UniProtKB - P23624 (SPO13_YEAST)
Protein
Meiosis-specific protein SPO13
Gene
SPO13
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for meiosis I segmentation (PubMed:2123556). Probably acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage (PubMed:25533956).1 Publication1 Publication
GO - Biological processi
- meiotic sister chromatid cohesion Source: SGD
- positive regulation of sister chromatid cohesion Source: SGD
- protein localization to chromosome, centromeric region Source: SGD
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Keywordsi
Biological process | Meiosis, Sporulation |
Names & Taxonomyi
Protein namesi | Recommended name: Meiosis-specific protein SPO13Alternative name(s): Sporulation-specific protein 13 |
Gene namesi | Name:SPO13 Ordered Locus Names:YHR014W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001056, SPO13 |
VEuPathDBi | FungiDB:YHR014W |
Subcellular locationi
Nucleus
- Nucleus Curated
Cytoskeleton
- meiotic spindle Source: SGD
Nucleus
- condensed nuclear chromosome, centromeric region Source: SGD
- nucleus Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072134 | 1 – 291 | Meiosis-specific protein SPO13Add BLAST | 291 |
Proteomic databases
PaxDbi | P23624 |
PRIDEi | P23624 |
PTM databases
iPTMneti | P23624 |
Interactioni
Binary interactionsi
P23624
With | #Exp. | IntAct |
---|---|---|
CDC5 [P32562] | 8 | EBI-17719,EBI-4440 |
Protein-protein interaction databases
BioGRIDi | 36441, 90 interactors |
DIPi | DIP-1655N |
IntActi | P23624, 8 interactors |
MINTi | P23624 |
STRINGi | 4932.YHR014W |
Miscellaneous databases
RNActi | P23624, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 3 – 6 | Nuclear localization signalSequence analysis | 4 |
Phylogenomic databases
HOGENOMi | CLU_956961_0_0_1 |
InParanoidi | P23624 |
OMAi | NDSESXL |
i Sequence
Sequence statusi: Complete.
P23624-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRKRFRLL ELGSPTHSKR KVQKPLQEKT PNLRVSPLAF KIGKEIKNKE
60 70 80 90 100
IRKTKKTESE NIFNSKHVDL RLESPHPGLN FVSDAQQYSK AGDVRYLKNK
110 120 130 140 150
SSNTLKNERQ TIERPSFDNS LRFEDIEQPP KSTSTPVLSQ SSQINVEREA
160 170 180 190 200
PMFPVPYYIA PSPMYNFSPY QNFVGNPTFL TPSHNPNLNY AIPIQRPELL
210 220 230 240 250
YPNVNVYDSP LFKKTRLPHQ TKSLDKEKNY QYLPIYPVSI SNNGDFVGQE
260 270 280 290
TPRAAPKLSK KRLSNTLDVN CSDYESSGQN ATYNDSESSL N
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38357 Genomic DNA Translation: AAA35071.1 U10400 Genomic DNA Translation: AAB68941.1 AY557825 Genomic DNA Translation: AAS56151.1 BK006934 Genomic DNA Translation: DAA06703.1 |
PIRi | A38426 |
RefSeqi | NP_011878.1, NM_001179144.1 |
Genome annotation databases
EnsemblFungii | YHR014W_mRNA; YHR014W; YHR014W |
GeneIDi | 856405 |
KEGGi | sce:YHR014W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M38357 Genomic DNA Translation: AAA35071.1 U10400 Genomic DNA Translation: AAB68941.1 AY557825 Genomic DNA Translation: AAS56151.1 BK006934 Genomic DNA Translation: DAA06703.1 |
PIRi | A38426 |
RefSeqi | NP_011878.1, NM_001179144.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36441, 90 interactors |
DIPi | DIP-1655N |
IntActi | P23624, 8 interactors |
MINTi | P23624 |
STRINGi | 4932.YHR014W |
PTM databases
iPTMneti | P23624 |
Proteomic databases
PaxDbi | P23624 |
PRIDEi | P23624 |
Genome annotation databases
EnsemblFungii | YHR014W_mRNA; YHR014W; YHR014W |
GeneIDi | 856405 |
KEGGi | sce:YHR014W |
Organism-specific databases
SGDi | S000001056, SPO13 |
VEuPathDBi | FungiDB:YHR014W |
Phylogenomic databases
HOGENOMi | CLU_956961_0_0_1 |
InParanoidi | P23624 |
OMAi | NDSESXL |
Miscellaneous databases
PROi | PR:P23624 |
RNActi | P23624, protein |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPO13_YEAST | |
Accessioni | P23624Primary (citable) accession number: P23624 Secondary accession number(s): D3DKV9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VIII
Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names