UniProtKB - P23625 (GNAQ_DROME)
G protein alpha q subunit
Galphaq
Functioni
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Could be the transducin analog, an amplifier and one of the transducers of a visual impulse that performs the coupling between opsin and cGMP-phosphodiesterase. Could mediate a subset of olfactory and gustatory responses.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 47 | MagnesiumBy similarity | 1 | |
Metal bindingi | 180 | MagnesiumBy similarity | 1 | |
Binding sitei | 325 | GTP; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 47 | GTPBy similarity | 8 | |
Nucleotide bindingi | 174 – 180 | GTPBy similarity | 7 | |
Nucleotide bindingi | 199 – 203 | GTPBy similarity | 5 | |
Nucleotide bindingi | 268 – 271 | GTPBy similarity | 4 |
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: GO_Central
- G protein-coupled receptor binding Source: GO_Central
- GTPase activity Source: FlyBase
- GTP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- activation of phospholipase C activity Source: FlyBase
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- axon midline choice point recognition Source: FlyBase
- cellular response to carbon dioxide Source: FlyBase
- flight behavior Source: FlyBase
- metarhodopsin inactivation Source: FlyBase
- mucosal immune response Source: FlyBase
- negative regulation of compound eye retinal cell programmed cell death Source: FlyBase
- neuron cellular homeostasis Source: FlyBase
- phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
- phototransduction Source: FlyBase
- regulation of neuromuscular synaptic transmission Source: FlyBase
- rhodopsin mediated signaling pathway Source: FlyBase
- sensory perception of smell Source: FlyBase
- stabilization of membrane potential Source: FlyBase
- thermotaxis Source: FlyBase
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Transducer |
Biological process | Sensory transduction, Vision |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-112043, PLC beta mediated events R-DME-202040, G-protein activation R-DME-416476, G alpha (q) signalling events R-DME-418592, ADP signalling through P2Y purinoceptor 1 R-DME-428930, Thromboxane signalling through TP receptor R-DME-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
SignaLinki | P23625 |
Names & Taxonomyi
Protein namesi | Recommended name: G protein alpha q subunitAlternative name(s): Guanine nucleotide-binding protein G(q) subunit alpha Guanine nucleotide-binding protein alpha-q dGQalpha |
Gene namesi | Name:Galphaq Synonyms:dgqImported, dGqalphaImported, GalphaImported, Galpha49bImported, GqImported, GqalphaImported ORF Names:CG17759Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004435, Galphaq |
VEuPathDBi | VectorBase:FBgn0004435 |
Subcellular locationi
Plasma Membrane
- heterotrimeric G-protein complex Source: FlyBase
- inaD signaling complex Source: FlyBase
- plasma membrane Source: FlyBase
Other locations
- rhabdomere Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203769 | 1 – 353 | G protein alpha q subunitAdd BLAST | 353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 3 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 4 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
PRIDEi | P23625 |
PTM databases
SwissPalmi | P23625 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | FBgn0004435, Expressed in head and 48 other tissues |
Genevisiblei | P23625, DM |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 62158, 20 interactors |
IntActi | P23625, 6 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 353 | G-alphaPROSITE-ProRule annotationAdd BLAST | 322 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 48 | G1 motifPROSITE-ProRule annotationAdd BLAST | 14 | |
Regioni | 172 – 180 | G2 motifPROSITE-ProRule annotation | 9 | |
Regioni | 195 – 204 | G3 motifPROSITE-ProRule annotation | 10 | |
Regioni | 264 – 271 | G4 motifPROSITE-ProRule annotation | 8 | |
Regioni | 323 – 328 | G5 motifPROSITE-ProRule annotation | 6 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000162569 |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P23625 |
PhylomeDBi | P23625 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR000654, Gprotein_alpha_Q IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00442, GPROTEINAQ |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MECCLSEEAK EQKRINQEIE KQLRRDKRDA RRELKLLLLG TGESGKSTFI
60 70 80 90 100
KQMRIIHGSG YSDEDKRGYI KLVFQNIFMA MQSMIKAMDM LKISYGQGEH
110 120 130 140 150
SELADLVMSI DYETVTTFED PYLNAIKTLW DDAGIQECYD RRREYQLTDS
160 170 180 190 200
AKYYLSDLAR IEQADYLPTE QDILRARVPT TGILEYPFDL DGIVFRMVDV
210 220 230 240 250
GGQRSERRKW IHCFENVTSI IFLVALSEYD QILFESDNEN RMEESKALFR
260 270 280 290 300
TIITYPWFQN SSVILFLNKK DLLEEKIMYS HLVDYFPEYD GPKQDHAAAK
310 320 330 340 350
QFVLKKYLAC NPDPERQCYS HFTTATDTEN IKLVFCAVKD TIMQNALKEF
NLG
The sequence of this isoform differs from the canonical sequence as follows:
156-194: SDLARIEQAD...EYPFDLDGIV → KDLDRVAQPA...EYPFDLEEIR
293-353: KQDHAAAKQF...QNALKEFNLG → QRDAITAREF...QSNLKEYNLV
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001835 | 156 – 194 | SDLAR…LDGIV → KDLDRVAQPAYLPTEQDILR VRVPTTGIIEYPFDLEEIR in isoform A. 2 PublicationsAdd BLAST | 39 | |
Alternative sequenceiVSP_001836 | 293 – 353 | KQDHA…EFNLG → QRDAITAREFILRMFVDLNP DSEKIIYSHFTCATDTENIR FVFAAVKDTILQSNLKEYNL V in isoform A. 2 PublicationsAdd BLAST | 61 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58016 Genomic DNA Translation: AAA28460.1 U31092 mRNA Translation: AAC46943.1 AE013599 Genomic DNA Translation: AAF58485.2 AE013599 Genomic DNA Translation: AAM68627.1 AE013599 Genomic DNA Translation: AAM68628.1 AE013599 Genomic DNA Translation: AAM68629.1 AE013599 Genomic DNA Translation: AAM68631.1 AY118511 mRNA Translation: AAM49880.1 BT024269 mRNA Translation: ABC86331.1 |
PIRi | JN0115 |
RefSeqi | NP_725191.1, NM_165919.2 [P23625-2] NP_725193.1, NM_165921.2 [P23625-2] NP_725194.1, NM_165922.2 [P23625-2] NP_725195.1, NM_165923.2 [P23625-2] NP_725196.1, NM_165924.2 [P23625-1] NP_725197.2, NM_165925.3 [P23625-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0087829; FBpp0086942; FBgn0004435 [P23625-2] FBtr0087830; FBpp0086943; FBgn0004435 [P23625-2] FBtr0087831; FBpp0086944; FBgn0004435 [P23625-2] FBtr0087832; FBpp0086945; FBgn0004435 [P23625-1] FBtr0087833; FBpp0086946; FBgn0004435 [P23625-2] FBtr0304955; FBpp0293494; FBgn0004435 [P23625-2] |
GeneIDi | 36384 |
KEGGi | dme:Dmel_CG17759 |
UCSCi | CG17759-RC, d. melanogaster |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58016 Genomic DNA Translation: AAA28460.1 U31092 mRNA Translation: AAC46943.1 AE013599 Genomic DNA Translation: AAF58485.2 AE013599 Genomic DNA Translation: AAM68627.1 AE013599 Genomic DNA Translation: AAM68628.1 AE013599 Genomic DNA Translation: AAM68629.1 AE013599 Genomic DNA Translation: AAM68631.1 AY118511 mRNA Translation: AAM49880.1 BT024269 mRNA Translation: ABC86331.1 |
PIRi | JN0115 |
RefSeqi | NP_725191.1, NM_165919.2 [P23625-2] NP_725193.1, NM_165921.2 [P23625-2] NP_725194.1, NM_165922.2 [P23625-2] NP_725195.1, NM_165923.2 [P23625-2] NP_725196.1, NM_165924.2 [P23625-1] NP_725197.2, NM_165925.3 [P23625-2] |
3D structure databases
AlphaFoldDBi | P23625 |
SMRi | P23625 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 62158, 20 interactors |
IntActi | P23625, 6 interactors |
PTM databases
SwissPalmi | P23625 |
Proteomic databases
PRIDEi | P23625 |
Protocols and materials databases
DNASUi | 36384 |
Genome annotation databases
EnsemblMetazoai | FBtr0087829; FBpp0086942; FBgn0004435 [P23625-2] FBtr0087830; FBpp0086943; FBgn0004435 [P23625-2] FBtr0087831; FBpp0086944; FBgn0004435 [P23625-2] FBtr0087832; FBpp0086945; FBgn0004435 [P23625-1] FBtr0087833; FBpp0086946; FBgn0004435 [P23625-2] FBtr0304955; FBpp0293494; FBgn0004435 [P23625-2] |
GeneIDi | 36384 |
KEGGi | dme:Dmel_CG17759 |
UCSCi | CG17759-RC, d. melanogaster |
Organism-specific databases
CTDi | 36384 |
FlyBasei | FBgn0004435, Galphaq |
VEuPathDBi | VectorBase:FBgn0004435 |
Phylogenomic databases
GeneTreei | ENSGT00940000162569 |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P23625 |
PhylomeDBi | P23625 |
Enzyme and pathway databases
Reactomei | R-DME-112043, PLC beta mediated events R-DME-202040, G-protein activation R-DME-416476, G alpha (q) signalling events R-DME-418592, ADP signalling through P2Y purinoceptor 1 R-DME-428930, Thromboxane signalling through TP receptor R-DME-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
SignaLinki | P23625 |
Miscellaneous databases
BioGRID-ORCSi | 36384, 0 hits in 3 CRISPR screens |
GenomeRNAii | 36384 |
PROi | PR:P23625 |
Gene expression databases
Bgeei | FBgn0004435, Expressed in head and 48 other tissues |
Genevisiblei | P23625, DM |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR000654, Gprotein_alpha_Q IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00442, GPROTEINAQ |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GNAQ_DROME | |
Accessioni | P23625Primary (citable) accession number: P23625 Secondary accession number(s): A4UZE6 Q9V6E2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | October 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families