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Protein

Inositol-trisphosphate 3-kinase A

Gene

ITPKA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Activity regulationi

IP3K is activated by calmodulin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197ATPCombined sources1 Publication1
Binding sitei209ATPCombined sources1 Publication1
Binding sitei262ATPCombined sources1 Publication1
Binding sitei264SubstrateCombined sources1 Publication1
Binding sitei285SubstrateCombined sources1 Publication1
Binding sitei336ATPCombined sources1 Publication1
Binding sitei416ATPCombined sources1 Publication1
Binding sitei419SubstrateCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi249 – 251ATPCombined sources1 Publication3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06405-MONOMER
BRENDAi2.7.1.127 2681
ReactomeiR-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
SIGNORiP23677

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase A (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase A
Short name:
IP3 3-kinase A
Short name:
IP3K A
Short name:
InsP 3-kinase A
Gene namesi
Name:ITPKA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137825.10
HGNCiHGNC:6178 ITPKA
MIMi147521 gene
neXtProtiNX_P23677

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3706
OpenTargetsiENSG00000137825
PharmGKBiPA29975

Chemistry databases

DrugBankiDB04395 Phosphoaminophosphonic Acid-Adenylate Ester
GuidetoPHARMACOLOGYi1447

Polymorphism and mutation databases

BioMutaiITPKA
DMDMi124807

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668651 – 461Inositol-trisphosphate 3-kinase AAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35Omega-N-methylarginineBy similarity1
Modified residuei55Omega-N-methylarginineBy similarity1
Modified residuei62Omega-N-methylarginineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP23677
MaxQBiP23677
PaxDbiP23677
PeptideAtlasiP23677
PRIDEiP23677
ProteomicsDBi54145

PTM databases

iPTMnetiP23677
PhosphoSitePlusiP23677

Expressioni

Gene expression databases

BgeeiENSG00000137825 Expressed in 106 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_ITPKA
ExpressionAtlasiP23677 baseline and differential
GenevisibleiP23677 HS

Organism-specific databases

HPAiHPA040454

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109911, 2 interactors
IntActiP23677, 1 interactor
STRINGi9606.ENSP00000260386

Chemistry databases

BindingDBiP23677

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP23677
SMRiP23677
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23677

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 295Calmodulin-bindingBy similarity9
Regioni312 – 319Substrate binding1 Publication8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00390000017438
HOGENOMiHOG000231765
HOVERGENiHBG052138
InParanoidiP23677
KOiK00911
OMAiNVMDCKM
OrthoDBiEOG091G03J3
PhylomeDBiP23677
TreeFamiTF318394

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P23677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLPGGPTGM ARPGGARPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA
60 70 80 90 100
AGEPRARGAK RRGGQVPNGL PRAPPAPVIP QLTVTAEEPD VPPTSPGPPE
110 120 130 140 150
RERDCLPAAG SSHLQQPRRL STSSVSSTGS SSLLEDSEDD LLSDSESRSR
160 170 180 190 200
GNVQLEAGED VGQKNHWQKI RTMVNLPVIS PFKKRYAWVQ LAGHTGSFKA
210 220 230 240 250
AGTSGLILKR CSEPERYCLA RLMADALRGC VPAFHGVVER DGESYLQLQD
260 270 280 290 300
LLDGFDGPCV LDCKMGVRTY LEEELTKARE RPKLRKDMYK KMLAVDPEAP
310 320 330 340 350
TEEEHAQRAV TKPRYMQWRE GISSSTTLGF RIEGIKKADG SCSTDFKTTR
360 370 380 390 400
SREQVLRVFE EFVQGDEEVL RRYLNRLQQI RDTLEVSEFF RRHEVIGSSL
410 420 430 440 450
LFVHDHCHRA GVWLIDFGKT TPLPDGQILD HRRPWEEGNR EDGYLLGLDN
460
LIGILASLAE R
Length:461
Mass (Da):51,009
Last modified:November 1, 1991 - v1
Checksum:i18CA214A091F5B19
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JC74C9JC74_HUMAN
Kinase
ITPKA
260Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71P → Q in AAH26331 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54938 mRNA Translation: CAA38700.1
BC026331 mRNA Translation: AAH26331.1
CCDSiCCDS10076.1
PIRiJN0129
RefSeqiNP_002211.1, NM_002220.2
UniGeneiHs.2722

Genome annotation databases

EnsembliENST00000260386; ENSP00000260386; ENSG00000137825
GeneIDi3706
KEGGihsa:3706
UCSCiuc001znz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54938 mRNA Translation: CAA38700.1
BC026331 mRNA Translation: AAH26331.1
CCDSiCCDS10076.1
PIRiJN0129
RefSeqiNP_002211.1, NM_002220.2
UniGeneiHs.2722

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W2CX-ray1.95A/B197-461[»]
1W2DX-ray1.94A/B197-461[»]
1W2FX-ray1.80A/B188-461[»]
4UPUX-ray2.34B158-183[»]
ProteinModelPortaliP23677
SMRiP23677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109911, 2 interactors
IntActiP23677, 1 interactor
STRINGi9606.ENSP00000260386

Chemistry databases

BindingDBiP23677
DrugBankiDB04395 Phosphoaminophosphonic Acid-Adenylate Ester
GuidetoPHARMACOLOGYi1447

PTM databases

iPTMnetiP23677
PhosphoSitePlusiP23677

Polymorphism and mutation databases

BioMutaiITPKA
DMDMi124807

Proteomic databases

EPDiP23677
MaxQBiP23677
PaxDbiP23677
PeptideAtlasiP23677
PRIDEiP23677
ProteomicsDBi54145

Protocols and materials databases

DNASUi3706
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260386; ENSP00000260386; ENSG00000137825
GeneIDi3706
KEGGihsa:3706
UCSCiuc001znz.4 human

Organism-specific databases

CTDi3706
DisGeNETi3706
EuPathDBiHostDB:ENSG00000137825.10
GeneCardsiITPKA
HGNCiHGNC:6178 ITPKA
HPAiHPA040454
MIMi147521 gene
neXtProtiNX_P23677
OpenTargetsiENSG00000137825
PharmGKBiPA29975
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00390000017438
HOGENOMiHOG000231765
HOVERGENiHBG052138
InParanoidiP23677
KOiK00911
OMAiNVMDCKM
OrthoDBiEOG091G03J3
PhylomeDBiP23677
TreeFamiTF318394

Enzyme and pathway databases

BioCyciMetaCyc:HS06405-MONOMER
BRENDAi2.7.1.127 2681
ReactomeiR-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
SIGNORiP23677

Miscellaneous databases

ChiTaRSiITPKA human
EvolutionaryTraceiP23677
GeneWikiiITPKA
GenomeRNAii3706
PROiPR:P23677
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137825 Expressed in 106 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_ITPKA
ExpressionAtlasiP23677 baseline and differential
GenevisibleiP23677 HS

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIP3KA_HUMAN
AccessioniPrimary (citable) accession number: P23677
Secondary accession number(s): Q8TAN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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