UniProtKB - P23685 (NAC1_CANLF)

BLAST

>sp|P23685|NAC1_CANLF Sodium/calcium exchanger 1 OS=Canis lupus familiaris OX=9615 GN=SLC8A1 PE=1 SV=1
MLQLRLLPTFSMGCHLLAVVALLFSHVDLISAETEMEGEGNETGECTGSYYCKKGVILPI
WEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETT
KTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIII
ALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP
ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDNF
LDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAF
YRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCG
TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD
IFEEDENFLVHLSNVKVSSEASEDGILEANHVSALACLGSPSTATVTIFDDDHAGIFTFE
EPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIV
KTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLYGQPVFRK
VHAREHPIPSTVITIAEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFK
STVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTV
FWKVLFAFVPPTEYWNGWACFIVSILMIGILTAFIGDLASHFGCTIGLKDSVTAVVFVAL
GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVS
PGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSS
LEAYCHIKGF

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History
Entry version 139 (07 Nov 2018)
Sequence version 1 (01 Nov 1991)
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Protein

Sodium/calcium exchanger 1

Gene

SLC8A1

Organism

Canis lupus familiaris (Dog) (Canis familiaris)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates the exchange of one Ca²⁺ ion against three to four Na⁺ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca²⁺ levels and Ca²⁺-dependent cellular processes (PubMed:1700476, PubMed:1785844, PubMed:9486131, PubMed:17962412). Contributes to Ca²⁺ transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca²⁺ levels due to release of Ca²⁺ stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca²⁺ from the cell during the next phase, so that cytoplasmic Ca²⁺ levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity).By similarity5 Publications

Activity regulationⁱ

Activated by micromolar levels of Ca²⁺. In the absence of regulatory Ca²⁺, channels open rapidly, and then inactivate rapidly. Inactivation is enhanced by Na⁺ and is inhibited by micromolar levels of Ca²⁺.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	417	Calcium 1Combined sources	1
Metal bindingⁱ	417	Calcium 2Combined sources	1
Metal bindingⁱ	417	Calcium 3Combined sources	1
Metal bindingⁱ	453	Calcium 1Combined sources	1
Metal bindingⁱ	453	Calcium 4Combined sources	1
Metal bindingⁱ	478	Calcium 2Combined sources	1
Metal bindingⁱ	479	Calcium 1Combined sources	1
Metal bindingⁱ	479	Calcium 2; via carbonyl oxygenCombined sources	1
Metal bindingⁱ	479	Calcium 3Combined sources	1
Metal bindingⁱ	479	Calcium 4Combined sources	1
Metal bindingⁱ	481	Calcium 3; via carbonyl oxygenCombined sources	1
Metal bindingⁱ	483	Calcium 1Combined sources	1
Metal bindingⁱ	483	Calcium 3Combined sources	1
Metal bindingⁱ	483	Calcium 4Combined sources	1
Metal bindingⁱ	486	Calcium 4Combined sources	1
Metal bindingⁱ	530	Calcium 3Combined sources	1
Metal bindingⁱ	531	Calcium 2Combined sources	1
Metal bindingⁱ	532	Calcium 2Combined sources	1
Metal bindingⁱ	532	Calcium 3Combined sources	1
Metal bindingⁱ	548	Calcium 5Combined sources	1
Metal bindingⁱ	584	Calcium 6Combined sources	1
Metal bindingⁱ	610	Calcium 5Combined sources	1
Metal bindingⁱ	610	Calcium 6Combined sources	1
Metal bindingⁱ	611	Calcium 6Combined sources	1
Metal bindingⁱ	612	Calcium 5; via carbonyl oxygenCombined sources	1
Metal bindingⁱ	612	Calcium 6Combined sources	1
Metal bindingⁱ	715	Calcium 5Combined sources	1

GO - Molecular functionⁱ

ankyrin binding Source: Ensembl
calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
Source: SynGO
Inferred from experimentⁱ
- 1700476
calcium:sodium antiporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17962412
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17962412
calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion import Source: Ensembl
calcium ion transmembrane transport
Source: UniProtKB
Inferred from direct assayⁱ
- 17962412
cell communication Source: InterPro
cellular sodium ion homeostasis Source: Ensembl
positive regulation of bone mineralization Source: Ensembl
positive regulation of the force of heart contraction Source: Ensembl
response to muscle stretch Source: Ensembl
sodium ion import across plasma membrane Source: Ensembl
sodium ion transmembrane transport
Source: UniProtKB
Inferred from direct assayⁱ
- 17962412

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding
Biological process	Antiport, Calcium transport, Ion transport, Sodium transport, Transport
Ligand	Calcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-CFA-418359 Reduction of cytosolic Ca++ levels R-CFA-425561 Sodium/Calcium exchangers R-CFA-5578775 Ion homeostasis

Reactomeⁱ

R-CFA-418359 Reduction of cytosolic Ca++ levels
R-CFA-425561 Sodium/Calcium exchangers
R-CFA-5578775 Ion homeostasis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium/calcium exchanger 1 Alternative name(s): Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
Gene namesⁱ	Name:SLC8A1 Synonyms:NCX11 Publication
Organismⁱ	Canis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifierⁱ	9615 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus
Proteomesⁱ	UP000002254 Componentⁱ: Chromosome 17

Organism-specific databases

VGNCⁱ	VGNC:46480 SLC8A1

VGNCⁱ

VGNC:46480 SLC8A1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	33 – 71	ExtracellularSequence analysisAdd BLAST	39
Transmembraneⁱ	72 – 92	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	93 – 133	CytoplasmicSequence analysisAdd BLAST	41
Transmembraneⁱ	134 – 154	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	155 – 167	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	168 – 188	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	189 – 201	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	202 – 222	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	223 – 228	ExtracellularSequence analysis	6
Transmembraneⁱ	229 – 249	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	250 – 797	CytoplasmicCuratedAdd BLAST	548
Transmembraneⁱ	798 – 818	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	819 – 821	ExtracellularSequence analysis	3
Transmembraneⁱ	822 – 842	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	843 – 871	CytoplasmicSequence analysisAdd BLAST	29
Transmembraneⁱ	872 – 892	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	893 – 903	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	904 – 924	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	925 – 941	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	942 – 962	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	963 – 970	ExtracellularSequence analysis	8

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	548	E → L: Abolishes regulation by micromolar Ca(2+). 1 Publication	1
Mutagenesisⁱ	584	D → V: No effect on regulation by micromolar Ca(2+). 1 Publication	1
Mutagenesisⁱ	610	D → V: Abolishes regulation by micromolar Ca(2+). 1 Publication	1
Mutagenesisⁱ	617	K → E: Decreases affinity for Ca(2+), but retains regulation by micromolar Ca(2+). 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 32	Sequence analysisAdd BLAST		32
ChainⁱPRO_0000019376	33 – 970	Sodium/calcium exchanger 1Add BLAST		938

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	157	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	282	PhosphoserineBy similarity	1
Modified residueⁱ	389	PhosphoserineSequence analysisBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P23685

PaxDbⁱ

P23685

PTM databases

iPTMnetⁱ	P23685
SwissPalmⁱ	P23685

Expressionⁱ

Tissue specificityⁱ

Cardiac sarcolemma (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSCAFG00000023592 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Bgeeⁱ

ENSCAFG00000023592 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Interactionⁱ

GO - Molecular functionⁱ

ankyrin binding Source: Ensembl
calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-59598N
STRINGⁱ	9615.ENSCAFP00000009692

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	316 – 333	Combined sources	18
Helixⁱ	339 – 354	Combined sources	16
Beta strandⁱ	403 – 409	Combined sources	7
Beta strandⁱ	411 – 416	Combined sources	6
Beta strandⁱ	419 – 431	Combined sources	13
Beta strandⁱ	437 – 448	Combined sources	12
Turnⁱ	450 – 452	Combined sources	3
Beta strandⁱ	458 – 463	Combined sources	6
Beta strandⁱ	469 – 476	Combined sources	8
Beta strandⁱ	486 – 496	Combined sources	11
Beta strandⁱ	515 – 518	Combined sources	4
Beta strandⁱ	522 – 529	Combined sources	8
Beta strandⁱ	536 – 540	Combined sources	5
Beta strandⁱ	542 – 547	Combined sources	6
Beta strandⁱ	552 – 561	Combined sources	10
Beta strandⁱ	567 – 578	Combined sources	12
Turnⁱ	580 – 583	Combined sources	4
Beta strandⁱ	584 – 586	Combined sources	3
Beta strandⁱ	589 – 594	Combined sources	6
Beta strandⁱ	600 – 607	Combined sources	8
Beta strandⁱ	615 – 623	Combined sources	9
Beta strandⁱ	627 – 629	Combined sources	3
Helixⁱ	687 – 696	Combined sources	10
Beta strandⁱ	708 – 714	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P23685
SMRⁱ	P23685
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P23685

EvolutionaryTraceⁱ

P23685

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	138 – 178	Alpha-1Add BLAST	41
Domainⁱ	393 – 493	Calx-beta 1Add BLAST	101
Domainⁱ	524 – 624	Calx-beta 2Add BLAST	101
Repeatⁱ	839 – 875	Alpha-2Add BLAST	37

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	251 – 270	Putative calmodulin-binding region1 PublicationAdd BLAST		20

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	236 – 239	Poly-Phe	4
Compositional biasⁱ	689 – 692	Poly-Glu	4
Compositional biasⁱ	756 – 760	Poly-Asp	5

Domainⁱ

The cytoplasmic Calx-beta domains bind the regulatory Ca²⁺. The first Calx-beta domain can bind up to four Ca²⁺ ions (PubMed:16774926, PubMed:19332552, PubMed:22768191). The second domain can bind another two Ca²⁺ ions that are essential for calcium-regulated ion exchange (PubMed:17962412).4 Publications

Sequence similaritiesⁱ

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1306 Eukaryota ENOG410XPJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110414
HOGENOMⁱ	HOG000266971
HOVERGENⁱ	HBG006441
InParanoidⁱ	P23685
KEGG Orthology (KO) More...KOⁱ	K05849
OMAⁱ	TVYVDFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EC1
TreeFamⁱ	TF314308

Family and domain databases

Gene3Dⁱ	2.60.40.2030, 1 hit
InterProⁱ	View protein in InterPro IPR038081 CalX-like_sf IPR003644 Calx_beta IPR001623 DnaJ_domain IPR004836 Na_Ca_Ex IPR032452 Na_Ca_Ex_C-exten IPR002987 NaCa_exhngr1 IPR004837 NaCa_Exmemb
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03160 Calx-beta, 2 hits PF01699 Na_Ca_ex, 2 hits PF16494 Na_Ca_ex_C, 1 hit
PRINTSⁱ	PR01259 NACAEXCHNGR PR01260 NACAEXCHNGR1
SMARTⁱ	View protein in SMART SM00237 Calx_beta, 2 hits
SUPFAMⁱ	SSF141072 SSF141072, 2 hits
TIGRFAMsⁱ	TIGR00845 caca, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P23685-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLQLRLLPTF SMGCHLLAVV ALLFSHVDLI SAETEMEGEG NETGECTGSY 
        60         70         80         90        100
YCKKGVILPI WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI 
       110        120        130        140        150
EVITSQEKEI TIKKPNGETT KTTVRIWNET VSNLTLMALG SSAPEILLSV 
       160        170        180        190        200
IEVCGHNFTA GDLGPSTIVG SAAFNMFIII ALCVYVVPDG ETRKIKHLRV 
       210        220        230        240        250
FFVTAAWSIF AYTWLYIILS VISPGVVEVW EGLLTFFFFP ICVVFAWVAD 
       260        270        280        290        300
RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP SSKTEIEMDG KVVNSHVDNF 
       310        320        330        340        350
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPEKEIE QLIELANYQV 
       360        370        380        390        400
LSQQQKSRAF YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNTEVAEN 
       410        420        430        440        450
DPVSKIFFEQ GTYQCLENCG TVALTIIRRG GDLTNTVFVD FRTEDGTANA 
       460        470        480        490        500
GSDYEFTEGT VVFKPGETQK EIRVGIIDDD IFEEDENFLV HLSNVKVSSE 
       510        520        530        540        550
ASEDGILEAN HVSALACLGS PSTATVTIFD DDHAGIFTFE EPVTHVSESI 
       560        570        580        590        600
GIMEVKVLRT SGARGNVIVP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV 
       610        620        630        640        650
KTISVKVIDD EEYEKNKTFF LEIGEPRLVE MSEKKALLLN ELGGFTITGK 
       660        670        680        690        700
YLYGQPVFRK VHAREHPIPS TVITIAEEYD DKQPLTSKEE EERRIAEMGR 
       710        720        730        740        750
PILGEHTKLE VIIEESYEFK STVDKLIKKT NLALVVGTNS WREQFIEAIT 
       760        770        780        790        800
VSAGEDDDDD ECGEEKLPSC FDYVMHFLTV FWKVLFAFVP PTEYWNGWAC 
       810        820        830        840        850
FIVSILMIGI LTAFIGDLAS HFGCTIGLKD SVTAVVFVAL GTSVPDTFAS 
       860        870        880        890        900
KVAATQDQYA DASIGNVTGS NAVNVFLGIG VAWSIAAIYH AANGEQFKVS 
       910        920        930        940        950
PGTLAFSVTL FTIFAFINVG VLLYRRRPEI GGELGGPRTA KLLTSCLFVL 
       960        970
LWLLYIFFSS LEAYCHIKGF

Length:970

Mass (Da):108,004

Last modified:November 1, 1991 - v1

Checksum:ⁱBBDBCC584846AE08

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F1PHW1	F1PHW1_CANLF	Sodium/calcium exchanger 1 Sodium/calcium exchanger 1	SLC8A1	335	Annotation score:
F1PHW2	F1PHW2_CANLF	Sodium/calcium exchanger 1 Sodium/calcium exchanger 1	SLC8A1	365	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57523 mRNA Translation: AAA62766.1
PIRⁱ	A36417
NCBI Reference Sequences More...RefSeqⁱ	NP_001291891.1, NM_001304962.1 XP_013975680.1, XM_014120205.1 XP_013975681.1, XM_014120206.1 XP_013975682.1, XM_014120207.1 XP_013975683.1, XM_014120208.1 XP_013975684.1, XM_014120209.1 XP_013975685.1, XM_014120210.1 XP_013975686.1, XM_014120211.1 XP_013975687.1, XM_014120212.1 XP_013975688.1, XM_014120213.1 XP_013975689.1, XM_014120214.1

Genome annotation databases

Ensemblⁱ	ENSCAFT00000010451; ENSCAFP00000009692; ENSCAFG00000023592
GeneIDⁱ	475738
KEGGⁱ	cfa:475738

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23685	Sodium/calcium exchanger 1		MOUSE		970	UniRef90_P70414
Sodium/calcium exchanger 1		HUMAN		973
Sodium/calcium exchanger 1		RAT		971
Sodium/calcium exchanger 1		BOVIN		970
Sodium/calcium exchanger 1		CAVPO		970
+603

Protein	Similar proteins		Species	Score	Length	Source
P23685	Sodium/calcium exchanger 1		MOUSE		970	UniRef50_P70414
Sodium/calcium exchanger 1		HUMAN		973
Sodium/calcium exchanger 1		RAT		971
Sodium/calcium exchanger 1		BOVIN		970
Sodium/calcium exchanger 1		FELCA		970
+2013

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M57523 mRNA Translation: AAA62766.1
PIRⁱ	A36417
RefSeqⁱ	NP_001291891.1, NM_001304962.1 XP_013975680.1, XM_014120205.1 XP_013975681.1, XM_014120206.1 XP_013975682.1, XM_014120207.1 XP_013975683.1, XM_014120208.1 XP_013975684.1, XM_014120209.1 XP_013975685.1, XM_014120210.1 XP_013975686.1, XM_014120211.1 XP_013975687.1, XM_014120212.1 XP_013975688.1, XM_014120213.1 XP_013975689.1, XM_014120214.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DPK	X-ray	2.50	A	402-541	[»]
	2FWS	NMR	-	A	403-541	[»]
	2FWU	NMR	-	A	533-724	[»]
	2QVK	X-ray	1.45	A	533-721	[»]
	2QVM	X-ray	1.70	A	533-721	[»]
	3GIN	X-ray	2.40	A/B	402-541	[»]
	3US9	X-ray	2.68	A	403-724	[»]
	6BV7	NMR	-	A	306-359	[»]
ProteinModelPortalⁱ	P23685
SMRⁱ	P23685
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-59598N
STRINGⁱ	9615.ENSCAFP00000009692

PTM databases

iPTMnetⁱ	P23685
SwissPalmⁱ	P23685

Proteomic databases

PaxDbⁱ	P23685

PaxDbⁱ

P23685

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSCAFT00000010451; ENSCAFP00000009692; ENSCAFG00000023592
GeneIDⁱ	475738
KEGGⁱ	cfa:475738

Organism-specific databases

CTDⁱ	6546
VGNCⁱ	VGNC:46480 SLC8A1

Phylogenomic databases

eggNOGⁱ	KOG1306 Eukaryota ENOG410XPJP LUCA
GeneTreeⁱ	ENSGT00730000110414
HOGENOMⁱ	HOG000266971
HOVERGENⁱ	HBG006441
InParanoidⁱ	P23685
KOⁱ	K05849
OMAⁱ	TVYVDFR
OrthoDBⁱ	EOG091G0EC1
TreeFamⁱ	TF314308

Enzyme and pathway databases

Reactomeⁱ	R-CFA-418359 Reduction of cytosolic Ca++ levels R-CFA-425561 Sodium/Calcium exchangers R-CFA-5578775 Ion homeostasis

Reactomeⁱ

R-CFA-418359 Reduction of cytosolic Ca++ levels
R-CFA-425561 Sodium/Calcium exchangers
R-CFA-5578775 Ion homeostasis

Miscellaneous databases

EvolutionaryTraceⁱ	P23685

EvolutionaryTraceⁱ

P23685

Gene expression databases

Bgeeⁱ	ENSCAFG00000023592 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Bgeeⁱ

ENSCAFG00000023592 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

Gene3Dⁱ	2.60.40.2030, 1 hit
InterProⁱ	View protein in InterPro IPR038081 CalX-like_sf IPR003644 Calx_beta IPR001623 DnaJ_domain IPR004836 Na_Ca_Ex IPR032452 Na_Ca_Ex_C-exten IPR002987 NaCa_exhngr1 IPR004837 NaCa_Exmemb
Pfamⁱ	View protein in Pfam PF03160 Calx-beta, 2 hits PF01699 Na_Ca_ex, 2 hits PF16494 Na_Ca_ex_C, 1 hit
PRINTSⁱ	PR01259 NACAEXCHNGR PR01260 NACAEXCHNGR1
SMARTⁱ	View protein in SMART SM00237 Calx_beta, 2 hits
SUPFAMⁱ	SSF141072 SSF141072, 2 hits
TIGRFAMsⁱ	TIGR00845 caca, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAC1_CANLF
Accessionⁱ	P23685Primary (citable) accession number: P23685
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	November 1, 1991
	Last modified:	November 7, 2018
	This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - P23685 (NAC1_CANLF)

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Sodium/calcium exchanger 1

SLC8A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ