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Protein

Insulin-like growth factor II

Gene

IGF2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling.By similarity
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.By similarity

Miscellaneous

The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48Important for interaction with integrinBy similarity1
Sitei58Important for interaction with integrinBy similarity1
Sitei61Important for interaction with integrinBy similarity1
Sitei62Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone, Mitogen
Biological processCarbohydrate metabolism, Glucose metabolism, Osteogenesis

Enzyme and pathway databases

ReactomeiR-SSC-114608 Platelet degranulation
R-SSC-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-SSC-2428928 IRS-related events triggered by IGF1R
R-SSC-2428933 SHC-related events triggered by IGF1R
R-SSC-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Cleaved into the following 2 chains:
Gene namesi
Name:IGF2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000001572725 – 91Insulin-like growth factor IIAdd BLAST67
PropeptideiPRO_000001572892 – 181E peptideAdd BLAST90
PeptideiPRO_000037037993 – 126PreptinAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 71By similarity
Disulfide bondi45 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity
Glycosylationi163O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP23695
PRIDEiP23695

Expressioni

Gene expression databases

ExpressionAtlasiP23695 differential

Interactioni

Subunit structurei

Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP23695
SMRiP23695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 52BAdd BLAST28
Regioni53 – 64CAdd BLAST12
Regioni65 – 85AAdd BLAST21
Regioni86 – 91D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000063856
HOVERGENiHBG006137
InParanoidiP23695
KOiK13769

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P23695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIPMRKPLL VLLVFLALAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF
60 70 80 90 100
YFSRPASRVN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV
110 120 130 140 150
LPDNFPRYPV GKFFRYDTWK QSAQRLRRGL PALLRARRGR TLAKELEAVR
160 170 180
EAKRHRPLTA RPTRDPAAHG GASPEASGHR K
Length:181
Mass (Da):20,313
Last modified:February 1, 1996 - v2
Checksum:i1816B935299B44E1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A287AGI2A0A287AGI2_PIG
Insulin-like growth factor II
IGF2
213Annotation score:
G9BFT6G9BFT6_PIG
Insulin-like growth factor 2 transc...
IGF2
184Annotation score:
A0A287AML9A0A287AML9_PIG
Insulin-like growth factor II
IGF2
427Annotation score:
A0A287BJL7A0A287BJL7_PIG
Insulin-like growth factor II
IGF2
583Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56094 mRNA Translation: CAA39574.1
AY044828 Genomic DNA Translation: AAL69551.1
AY242098 Genomic DNA Translation: AAQ00953.1
AY242099 Genomic DNA Translation: AAQ00955.1
AY242100 Genomic DNA Translation: AAQ00958.1
AY242101 Genomic DNA Translation: AAQ00961.1
AY242102 Genomic DNA Translation: AAQ00964.1
AY242103 Genomic DNA Translation: AAQ00967.1
AY242104 Genomic DNA Translation: AAQ00970.1
AY242105 Genomic DNA Translation: AAQ00973.1
AY242106 Genomic DNA Translation: AAQ00976.1
AY242107 Genomic DNA Translation: AAQ00979.1
AY242108 Genomic DNA Translation: AAQ00982.1
AY242109 Genomic DNA Translation: AAQ00984.1
AY242110 Genomic DNA Translation: AAQ00986.1
AY242111 Genomic DNA Translation: AAQ00988.1
AY242112 Genomic DNA Translation: AAQ00991.1
PIRiS12614 B60738
RefSeqiNP_999048.1, NM_213883.2
UniGeneiSsc.9365

Genome annotation databases

EnsembliENSSSCT00000038020; ENSSSCP00000038276; ENSSSCG00000035293
ENSSSCT00000048823; ENSSSCP00000033333; ENSSSCG00000035293
ENSSSCT00000057550; ENSSSCP00000051427; ENSSSCG00000035293
GeneIDi396916
KEGGissc:396916

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56094 mRNA Translation: CAA39574.1
AY044828 Genomic DNA Translation: AAL69551.1
AY242098 Genomic DNA Translation: AAQ00953.1
AY242099 Genomic DNA Translation: AAQ00955.1
AY242100 Genomic DNA Translation: AAQ00958.1
AY242101 Genomic DNA Translation: AAQ00961.1
AY242102 Genomic DNA Translation: AAQ00964.1
AY242103 Genomic DNA Translation: AAQ00967.1
AY242104 Genomic DNA Translation: AAQ00970.1
AY242105 Genomic DNA Translation: AAQ00973.1
AY242106 Genomic DNA Translation: AAQ00976.1
AY242107 Genomic DNA Translation: AAQ00979.1
AY242108 Genomic DNA Translation: AAQ00982.1
AY242109 Genomic DNA Translation: AAQ00984.1
AY242110 Genomic DNA Translation: AAQ00986.1
AY242111 Genomic DNA Translation: AAQ00988.1
AY242112 Genomic DNA Translation: AAQ00991.1
PIRiS12614 B60738
RefSeqiNP_999048.1, NM_213883.2
UniGeneiSsc.9365

3D structure databases

ProteinModelPortaliP23695
SMRiP23695
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiP23695
PRIDEiP23695

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000038020; ENSSSCP00000038276; ENSSSCG00000035293
ENSSSCT00000048823; ENSSSCP00000033333; ENSSSCG00000035293
ENSSSCT00000057550; ENSSSCP00000051427; ENSSSCG00000035293
GeneIDi396916
KEGGissc:396916

Organism-specific databases

CTDi3481

Phylogenomic databases

GeneTreeiENSGT00530000063856
HOVERGENiHBG006137
InParanoidiP23695
KOiK13769

Enzyme and pathway databases

ReactomeiR-SSC-114608 Platelet degranulation
R-SSC-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-SSC-2428928 IRS-related events triggered by IGF1R
R-SSC-2428933 SHC-related events triggered by IGF1R
R-SSC-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Gene expression databases

ExpressionAtlasiP23695 differential

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 2 hits
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIGF2_PIG
AccessioniPrimary (citable) accession number: P23695
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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