UniProtKB - P23696 (PP2A_DROME)
Protein
Serine/threonine-protein phosphatase PP2A
Gene
mts
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
Cofactori
Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 57 | Manganese 1By similarity | 1 | |
Metal bindingi | 59 | Manganese 1By similarity | 1 | |
Metal bindingi | 85 | Manganese 1By similarity | 1 | |
Metal bindingi | 85 | Manganese 2By similarity | 1 | |
Metal bindingi | 117 | Manganese 2By similarity | 1 | |
Active sitei | 118 | Proton donorBy similarity | 1 | |
Metal bindingi | 167 | Manganese 2By similarity | 1 | |
Metal bindingi | 241 | Manganese 2By similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- phosphatase regulator activity Source: FlyBase
- protein serine/threonine phosphatase activity Source: FlyBase
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- asymmetric neuroblast division Source: FlyBase
- autophagy Source: FlyBase
- centriole replication Source: FlyBase
- centrosome cycle Source: FlyBase
- chromosome segregation Source: FlyBase
- circadian rhythm Source: Reactome
- establishment of epithelial cell polarity Source: FlyBase
- microtubule cytoskeleton organization Source: FlyBase
- mitotic cell cycle Source: FlyBase
- negative regulation of hippo signaling Source: FlyBase
- negative regulation of insulin receptor signaling pathway Source: FlyBase
- negative regulation of neuroblast proliferation Source: FlyBase
- negative regulation of protein kinase B signaling Source: FlyBase
- negative regulation of protein phosphorylation Source: FlyBase
- negative regulation of smoothened signaling pathway Source: FlyBase
- oogenesis Source: FlyBase
- positive regulation of canonical Wnt signaling pathway Source: FlyBase
- positive regulation of smoothened signaling pathway Source: FlyBase
- protein dephosphorylation Source: FlyBase
- R7 cell fate commitment Source: FlyBase
- response to light stimulus Source: FlyBase
- spindle assembly Source: FlyBase
- spindle organization Source: FlyBase
- wing disc dorsal/ventral pattern formation Source: FlyBase
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DME-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-1295596, Spry regulation of FGF signaling R-DME-195253, Degradation of beta-catenin by the destruction complex R-DME-196299, Beta-catenin phosphorylation cascade R-DME-198753, ERK/MAPK targets R-DME-202670, ERKs are inactivated R-DME-209155, Phosphorylation of AXN and APC R-DME-209190, Phosphorylation of CI R-DME-209214, Phosphorylation of SMO R-DME-209360, Ubiquitination and proteolysis of phosphorylated CI R-DME-209396, Phosphorylation of ARM R-DME-209413, Assembly of the 'destruction complex' R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209461, Ubiquitination and degradation of phosphorylated ARM R-DME-2995383, Initiation of Nuclear Envelope (NE) Reformation R-DME-389513, CTLA4 inhibitory signaling R-DME-432553, Phosphorylation of PER and TIM R-DME-432620, Dephosphorylation of PER R-DME-432626, Circadian Clock pathway R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-69231, Cyclin D associated events in G1 R-DME-69273, Cyclin A/B1/B2 associated events during G2/M transition R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P23696 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase PP2A (EC:3.1.3.16)Alternative name(s): Protein microtubule star |
Gene namesi | Name:mts Synonyms:PP2A, Pp2A-28D ORF Names:CG7109 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004177, mts |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
- FAR/SIN/STRIPAK complex Source: FlyBase
- protein phosphatase type 2A complex Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058850 | 1 – 309 | Serine/threonine-protein phosphatase PP2AAdd BLAST | 309 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 309 | Leucine methyl esterBy similarity | 1 |
Post-translational modificationi
Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization (By similarity).By similarity
Keywords - PTMi
MethylationProteomic databases
PaxDbi | P23696 |
PRIDEi | P23696 |
Expressioni
Gene expression databases
Bgeei | FBgn0004177, Expressed in embryo and 43 other tissues |
ExpressionAtlasi | P23696, baseline and differential |
Genevisiblei | P23696, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 70018, 92 interactors |
DIPi | DIP-17814N |
IntActi | P23696, 7 interactors |
MINTi | P23696 |
STRINGi | 7227.FBpp0079148 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0371, Eukaryota |
HOGENOMi | CLU_004962_0_5_1 |
InParanoidi | P23696 |
OMAi | EGYNWGQ |
OrthoDBi | 808922at2759 |
PhylomeDBi | P23696 |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR006186, Ser/Thr-sp_prot-phosphatase |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P23696-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDKATTKDL DQWIEQLNEC NQLTETQVRT LCDKAKEILS KESNVQEVKC
60 70 80 90 100
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
110 120 130 140 150
VALKVRYRER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
160 170 180 190 200
DYLPLTALVD GQIFCLHGGL SPSIDSLDHI RALDRLQEVP HEGPMCDLLW
210 220 230 240 250
SDPDDRGGWG ISPRGAGYTF GQDISETFNN TNGLTLVSRA HQLVMEGYNW
260 270 280 290 300
CHDRNVVTIF SAPNYCYRCG NQAALMELDD SLKFSFLQFD PAPRRGEPHV
TRRTPDYFL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX2JDI1 | X2JDI1_DROME | Serine/threonine-protein phosphatas... | mts 5559, Dmel\CG7109, DmPp2A-28D, dPP2A, dPP2A-C | 309 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55199 mRNA Translation: CAA38984.1 X78577 mRNA Translation: CAA55315.1 AE014134 Genomic DNA Translation: AAF52567.2 AY058571 mRNA Translation: AAL13800.1 |
PIRi | S12961 |
RefSeqi | NP_001285724.1, NM_001298795.1 NP_001285725.1, NM_001298796.1 NP_476805.1, NM_057457.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0079525; FBpp0079148; FBgn0004177 FBtr0343416; FBpp0310062; FBgn0004177 FBtr0343417; FBpp0310063; FBgn0004177 |
GeneIDi | 45959 |
KEGGi | dme:Dmel_CG7109 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55199 mRNA Translation: CAA38984.1 X78577 mRNA Translation: CAA55315.1 AE014134 Genomic DNA Translation: AAF52567.2 AY058571 mRNA Translation: AAL13800.1 |
PIRi | S12961 |
RefSeqi | NP_001285724.1, NM_001298795.1 NP_001285725.1, NM_001298796.1 NP_476805.1, NM_057457.4 |
3D structure databases
SMRi | P23696 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 70018, 92 interactors |
DIPi | DIP-17814N |
IntActi | P23696, 7 interactors |
MINTi | P23696 |
STRINGi | 7227.FBpp0079148 |
Proteomic databases
PaxDbi | P23696 |
PRIDEi | P23696 |
Genome annotation databases
EnsemblMetazoai | FBtr0079525; FBpp0079148; FBgn0004177 FBtr0343416; FBpp0310062; FBgn0004177 FBtr0343417; FBpp0310063; FBgn0004177 |
GeneIDi | 45959 |
KEGGi | dme:Dmel_CG7109 |
Organism-specific databases
CTDi | 45959 |
FlyBasei | FBgn0004177, mts |
Phylogenomic databases
eggNOGi | KOG0371, Eukaryota |
HOGENOMi | CLU_004962_0_5_1 |
InParanoidi | P23696 |
OMAi | EGYNWGQ |
OrthoDBi | 808922at2759 |
PhylomeDBi | P23696 |
Enzyme and pathway databases
Reactomei | R-DME-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-DME-1295596, Spry regulation of FGF signaling R-DME-195253, Degradation of beta-catenin by the destruction complex R-DME-196299, Beta-catenin phosphorylation cascade R-DME-198753, ERK/MAPK targets R-DME-202670, ERKs are inactivated R-DME-209155, Phosphorylation of AXN and APC R-DME-209190, Phosphorylation of CI R-DME-209214, Phosphorylation of SMO R-DME-209360, Ubiquitination and proteolysis of phosphorylated CI R-DME-209396, Phosphorylation of ARM R-DME-209413, Assembly of the 'destruction complex' R-DME-209440, Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM R-DME-209461, Ubiquitination and degradation of phosphorylated ARM R-DME-2995383, Initiation of Nuclear Envelope (NE) Reformation R-DME-389513, CTLA4 inhibitory signaling R-DME-432553, Phosphorylation of PER and TIM R-DME-432620, Dephosphorylation of PER R-DME-432626, Circadian Clock pathway R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-DME-69231, Cyclin D associated events in G1 R-DME-69273, Cyclin A/B1/B2 associated events during G2/M transition R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P23696 |
Miscellaneous databases
BioGRID-ORCSi | 45959, 0 hits in 3 CRISPR screens |
ChiTaRSi | mts, fly |
GenomeRNAii | 45959 |
PROi | PR:P23696 |
Gene expression databases
Bgeei | FBgn0004177, Expressed in embryo and 43 other tissues |
ExpressionAtlasi | P23696, baseline and differential |
Genevisiblei | P23696, DM |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR006186, Ser/Thr-sp_prot-phosphatase |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PP2A_DROME | |
Accessioni | P23696Primary (citable) accession number: P23696 Secondary accession number(s): Q9VLW4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 10, 2021 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families