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Protein

Serine/threonine-protein kinase fused

Gene

fu

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable serine/threonine-protein kinase; maternally required for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: FlyBase

GO - Biological processi

  • germarium-derived egg chamber formation Source: FlyBase
  • intraciliary transport Source: FlyBase
  • negative regulation of BMP signaling pathway Source: FlyBase
  • positive regulation of hh target transcription factor activity Source: FlyBase
  • positive regulation of protein ubiquitination Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of protein stability Source: FlyBase
  • regulation of proteolysis Source: FlyBase
  • segment polarity determination Source: FlyBase
  • smoothened signaling pathway Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Kinase, Segmentation polarity protein, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 1994
ReactomeiR-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209338 Assembly of the 'signalling complexes'
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-216119 Activation of CI
R-DME-216217 Activation of SMO
SignaLinkiP23647

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase fused (EC:2.7.11.1)
Gene namesi
Name:fu
ORF Names:CG6551
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0001079 fu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi139 – 141Missing in FU-62. 1 Publication3
Mutagenesisi147A → T in FU-H63. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859541 – 805Serine/threonine-protein kinase fusedAdd BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei422Phosphoserine1 Publication1
Modified residuei429Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP23647
PRIDEiP23647

PTM databases

iPTMnetiP23647

Expressioni

Tissue specificityi

Expressed in all imaginal disks, higher level in wing disk.1 Publication

Developmental stagei

Expressed both maternally and zygotically, low expression is present in males, larvae and pupae.

Gene expression databases

BgeeiFBgn0001079
ExpressionAtlasiP23647 differential
GenevisibleiP23647 DM

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi59167, 48 interactors
ComplexPortaliCPX-1897 Fused-Smurf ubiquitin ligase complex
DIPiDIP-492N
IntActiP23647, 44 interactors
STRINGi7227.FBpp0074373

Structurei

3D structure databases

ProteinModelPortaliP23647
SMRiP23647
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 254Protein kinasePROSITE-ProRule annotationAdd BLAST251

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0597 Eukaryota
ENOG410XRQ6 LUCA
InParanoidiP23647
KOiK06228
OrthoDBiEOG091G04G9
PhylomeDBiP23647

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P23647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRYAVSSLV GQGSFGCVYK ATRKDDSKVV AIKVISKRGR ATKELKNLRR
60 70 80 90 100
ECDIQARLKH PHVIEMIESF ESKTDLFVVT EFALMDLHRY LSYNGAMGEE
110 120 130 140 150
PARRVTGHLV SALYYLHSNR ILHRDLKPQN VLLDKNMHAK LCDFGLARNM
160 170 180 190 200
TLGTHVLTSI KGTPLYMAPE LLAEQPYDHH ADMWSLGCIA YESMAGQPPF
210 220 230 240 250
CASSILHLVK MIKHEDVKWP STLTSECRSF LQGLLEKDPG LRISWTQLLC
260 270 280 290 300
HPFVEGRIFI AETQAEAAKE SPFTNPEAKV KSSKQSDPEV GDLDEALAAL
310 320 330 340 350
DFGESRQENL TTSRDSINAI APSDVEHLET DVEDNMQRVV VPFADLSYRD
360 370 380 390 400
LSGVRAMPMV HQPVINSHTC FVSGNSNMIL NHMNDNFDFQ ASLRGGGVAA
410 420 430 440 450
KPIVAPTVRQ SRSKDLEKRK LSQNLDNFSV RLGHSVDHEA QRKATEIATQ
460 470 480 490 500
EKHNQENKPP AEAISYANSQ PPQQQPQQLK HSMHSTNEEK LSSDNTPPCL
510 520 530 540 550
LPGWDSCDES QSPPIENDEW LAFLNRSVQE LLDGELDSLK QHNLVSIIVA
560 570 580 590 600
PLRNSKAIPR VLKSVAQLLS LPFVLVDPVL IVDLELIRNV YVDVKLVPNL
610 620 630 640 650
MYACKLLLSH KQLSDSAASA PLTTGSLSRT LRSIPELTVE ELETACSLYE
660 670 680 690 700
LVCHLVHLQQ QFLTQFCDAV AILAASDLFL NFLTHDFRQS DSDAASVRLA
710 720 730 740 750
GCMLALMGCV LRELPENAEL VERIVFNPRL NFVSLLQSRH HLLRQRSCQL
760 770 780 790 800
LRLLARFSLR GVQRIWNGEL RFALQQLSEH HSYPALRGEA AQTLDEISHF

TFFVT
Length:805
Mass (Da):90,347
Last modified:December 1, 2000 - v2
Checksum:iA7804E2749B79D0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → M in AAF48871 (PubMed:10731132).Curated1
Sequence conflicti15F → L in CAA56640 (PubMed:8155575).Curated1
Sequence conflicti15F → L in AAA28552 (PubMed:8155575).Curated1
Sequence conflicti37K → KVSGAGQVIKQQVHTTSSHH IHVLQ (PubMed:2168522).Curated1
Sequence conflicti174 – 175EQ → DE (PubMed:8155575).Curated2
Sequence conflicti174 – 175EQ → DE (PubMed:2168522).Curated2
Sequence conflicti225S → C (PubMed:8155575).Curated1
Sequence conflicti225S → C (PubMed:2168522).Curated1
Sequence conflicti326E → D in CAA56640 (PubMed:8155575).Curated1
Sequence conflicti326E → D in AAA28552 (PubMed:8155575).Curated1
Sequence conflicti397G → V in CAA56640 (PubMed:8155575).Curated1
Sequence conflicti397G → V in AAA28552 (PubMed:8155575).Curated1
Sequence conflicti708G → S in CAA56640 (PubMed:8155575).Curated1
Sequence conflicti708G → S in AAA28552 (PubMed:8155575).Curated1
Sequence conflicti744R → G in CAA56640 (PubMed:8155575).Curated1
Sequence conflicti744R → G in AAA28552 (PubMed:8155575).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80468 Genomic DNA Translation: CAA56640.1
L34782 Genomic DNA Translation: AAA28552.1
AE014298 Genomic DNA Translation: AAF48871.1
S69165 Genomic DNA Translation: AAB29840.1
S69166 Genomic DNA Translation: AAB29841.1
X55759 Genomic DNA Translation: CAA39285.1
PIRiS11380
RefSeqiNP_477499.1, NM_058151.5

Genome annotation databases

GeneIDi32855
KEGGidme:Dmel_CG6551

Similar proteinsi

Entry informationi

Entry nameiFUSED_DROME
AccessioniPrimary (citable) accession number: P23647
Secondary accession number(s): Q26346
, Q26347, Q27412, Q9VWR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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