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UniProtKB - P23586 (STP1_ARATH)
Protein
Sugar transport protein 1
Gene
STP1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Major hexose transporter. Mediates an active uptake of hexoses, by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings.
5 PublicationsKineticsi
- KM=20 µM for glucose (at pH 6.0 and 32 degrees Celsius)1 Publication
- KM=100 µM for 3-O-methylglucose (at pH 6.0 and 32 degrees Celsius)1 Publication
GO - Molecular functioni
- monosaccharide transmembrane transporter activity Source: TAIR
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- monosaccharide transmembrane transport Source: TAIR
Keywordsi
Biological process | Sugar transport, Symport, Transport |
Protein family/group databases
TCDBi | 2.A.1.1.60, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Sugar transport protein 1Alternative name(s): Glucose transporter Hexose transporter 1 |
Gene namesi | Name:STP1 Ordered Locus Names:At1g11260 ORF Names:T28P6.9 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G11260 |
TAIRi | locus:2202044, AT1G11260 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications1 Publication; Multi-pass membrane protein 2 Publications
Extracellular region or secreted
- extracellular region Source: TAIR
Plasma Membrane
- plasma membrane Source: TAIR
Vacuole
- plant-type vacuole Source: TAIR
Other locations
- integral component of membrane Source: UniProtKB-KW
- plasmodesma Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 43 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 44 – 79 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 80 – 100 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 101 – 117 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 118 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 140 | ExtracellularSequence analysis | 2 | |
Transmembranei | 141 – 161 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 162 – 171 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 172 – 192 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 202 | ExtracellularSequence analysis | 10 | |
Transmembranei | 203 – 223 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 224 – 289 | CytoplasmicSequence analysisAdd BLAST | 66 | |
Transmembranei | 290 – 310 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 311 – 321 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 322 – 342 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 343 – 348 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 349 – 369 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 370 – 384 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 385 – 405 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 406 – 427 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 428 – 448 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 449 – 452 | ExtracellularSequence analysis | 4 | |
Transmembranei | 453 – 473 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 474 – 522 | CytoplasmicSequence analysisAdd BLAST | 49 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050431 | 1 – 522 | Sugar transport protein 1Add BLAST | 522 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 252 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P23586 |
PRIDEi | P23586 |
ProteomicsDBi | 228428 |
PTM databases
iPTMneti | P23586 |
Expressioni
Tissue specificityi
Mostly expressed in young leaves, especially in guard cells (at protein level). Also present in roots.3 Publications
Inductioni
Strong increase at the onset of the dark period followed by a progressive decrease. Transient increase at midday.1 Publication
Gene expression databases
ExpressionAtlasi | P23586, baseline and differential |
Genevisiblei | P23586, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 22907, 7 interactors |
IntActi | P23586, 1 interactor |
STRINGi | 3702.AT1G11260.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P23586 |
OMAi | SFFTRFI |
OrthoDBi | 430696at2759 |
PhylomeDBi | P23586 |
Family and domain databases
CDDi | cd17361, MFS_STP, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044778, MFS_STP/MST-like_plant IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR045262, STP/PLT_plant IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23500, PTHR23500, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P23586-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAGGFVVGD GQKAYPGKLT PFVLFTCVVA AMGGLIFGYD IGISGGVTSM
60 70 80 90 100
PSFLKRFFPS VYRKQQEDAS TNQYCQYDSP TLTMFTSSLY LAALISSLVA
110 120 130 140 150
STVTRKFGRR LSMLFGGILF CAGALINGFA KHVWMLIVGR ILLGFGIGFA
160 170 180 190 200
NQAVPLYLSE MAPYKYRGAL NIGFQLSITI GILVAEVLNY FFAKIKGGWG
210 220 230 240 250
WRLSLGGAVV PALIITIGSL VLPDTPNSMI ERGQHEEAKT KLRRIRGVDD
260 270 280 290 300
VSQEFDDLVA ASKESQSIEH PWRNLLRRKY RPHLTMAVMI PFFQQLTGIN
310 320 330 340 350
VIMFYAPVLF NTIGFTTDAS LMSAVVTGSV NVAATLVSIY GVDRWGRRFL
360 370 380 390 400
FLEGGTQMLI CQAVVAACIG AKFGVDGTPG ELPKWYAIVV VTFICIYVAG
410 420 430 440 450
FAWSWGPLGW LVPSEIFPLE IRSAAQSITV SVNMIFTFII AQIFLTMLCH
460 470 480 490 500
LKFGLFLVFA FFVVVMSIFV YIFLPETKGI PIEEMGQVWR SHWYWSRFVE
510 520
DGEYGNALEM GKNSNQAGTK HV
Sequence cautioni
The sequence BAD95185 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 333 | A → G in CAA39037 (PubMed:2209537).Curated | 1 | |
Sequence conflicti | 431 | S → F (Ref. 7) Curated | 1 | |
Sequence conflicti | 470 | V → E in AAM67326 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55350 mRNA Translation: CAA39037.1 AC007259 Genomic DNA Translation: AAD49995.1 CP002684 Genomic DNA Translation: AEE28705.1 AY059781 mRNA Translation: AAL24129.1 AY054249 mRNA Translation: AAL06908.1 AY133845 mRNA Translation: AAM91779.1 AY087292 mRNA Translation: AAM67326.1 AF083803 mRNA Translation: AAN60361.1 AK221157 mRNA Translation: BAD95185.1 Different initiation. |
PIRi | E86246 S12042 |
RefSeqi | NP_172592.1, NM_100998.4 |
Genome annotation databases
EnsemblPlantsi | AT1G11260.1; AT1G11260.1; AT1G11260 |
GeneIDi | 837667 |
Gramenei | AT1G11260.1; AT1G11260.1; AT1G11260 |
KEGGi | ath:AT1G11260 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55350 mRNA Translation: CAA39037.1 AC007259 Genomic DNA Translation: AAD49995.1 CP002684 Genomic DNA Translation: AEE28705.1 AY059781 mRNA Translation: AAL24129.1 AY054249 mRNA Translation: AAL06908.1 AY133845 mRNA Translation: AAM91779.1 AY087292 mRNA Translation: AAM67326.1 AF083803 mRNA Translation: AAN60361.1 AK221157 mRNA Translation: BAD95185.1 Different initiation. |
PIRi | E86246 S12042 |
RefSeqi | NP_172592.1, NM_100998.4 |
3D structure databases
SMRi | P23586 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 22907, 7 interactors |
IntActi | P23586, 1 interactor |
STRINGi | 3702.AT1G11260.1 |
Protein family/group databases
TCDBi | 2.A.1.1.60, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | P23586 |
Proteomic databases
PaxDbi | P23586 |
PRIDEi | P23586 |
ProteomicsDBi | 228428 |
Genome annotation databases
EnsemblPlantsi | AT1G11260.1; AT1G11260.1; AT1G11260 |
GeneIDi | 837667 |
Gramenei | AT1G11260.1; AT1G11260.1; AT1G11260 |
KEGGi | ath:AT1G11260 |
Organism-specific databases
Araporti | AT1G11260 |
TAIRi | locus:2202044, AT1G11260 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P23586 |
OMAi | SFFTRFI |
OrthoDBi | 430696at2759 |
PhylomeDBi | P23586 |
Miscellaneous databases
PROi | PR:P23586 |
Gene expression databases
ExpressionAtlasi | P23586, baseline and differential |
Genevisiblei | P23586, AT |
Family and domain databases
CDDi | cd17361, MFS_STP, 1 hit |
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR044778, MFS_STP/MST-like_plant IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR045262, STP/PLT_plant IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
PANTHERi | PTHR23500, PTHR23500, 1 hit |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STP1_ARATH | |
Accessioni | P23586Primary (citable) accession number: P23586 Secondary accession number(s): Q56Z12 Q9SXB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1991 |
Last sequence update: | June 20, 2002 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families