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UniProtKB - P23528 (COF1_HUMAN)

Entry version 235 (29 Sep 2021)
Sequence version 3 (23 Jan 2007)
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Protein

Cofilin-1

Gene

CFL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157).

In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268).

Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity).

Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987).

Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677).

Required for neural tube morphogenesis and neural crest cell migration (By similarity).

By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P23528

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-5627117, RHO GTPases Activate ROCKs
R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P23528

SIGNOR Signaling Network Open Resource

More...SIGNORi		P23528

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cofilin-1
Alternative name(s):
18 kDa phosphoprotein
Short name:
p18
Cofilin, non-muscle isoform
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFL1
Synonyms:CFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1874, CFL1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601442, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P23528

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000172757

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1072

Open Targets

More...OpenTargetsi		ENSG00000172757

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26423

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P23528, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1075129

Drug and drug target database

More...DrugBanki		DB11638, Artenimol
DB09130, Copper
DB04147, Dodecyldimethylamine N-oxide

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CFL1

Domain mapping of disease mutations (DMDM)

More...DMDMi		116848

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002148982 – 166Cofilin-1Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei3Phosphoserine; by NRKCombined sources2 Publications1
Modified residuei8PhosphoserineBy similarity1
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei25PhosphothreonineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei63Phosphothreonine1 Publication1
Modified residuei68PhosphotyrosineCombined sources1
Modified residuei73N6-acetyllysineCombined sources1
Modified residuei82Phosphotyrosine1 Publication1
Modified residuei108Phosphoserine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei140PhosphotyrosineCombined sources1
Modified residuei144N6-acetyllysineCombined sources1
Modified residuei156PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.By similarity2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P23528

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P23528

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P23528

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P23528

PeptideAtlas

More...PeptideAtlasi		P23528

PRoteomics IDEntifications database

More...PRIDEi		P23528

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54128

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P23528

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P23528

USC-OGP 2-DE database

More...OGPi		P23528

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00012011

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P23528

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P23528

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P23528

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P23528, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P23528

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P23528

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P23528

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P23528

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely distributed in various tissues.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172757, Expressed in cerebellum and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P23528, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P23528, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172757, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can bind G- and F-actin in a 1:1 ratio of cofilin to actin (PubMed:11812157). It is a major component of intranuclear and cytoplasmic actin rods (By similarity).

Interacts with the subcortical maternal complex (SCMC) via interaction with TLE6 isoform 1 and NLRP5 (By similarity).

By similarity1 Publication

(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) matrix protein; this interaction probably facilitates viral replication.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107499, 252 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P23528

Database of interacting proteins

More...DIPi		DIP-33000N

Protein interaction database and analysis system

More...IntActi		P23528, 116 interactors

Molecular INTeraction database

More...MINTi		P23528

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000432660

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P23528, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P23528

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P23528

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P23528

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi30 – 34Nuclear localization signalSequence analysis5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1735, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183000

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P23528

Identification of Orthologs from Complete Genome Data

More...OMAi		WVPSDTP

Database of Orthologous Groups

More...OrthoDBi		1370477at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P23528

TreeFam database of animal gene trees

More...TreeFami		TF328601

Family and domain databases

Conserved Domains Database

More...CDDi		cd11286, ADF_cofilin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.20.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00627

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002108, ADF-H
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR017904, ADF/Cofilin
IPR027234, Cofilin_1

The PANTHER Classification System

More...PANTHERi		PTHR11913, PTHR11913, 1 hit
PTHR11913:SF17, PTHR11913:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00241, Cofilin_ADF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00006, COFILIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00102, ADF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51263, ADF_H, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P23528-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE 
        60         70         80         90        100
EGKEILVGDV GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV 
       110        120        130        140        150
FIFWAPESAP LKSKMIYASS KDAIKKKLTG IKHELQANCY EEVKDRCTLA 
       160 
EKLGGSAVIS LEGKPL
Length:166
Mass (Da):18,502
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i589EF8FC1EC13719
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK25E9PK25_HUMAN
Cofilin, non-muscle isoform
CFL1
204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQB7E9PQB7_HUMAN
Cofilin, non-muscle isoform
CFL1
122Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1A4G3V1A4_HUMAN
Cofilin, non-muscle isoform
CFL1 hCG_2039457
149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP50E9PP50_HUMAN
Cofilin, non-muscle isoform
CFL1
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS23E9PS23_HUMAN
Cofilin, non-muscle isoform
CFL1
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLJ3E9PLJ3_HUMAN
Cofilin, non-muscle isoform
CFL1
79Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D00682 mRNA Translation: BAA00589.1
U21909 mRNA Translation: AAA64501.1
X95404 mRNA Translation: CAA64685.1
BT006846 mRNA Translation: AAP35492.1
AK097690 mRNA Translation: BAG53513.1
CH471076 Genomic DNA Translation: EAW74449.1
BC011005 mRNA Translation: AAH11005.1
BC012265 mRNA Translation: AAH12265.1
BC012318 mRNA Translation: AAH12318.1
BC018256 mRNA Translation: AAH18256.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8114.1

Protein sequence database of the Protein Information Resource

More...PIRi		S12632

NCBI Reference Sequences

More...RefSeqi		NP_005498.1, NM_005507.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308162; ENSP00000309629; ENSG00000172757
ENST00000525451; ENSP00000432660; ENSG00000172757

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1072

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Cofilin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00682 mRNA Translation: BAA00589.1
U21909 mRNA Translation: AAA64501.1
X95404 mRNA Translation: CAA64685.1
BT006846 mRNA Translation: AAP35492.1
AK097690 mRNA Translation: BAG53513.1
CH471076 Genomic DNA Translation: EAW74449.1
BC011005 mRNA Translation: AAH11005.1
BC012265 mRNA Translation: AAH12265.1
BC012318 mRNA Translation: AAH12318.1
BC018256 mRNA Translation: AAH18256.1
CCDSiCCDS8114.1
PIRiS12632
RefSeqiNP_005498.1, NM_005507.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q8GNMR-A1-166[»]
1Q8XNMR-A1-166[»]
3J0Selectron microscopy9.00M/N/O/P/Q/R/S/T/U/V/W/X1-166[»]
4BEXX-ray2.8011-166[»]
5HVKX-ray3.50B/D2-166[»]
5L6WX-ray2.53C1-166[»]
6UBYelectron microscopy7.50I1-166[»]
6UC0electron microscopy7.50I1-166[»]
6UC4electron microscopy9.20I/M/N/O/P1-166[»]
6VAOelectron microscopy3.40F/G/H/I/J1-166[»]
BMRBiP23528
SMRiP23528
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107499, 252 interactors
CORUMiP23528
DIPiDIP-33000N
IntActiP23528, 116 interactors
MINTiP23528
STRINGi9606.ENSP00000432660

Chemistry databases

ChEMBLiCHEMBL1075129
DrugBankiDB11638, Artenimol
DB09130, Copper
DB04147, Dodecyldimethylamine N-oxide

PTM databases

CarbonylDBiP23528
GlyGeniP23528, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP23528
MetOSiteiP23528
PhosphoSitePlusiP23528
SwissPalmiP23528

Genetic variation databases

BioMutaiCFL1
DMDMi116848

2D gel databases

DOSAC-COBS-2DPAGEiP23528
OGPiP23528
REPRODUCTION-2DPAGEiIPI00012011
SWISS-2DPAGEiP23528
UCD-2DPAGEiP23528

Proteomic databases

EPDiP23528
jPOSTiP23528
MassIVEiP23528
PaxDbiP23528
PeptideAtlasiP23528
PRIDEiP23528
ProteomicsDBi54128
TopDownProteomicsiP23528

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16010, 1058 antibodies

The DNASU plasmid repository

More...DNASUi		1072

Genome annotation databases

EnsembliENST00000308162; ENSP00000309629; ENSG00000172757
ENST00000525451; ENSP00000432660; ENSG00000172757
GeneIDi1072
KEGGihsa:1072

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1072
DisGeNETi1072

GeneCards: human genes, protein and diseases

More...GeneCardsi		CFL1
HGNCiHGNC:1874, CFL1
HPAiENSG00000172757, Low tissue specificity
MIMi601442, gene
neXtProtiNX_P23528
OpenTargetsiENSG00000172757
PharmGKBiPA26423
VEuPathDBiHostDB:ENSG00000172757

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1735, Eukaryota
GeneTreeiENSGT00950000183000
InParanoidiP23528
OMAiWVPSDTP
OrthoDBi1370477at2759
PhylomeDBiP23528
TreeFamiTF328601

Enzyme and pathway databases

PathwayCommonsiP23528
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-5627117, RHO GTPases Activate ROCKs
R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkiP23528
SIGNORiP23528

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1072, 394 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CFL1, human
EvolutionaryTraceiP23528

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cofilin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1072
PharosiP23528, Tbio

Protein Ontology

More...PROi		PR:P23528
RNActiP23528, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172757, Expressed in cerebellum and 257 other tissues
ExpressionAtlasiP23528, baseline and differential
GenevisibleiP23528, HS

Family and domain databases

CDDicd11286, ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
IDEALiIID00627
InterProiView protein in InterPro
IPR002108, ADF-H
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR017904, ADF/Cofilin
IPR027234, Cofilin_1
PANTHERiPTHR11913, PTHR11913, 1 hit
PTHR11913:SF17, PTHR11913:SF17, 1 hit
PfamiView protein in Pfam
PF00241, Cofilin_ADF, 1 hit
PRINTSiPR00006, COFILIN
SMARTiView protein in SMART
SM00102, ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263, ADF_H, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P23528
Secondary accession number(s): B3KUQ1, Q53Y87, Q9UCA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 235 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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