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Entry version 175 (07 Apr 2021)
Sequence version 1 (01 Nov 1991)
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Protein

Mitochondrial import receptor subunit TOM40

Gene

TOM40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Channel-forming protein essential for import of protein precursors into mitochondria.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.8.2.1, the mitochondrial and plastid porin (mpp) family
3.A.8.1.1, the mitochondrial protein translocase (mpt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40
Alternative name(s):
Mitochondrial import site protein ISP42
Translocase of outer membrane 40 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOM40
Synonyms:ISP42, MOM38
Ordered Locus Names:YMR203W
ORF Names:YM8325.04
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004816, TOM40

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YMR203W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515351 – 387Mitochondrial import receptor subunit TOM40Add BLAST387

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P23644

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P23644

PRoteomics IDEntifications database

More...
PRIDEi
P23644

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P23644

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70).

Interacts with mitochondrial targeting sequences.

Interacts with FCJ1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
35381, 63 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-473, TOM40 mitochondrial outer membrane translocase core complex
CPX-474, TOM40 mitochondrial outer membrane translocase holocomplex

Database of interacting proteins

More...
DIPi
DIP-2540N

Protein interaction database and analysis system

More...
IntActi
P23644, 17 interactors

Molecular INTeraction database

More...
MINTi
P23644

STRING: functional protein association networks

More...
STRINGi
4932.YMR203W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P23644, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P23644

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3296, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003308

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_042174_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P23644

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFRMSTF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07305, Porin3_Tom40, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023614, Porin_dom_sf
IPR027246, Porin_Euk/Tom40
IPR037930, Tom40
IPR005686, Tom40_fungi

The PANTHER Classification System

More...
PANTHERi
PTHR10802, PTHR10802, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01459, Porin_3, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00989, 3a0801s07tom40, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P23644-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS
60 70 80 90 100
HRQSLELVNP GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT
110 120 130 140 150
SHTFSIGSQA LPKYAFSALF ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI
160 170 180 190 200
SKVNLQISDG QPTMCQLEQD YQASDFSVNV KTLNPSFSEK GEFTGVAVAS
210 220 230 240 250
FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK QDWIFSGQLQ
260 270 280 290 300
ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS
310 320 330 340 350
TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND
360 370 380
TKIGCGLQFE TAGNQELLML QQGLDADGNP LQALPQL
Length:387
Mass (Da):42,038
Last modified:November 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6436FBBA4020464B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti387L → M in AAT93040 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56885 Genomic DNA Translation: CAA40206.1
Z48755 Genomic DNA Translation: CAA88644.1
AY693021 Genomic DNA Translation: AAT93040.1
BK006946 Genomic DNA Translation: DAA10102.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S12773

NCBI Reference Sequences

More...
RefSeqi
NP_013930.1, NM_001182710.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YMR203W_mRNA; YMR203W; YMR203W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
855243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YMR203W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56885 Genomic DNA Translation: CAA40206.1
Z48755 Genomic DNA Translation: CAA88644.1
AY693021 Genomic DNA Translation: AAT93040.1
BK006946 Genomic DNA Translation: DAA10102.1
PIRiS12773
RefSeqiNP_013930.1, NM_001182710.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6JNFelectron microscopy3.81A/F1-387[»]
6UCUelectron microscopy3.06A/I1-387[»]
6UCVelectron microscopy4.10A/I/a/i1-387[»]
SMRiP23644
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi35381, 63 interactors
ComplexPortaliCPX-473, TOM40 mitochondrial outer membrane translocase core complex
CPX-474, TOM40 mitochondrial outer membrane translocase holocomplex
DIPiDIP-2540N
IntActiP23644, 17 interactors
MINTiP23644
STRINGi4932.YMR203W

Protein family/group databases

TCDBi1.B.8.2.1, the mitochondrial and plastid porin (mpp) family
3.A.8.1.1, the mitochondrial protein translocase (mpt) family

PTM databases

iPTMnetiP23644

Proteomic databases

MaxQBiP23644
PaxDbiP23644
PRIDEiP23644

Genome annotation databases

EnsemblFungiiYMR203W_mRNA; YMR203W; YMR203W
GeneIDi855243
KEGGisce:YMR203W

Organism-specific databases

SGDiS000004816, TOM40
VEuPathDBiFungiDB:YMR203W

Phylogenomic databases

eggNOGiKOG3296, Eukaryota
GeneTreeiENSGT00390000003308
HOGENOMiCLU_042174_0_0_1
InParanoidiP23644
OMAiDFRMSTF

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P23644
RNActiP23644, protein

Family and domain databases

CDDicd07305, Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614, Porin_dom_sf
IPR027246, Porin_Euk/Tom40
IPR037930, Tom40
IPR005686, Tom40_fungi
PANTHERiPTHR10802, PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459, Porin_3, 1 hit
TIGRFAMsiTIGR00989, 3a0801s07tom40, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOM40_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23644
Secondary accession number(s): D6W028, Q6B1Q9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 7, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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