CFL1

Functionⁱ

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).By similarity4 Publications

GO - Molecular functionⁱ

actin filament binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11812157
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: ProtInc
Traceable author statementⁱ
- 10436159
actin filament depolymerization
Source: UniProtKB
Inferred from direct assayⁱ
- 11812157
actin filament fragmentation Source: Ensembl
cytoskeleton organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21834987
establishment of cell polarity Source: Ensembl
interleukin-12-mediated signaling pathway Source: Reactome
mitotic cytokinesis Source: Ensembl
negative regulation of apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 16130169
neural crest cell migration Source: Ensembl
neural fold formation Source: Ensembl
positive regulation by host of viral process
Source: AgBase
Inferred from mutant phenotypeⁱ
- 25556234
positive regulation of actin filament depolymerization Source: Ensembl
protein phosphorylation Source: Ensembl
regulation of cell morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21834987
regulation of dendritic spine morphogenesis
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 24464040
response to amino acid Source: Ensembl
response to virus
Source: UniProtKB
Inferred from expression patternⁱ
- 16548883
Rho protein signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10436159

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-3928662 EPHB-mediated forward signaling R-HSA-399954 Sema3A PAK dependent Axon repulsion R-HSA-5627117 RHO GTPases Activate ROCKs R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkⁱ	P23528
SIGNORⁱ	P23528

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cofilin-1 Alternative name(s): 18 kDa phosphoprotein Short name: p18 Cofilin, non-muscle isoform
Gene namesⁱ	Name:CFL1 Synonyms:CFL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172757.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1874 CFL1
MIMⁱ	601442 gene
neXtProtⁱ	NX_P23528

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1072
Open Targets More...OpenTargetsⁱ	ENSG00000172757
PharmGKBⁱ	PA26423

Chemistry databases

ChEMBLⁱ	CHEMBL1075129
Drug and drug target database More...DrugBankⁱ	DB04147 Lauryl Dimethylamine-N-Oxide

Polymorphism and mutation databases

BioMutaⁱ	CFL1
DMDMⁱ	116848

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources2 Publications
ChainⁱPRO_0000214898	2 – 166	Cofilin-1Add BLAST		165

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	3	Phosphoserine; by NRKCombined sources1 Publication	1
Modified residueⁱ	8	PhosphoserineBy similarity	1
Modified residueⁱ	13	N6-acetyllysineCombined sources	1
Modified residueⁱ	25	PhosphothreonineCombined sources	1
Modified residueⁱ	41	PhosphoserineCombined sources	1
Modified residueⁱ	68	PhosphotyrosineCombined sources	1
Modified residueⁱ	73	N6-acetyllysineCombined sources	1
Cross-linkⁱ	132	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	140	PhosphotyrosineCombined sources	1
Modified residueⁱ	144	N6-acetyllysineCombined sources	1
Modified residueⁱ	156	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.By similarity2 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P23528
PaxDbⁱ	P23528
PeptideAtlas More...PeptideAtlasⁱ	P23528
PRIDEⁱ	P23528
ProteomicsDBⁱ	54128
TopDownProteomicsⁱ	P23528

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	P23528
USC-OGP 2-DE database More...OGPⁱ	P23528
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00012011
SWISS-2DPAGEⁱ	P23528
UCD-2DPAGEⁱ	P23528

PTM databases

CarbonylDBⁱ	P23528
iPTMnetⁱ	P23528
PhosphoSitePlusⁱ	P23528
SwissPalmⁱ	P23528

Miscellaneous databases

PMAP-CutDBⁱ	P23528

PMAP-CutDBⁱ

P23528

Expressionⁱ

Tissue specificityⁱ

Widely distributed in various tissues.

Inductionⁱ

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172757 Expressed in 244 organ(s), highest expression level in cerebellum
ExpressionAtlasⁱ	P23528 baseline and differential
Genevisibleⁱ	P23528 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB033687 CAB037077 HPA053761

HPAⁱ

CAB033687
CAB037077
HPA053761

Interactionⁱ

Subunit structureⁱ

Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACTB	P60709	6	EBI-352733,EBI-353944
ACTG1	P63261	8	EBI-352733,EBI-351292
ATXN1	P54253	5	EBI-352733,EBI-930964
CFL2	Q549N0	3	EBI-352733,EBI-10201319
HUNK	P57058	2	EBI-352733,EBI-3959804
LIMK1	P53667	3	EBI-352733,EBI-444403
M	P0DOE7	2	EBI-352733,EBI-10042882	From Human respiratory syncytial virus A (strain A2).
PLD1	Q13393	4	EBI-352733,EBI-2827556
PLD2	O14939	2	EBI-352733,EBI-1053996
PS1TP5BP1	Q1KLZ0	3	EBI-352733,EBI-9978131
SSH1	Q8WYL5	2	EBI-352733,EBI-1222387
YWHAZ	P63104	3	EBI-352733,EBI-347088

GO - Molecular functionⁱ

actin filament binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11812157
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107499, 156 interactors
CORUMⁱ	P23528
Database of interacting proteins More...DIPⁱ	DIP-33000N
IntActⁱ	P23528, 83 interactors
Molecular INTeraction database More...MINTⁱ	P23528
STRINGⁱ	9606.ENSP00000309629

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 19	Combined sources	11
Helixⁱ	26 – 31	Combined sources	6
Beta strandⁱ	33 – 40	Combined sources	8
Beta strandⁱ	44 – 56	Combined sources	13
Helixⁱ	57 – 59	Combined sources	3
Turnⁱ	61 – 63	Combined sources	3
Helixⁱ	67 – 74	Combined sources	8
Beta strandⁱ	77 – 79	Combined sources	3
Beta strandⁱ	81 – 90	Combined sources	10
Beta strandⁱ	95 – 104	Combined sources	10
Helixⁱ	111 – 127	Combined sources	17
Beta strandⁱ	134 – 139	Combined sources	6
Helixⁱ	140 – 144	Combined sources	5
Helixⁱ	147 – 154	Combined sources	8
Helixⁱ	155 – 157	Combined sources	3
Beta strandⁱ	160 – 165	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P23528
SMRⁱ	P23528
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P23528

EvolutionaryTraceⁱ

P23528

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 153	ADF-HPROSITE-ProRule annotationAdd BLAST		150

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	30 – 34	Nuclear localization signalSequence analysis		5

Sequence similaritiesⁱ

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1735 Eukaryota ENOG41122P5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033289
HOGENOMⁱ	HOG000039697
HOVERGENⁱ	HBG000381
InParanoidⁱ	P23528
KEGG Orthology (KO) More...KOⁱ	K05765
PhylomeDBⁱ	P23528
TreeFamⁱ	TF328601

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11286 ADF_cofilin_like, 1 hit
Gene3Dⁱ	3.40.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR017904 ADF/Cofilin IPR027234 Cofilin_1
PANTHERⁱ	PTHR11913 PTHR11913, 1 hit PTHR11913:SF17 PTHR11913:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 1 hit
PRINTSⁱ	PR00006 COFILIN
SMARTⁱ	View protein in SMART SM00102 ADF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

P23528-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE 
        60         70         80         90        100
EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV 
       110        120        130        140        150
FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA 
       160 
EKLGGSAVIS LEGKPL

Length:166

Mass (Da):18,502

Last modified:January 23, 2007 - v3

Checksum:ⁱ589EF8FC1EC13719

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PK25	E9PK25_HUMAN	Cofilin-1 Cofilin-1	CFL1	204	Annotation score:
E9PQB7	E9PQB7_HUMAN	Cofilin-1 Cofilin-1	CFL1	122	Annotation score:
E9PP50	E9PP50_HUMAN	Cofilin-1 Cofilin-1	CFL1	159	Annotation score:
G3V1A4	G3V1A4_HUMAN	Cofilin 1 (Non-muscle), isoform CRA... Cofilin 1 (Non-muscle), isoform CRA_a (Cofilin-1)	CFL1 hCG_2039457	149	Annotation score:
E9PS23	E9PS23_HUMAN	Cofilin-1 Cofilin-1	CFL1	90	Annotation score:
E9PLJ3	E9PLJ3_HUMAN	Cofilin-1 Cofilin-1	CFL1	79	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D00682 mRNA Translation: BAA00589.1 U21909 mRNA Translation: AAA64501.1 X95404 mRNA Translation: CAA64685.1 BT006846 mRNA Translation: AAP35492.1 AK097690 mRNA Translation: BAG53513.1 CH471076 Genomic DNA Translation: EAW74449.1 BC011005 mRNA Translation: AAH11005.1 BC012265 mRNA Translation: AAH12265.1 BC012318 mRNA Translation: AAH12318.1 BC018256 mRNA Translation: AAH18256.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8114.1
PIRⁱ	S12632
NCBI Reference Sequences More...RefSeqⁱ	NP_005498.1, NM_005507.2
UniGeneⁱ	Hs.170622

Genome annotation databases

Ensemblⁱ	ENST00000308162; ENSP00000309629; ENSG00000172757 ENST00000525451; ENSP00000432660; ENSG00000172757
GeneIDⁱ	1072
KEGGⁱ	hsa:1072

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P23528	Cofilin 1 (Non-muscle), isoform CRA_a		HUMAN		149	UniRef100_P23528
Uncharacterized protein (Fragment)		AILME		165
CFL1 isoform 12 (Fragment)		PONAB		160
CFL1 isoform 13 (Fragment)		PANTR		122
Uncharacterized protein		AOTNA		149
+20

Protein	Similar proteins		Species	Score	Length	Source
P23528	Cofilin-1		RAT		166	UniRef90_P45592
cofilin-1		BALAS		243
cofilin-1		MESAU		166
Cofilin-1		CRIGR		166
Uncharacterized protein		NEOLE		166
+36

Protein	Similar proteins		Species	Score	Length	Source
P23528	Cofilin-1		RAT		166	UniRef50_P45592
Cofilin-1		BOVIN		166
Cofilin-1		MACFA		166
Cofilin-1		PIG		166
Cofilin-1		SHEEP		166
+89

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Cofilin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D00682 mRNA Translation: BAA00589.1 U21909 mRNA Translation: AAA64501.1 X95404 mRNA Translation: CAA64685.1 BT006846 mRNA Translation: AAP35492.1 AK097690 mRNA Translation: BAG53513.1 CH471076 Genomic DNA Translation: EAW74449.1 BC011005 mRNA Translation: AAH11005.1 BC012265 mRNA Translation: AAH12265.1 BC012318 mRNA Translation: AAH12318.1 BC018256 mRNA Translation: AAH18256.1
CCDSⁱ	CCDS8114.1
PIRⁱ	S12632
RefSeqⁱ	NP_005498.1, NM_005507.2
UniGeneⁱ	Hs.170622

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Q8G	NMR	-	A	1-166	[»]
	1Q8X	NMR	-	A	1-166	[»]
	3J0S	electron microscopy	9.00	M/N/O/P/Q/R/S/T/U/V/W/X	1-166	[»]
	4BEX	X-ray	2.80	1	1-166	[»]
	5HVK	X-ray	3.50	B/D	2-166	[»]
	5L6W	X-ray	2.53	C	1-166	[»]
ProteinModelPortalⁱ	P23528
SMRⁱ	P23528
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107499, 156 interactors
CORUMⁱ	P23528
DIPⁱ	DIP-33000N
IntActⁱ	P23528, 83 interactors
MINTⁱ	P23528
STRINGⁱ	9606.ENSP00000309629

Chemistry databases

ChEMBLⁱ	CHEMBL1075129
DrugBankⁱ	DB04147 Lauryl Dimethylamine-N-Oxide

PTM databases

CarbonylDBⁱ	P23528
iPTMnetⁱ	P23528
PhosphoSitePlusⁱ	P23528
SwissPalmⁱ	P23528

Polymorphism and mutation databases

BioMutaⁱ	CFL1
DMDMⁱ	116848

2D gel databases

DOSAC-COBS-2DPAGEⁱ	P23528
OGPⁱ	P23528
REPRODUCTION-2DPAGEⁱ	IPI00012011
SWISS-2DPAGEⁱ	P23528
UCD-2DPAGEⁱ	P23528

Proteomic databases

EPDⁱ	P23528
PaxDbⁱ	P23528
PeptideAtlasⁱ	P23528
PRIDEⁱ	P23528
ProteomicsDBⁱ	54128
TopDownProteomicsⁱ	P23528

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1072
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308162; ENSP00000309629; ENSG00000172757 ENST00000525451; ENSP00000432660; ENSG00000172757
GeneIDⁱ	1072
KEGGⁱ	hsa:1072

Organism-specific databases

CTDⁱ	1072
DisGeNETⁱ	1072
EuPathDBⁱ	HostDB:ENSG00000172757.12
GeneCardsⁱ	CFL1
H-InvDBⁱ	HIX0009009
HGNCⁱ	HGNC:1874 CFL1
HPAⁱ	CAB033687 CAB037077 HPA053761
MIMⁱ	601442 gene
neXtProtⁱ	NX_P23528
OpenTargetsⁱ	ENSG00000172757
PharmGKBⁱ	PA26423
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1735 Eukaryota ENOG41122P5 LUCA
GeneTreeⁱ	ENSGT00440000033289
HOGENOMⁱ	HOG000039697
HOVERGENⁱ	HBG000381
InParanoidⁱ	P23528
KOⁱ	K05765
PhylomeDBⁱ	P23528
TreeFamⁱ	TF328601

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-3928662 EPHB-mediated forward signaling R-HSA-399954 Sema3A PAK dependent Axon repulsion R-HSA-5627117 RHO GTPases Activate ROCKs R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkⁱ	P23528
SIGNORⁱ	P23528

Miscellaneous databases

ChiTaRSⁱ	CFL1 human
EvolutionaryTraceⁱ	P23528
GeneWikiⁱ	Cofilin_1
GenomeRNAiⁱ	1072
PMAP-CutDBⁱ	P23528
Protein Ontology More...PROⁱ	PR:P23528
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172757 Expressed in 244 organ(s), highest expression level in cerebellum
ExpressionAtlasⁱ	P23528 baseline and differential
Genevisibleⁱ	P23528 HS

Family and domain databases

CDDⁱ	cd11286 ADF_cofilin_like, 1 hit
Gene3Dⁱ	3.40.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR017904 ADF/Cofilin IPR027234 Cofilin_1
PANTHERⁱ	PTHR11913 PTHR11913, 1 hit PTHR11913:SF17 PTHR11913:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 1 hit
PRINTSⁱ	PR00006 COFILIN
SMARTⁱ	View protein in SMART SM00102 ADF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COF1_HUMAN
Accessionⁱ	P23528Primary (citable) accession number: P23528 Secondary accession number(s): B3KUQ1, Q53Y87, Q9UCA2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 213 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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Supporting data

UniProtKB - P23528 (COF1_HUMAN)

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Cofilin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ