STP1

Functionⁱ

Major hexose transporter. Mediates an active uptake of hexoses, by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings.5 Publications

Keywordsⁱ

Biological process	Sugar transport, Symport, Transport

Biological process

Sugar transport, Symport, Transport

Protein family/group databases

TCDBⁱ	2.A.1.1.60 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.60 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sugar transport protein 1 Alternative name(s): Glucose transporter Hexose transporter 1
Gene namesⁱ	Name:STP1 Ordered Locus Names:At1g11260 ORF Names:T28P6.9
Organismⁱ	Arabidopsis thaliana (Mouse-ear cress)
Taxonomic identifierⁱ	3702 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Mesangiospermae › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesⁱ	UP000006548 Componentⁱ: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal More...Araportⁱ	AT1G11260
TAIRⁱ	locus:2202044 AT1G11260

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 22	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	23 – 43	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	44 – 79	ExtracellularSequence analysisAdd BLAST	36
Transmembraneⁱ	80 – 100	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	101 – 117	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	118 – 138	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	139 – 140	ExtracellularSequence analysis	2
Transmembraneⁱ	141 – 161	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	162 – 171	CytoplasmicSequence analysis	10
Transmembraneⁱ	172 – 192	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	193 – 202	ExtracellularSequence analysis	10
Transmembraneⁱ	203 – 223	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	224 – 289	CytoplasmicSequence analysisAdd BLAST	66
Transmembraneⁱ	290 – 310	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	311 – 321	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	322 – 342	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	343 – 348	CytoplasmicSequence analysis	6
Transmembraneⁱ	349 – 369	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	370 – 384	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	385 – 405	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	406 – 427	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	428 – 448	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	449 – 452	ExtracellularSequence analysis	4
Transmembraneⁱ	453 – 473	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	474 – 522	CytoplasmicSequence analysisAdd BLAST	49

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050431	1 – 522	Sugar transport protein 1Add BLAST		522

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	252	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P23586
PRIDEⁱ	P23586

PTM databases

iPTMnetⁱ	P23586

iPTMnetⁱ

P23586

Expressionⁱ

Tissue specificityⁱ

Mostly expressed in young leaves, especially in guard cells (at protein level). Also present in roots.3 Publications

Inductionⁱ

Strong increase at the onset of the dark period followed by a progressive decrease. Transient increase at midday.1 Publication

Gene expression databases

ExpressionAtlasⁱ	P23586 baseline and differential
Genevisibleⁱ	P23586 AT

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	22907, 4 interactors
IntActⁱ	P23586, 1 interactor
STRINGⁱ	3702.AT1G11260.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23586
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0254 Eukaryota ENOG410XNQK LUCA
HOGENOMⁱ	HOG000202867
InParanoidⁱ	P23586
OMAⁱ	ISTGSFC
Database of Orthologous Groups More...OrthoDBⁱ	EOG093608DR
PhylomeDBⁱ	P23586

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P23586-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPAGGFVVGD GQKAYPGKLT PFVLFTCVVA AMGGLIFGYD IGISGGVTSM 
        60         70         80         90        100
PSFLKRFFPS VYRKQQEDAS TNQYCQYDSP TLTMFTSSLY LAALISSLVA 
       110        120        130        140        150
STVTRKFGRR LSMLFGGILF CAGALINGFA KHVWMLIVGR ILLGFGIGFA 
       160        170        180        190        200
NQAVPLYLSE MAPYKYRGAL NIGFQLSITI GILVAEVLNY FFAKIKGGWG 
       210        220        230        240        250
WRLSLGGAVV PALIITIGSL VLPDTPNSMI ERGQHEEAKT KLRRIRGVDD 
       260        270        280        290        300
VSQEFDDLVA ASKESQSIEH PWRNLLRRKY RPHLTMAVMI PFFQQLTGIN 
       310        320        330        340        350
VIMFYAPVLF NTIGFTTDAS LMSAVVTGSV NVAATLVSIY GVDRWGRRFL 
       360        370        380        390        400
FLEGGTQMLI CQAVVAACIG AKFGVDGTPG ELPKWYAIVV VTFICIYVAG 
       410        420        430        440        450
FAWSWGPLGW LVPSEIFPLE IRSAAQSITV SVNMIFTFII AQIFLTMLCH 
       460        470        480        490        500
LKFGLFLVFA FFVVVMSIFV YIFLPETKGI PIEEMGQVWR SHWYWSRFVE 
       510        520 
DGEYGNALEM GKNSNQAGTK HV

Length:522

Mass (Da):57,611

Last modified:June 20, 2002 - v2

Checksum:ⁱ813AFC8AFA7AA583

GO

Sequence cautionⁱ

The sequence BAD95185 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	333	A → G in CAA39037 (PubMed:2209537).Curated	1
Sequence conflictⁱ	431	S → F (Ref. 7) Curated	1
Sequence conflictⁱ	470	V → E in AAM67326 (Ref. 5) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55350 mRNA Translation: CAA39037.1 AC007259 Genomic DNA Translation: AAD49995.1 CP002684 Genomic DNA Translation: AEE28705.1 AY059781 mRNA Translation: AAL24129.1 AY054249 mRNA Translation: AAL06908.1 AY133845 mRNA Translation: AAM91779.1 AY087292 mRNA Translation: AAM67326.1 AF083803 mRNA Translation: AAN60361.1 AK221157 mRNA Translation: BAD95185.1 Different initiation.
PIRⁱ	E86246 S12042
NCBI Reference Sequences More...RefSeqⁱ	NP_172592.1, NM_100998.4
UniGeneⁱ	At.24793 At.67772 At.74867

Genome annotation databases

EnsemblPlantsⁱ	AT1G11260.1; AT1G11260.1; AT1G11260
GeneIDⁱ	837667
Grameneⁱ	AT1G11260.1; AT1G11260.1; AT1G11260
KEGGⁱ	ath:AT1G11260

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23586	STP1		ARATH		522	UniRef100_P23586

Protein	Similar proteins		Species	Score	Length	Source
P23586	STP1		ARATH		522	UniRef90_P23586
Uncharacterized protein		BRARP		522
BnaC05g08610D protein		BRANA		522
Uncharacterized protein		ARALL		522
Sugar transport protein 1		NOCCA		521
+17

Protein	Similar proteins		Species	Score	Length	Source
P23586	Sugar transport protein MST5		ORYSJ		519	UniRef50_P23586
Sugar carrier protein C		RICCO		523
Sugar transport protein 3		ARATH		514
Uncharacterized protein		BRARP		522
Uncharacterized protein		ARALL		522
+585

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X55350 mRNA Translation: CAA39037.1 AC007259 Genomic DNA Translation: AAD49995.1 CP002684 Genomic DNA Translation: AEE28705.1 AY059781 mRNA Translation: AAL24129.1 AY054249 mRNA Translation: AAL06908.1 AY133845 mRNA Translation: AAM91779.1 AY087292 mRNA Translation: AAM67326.1 AF083803 mRNA Translation: AAN60361.1 AK221157 mRNA Translation: BAD95185.1 Different initiation.
PIRⁱ	E86246 S12042
RefSeqⁱ	NP_172592.1, NM_100998.4
UniGeneⁱ	At.24793 At.67772 At.74867

3D structure databases

ProteinModelPortalⁱ	P23586
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	22907, 4 interactors
IntActⁱ	P23586, 1 interactor
STRINGⁱ	3702.AT1G11260.1

Protein family/group databases

TCDBⁱ	2.A.1.1.60 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.1.60 the major facilitator superfamily (mfs)

PTM databases

iPTMnetⁱ	P23586

iPTMnetⁱ

P23586

Proteomic databases

PaxDbⁱ	P23586
PRIDEⁱ	P23586

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblPlantsⁱ	AT1G11260.1; AT1G11260.1; AT1G11260
GeneIDⁱ	837667
Grameneⁱ	AT1G11260.1; AT1G11260.1; AT1G11260
KEGGⁱ	ath:AT1G11260

Organism-specific databases

Araportⁱ	AT1G11260
TAIRⁱ	locus:2202044 AT1G11260

Phylogenomic databases

eggNOGⁱ	KOG0254 Eukaryota ENOG410XNQK LUCA
HOGENOMⁱ	HOG000202867
InParanoidⁱ	P23586
OMAⁱ	ISTGSFC
OrthoDBⁱ	EOG093608DR
PhylomeDBⁱ	P23586

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P23586

PROⁱ

PR:P23586

Gene expression databases

ExpressionAtlasⁱ	P23586 baseline and differential
Genevisibleⁱ	P23586 AT

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 1 hit PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STP1_ARATH
Accessionⁱ	P23586Primary (citable) accession number: P23586 Secondary accession number(s): Q56Z12 , Q8H775, Q8LBC8, Q9SXB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	June 20, 2002
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Plant Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P23586 (STP1_ARATH)

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Sugar transport protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Plasma Membrane

Vacuole

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ