyB, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS50990, PEPTIDASE_C39, 1 hit |
i Sequence
Sequence statusi: Complete.
P23702-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSQKNTNLA LQALEVLAQY HNISINPEEI KHKFDIDGHG LNQTKWLLAA
60 70 80 90 100
KSLGLKVRTA NKTVDRLPFL HLPALAWRDD GEHFILLKID QETDRYLIFD
110 120 130 140 150
LIQKNPIVLD KNEFEERYQS KVILIASRAS IVGNLAKFDF TWFIPAVIKY
160 170 180 190 200
RKIFIETLIV SIFLQIFALI TPLFFQVVMD KVLVHRGFST LNVITVALAI
210 220 230 240 250
VVLFEIILGG LRTYVFAHST SRIDVELGAR LFRHLLALPI SYFEARRVGD
260 270 280 290 300
TVARVRELDQ IRNFLTGQAL TSILDLLFSF IFFAVMWYYS PKLTLVVLGS
310 320 330 340 350
LPCYVIWSVF ISPILRRRLD DKFARNADNQ SFLVESVTAI NTIKAMAISP
360 370 380 390 400
QMTNIWDKQL ASYVAVSFKV TVLATIGQQG IQLIQKAVMV INLWLGAHLV
410 420 430 440 450
ISGDLSIGQL IAFNMLAGQI ISPVIRLAQI WQDFQQVGIS VTRLGDVLNS
460 470 480 490 500
PTENNTASVS LPEIQGEISF RNIKFRYKPD SPMILNNINL DISQGEVIGI
510 520 530 540 550
VGRSGSGKST LTKLIQRFYI PEQGQVLIDG HDLALADPNW LRRQVGVVLQ
560 570 580 590 600
DNVLLNRSIR ENIALTNPGM PMEKVIAAAK LAGAHDFISE LREGYNTVVG
610 620 630 640 650
EQGAGLSGGQ RQRIAIARAL VNNPRILIFD EATSALDYES ENIIMHNMHK
660 670 680 690 700
ICQNRTVLII AHRLSTVKNA DRIIVMDKGE IIEQGKHQEL LKDEKGLYSY
LHQLQVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53955 Genomic DNA Translation: CAA37906.1 |
PIRi | A61378 |
RefSeqi | WP_025298517.1, NZ_CP065604.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53955 Genomic DNA Translation: CAA37906.1 |
PIRi | A61378 |
RefSeqi | WP_025298517.1, NZ_CP065604.1 |
3D structure databases
SMRi | P23702 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 714.ACT75_09610 |
Protein family/group databases
TCDBi | 3.A.1.109.8, the atp-binding cassette (abc) superfamily |
Phylogenomic databases
eggNOGi | COG2274, Bacteria |
Family and domain databases
CDDi | cd02417, Peptidase_C39_likeA, 1 hit |
Gene3Di | 1.20.1560.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR010132, ATPase_T1SS_HlyB IPR027417, P-loop_NTPase IPR005074, Peptidase_C39 IPR039395, Peptidase_C39-like_A IPR039421, Type_1_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 1 hit PF00005, ABC_tran, 1 hit PF03412, Peptidase_C39, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF90123, SSF90123, 1 hit |
TIGRFAMsi | TIGR01846, type_I_sec_HlyB, 1 hit |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 1 hit PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS50990, PEPTIDASE_C39, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LTXB_AGGAC | |
Accessioni | P23702Primary (citable) accession number: P23702 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |