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UniProtKB - P23685 (NAC1_CANLF)

Entry version 152 (02 Dec 2020)
Sequence version 1 (01 Nov 1991)
Previous versions | rss
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Protein

Sodium/calcium exchanger 1

Gene

SLC8A1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).By similarity5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by micromolar levels of Ca2+. In the absence of regulatory Ca2+, channels open rapidly, and then inactivate rapidly. Inactivation is enhanced by Na+ and is inhibited by micromolar levels of Ca2+.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi417Calcium 1Combined sources1
Metal bindingi417Calcium 2Combined sources1
Metal bindingi417Calcium 3Combined sources1
Metal bindingi453Calcium 1Combined sources1
Metal bindingi453Calcium 4Combined sources1
Metal bindingi478Calcium 2Combined sources1
Metal bindingi479Calcium 1Combined sources1
Metal bindingi479Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi479Calcium 3Combined sources1
Metal bindingi479Calcium 4Combined sources1
Metal bindingi481Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi483Calcium 1Combined sources1
Metal bindingi483Calcium 3Combined sources1
Metal bindingi483Calcium 4Combined sources1
Metal bindingi486Calcium 4Combined sources1
Metal bindingi530Calcium 3Combined sources1
Metal bindingi531Calcium 2Combined sources1
Metal bindingi532Calcium 2Combined sources1
Metal bindingi532Calcium 3Combined sources1
Metal bindingi548Calcium 5Combined sources1
Metal bindingi584Calcium 6Combined sources1
Metal bindingi610Calcium 5Combined sources1
Metal bindingi610Calcium 6Combined sources1
Metal bindingi611Calcium 6Combined sources1
Metal bindingi612Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi612Calcium 6Combined sources1
Metal bindingi715Calcium 5Combined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processAntiport, Calcium transport, Ion transport, Sodium transport, Transport
LigandCalcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CFA-418359, Reduction of cytosolic Ca++ levels
R-CFA-425561, Sodium/Calcium exchangers
R-CFA-5578775, Ion homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/calcium exchanger 1
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 1
Solute carrier family 8 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC8A1
Synonyms:NCX11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 71ExtracellularSequence analysisAdd BLAST39
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 133CytoplasmicSequence analysisAdd BLAST41
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 167ExtracellularSequence analysisAdd BLAST13
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 228ExtracellularSequence analysis6
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 797CytoplasmicCuratedAdd BLAST548
Transmembranei798 – 818HelicalSequence analysisAdd BLAST21
Topological domaini819 – 821ExtracellularSequence analysis3
Transmembranei822 – 842HelicalSequence analysisAdd BLAST21
Topological domaini843 – 871CytoplasmicSequence analysisAdd BLAST29
Transmembranei872 – 892HelicalSequence analysisAdd BLAST21
Topological domaini893 – 903ExtracellularSequence analysisAdd BLAST11
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Topological domaini925 – 941CytoplasmicSequence analysisAdd BLAST17
Transmembranei942 – 962HelicalSequence analysisAdd BLAST21
Topological domaini963 – 970ExtracellularSequence analysis8

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi548E → L: Abolishes regulation by micromolar Ca(2+). 1 Publication1
Mutagenesisi584D → V: No effect on regulation by micromolar Ca(2+). 1 Publication1
Mutagenesisi610D → V: Abolishes regulation by micromolar Ca(2+). 1 Publication1
Mutagenesisi617K → E: Decreases affinity for Ca(2+), but retains regulation by micromolar Ca(2+). 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001937633 – 970Sodium/calcium exchanger 1Add BLAST938

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei282PhosphoserineBy similarity1
Modified residuei389PhosphoserineSequence analysisBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23685

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23685

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P23685

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cardiac sarcolemma (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSCAFG00000023592, Expressed in cardiac muscle of left ventricle and 50 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-59598N

STRING: functional protein association networks

More...STRINGi		9612.ENSCAFP00000009692

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1970
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P23685

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23685

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23685

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati138 – 178Alpha-1Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini393 – 493Calx-beta 1Add BLAST101
Domaini524 – 624Calx-beta 2Add BLAST101
Repeati839 – 875Alpha-2Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 270Putative calmodulin-binding region1 PublicationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi236 – 239Poly-Phe4
Compositional biasi689 – 692Poly-Glu4
Compositional biasi756 – 760Poly-Asp5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic Calx-beta domains bind the regulatory Ca2+. The first Calx-beta domain can bind up to four Ca2+ ions (PubMed:16774926, PubMed:19332552, PubMed:22768191). The second domain can bind another two Ca2+ ions that are essential for calcium-regulated ion exchange (PubMed:17962412).4 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1306, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012872_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23685

Identification of Orthologs from Complete Genome Data

More...OMAi		HFICLFW

Database of Orthologous Groups

More...OrthoDBi		490546at2759

TreeFam database of animal gene trees

More...TreeFami		TF314308

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.2030, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR001623, DnaJ_domain
IPR004836, Na_Ca_Ex
IPR032452, Na_Ca_Ex_C-exten
IPR002987, NaCa_exhngr1
IPR004837, NaCa_Exmemb

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03160, Calx-beta, 2 hits
PF01699, Na_Ca_ex, 2 hits
PF16494, Na_Ca_ex_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01259, NACAEXCHNGR
PR01260, NACAEXCHNGR1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00237, Calx_beta, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141072, SSF141072, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00845, caca, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P23685-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQLRLLPTF SMGCHLLAVV ALLFSHVDLI SAETEMEGEG NETGECTGSY 
        60         70         80         90        100
YCKKGVILPI WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI 
       110        120        130        140        150
EVITSQEKEI TIKKPNGETT KTTVRIWNET VSNLTLMALG SSAPEILLSV 
       160        170        180        190        200
IEVCGHNFTA GDLGPSTIVG SAAFNMFIII ALCVYVVPDG ETRKIKHLRV 
       210        220        230        240        250
FFVTAAWSIF AYTWLYIILS VISPGVVEVW EGLLTFFFFP ICVVFAWVAD 
       260        270        280        290        300
RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP SSKTEIEMDG KVVNSHVDNF 
       310        320        330        340        350
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV 
       360        370        380        390        400
LSQQQKSRAF YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNTEVAEN 
       410        420        430        440        450
DPVSKIFFEQ GTYQCLENCG TVALTIIRRG GDLTNTVFVD FRTEDGTANA 
       460        470        480        490        500
GSDYEFTEGT VVFKPGETQK EIRVGIIDDD IFEEDENFLV HLSNVKVSSE 
       510        520        530        540        550
ASEDGILEAN HVSALACLGS PSTATVTIFD DDHAGIFTFE EPVTHVSESI 
       560        570        580        590        600
GIMEVKVLRT SGARGNVIVP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV 
       610        620        630        640        650
KTISVKVIDD EEYEKNKTFF LEIGEPRLVE MSEKKALLLN ELGGFTITGK 
       660        670        680        690        700
YLYGQPVFRK VHAREHPIPS TVITIAEEYD DKQPLTSKEE EERRIAEMGR 
       710        720        730        740        750
PILGEHTKLE VIIEESYEFK STVDKLIKKT NLALVVGTNS WREQFIEAIT 
       760        770        780        790        800
VSAGEDDDDD ECGEEKLPSC FDYVMHFLTV FWKVLFAFVP PTEYWNGWAC 
       810        820        830        840        850
FIVSILMIGI LTAFIGDLAS HFGCTIGLKD SVTAVVFVAL GTSVPDTFAS 
       860        870        880        890        900
KVAATQDQYA DASIGNVTGS NAVNVFLGIG VAWSIAAIYH AANGEQFKVS 
       910        920        930        940        950
PGTLAFSVTL FTIFAFINVG VLLYRRRPEI GGELGGPRTA KLLTSCLFVL 
       960        970
LWLLYIFFSS LEAYCHIKGF
Length:970
Mass (Da):108,004
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBBDBCC584846AE08
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M57523 mRNA Translation: AAA62766.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36417

NCBI Reference Sequences

More...RefSeqi		NP_001291891.1, NM_001304962.1
XP_013975680.1, XM_014120205.1
XP_013975681.1, XM_014120206.1
XP_013975682.1, XM_014120207.1
XP_013975683.1, XM_014120208.1
XP_013975684.1, XM_014120209.1
XP_013975685.1, XM_014120210.1
XP_013975686.1, XM_014120211.1
XP_013975687.1, XM_014120212.1
XP_013975688.1, XM_014120213.1
XP_013975689.1, XM_014120214.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		475738

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cfa:475738

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57523 mRNA Translation: AAA62766.1
PIRiA36417
RefSeqiNP_001291891.1, NM_001304962.1
XP_013975680.1, XM_014120205.1
XP_013975681.1, XM_014120206.1
XP_013975682.1, XM_014120207.1
XP_013975683.1, XM_014120208.1
XP_013975684.1, XM_014120209.1
XP_013975685.1, XM_014120210.1
XP_013975686.1, XM_014120211.1
XP_013975687.1, XM_014120212.1
XP_013975688.1, XM_014120213.1
XP_013975689.1, XM_014120214.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DPKX-ray2.50A402-541[»]
2FWSNMR-A403-541[»]
2FWUNMR-A533-724[»]
2QVKX-ray1.45A533-721[»]
2QVMX-ray1.70A533-721[»]
3GINX-ray2.40A/B402-541[»]
3US9X-ray2.68A403-724[»]
6BV7NMR-A306-359[»]
BMRBiP23685
SMRiP23685
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59598N
STRINGi9612.ENSCAFP00000009692

PTM databases

iPTMnetiP23685
SwissPalmiP23685

Proteomic databases

PaxDbiP23685

Genome annotation databases

GeneIDi475738
KEGGicfa:475738

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6546

Phylogenomic databases

eggNOGiKOG1306, Eukaryota
HOGENOMiCLU_012872_1_0_1
InParanoidiP23685
OMAiHFICLFW
OrthoDBi490546at2759
TreeFamiTF314308

Enzyme and pathway databases

ReactomeiR-CFA-418359, Reduction of cytosolic Ca++ levels
R-CFA-425561, Sodium/Calcium exchangers
R-CFA-5578775, Ion homeostasis

Miscellaneous databases

EvolutionaryTraceiP23685

Gene expression databases

BgeeiENSCAFG00000023592, Expressed in cardiac muscle of left ventricle and 50 other tissues

Family and domain databases

Gene3Di2.60.40.2030, 1 hit
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR001623, DnaJ_domain
IPR004836, Na_Ca_Ex
IPR032452, Na_Ca_Ex_C-exten
IPR002987, NaCa_exhngr1
IPR004837, NaCa_Exmemb
PfamiView protein in Pfam
PF03160, Calx-beta, 2 hits
PF01699, Na_Ca_ex, 2 hits
PF16494, Na_Ca_ex_C, 1 hit
PRINTSiPR01259, NACAEXCHNGR
PR01260, NACAEXCHNGR1
SMARTiView protein in SMART
SM00237, Calx_beta, 2 hits
SUPFAMiSSF141072, SSF141072, 2 hits
TIGRFAMsiTIGR00845, caca, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAC1_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23685
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: December 2, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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