Ina

Functionⁱ

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity).By similarity

GO - Molecular functionⁱ

protein heterodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 9388258
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
nervous system development Source: UniProtKB-KW
tissue regeneration
Source: RGD
Inferred from expression patternⁱ
- 12077192

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Neurogenesis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-internexin Short name: Alpha-Inx
Gene namesⁱ	Name:Ina Synonyms:Inexa
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2911 Ina

RGDⁱ

2911 Ina

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000063785	1 – 505	Alpha-internexinAdd BLAST		505

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	72	PhosphoserineBy similarity	1
Modified residueⁱ	219	PhosphoserineBy similarity	1
Modified residueⁱ	290	N6-acetyllysineBy similarity	1
Modified residueⁱ	335	PhosphoserineCombined sources	1
Modified residueⁱ	474	PhosphoserineCombined sources	1
Modified residueⁱ	502	PhosphoserineBy similarity	1

Post-translational modificationⁱ

O-glycosylated.By similarity

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P23565
PRIDEⁱ	P23565

2D gel databases

The World-2DPAGE database More...World-2DPAGEⁱ	0004:P23565

World-2DPAGEⁱ

0004:P23565

PTM databases

iPTMnetⁱ	P23565
PhosphoSitePlusⁱ	P23565

Expressionⁱ

Developmental stageⁱ

Levels of this protein reach a maximum at embryonic day 16 and decline into adulthood.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Nsmf	Q9EPI6	5	EBI-6899875,EBI-6899705

With

Entry

#Exp.

IntAct

Notes

Nsmf

Q9EPI6

5

EBI-6899875,EBI-6899705

GO - Molecular functionⁱ

protein heterodimerization activity
Source: RGD
Inferred from direct assayⁱ
- 9388258

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	246662, 3 interactors
IntActⁱ	P23565, 4 interactors
Molecular INTeraction database More...MINTⁱ	P23565
STRINGⁱ	10116.ENSRNOP00000027417

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P23565
SMRⁱ	P23565
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	94 – 407	IF rodPROSITE-ProRule annotationAdd BLAST		314

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 87	HeadAdd BLAST	87
Regionⁱ	88 – 129	Coil 1AAdd BLAST	42
Regionⁱ	130 – 142	Linker 1Add BLAST	13
Regionⁱ	143 – 238	Coil 1BAdd BLAST	96
Regionⁱ	239 – 262	Linker 2Add BLAST	24
Regionⁱ	263 – 408	Coil 2Add BLAST	146
Regionⁱ	409 – 505	TailAdd BLAST	97

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	449 – 458	Poly-Glu		10

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IGME Eukaryota ENOG410XPTM LUCA
HOGENOMⁱ	HOG000230977
HOVERGENⁱ	HBG013015
InParanoidⁱ	P23565
PhylomeDBⁱ	P23565

Family and domain databases

InterProⁱ	View protein in InterPro IPR027703 Alpha-Inx IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR006821 Intermed_filament_DNA-bd
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit PTHR23239:SF132 PTHR23239:SF132, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF04732 Filament_head, 1 hit
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P23565-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFGSEHYLC SASSYRKVFG DGSRLSARLS GPGASGSFRS QSLSRSNVAS 
        60         70         80         90        100
TAACSSASSL GLGLAYRRLP ASDGLDLSQA AARTNEYKII RTNEKEQLQG 
       110        120        130        140        150
LNDRFAVFIE KVHQLETQNR ALEAELAALR QRHAEPSRVG ELFQRELREL 
       160        170        180        190        200
RAQLEEASSA RAQALLERDG LAEEVQRLRA RCEEESRGRE GAERALKAQQ 
       210        220        230        240        250
RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA TLQASSQAAA 
       260        270        280        290        300
EVDVAVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR 
       310        320        330        340        350
STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE 
       360        370        380        390        400
VAGYQDSIGQ LESDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL 
       410        420        430        440        450
EGEETRFSTS GLSISGLNPL PNPSYLLPPR ILSSTTSKVS SAGLSLKKEE 
       460        470        480        490        500
EEEEEEEEGA SKEVTKKTSK VGESFEETLE ETVVSTKKTE KSTIEEITTS 

SSQKM

Length:505

Mass (Da):56,115

Last modified:October 1, 1996 - v2

Checksum:ⁱ287E548F0DA4D818

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	152 – 153	AQ → GE in CAA36264 (PubMed:2311576).Curated	2
Sequence conflictⁱ	239 – 242	Missing AA sequence (PubMed:2311576).Curated	4
Sequence conflictⁱ	458	Missing AA sequence (PubMed:2311576).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52017 mRNA Translation: CAA36264.1 M73049 Genomic DNA Translation: AAA41444.1
PIRⁱ	A41023
UniGeneⁱ	Rn.88941

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2911 rat

UCSCⁱ

RGD:2911 rat

Protein	Similar proteins		Species	Score	Length
P23565	Alpha-internexin		HUMAN		499
Uncharacterized protein		NEOLE		511
Alpha-internexin		RAT		506
UPI0003332899		JACJA		505
UPI00057B008E		CAMBA		505
+81

Protein	Similar proteins		Species	Score	Length
P23565	Alpha-internexin		HUMAN		499
Uncharacterized protein		NEOLE		511
Alpha-internexin		RAT		506
UPI00057B008E		CAMBA		505
UPI0003332899		JACJA		505
+215

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52017 mRNA Translation: CAA36264.1 M73049 Genomic DNA Translation: AAA41444.1
PIRⁱ	A41023
UniGeneⁱ	Rn.88941

3D structure databases

ProteinModelPortalⁱ	P23565
SMRⁱ	P23565
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	246662, 3 interactors
IntActⁱ	P23565, 4 interactors
Molecular INTeraction database More...MINTⁱ	P23565
STRINGⁱ	10116.ENSRNOP00000027417

PTM databases

iPTMnetⁱ	P23565
PhosphoSitePlusⁱ	P23565

2D gel databases

The World-2DPAGE database More...World-2DPAGEⁱ	0004:P23565

World-2DPAGEⁱ

0004:P23565

Proteomic databases

PaxDbⁱ	P23565
PRIDEⁱ	P23565

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2911 rat

UCSCⁱ

RGD:2911 rat

Organism-specific databases

Rat genome database More...RGDⁱ	2911 Ina

RGDⁱ

2911 Ina

Phylogenomic databases

eggNOGⁱ	ENOG410IGME Eukaryota ENOG410XPTM LUCA
HOGENOMⁱ	HOG000230977
HOVERGENⁱ	HBG013015
InParanoidⁱ	P23565
PhylomeDBⁱ	P23565

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P23565

PROⁱ

PR:P23565

Family and domain databases

InterProⁱ	View protein in InterPro IPR027703 Alpha-Inx IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR006821 Intermed_filament_DNA-bd
PANTHERⁱ	PTHR23239 PTHR23239, 1 hit PTHR23239:SF132 PTHR23239:SF132, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF04732 Filament_head, 1 hit
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AINX_RAT
Accessionⁱ	P23565Primary (citable) accession number: P23565
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	October 1, 1996
	Last modified:	May 23, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - P23565 (AINX_RAT)

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Alpha-internexin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ